期刊
SURGERY FOR OBESITY AND RELATED DISEASES
卷 12, 期 6, 页码 1230-1235出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.soard.2016.05.008
关键词
Gastric bypass surgery; GLP-1; Hyperinsulinemia; Diabetes; Hypoglycemia
类别
资金
- National Institutes of Health [DK105379, DK083554, DK101991]
Bariatric surgery is the most effective treatment for obesity and diabetes. The 2 most commonly performed weight-loss procedures, Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy, improve glycemic control in patients with type 2 diabetes independent of weight loss. One of the early hypotheses raised to explain the immediate antidiabetic effect of RYGB was that rapid delivery of nutrients from the stomach pouch into the distal small intestine enhances enterolnsular signaling to promote insulin signaling. Given the tenfold increase in postmeal glucagon-like peptide-1 (GLP-1) response compared to unchanged integrated levels of postprandial glucose-dependent insulinotropic peptide after RYGB, enhanced meal-induced insulin secretion after this procedure was thought to be the result of elevated glucose and GLP-1 levels. In this contribution to the larger point counterpoint debate about the role of GLP-1 after bariatric surgery, most of the focus will be on RYGB. (C) 2016 American Society for Metabolic and Bariatric Surgery. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据