Article
Cardiac & Cardiovascular Systems
Nicholas H. Adamstein, Jean G. MacFadyen, Lynda M. Rose, Robert J. Glynn, Amit K. Dey, Peter Libby, Ira A. Tabas, Nehal N. Mehta, Paul M. Ridker
Summary: The study demonstrates that the neutrophil-lymphocyte ratio (NLR) can predict cardiovascular events and mortality risk, and can be reduced by anti-inflammatory therapy with canakinumab.
EUROPEAN HEART JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Zsolt Bagyura, Loretta Kiss, Arpad Lux, Csaba Csobay-Novak, Adam L. Jermendy, Livia Polgar, Adam G. Tabak, Pal Soos, Zsolt Szelid, Bela Merkely, Laszlo Kohidai, Eva Pallinger
Summary: Several inflammatory biomarkers are associated with an increased risk of cardiovascular disease. Neutrophil-to-lymphocyte ratio (NLR) and visceral adiposity index (VAI) are markers of subclinical inflammation and reflect the function and extent of adipose tissue. This study aimed to examine the association between NLR and coronary artery calcium score (CACS) in asymptomatic patients across different VAI tertiles.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Sang-Hwa Lee, Jong-Ho Kim, Young-Suk Kwon, Jong-Hee Sohn
Summary: The study found that peripheral inflammatory markers (PIMs) significantly increased during migraine attacks, indicating that inflammation may play a role in migraines. Among different markers, NLR and NMR had poor ability to differentiate between migraine and non-migraine headaches, but performed well in distinguishing migraines from other types of headaches.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Qiang Hu, Weipu Mao, Tiange Wu, Zhipeng Xu, Junjie Yu, Can Wang, Saisai Chen, Shuqiu Chen, Bin Xu, Yueshuang Xu, Ming Chen
Summary: In RCC patients undergoing laparoscopic partial or radical nephrectomy, NLR and PLR were identified as biomarkers of systemic inflammation associated with increased risk of sarcopenia. The best cutoff points for predicting sarcopenia risk were NLR >2.88 and PLR >135.63, with higher levels indicating a greater risk. Adjusting for various variables, patients with NLR >2.88 and PLR >135.63 had significantly higher risks of developing sarcopenia compared to those with lower NLR or PLR levels.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, General & Internal
Murat Sahin, Ayten Oguz, Dilek Tuzun, Okay Isiktas, Songul Isiktas, Cansu ulgen, Hatice Sahin, Kamile Gul
Summary: This study aimed to investigate whether the neutrophil-lymphocyte ratio (NLR), an indicator of systemic inflammation, could predict gestational diabetes mellitus (GDM). The results showed a significant increase in NLR in the 1st and 3rd trimesters in the GDM group, supporting the presence of systemic inflammation in early pregnancy and throughout pregnancy. The study also found a positive correlation between NLR and fasting plasma glucose and body mass index in both trimesters. The first trimester NLR was found to independently predict the development of GDM.
Article
Immunology
Qian Song, Song-Xiao Xu, Jun-Zhou Wu, Lin Ling, Sheng Wang, Xin-Hua Shu, Dan-Ni Ying, Wang-Wei Pei, Yu-Chen Wu, Su-Fang Sun, Yi-Ning Zhang, Si-Hang Zhou, Zhu-Yan Shao
Summary: This study analyzed data from 991 ovarian cancer patients and found that the lymphocyte to monocyte ratio (LMR) and platelet to neutrophil ratio (PNR) were independent prognostic indicators of ovarian cancer. In contrast, the platelet to lymphocyte ratio (PLR) and systemic immune-inflammation index (SII) had limited prognostic value. In conclusion, LMR and PNR are superior prognostic indicators in ovarian cancer.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Tetsuya Akaishi, Tatsuro Misu, Kazuo Fujihara, Naoki Nakaya, Tomohiro Nakamura, Mana Kogure, Rieko Hatanaka, Fumi Itabashi, Ikumi Kanno, Toshiyuki Takahashi, Hiroshi Kuroda, Juichi Fujimori, Yoshiki Takai, Shuhei Nishiyama, Kimihiko Kaneko, Tadashi Ishii, Masashi Aoki, Ichiro Nakashima, Atsushi Hozawa
Summary: Patients with multiple sclerosis showed elevated counts of total white blood cells, monocytes, basophils, and neutrophils at the time of diagnosis. However, the clinical relevance of these biomarkers in the context of the development and progression of MS remains unclear.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Aysun Firat, Aysegul Ercan, Cengiz Mordeniz, Fatma Ferda Verit Atmaca
Summary: This study aimed to investigate whether the pretreatment hemogram parameters and their ratios can predict the endometrial transformation in patients with abnormal uterine bleeding. The study found that age, postmenopausal state, obesity, diabetes, and increased estrogen exposure were risk factors for endometrial atypia and carcinoma. Hemoglobin and hematocrit levels were significantly higher in early and advanced endometrial cancer groups, while platelet value was significantly higher in atypia and carcinoma groups.
Review
Immunology
Tracy Bhikram, Paul Sandor
Summary: The review found that NLR is elevated in certain adult psychiatric disorders like schizophrenia, major depressive disorder, and bipolar disorder, but the associations with symptom severity and clinical parameters are not entirely clear. Results in youth populations are similar to those in adults, indicating a need for further research to better understand the relationship between NLR and specific psychiatric disorders. Future work is required to determine the neuroinflammatory mechanisms underlying these disorders.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Medicine, Research & Experimental
Necati Uzun, Mehmet Akif Akinci
Summary: This study found that levels of white blood cells and neutrophils were significantly higher in children and adolescents with anxiety disorders compared to the control group. In addition, ratios such as neutrophil/lymphocyte, monocyte/lymphocyte, and platelet/lymphocyte were also significantly higher in the anxiety disorder group. Other hematological markers did not show significant differences between the study groups, except for RDW-CV which was higher in the AD-NOS group compared to GAD. These results suggest an association between inflammation and anxiety disorders, indicating that hematological parameters could potentially serve as markers for monitoring patients with anxiety disorders.
MEDICAL HYPOTHESES
(2021)
Article
Medicine, General & Internal
Hulya Albayrak
Summary: This study found that the neutrophil-to-lymphocyte ratio (NLR), neutrophil-to-monocyte ratio (NMR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII) can be important indicators for evaluating the treatment of psoriasis patients. The SII showed strong positive correlations with the NLR, NMR, and PLR. TNF-α blockers such as Adalimumab, etanercept, and infliximab were found to be especially effective on PLR, NLR, and NMR.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Veterinary Sciences
Ryan C. Fries, Saki Kadotani, Jonathan P. Stack, Leah Kruckman, Gabrielle Wallace
Summary: This study assessed the predictive value of NLR for cardiac death in cats with hypertrophic cardiomyopathy. The results showed that cats with higher NLR had a higher risk of cardiac death, and NLR was significantly associated with echocardiographic measurements.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Oncology
Zhenhua Liu, Haijue Ge, Zhilong Miao, Shoupeng Shao, Hongtai Shi, Congsong Dong
Summary: The systemic inflammation response index (SIRI) is a reliable indicator for evaluating the prognosis of patients with operable gastric cancer. The dynamic change in SIRI before and after surgery is significantly related to the prognosis of patients with gastric cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Clinical Neurology
Wenyuan Ma, Changmeng Cui, Song Feng, Genhua Li, Guangkui Han, Jilan Liu, Xianyun Qin, Yawei Hu, Mengjie Wang, Lu Zhang, Feng Jin
Summary: There appears to be a positive correlation between PLR and NLR in patients with MMD, suggesting a potential role of inflammation in the development and progression of the disease.
FRONTIERS IN NEUROLOGY
(2021)
Article
Cell Biology
Baorui Zhang, Lin Lin, Fei Yuan, Guangrong Song, Qing Chang, Zhongxue Wu, Zhongrong Miao, Dapeng Mo, Xiaochuan Huo, Aihua Liu
Summary: High neutrophil-to-lymphocyte ratio (NLR) is associated with poor outcomes and delayed cerebral ischemia (DCI) in patients with intracranial aneurysms (IAs), as well as an increased risk of rupture in unruptured aneurysms. NLR has a similar predictive ability for aneurysm size and treatment prognosis as C-reactive protein concentration. In patients with ruptured IAs and DCI, the NLR is lower at discharge compared to admission.
Article
Peripheral Vascular Disease
Sait Demirkol, Sevket Balta, Turgay Celik, Murat Unlu, Zekeriya Arslan, Mustafa Cakar, Ugur Kucuk, Atila Iyisoy, Cem Barcin, Seref Demirbas, Necmettin Kocak, Tuncer Cayci
Article
Cardiac & Cardiovascular Systems
Mohsen Mazidi, Dimitri P. Mikhailidis, Maciej Banach
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2019)
Review
Pharmacology & Pharmacy
Genovefa D. Kolovou, Gerald F. Watts, Dimitri P. Mikhailidis, Pablo Perez-Martinez, Samia Mora, Helen Bilianou, George Panotopoulos, Niki Katsiki, Teik C. Ooi, Jose Lopez-Miranda, Anne Tybjaerg-Hansen, Nicholas Tentolouris, Borge G. Nordestgaard
CURRENT VASCULAR PHARMACOLOGY
(2019)
Review
Cardiac & Cardiovascular Systems
K. I. Paraskevas, G. Geroulakos, F. J. Veith, D. P. Mikhailidis
CURRENT OPINION IN CARDIOLOGY
(2020)
Review
Pharmacology & Pharmacy
Sevket Balta
Summary: Vascular diseases are a major cause of morbidity and mortality worldwide. Endothelial dysfunction plays a key role in inflammation, coagulation, and angiogenesis in the earlier phase of vascular diseases. Various non-invasive tests and biomarkers can be used to assess endothelial function and dysfunction in relation to vascular disease.
CURRENT VASCULAR PHARMACOLOGY
(2021)
Editorial Material
Peripheral Vascular Disease
Sevket Balta
Review
Biochemistry & Molecular Biology
Niki Katsiki, Anca Pantea Stoian, Paschalis Steiropoulos, Nikolaos Papanas, Andra-Iulia Suceveanu, Dimitri P. Mikhailidis
Review
Pharmacology & Pharmacy
Juliette Raffort, Fabien Lareyre, Niki Katsiki, Dimitri P. Mikhailidis
Summary: This article is a narrative review on contrast-induced nephropathy (CIN) after non-cardiac vascular diagnostic and therapeutic procedures. The article summarizes the available literature on the definition, pathophysiology, incidence, risk factors, biomarkers, and consequences of CIN in these settings, as well as preventive strategies and alternatives to limit the use of iodinated contrast medium. This is an important field that requires further research.
CURRENT VASCULAR PHARMACOLOGY
(2022)
Letter
Andrology
Sevket Balta, Dimitri P. Mikhailidis
Article
Peripheral Vascular Disease
Ilknur Balta, Sevket Balta
Summary: In this study, researchers assessed the correlation between CAR and cIMT in patients with psoriasis vulgaris, finding that patients had higher CAR values and significantly increased cIMT, with a positive correlation between PASI scores and CAR values. CAR could be a useful clinical marker and potential cardiovascular risk indicator in these patients.
Review
Peripheral Vascular Disease
Sevket Balta
Summary: Non-alcoholic fatty liver disease (NAFLD) is a common disease characterized by excessive fat deposition in the liver. It is associated with insulin resistance, obesity, and dysregulation of hepatic fatty acid metabolism. NAFLD has been linked to atherosclerosis and may affect lipid-glucose metabolism, increasing the risk of hypertension and systemic inflammation.
Review
Pharmacology & Pharmacy
Sevket Balta, Ilknur Balta
Summary: This review assesses the relationship between inflammatory markers and COVID-19 infection, including both known and emerging markers. These markers play important roles in follow-up, treatment response assessment, and risk stratification.
CURRENT VASCULAR PHARMACOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Kosmas I. Paraskevas, J. David Spence, Dimitri P. Mikhailidis, Pier Luigi Antignani, Peter Gloviczki, Hans-Henning Eckstein, Francesco Spinelli, Francesco Stilo, Luca Saba, Pavel Poredos, Alan Dardik, Christos D. Liapis, Armando Mansilha, Gianluca Faggioli, Rodolfo Pini, Mateja K. Jezovnik, Sherif Sultan, Piotr Musia, Guillaume Goudot, George S. Lavenson, Arkadiusz Jawien, Ales Blinc, Piotr Myrcha, Jose Fernandes e Fernandes, George Geroulakos, Stavros K. Kakkos, Michael Knoflach, Robert M. Proczka, Laura Capoccia, Tatjana Rundek, Alexei S. Svetlikov, Mauro Silvestrini, Jean-Baptiste Ricco, Alun H. Davies, Vincenzo Di Lazzaro, Jasjit S. Suri, Gaetano Lanza, Gustav Fraedrich, Clark J. Zeebregts, Andrew N. Nicolaides
Summary: Current guidelines do not recommend screening for asymptomatic carotid artery stenosis (AsxCS) due to the potential risks associated with unnecessary interventions. Conversely, screening for abdominal aortic aneurysms is strongly recommended.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Review
Medicine, General & Internal
Tamara Brown, Rachel B. Forster, Marcus Cleanthis, Dimitri P. Mikhailidis, Gerard Stansby, Marlene Stewart
Summary: Cilostazol improves walking distance in patients with PAD, but may lead to side effects such as headache. The evidence on its effectiveness for serious events like amputation, revascularisation, and cardiovascular events is insufficient. There is also limited data on the comparison between cilostazol and pentoxifylline.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2021)
Article
Public, Environmental & Occupational Health
Sevket Balta, Dimitri P. Mikhailidis
AMERICAN JOURNAL OF MENS HEALTH
(2019)
