期刊
TETRAHEDRON LETTERS
卷 57, 期 29, 页码 3121-3123出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2016.06.002
关键词
Koshikalide; Total synthesis; Marine cyanobacteria; Macrolide; Marine natural products
资金
- Japan Society for the Promotion of Science [24310160]
- MEXT from the Ministry of Education, Culture, Sports, Science, and Technology, Japan
The first total synthesis of koshikalide, a 14-membered macrolide that contains three olefins, was achieved. The skipped diene in the cyclic system was efficiently constructed by very mild Stille coupling at low temperature. The absolute stereochemistry was established by comparison of the specific optical rotations of natural and synthesized koshikalide. (C) 2016 Elsevier Ltd. All rights reserved.
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