Article
Toxicology
Jochem Louisse, Patrick P. J. Mulder, Arjen Gerssen, Geert Stoopen, Deborah Rijkers, Milou G. M. van de Schans, Ad A. C. M. Peijnenburg
Summary: “The study utilized a bioassay-directed analysis approach to identify potentially toxic PAs not yet included in monitoring programs. The findings suggest that this method is effective in identifying candidate PAs with genotoxic activity.”
ARCHIVES OF TOXICOLOGY
(2022)
Article
Chemistry, Applied
Jiangyi Luo, Ling Liang, Qinling Xie, Yixing Qiu, Sai Jiang, Yupei Yang, Lijuan Zhu, Yangfen Fu, Shenghuang Chen, Wei Wang, Hanwen Yuan
Summary: This study explored the differences in phytochemical composition, bioactive properties, and antioxidant activity of five citrus by-products in China. Essential compounds for identification were established, and the spectrum-effect relationship analysis revealed the differential markers contributing to the antioxidant activity. The results highlight the potential for enhancing and utilizing citrus by-products.
Article
Chemistry, Analytical
Wenwen Huang, Zhonglian Zhang, Lu Niu, Xiaohan Hu, Tekleab Teka, Lifeng Han, Guixiang Pan, Qilong Wang
Summary: This study explored the vasorelaxation effects of different species of Uncaria on isolated rat mesenteric artery rings, identified potential vasodilative compounds through metabolite profiling and correlation analysis. The results suggest that metabolomics combined with correlation analysis is an effective strategy for rapidly discovering active compounds in traditional Chinese medicine.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2021)
Article
Chemistry, Analytical
Shai Dagan, Dana Marder, Nitzan Tzanani, Eyal Drug, Hagit Prihed, Lilach Yishai-Aviram
Summary: This study investigated the impact of matrix complexity on nontargeted detection by LC-MS/MS (Orbitrap) analysis. The results showed that detection limits for nontargets were higher in complex matrices and required higher concentrations. A quantitative method was used to assess and compare the complexity of matrices and predict the typical detection limits of unknowns.
ANALYTICAL CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Donghui Lao, Rong Liu, Jianying Liang
Summary: By applying metabolomics, potential biomarkers for AIDS patients have been identified and verified, suggesting their potential role in the diagnosis of HIV/AIDS.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Applied
Ting Zeng, Baohua Fang, Fenglin Huang, Li Dai, Zhi Tang, Jinglin Tian, Guodong Cao, Xuanlin Meng, Yuanchen Liu, Bo Lei, Minghua Lu, Zongwei Cai
Summary: Through metabolomics analysis, it was found that under cadmium stress, most carbohydrates and amino acids were down-regulated as the cadmium concentration increased in rice grains, except for myoinositol which can prevent cadmium toxicity. D-Mannitol and L-cysteine were up-regulated in low-cadmium-accumulating rice with the increase of cadmium concentration. Organic acids, especially 13-(S)-hydroperoxy-9(Z),11(E),15(Z)-octadecatrienoic acid related to alphalinolenic acid metabolism and jasmonic acid production, were activated.
Article
Biochemistry & Molecular Biology
Hassan Shikshaky, Eman Abdelnaby Ahmed, Ali Mostafa Anwar, Aya Osama, Shahd Ezzeldin, Antony Nasr, Sebaey Mahgoub, Sameh Magdeldin
Summary: This article aims to develop a novel SWATH platform for metabolite identification using accurate mass spectral library, providing new avenues for clinical diagnosis, molecular medicine, and therapeutic drug monitoring and development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
John Quinones, Rommy Diaz, Jorge F. Beltran, Lidiana Velazquez, David Cancino, Erwin Munoz, Patricio Dantagnan, Adrian Hernandez, Nestor Sepulveda, Jorge G. Farias
Summary: This study analyzed the effects of different feeds on the lipid composition of juvenile Oncorhynchus mykiss muscle and found that the inclusion of Brassica napus oil significantly increased certain lipid levels, while Durvillaea antarctica meal had a less significant impact on lipid variation.
Article
Medicine, Research & Experimental
Cheng Hu, Tao Wang, Xiaoyu Zhuang, Qiaoli Sun, Xiaochun Wang, Hui Lin, Mingli Feng, Jiaqi Zhang, Qin Cao, Yuanye Jiang
Summary: Through high-throughput mass spectrometry analysis, this study identified 15 serum metabolites strongly associated with early-stage NAFLD, which may have significant clinical implications for early diagnosis and monitoring response to therapeutic interventions for NAFLD.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Environmental Sciences
Hyeon-Jeong Lee, Jonghwa Jin, Yoondam Seo, Inseon Kang, Junghyun Son, Eugene C. Yi, Hophil Min
Summary: This study explores the metabolic profiles of rats exposed to DEHP, revealing the specific toxic effects of DEHP based on sex and sexual maturity. The study shows disruptions to steroid hormone and primary bile acid biosynthesis, as well as associations with heart, liver, and kidney damage. The findings contribute to our understanding of the health risks associated with DEHP exposure.
Article
Food Science & Technology
Pufan Zheng, Mei Zhang, Xin Fang, Lili Tang, Zhixue Wang, Fuchen Shi
Summary: This study identified and quantified metabolites in three pear species using a targeted LC-MS/MS approach. The results showed distinct differences in metabolite composition between cultivars, and identified metabolic pathways related to fruit quality. D-xylose, formononetin, procyanidin A1 and beta-nicotinamide mononucleotide were identified as major differentially expressed metabolites.
Article
Horticulture
Yun Liu, Fangmeng Zhao, Zheng Zhang, Tian Li, Haipeng Zhang, Juan Xu, Junli Ye, Xiuxin Deng
Summary: The study revealed the structural diversity and tissue distribution of limonoids in pummelo fruit, with seeds containing the most abundant limonoids and the flavedo accumulating fewer major limonoids. Significant positive correlations were found between juice vesicles and seeds, as well as between albedo and segment membranes in limonoid metabolism. The research also identified potential biomarkers for limonoid characterization in different tissues or parts.
SCIENTIA HORTICULTURAE
(2021)
Article
Endocrinology & Metabolism
Ivayla Roberts, Marina Wright Muelas, Joseph M. Taylor, Andrew S. Davison, Yun Xu, Justine M. Grixti, Nigel Gotts, Anatolii Sorokin, Royston Goodacre, Douglas B. Kell
Summary: This study utilizes untargeted metabolomics analysis to evaluate 120 samples of COVID-19 patients and predict the severity and outcome of the infection. The study identifies a group of metabolites with relevant biological functions, such as deoxycytidine and ureidopropionate (indirectly reflecting viral load), kynurenine (reflecting host inflammatory response), and multiple short chain acylcarnitines (energy metabolism) that can predict disease severity and outcome.
Article
Biochemistry & Molecular Biology
Zhaoxin Li, Yunlong Cheng, Jinxin Chen, Weijun Xu, Wentao Ma, Sheng Li, Erxia Du
Summary: Insect metabolites are essential for regulating the physiology, behavior, and adaptations of insects, but the systematic metabolomics within insects remains unclear. This study used HPLC-MS/MS technology to perform a comprehensive metabolomics analysis and constructed an integrated metabolic database of nine insect species with different metamorphosis types. A total of 1442 metabolites were identified, including amino acids, organic acids, fatty acids, glycerophospholipids, nucleotides, and benzene derivatives. The metabolites were enriched in important pathways related to arachidonic acid metabolism, tyrosine metabolism, phenylalanine metabolism, and insect hormone biosynthesis. The study revealed a correlation between the evolutionary relationships of species and the types of metabolites present, while the quantities of metabolites varied greatly among species. The metabolome of these representative insects provides a valuable platform for studying insect systemic metabolites and biological events at the metabolic level.
Review
Agronomy
Anjar Windarsih, Abdul Rohman, Florentinus Dika Octa Riswanto, Dachriyanus, Nancy Dewi Yuliana, Nor Kartini Abu Bakar
Summary: Halal meats are allowed to be consumed by Muslim societies according to Islamic law. This study focuses on the recent application of LC-MS/MS combined with chemometrics for the detection and identification of non-halal meats in food products. The results show that chemometrics analysis can identify potential biomarkers of non-halal meats.
Article
Genetics & Heredity
Songbiao Zhu, Wenxi Ding, Yuling Chen, Weixuan Wang, Renhua Xu, Chongdong Liu, Xiaohui Liu, Haiteng Deng
Summary: High expression of VHL is correlated with better disease-free survival in ccRCC patients. VHL overexpression inhibits EMT, triglyceride synthesis, and cell proliferation in ccRCC cells, and renders them more sensitive to interferon treatment.
GENOMICS PROTEOMICS & BIOINFORMATICS
(2022)
Letter
Cell Biology
Shuyuan Zhang, Qingtai Liang, Xinheng He, Chongchong Zhao, Wenlin Ren, Ziqing Yang, Ziyi Wang, Qiang Ding, Haiteng Deng, Tong Wang, Linqi Zhang, Xinquan Wang
Article
Biochemistry & Molecular Biology
Chengting Luo, Changmei Yang, Xueying Wang, Yuling Chen, Xiaohui Liu, Haiteng Deng
Summary: Research showed that nicotinamide supplementation can reduce fat mass in obese mice, improve glucose tolerance, and enhance mitochondrial function in adipose tissue. Nicotinamide activates NAMPT and increases cellular NAD(+) levels to reprogram cellular metabolism for better adipose tissue function.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Biochemical Research Methods
Yingying Ma, Songbiao Zhu, Meiqi Yi, Wenhao Zhang, Yuanyuan Xue, Xiaohui Liu, Haiteng Deng
Summary: Protein S-glutathionylation is an important post-translational modification that regulates cellular processes. This study investigated the changes in glutathionylome during epithelial-mesenchymal transition (EMT) and found that the glutathionylation level of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) increased, inhibiting its enzymatic activity and promoting EMT.
JOURNAL OF PROTEOME RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Yaqi Chen, Sha Zhou, Kairui Wan, Long Yu, Chongchong Zhao, Haiteng Deng, Qingjian Ou, Jiayi Qin, Junbo Hu, Zhenlin Hou
Summary: RIO kinase 1 (RIOK1) plays an important role in the radioresistance of colorectal cancer (CRC) by suppressing the p53 signaling pathway. Targeting RIOK1 may alleviate the CRC tumor burden in patients. This study also revealed the interaction between RIOK1 and G3BP2, and the phosphorylation of G3BP2 by RIOK1 enhances the ubiquitination of p53.
Review
Cell Biology
Weixuan Wang, Changmei Yang, Tianxiang Wang, Haiteng Deng
Summary: Nicotinamide N-methyltransferase (NNMT) plays critical roles in cancer progression by affecting cellular methylation reactions and signaling pathways, and it has been identified as a potential biomarker and therapeutic target for tumor diagnosis and treatment.
CELL DEATH & DISEASE
(2022)
Article
Cell Biology
Chengting Luo, Wenxi Ding, Songbiao Zhu, Yuling Chen, Xiaohui Liu, Haiteng Deng
Summary: It has been reported that the activities of NAD(+)-dependent deacetylase decrease in the aging mouse liver, while NMN treatment can increase healthspans. However, the changes in the acetylomic landscape and the effects of NMN treatment on protein acetylation in the aging liver have not been studied. In this study, immunoprecipitation coupled with label-free quantitative LC-MS/MS was used to identify the acetylome and investigate the effects of aging and NMN on liver protein acetylation. The results showed that the acetylation levels of proteins involved in oxidation-reduction and metabolic processes increased in aged livers, while the acetylation levels of proteins involved in transport and translation processes decreased. NMN treatment inhibited the age-related increase in acetylation of proteins regulating fatty acid beta oxidation, the TCA cycle and valine degradation.
Article
Biochemical Research Methods
Chengting Luo, Wenxi Ding, Changmei Yang, Wenhao Zhang, Xiaohui Liu, Haiteng Deng
Summary: In this study, the researchers found that the oxidation-reduction process was associated with aging in the mouse liver. They also discovered that oxidative stress activates Nrf2 and its downstream genes, but supplementation of NMN reduced oxidative stress and restored adaptive homeostasis through the Sirt3-Nrf2 axis.
JOURNAL OF PROTEOME RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Shengli Zhuang, Dong Chen, Wentao Fan, Jinyun Yuan, Lingwen Liao, Yan Zhao, Jin Li, Haiteng Deng, Jun Yang, Jinlong Yang, Zhikun Wu
Summary: This study proposes the concept of single-atom-kernelled nanoclusters and synthesizes a Pd-based trimetal nanocluster with a single-Ag atom-kernel using an alloying strategy. The nanoclusters with single-silver atom kernels exhibit higher activity and selectivity compared to the bimetal precursor nanoclusters. The single atoms in the kernel have significant influence on catalytic performance by affecting the electronic configuration.
Article
Nanoscience & Nanotechnology
Jun Zha, Xiangfu Meng, Wentao Fan, Qing You, Nan Xia, Wanmiao Gu, Yan Zhao, Lin Hu, Jin Li, Haiteng Deng, Hui Wang, Nan Yan, Zhikun Wu
Summary: In this study, surface site specific antigalvanic replacement with remaining composition/structure and surface replacement-dependent selectivity in the electrocatalytic reduction of CO2 was achieved for the first time. Density functional theory calculations explained the catalysis selectivity switch induced by replacing Ag with Cu and the facilitation of C2 production by Cu replacement. Furthermore, CO2 electroreduction to C2 on well-defined metal nanoclusters was reported for the first time in this study.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Physical
Wentao Fan, Ying Yang, Qing You, Jin Li, Haiteng Deng, Nan Yan, Zhikun Wu
Summary: There are unresolved fundamental issues regarding metal nanoclusters, including the transformation from face-centered cubic (fcc) to hexagonal close-packed (hcp) structures and photoexcitation electron transfer. This study successfully achieved the fcc-to-hcp structure transformation and revealed size and shape-dependent photoexcitation electron transfer for metal nanoclusters. A new thermally induced ligand exchange method was developed to synthesize a rod-shaped hcp Au42(SCH2Ph)32 nanocluster, which exhibited specific absorption and dual emission properties. The findings also suggest a possible structure transformation pathway and predict a novel rod-shaped hcp Au58(SR)40 nanocluster with a larger aspect ratio. Additionally, a kernel-based middle-to-both ends sp <- sp photoexcitation electron transfer mechanism was observed in rod-like gold nanoclusters, indicating the potential for tunable and practical applications.
JOURNAL OF PHYSICAL CHEMISTRY C
(2023)
Article
Biochemical Research Methods
Xueying Wang, Chengting Luo, Lina Xu, Yusong Wang, Lv Jun Guo, Yupei Jiao, Haiteng Deng, Xiaohui Liu
Summary: Isotope tracing assisted metabolic analysis is a useful tool to understand metabolic regulation. This study presents a strategy called pseudo-targeted profiling of isotopic metabolomics (PtPIM) to expand the analysis of isotope labeled metabolites. The PtPIM method successfully broadened metabolite coverage in isotope tracing analysis and revealed the effects of rotenone on mitochondrial function.
JOURNAL OF CHROMATOGRAPHY A
(2023)
Article
Biochemistry & Molecular Biology
Zhiwen Zhu, Dongdong Li, Zeran Jia, Wenhao Zhang, Yuling Chen, Ruixue Zhao, Yan-Ping Zhang, Wen-Hong Zhang, Haiteng Deng, Yinqing Li, Wei Li, Shouhong Guang, Guangshuo Ou
Summary: Eukaryotic organisms adapt to environmental fluctuations by altering their epigenomic landscapes and transcriptional programs. Histone H2Bs are globally degraded in Caenorhabditis elegans during starvation, and the mechanisms underlying this degradation involve ubiquitin and ubiquitin-related enzymes. The retention of aberrant nucleosomal H2Bs leads to abnormal gene expression and impacts animal viability. Furthermore, the ubiquitin-proteasome system regulates chromosomal histone turnover in human cells.
Article
Multidisciplinary Sciences
Qian Gong, Yunjing Wang, Linfang He, Fan Huang, Danfeng Zhang, Yan Wang, Xiang Wei, Meng Han, Haiteng Deng, Lan Luo, Feng Cui, Yiguo Hong, Yule Liu
Summary: This study reveals the mechanism of airborne defense (AD) against aphids and viruses. The volatile compound MeSA is perceived by neighboring plants and converted into salicylic acid, which activates a signaling cascade to induce plant anti-aphid immunity and reduce virus transmission. Aphid-transmitted viruses encode proteins that suppress AD, making plants less repellent to aphids and more suitable for aphid survival, infestation, and viral transmission.
Article
Biochemistry & Molecular Biology
Huaijin Zhang, Yuling Chen, Xiaohui Liu, Haiteng Deng
Summary: This study found that mitochondrial dysfunction, rotenone treatment, elevated Ca2+ levels, and activation of the JNK-STAT3 pathway all contribute to increased resistance of glioblastoma to TMZ. Inhibiting JNK or STAT3 can increase sensitivity to TMZ. Co-administration of TMZ with a JNK or STAT3 inhibitor holds promise as an effective treatment for glioblastoma.
Article
Chemistry, Analytical
Qian Wu, Li Tian, Xiangyu Shan, Huiling Li, Chao Li, Juan Lu
Summary: A novel ECL sensor was developed by modifying Fe3CuO4-Ru(bpy)3+ and GO-CdS@ZnS on the electrode for the detection of permethrin. The sensor exhibited high sensitivity and a wide detection range.
Article
Chemistry, Analytical
Tingting Gong, Lei Liao, Bingying Jiang, Ruo Yuan, Yun Xiang
Summary: In this study, a fluorescent biosensing system for high sensitivity detection of MT was established using a new Ag+-stabilized DNA triplex probe (Ag+-SDTP) combined with catalytic hairpin assembly (CHA) and CRISPR/Cas12a signal enhancements. The sensing method is able to selectively detect MT from other non-specific molecules and can achieve low level detection of MT in diluted human serums, demonstrating its potential for monitoring disease-specific MT biomarker at trace levels.
Article
Chemistry, Analytical
Estrella Sanz Rodriguez, Kyra Wood, Paul R. Haddad, Brett Paull
Summary: This study presents a simple, rapid, and reliable method for determining boron in aqueous solutions using suppressed ion chromatography coupled to electrospray ionisation-triple quadrupole mass spectrometry. The method achieved a low limit of detection and demonstrated excellent analytical performance.
Article
Chemistry, Analytical
Aline Cournut, Paul Moustiez, Yannick Coffinier, Christine Enjalbal, Claudia Bich
Summary: Alzheimer's disease is a major cause of senile dementia and is characterized by the aggregation of neurofibrillary tangles and amyloid plaques in the brain. The A beta 1-42 peptide is considered the primary cause of neurotoxicity due to its insolubility and subsequent aggregation. A beta 1-42 and A beta 1-40 have been identified as relevant biomarkers for AD diagnosis, and SurfaceAssisted Laser Desorption/Ionization Mass Spectrometry (SALDI-MS) was used to monitor the A beta 1-42/A beta 1-40 ratio without prior sample treatment.
Article
Chemistry, Analytical
Dotse Selali Chormey, Buse Tugba Zaman, Tulay Borahan Kustanto, Sezin Erarpat Bodur, Suleyman Bodur, Elif Ozturk Er, Sezgin Bakirdere
Summary: This review provides an overview of the harmful effects of endocrine disrupting chemicals (EDCs) on human health and introduces the methods for analyzing EDCs. Recent research has focused on using green chemicals, such as deep eutectic solvents (DESs), for microextraction to ensure environmental safety.
Article
Chemistry, Analytical
Yan Zhang, Renfeng Xu, Jingjing Wu, Zhenghong Zhang, Yuhuang Wang, Hongqin Yang, Sheng Zhang
Summary: This study visualized the pore-like structures in prostate cancer cell membranes after treatment with the anticancer drug paclitaxel, demonstrating its mechanism of action related to oxidative damage.
Article
Chemistry, Analytical
Chihong Ma, Qin Zhou, Jinjin Shi, Hua Gao, Di Huang, Huimin Xue, Han Wang, Zhenzhong Zhang, Sen Yang, Junli Zhang, Kaixiang Zhang
Summary: We developed a CRISPR-empowered electrochemical biosensor, named PER-E-CRISPR, for amplification-free and sensitive detection of miR-21. The biosensor combines the advantages of CRISPR/Cas13a and primer exchange reaction (PER) for target amplification. Under optimized conditions, the PER-E-CRISPR assay exhibits a linear range from 10-13 to 10-7 M and a limit of detection of 30.2 fM. The biosensor shows excellent performance in actual plasma, indicating promising prospects for miRNA detection in molecular diagnosis.
Article
Chemistry, Analytical
Gang Liang, Jie Zhao, Yufei Gao, Tao Xie, Jianhui Zhen, Ligang Pan, Wenwen Gong
Summary: Molecular docking (MD) analysis is widely used for studying the interaction between aptamers and small molecules. This study established steady-state aptamers of tertiary structures (SATS) using specific aptamers of tetracycline antibiotics as docking models. Molecular docking results revealed multiple binding sites in the SATS of aptamers, with significant variations in binding free energy (BFE) and docking score (DS). The study also proposed a method for MD analysis based on SATS, providing insights into binding mode and predicting binding sites.
Article
Chemistry, Analytical
Yixuan Xu, Changchang Teng, Huiping Dang, Dalong Yin, Lifeng Yan
Summary: Stable organic radical molecules with high NIR fluorescence quantum efficiency have been synthesized and encapsulated into nanoparticles, which show great potential for both photodynamic therapy (PDT) and photothermal therapy (PTT) of tumors.
Article
Chemistry, Analytical
Yu Su, Dandan Yang, Yanjie Wang, Jie Ding, Lan Ding, Daqian Song
Summary: In this study, a highly selective molecularly imprinted polymer Cu-MIPs@CS was designed and synthesized for bisphenol A (BPA). Cu-MIPs@CS showed significantly enhanced imprinting factor and selective factor towards BPA compared to MIPs@CS. It also exhibited superior discrimination ability between BPA and its structural analogue. Additionally, Cu-MIPs@CS were successfully applied as a solid phase extraction adsorbent for the determination of BPA in drinking water samples.
Article
Chemistry, Analytical
Yi Qiao, Qiongdan Zhang, Yukun He, Tianguang Cheng, Jing Tu
Summary: Single cell heterogeneity plays an important role in many biological phenomena, and distinguishing cells with specific mutations is beneficial for clinical diagnosis and drug screening. This study introduces a gel plate platform that can distinguish cell types based on their phenotypes, with low equipment requirement. The gel platform has potential in point-of-care circumstances and single-cell stimulation responses that prioritize efficiency and simplicity.
Article
Chemistry, Analytical
Chengke Wang, Shuyang Sun, Ping Wang, Huawei Zhao, Wenling Li
Summary: The food safety of aquatic products is a global concern. Nanotechnology-based analyses have advantages in the detection of bacteria, metal ions, and small molecule contaminants. This review summarizes the recent advances in biosensing strategies for aquatic products and highlights the application of nanomaterials, lateral flow-based biosensors, surface-enhanced Raman scattering, microfluidic chips, and molecular imprinting technologies.
Article
Chemistry, Analytical
Liping Zhu, Zeng Tang, Xuemei Zhang, Li Zhu, Tian Meng, Linying Yu, Ting Xiao, Shasha Lu, Xiaoli Xiong, Xiurong Yang
Summary: A sensitive off-on electrochemiluminescence DNA sensor was developed using Exo III-assisted cascade amplification system. The sensor achieved high selectivity and ultra-high sensitivity in detecting target DNA by utilizing ECL and SPR effects. This study provides a new perspective for designing highly sensitive and programmable ECL biosensors.
Article
Chemistry, Analytical
Tong Li, Mengxu Sun, Suping Xia, Ting Huang, Rong-Tian Li, Chunrong Li, Zong Dai, Jin-Xiang Chen, Jun Chen, Nuan Jia
Summary: Here, we developed a binary system based on DNA tetrahedron and fluorogenic RNA aptamers for highly specific and label-free mRNA imaging in living cells. This system achieved high specificity label-free detection of nucleic acids with a detection limit of 1.34 nM. The method has potential applications in early disease diagnosis and new drug development.
Article
Chemistry, Analytical
Yao Zhao, Shu Zhang, Wang Yao, Yuxuan Zhu, Jing Qian, Juan Yang, Nianjun Yang
Summary: A new hierarchical nanostructured composite with high conductivity and catalytic activity is synthesized. The sensor exhibits significant catalytic effect and high sensitivity for monitoring the environmental endocrine disruptor bisphenol A (BPA).
