Catalytic carbon-carbon sigma-bond hydrogenolysis

Catalytic hydrogenolysis of carbon-carbon sigma bond in organic substrates represents an interesting, yet less common reduction methodology in chemical transformations. In the past few decades, there are impressive works aiming at mechanistic understanding via strategic reaction design. Efforts to expand synthetic usefulness have been observed. This digest summarizes the recent achievements in transition metal catalyzed reductive C-C sigma bond cleavage to give C-H bonds by hydrogenolysis. (C) 2016 Elsevier Ltd. All rights reserved.