期刊
TETRAHEDRON
卷 72, 期 35, 页码 5472-5478出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2016.07.031
关键词
Marine natural products; Okeania; Cyclic depsipeptide; Cytotoxicity
资金
- Ministry of Education, Culture, Sports, Science and Technology, Japan [21710237]
- University of the Ryukyus Strategic Research Grant
- Takeda Science Foundation
- Japan Society for the Promotion of Science Research Fellowships for Young Scientists [15J05499]
- Grants-in-Aid for Scientific Research [21710237, 15J05499, 15K01803] Funding Source: KAKEN
The bioassay-guided fractionation of the Okinawan marine cyanobacterium Okeania sp. led to the isolation of the 26-membered cyclodepsipeptide odoamide (1). The gross structure of 1 was determined by 1D and 2D NMR analyses, whereas its absolute stereochemistry was determined using a variety of different methods, including synthesis and chemical degradation followed by chiral HPLC analysis. Notably, odoamide (1) showed potent cytotoxicity against HeLa S3 human cervical cancer cells with an IC50 value of 263 nM. (C) 2016 Elsevier Ltd. All rights reserved.
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