期刊
CLINICAL AND EXPERIMENTAL ALLERGY
卷 46, 期 1, 页码 21-41出版社
WILEY
DOI: 10.1111/cea.12666
关键词
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资金
- Ernest S. Bazley Foundation from the National Institute of Health [U19 AI106683, R37 HL068546, R01 HL078860]
- [R01 AT007143-05]
- [R01 AA023417-02]
- [R01 AA020216-05]
- National Center for Complementary & Integrative Health [R01AT007143] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R37HL068546, R01HL078860] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [U19AI106683] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM [R01AA023417, R01AA020216] Funding Source: NIH RePORTER
Chronic rhinosinusitis (CRS) has been known as a disease with strong infectious and inflammatory components for decades. The recent advancement in methods identifying microbes has helped implicate the airway microbiome in inflammatory respiratory diseases such as asthma and COPD. Such studies support a role of resident microbes in both health and disease of host tissue, especially in the case of inflammatory mucosal diseases. Identifying interactive events between microbes and elements of the immune system can help us to uncover the pathogenic mechanisms underlying CRS. Here we provide a review of the findings on the complex upper respiratory microbiome in CRS in comparison with healthy controls. Furthermore, we have reviewed the defects and alterations of the host immune system that interact with microbes and could be associated with dysbiosis in CRS.
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