期刊
SYNTHESIS-STUTTGART
卷 49, 期 3, 页码 587-592出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0035-1562627
关键词
marmycin; anthraquinone; natural products; total synthesis; Ullmann; Friedel-Crafts
资金
- CNRS
- European Research Council [647973]
- Fondation pour la Recherche Medicale [AJE20141031486]
- Emergence Ville de Paris Program
- Ligue Nationale Contre le Cancer
A methodological study towards the total synthesis of marmycin A/B is described exploiting a commercial anthraquinone molecule as model compound. The challenging synthetic pathway uncovers a copper-catalysed Ullmann cross-coupling to attach the sugar backbone by means of C-N bond formation and, finally, an intramolecular Friedel-Crafts C-C glycosylation to successfully afford the core structure of marmycin A. This methodology has been successfully applied to the genuine anthraquinone moiety leading to the natural product and simpler structural analogues.
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