Article
Endocrinology & Metabolism
Zhen Yang, Dongsheng Zhang, Guangjun Shi
Summary: The optimal management of small NF-PanNETs remains disputable, and expectant observation may be a reasonable alternative to surgery. However, other important clinicopathological factors should also be considered when making the decision.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hai-bin Zhu, Pei Nie, Liu Jiang, Juan Hu, Xiao-Yan Zhang, Xiao-Ting Li, Ming Lu, Ying-Shi Sun
Summary: The study demonstrated that MRI features can be used to predict lymph node metastasis preoperatively in NF-PNETs patients, with regular shape of primary tumor and short axis of largest lymph node in the regional area being independent predictors, helping surgeons make risk stratification decisions.
INSIGHTS INTO IMAGING
(2022)
Article
Surgery
Anna Battistella, Stefano Partelli, Valentina Andreasi, Ilaria Marinoni, Diego Palumbo, Matteo Tacelli, Marco Schiavo Lena, Francesca Muffatti, Junaid Mushtaq, Gabriele Capurso, Paolo Giorgio Arcidiacono, Francesco De Cobelli, Claudio Doglioni, Aurel Perren, Massimo Falconi
Summary: This study investigated the relationship between microvessel density and aggressiveness of nonfunctioning pancreatic neuroendocrine tumors, and evaluated the ability of contrast-enhanced computed tomography and contrast-enhanced endoscopic ultrasound in predicting tumor microvessel density.
Article
Gastroenterology & Hepatology
Estela Regina Ramos Figueira, Julia Fray Ribeiro, Thiago Costa Ribeiro, Ricardo Jureidini, Guilherme Naccache Namur, Thiago Nogueira Costa, Telesforo Bacchella, Ivan Cecconello
Summary: The study analyzed the outcomes of surgical resection of 14 patients with small NF-PNETs. The results showed that surgical treatment is safe, with low mortality and high patient survival rates. Additionally, there were differences in tumor pathological grading among tumors in different locations.
GASTROENTEROLOGY RESEARCH AND PRACTICE
(2021)
Article
Oncology
Shota Amano, Teijiro Hirashita, Yoko Kawano, Haruto Nishida, Hiroki Orimoto, Masahiro Kawamura, Takahide Kawasaki, Takashi Masuda, Yuichi Endo, Masayuki Ohta, Tsutomu Daa, Masafumi Inomata
Summary: Survivin and XIAP expression correlated with the malignancy of PanNET, with XIAP expression associated with a poor prognosis. The expression of these proteins may serve as useful indicators for selecting optimal therapeutic agents in PanNET.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
In Woong Han, Jangho Park, Eun Young Park, So Jeong Yoon, Gang Jin, Dae Wook Hwang, Kuirong Jiang, Wooil Kwon, Xuefeng Xu, Jin Seok Heo, De-Liang Fu, Woo Jung Lee, Xueli Bai, Yoo-Seok Yoon, Yin-Mo Yang, Keun Soo Ahn, Chunhui Yuan, Hyeon Kook Lee, Bei Sun, Eun Kyu Park, Seung Eun Lee, Sunghwa Kang, Wenhui Lou, Sang-Jae Park
Summary: No consensus has been reached on whether nonmetastatic nonfunctioning neuroendocrine tumors of the pancreas (NF-pNETs) ≤ 2 cm should be resected or observed. This study found that NF-pNETs ≤ 2 cm have a poor prognosis after resection if the tumor is larger than 1.5 cm, Ki-67 index >= 3%, or nodal metastasis is present. NF-pNET patients with tumors ≤ 1.5 cm can be observed if the preoperative Ki-67 index is < 3% and if nodal metastasis is not suspected in preoperative radiologic studies.
Article
Surgery
Louisa Bolm, Martina Nebbia, Alice C. Wei, Amer H. Zureikat, Carlos Fernandez-del Castillo, Jian Zheng, Alessandra Pulvirenti, Ammar A. Javed, Yurie Sekigami, Natalie Petruch, Motaz Qadan, Keith D. Lillemoe, Jin He, Cristina R. Ferrone
Summary: This study compared the postoperative and long-term outcomes of parenchyma-sparing resections (PSR) and lymph node dissection with oncologic resections in patients with small nonfunctional pancreatic neuroendocrine tumors (PNET). The results showed that PSR and lymph node-sparing resections have advantages in terms of less blood loss, shorter operative times, and lower complication rates compared to oncologic resections.
Article
Medicine, General & Internal
Lina Ge, Haijin Li, Liang Dong, Guanmin Shang, Weiying Wang, Ying Li, Liping Qi, Jiangang Zhao, Dengfu Peng, Guoqi Tong
Summary: This study established a nomogram model for patients with metastatic nonfunctioning pancreatic neuroendocrine tumors (NFpNETs), which can help clinicians identify high-risk patients and more accurately assess patient survival times.
Article
Endocrinology & Metabolism
V Andreasi, S. Partelli, M. F. Manzoni, F. Muffatti, L. Di Filippo, S. Crippa, A. Corti, M. Falconi
Summary: VS-1 is a more accurate biomarker than total-CgA for assessing the effectiveness of surgical resection in NF-PanNETs. PST and VS-2 have no clinical utility in this setting.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2022)
Article
Gastroenterology & Hepatology
Hoonsub So, Sung Woo Ko, Seung Hwan Shin, Eun Ha Kim, Jimin Son, SuHyun Ha, Ki Byung Song, Hwa Jung Kim, Myung-Hwan Kim, Do Hyun Park
Summary: Compared with surgery, EUS-EA is a safer and less invasive treatment option for small nonfunctioning PNETs, with a shorter length of hospital stay.
GASTROINTESTINAL ENDOSCOPY
(2023)
Article
Medicine, General & Internal
Ryuta Shintakuya, Kenichiro Uemura, Tatsuaki Sumiyoshi, Kenjiro Okada, Kenta Baba, Takumi Harada, Yoshiaki Murakami, Masahiro Serikawa, Yasutaka Ishii, Koji Arihiro, Shinya Takahashi
Summary: This study aimed to evaluate the optimal extent of lymphadenectomy in patients with nonfunctioning pancreatic neuroendocrine neoplasms. The results showed that lymph node metastasis was the only independent factor of poor prognosis. Peri-pancreatic lymphadenectomy might be recommended for nonfunctioning pancreatic neuroendocrine neoplasms.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Woo Hyun Paik, Kyong Joo Lee
Summary: The incidence of small and asymptomatic pancreatic neuroendocrine neoplasms (PNENs) has increased due to the widespread use of high-resolution diagnostic imaging in screening programs. The management of small, nonfunctioning PNENs remains under debate, and the decision on how to manage them is challenging. This review focuses on the management of small nonfunctioning PNENs, highlighting their malignant potential and discussing the current guidelines and future directions for their management.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Hematology
Daohui Yang, Dansong Wang, Yijie Qiu, Xiaofan Tian, Dan Zuo, Yi Dong, Wenhui Lou, Wenping Wang
Summary: This retrospective study analyzed the CEUS features of nonfunctioning pNETs and compared them with PDACs. The results showed that CEUS features are helpful for preoperative non-invasive differential diagnosis of nonfunctioning pNETs.
CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
(2022)
Article
Medicine, General & Internal
Anna Caterina Milanetto, Anna-Lea Gais Zurcher, Alina David, Matteo Fassan, Claudio Pasquali
Summary: This retrospective study evaluated the possible prognostic role of clinic-pathological features and surgery in pancreatic neuroendocrine neoplasms (pNENs). The results showed that about 20% of pNENs had a size > 4 cm, 78% were nonfunctioning, and 55% had distant metastases at diagnosis. However, long-term survival of more than five years can be achieved after surgery.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Oncology
Sergio Portovedo, Leonardo Vieira Neto, Paula Soares, Denise Pires de Carvalho, Christina Maeda Takiya, Leandro Miranda-Alves
Summary: This article discusses the aggressive behavior of nonfunctioning pituitary neuroendocrine tumors (NF-PitNETs) and emphasizes the need for a comprehensive definition of aggressive NF-PitNETs based on a multifactorial combination and emerging markers.
BRAIN TUMOR PATHOLOGY
(2022)
Article
Surgery
Abdelkader Taibi, Sophiane Derbal, Sylvaine Durand Fontanier, Niki Christou, Fabien Fredon, Stephane Bouvier, Anne Fabre, Thibaud Rivaille, Denis Valleix, Muriel Mathonnet
Summary: The study showed that postoperative surgical site infections, complications of Clavien-Dindo grade III or higher, absence of fascial closure in front of the mesh, operating time longer than 180 minutes, and VHWG score higher than 2 increase the risk of incisional hernia recurrence.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Gastroenterology & Hepatology
Frederic Borie, Muriel Mathonnet, Alain Deleuze, Jean-Francois Gravie, Jean Gugenheim
Summary: The study found that the diagnosis rate of bile duct injury was significantly higher in patients who underwent IOC, while the number of therapeutic procedures was higher in patients who did not undergo IOC. The treatment cost was higher in patients who did not undergo IOC, potentially leading to significant economic losses.
JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Article
Cell Biology
Sabrina Blondy, Hugo Talbot, Sofiane Saada, Niki Christou, Serge Battu, Julie Pannequin, Marie-Odile Jauberteau, Fabrice Lalloue, Mireille Verdier, Muriel Mathonnet, Aurelie Perraud
Summary: Colorectal cancer (CRC) is the third most common cancer worldwide, and resistance to 5-fluorouracil (5-FU) can lead to poor clinical outcomes. Sortilin overexpression has been identified as a potential biomarker of 5-FU resistance in CRC, with higher levels correlating with tumor grades. This new prognostic factor may be used to combat CRC aggressiveness.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Surgery
Margaux Mekann Bouv-Hez, Aurelie Charissoux, Stephane Bouvier, Muriel Mathonnet, Niki Christou
Summary: SEP is a rare chronic fibro-inflammatory disease of the peritoneum, with poor knowledge around it. Imaging plays a helpful role in diagnosis despite its rarity.
ACTA CHIRURGICA BELGICA
(2022)
Review
Oncology
Celine Hervieu, Niki Christou, Serge Battu, Muriel Mathonnet
Summary: This review highlights the significance of colorectal cancer stem cells (CCSCs) in tumor growth, therapy resistance, and metastasis, while also discussing the methods for isolating and characterizing them, as well as ongoing clinical trials targeting CCSCs. The complexity of studying CSCs in CRC poses challenges in developing effective treatments that address therapy resistance and tumor initiation.
Review
Oncology
Clement Auger, Niki Christou, Aude Brunel, Aurelie Perraud, Mireille Verdier
Summary: Cancer stem cells (CSCs) utilize autophagy and the secretion of extracellular vesicles (EVs) to enhance their survival abilities under stressful conditions. However, targeting CSCs remains challenging due to the lack of specific markers identified. Investigating the crosstalk between autophagy and EVs secretion is crucial for better targeting of CSCs.
Review
Biochemistry & Molecular Biology
Lea Veyrune, David N. Naumann, Niki Christou
Summary: Detection of CTCs shows potential as prognostic biomarkers for CRC, with applications in survival prediction, chemotherapy resistance, and surgical planning. Both cell count and features of CTCs are promising prognosis biomarkers, and new tools are being developed to improve detection efficiency. Further research is needed to better understand the practical value of CTCs in clinical practice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biology
Niki Christou, Clement Auger, Serge Battu, Fabrice Lalloue, Marie-Odile Jauberteau-Marchan, Celine Hervieu, Mireille Verdier, Muriel Mathonnet
Summary: This review emphasizes the evolution of intraperitoneal chemotherapy for peritoneal metastasis and highlights the need for more large randomized controlled trials to demonstrate its efficacy.
Article
Medicine, Research & Experimental
Muriel Mathonnet, Mathieu Vanderstraete, Christophe Bounaix Morand du Puch, Stephanie Giraud, Christophe Lautrette, Mehdi Ouaissi, Nicolas Tabchouri, Abdelkader Taibi, Renaud Martin, Isabelle Herafa, Achille Tchalla, Niki Christou
Summary: Colorectal cancer is the second deadliest cancer in the world, with high survival rates for localized forms but poor prognosis for metastatic colorectal cancer. There is currently no efficient means of predicting the efficacy of chemotherapy protocols for this disease, leading to treatment decisions often being made based on empirical assessment.
Article
Biochemistry & Molecular Biology
Clement Auger, Aude Brunel, Tiffany Darbas, Hussein Akil, Aurelie Perraud, Gaelle Begaud, Barbara Bessette, Niki Christou, Mireille Verdier
Summary: Cancer cells secrete extracellular vesicles to communicate with their environment, with RAB27A playing a key role in this process. The study found that NanoSight technology was insufficient in detecting a decrease in EVs secretion, leading to exploration of alternative methods. Tracking EVs secretion using NTA revealed limitations in assessing secretion decrease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Gaetan Des Guetz, Thierry Landre, Marc A. Bollet, Muriel Mathonnet, Laurent Quero
Summary: Neoadjuvant chemotherapy plays a crucial role in rectal cancer patients, and the combination of oxaliplatin with fluoropyrimidine (5-FU or capecitabine) significantly improves DFS, reduces metastatic progression, and increases the rate of pathological complete response. However, close attention is needed when managing adverse events, as there is a higher risk of diarrhea with the oxaliplatin and 5-FU combination.
Article
Cell Biology
Celine Hervieu, Mireille Verdier, Elodie Barthout, Gaelle Begaud, Niki Christou, Magali Sage, Julie Pannequin, Serge Battu, Muriel Mathonnet
Summary: In this study, we used the label-free sedimentation field-flow fractionation technique to separate cell subpopulations of colorectal cancer cell lines and primary cultures based on their biophysical properties. One of the sorted cell subpopulations exhibited characteristics of cancer stem cells and showed higher tumorigenicity and frequency of tumor-initiating cells. This cancer stem cell subpopulation also displayed chemoresistance, highlighting its therapeutic relevance. The study reveals the major implication of intra-tumor cellular heterogeneity, including cancer stem cells, in treatment resistance and offers new perspectives for personalized therapy.
Article
Medicine, General & Internal
Sotirios Georgios Popeskou, Niki Christou, Sofoklis Panteleimonitis, Ed Langford, Tahseen Qureshi, Amjad Parvaiz
Summary: This study suggests that a 24-hour discharge following elective laparoscopic colorectal interventions is safe and feasible in selected patients. Standardized surgical approach and strict adherence to an enhanced recovery protocol are essential for achieving this goal.
JOURNAL OF CLINICAL MEDICINE
(2022)