Review
Medical Laboratory Technology
Adam Rossiter, Ashley La, Jay L. Koyner, Lui G. Forni
Summary: Acute kidney injury (AKI) is a commonly encountered clinical syndrome, especially in hospitalized patients, particularly those who are critically ill or who have undergone major surgery. AKI is associated with an increase in both mortality and morbidity, and efforts have focused on new biomarkers associated with AKI that may allow early recognition of this syndrome with improved patient outcomes.
CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Saiqi Qi, Jie Song, Linjun Chen, Huachun Weng
Summary: This article addresses the important roles of m6A modification in kidney diseases and its molecular mechanisms. The m6A modification has been shown to regulate RNA expression through splicing, export, attenuation, and translation initiation efficiency. Understanding the impact of m6A modification in kidney diseases can provide valuable insights for diagnosis and clinical management.
MOLECULAR MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Marya Morevati, Evandro Fei Fang, Maria L. Mace, Mehmet Kanbay, Eva Gravesen, Anders Nordholm, Soren Egstrand, Mads Hornum
Summary: This article reviews recent progress in the field of nicotinamide adenine dinucleotide (oxidized form, NAD(+)), mainly focusing on its role in acute kidney injury (AKI) and chronic kidney disease (CKD). While NAD(+) levels are reduced in AKI and conflicting results exist for CKD, increasing NAD(+) has been found beneficial for AKI. The article also discusses the compromised NAD(+) levels in renal fibrosis and senescence cells in the case of CKD. Further studies on NAD(+) in relation to AKI/CKD may provide insights for novel therapeutics, considering the urgent need for more effective treatments for patients with injured kidneys.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Urology & Nephrology
Fang Wang, Jie Ding
Summary: The use of consensus AKI criteria has improved our understanding of pediatric AKI epidemiology, and an association between AKI and CKD in pediatric populations has been endorsed. However, further studies are needed to better answer a definitive causal relationship between pediatric AKI and the subsequent development of CKD.
Article
Surgery
Stephen A. Smith, Paul E. Ronksley, Zhi Tan, Elijah Dixon, Brenda R. Hemmelgarn, W. Donald Buie, Neesh Pannu, Matthew T. James
Summary: This study found a strong association between ileostomy formation and subsequent kidney disease, leading to acute kidney injury and chronic kidney disease. Vigilance for this complication and new strategies for prevention and treatment are necessary.
Article
Biochemistry & Molecular Biology
Johanna Stoermer, Wilfried Gwinner, Katja Derlin, Stephan Immenschuh, Song Rong, Mi-Sun Jang, Nelli Shushakova, Hermann Haller, Faikah Gueler, Robert Greite
Summary: This study investigated the effects of diclofenac on the progression of AKI and long-term renal consequences in the setting of pre-existing subclinical AKI. The results showed that diclofenac aggravated renal injury in a dose and time-dependent manner and even a single dose can cause progression to chronic kidney disease.
Article
Medicine, General & Internal
Lukasz Kuzma, Anna Tomaszuk-Kazberuk, Anna Kurasz, Malgorzata Zalewska-Adamiec, Hanna Bachorzewska-Gajewska, Slawomir Dobrzycki, Marlena Kwiatkowska, Jolanta Malyszko
Summary: Patients with atrial fibrillation (AF) scheduled for coronary angiography are at higher risk of post-contrast acute kidney injury (PC-AKI), especially those with chronic kidney disease (CKD). This study found that kidney impairment was twice as common in AF patients undergoing coronary angiography, highlighting the need for extra caution in these cases.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Jin Sun Cho, Jae-Kwang Shim, Sak Lee, Jong-Wook Song, Nakcheol Choi, Sugeun Lee, Young-Lan Kwak
Summary: The study revealed that postoperative AKI in valvular heart surgery patients increases the risk of AKD and CKD development, with persistent AKI further escalating this risk. Additionally, heart failure and high right ventricular pressure postoperatively were identified as independent risk factors for CKD.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Article
Medicine, General & Internal
Chih-Hsiang Chang, Shao-Wei Chen, Jia-Jin Chen, Yi-Hsin Chan, Chieh-Li Yen, Tao Han Lee, Yu-Ting Cheng
Summary: This study found that approximately one quarter of patients undergoing surgery for acute type A aortic dissection will develop AKD. Patients with AKD, with or without AKI, are at higher risk for MAKEs and readmission. Higher-stage AKD is associated with a trend of persistent decline in kidney function.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medicine, General & Internal
Anna Faivre, Thomas Verissimo, Hannah Auwerx, David Legouis, Sophie de Seigneux
Summary: Acute and chronic kidney disease result in significant healthcare costs worldwide. Kidney metabolism undergoes profound changes during injury, potentially affecting fibrosis progression. Glucose metabolism may play a crucial role in both acute and chronic phases of renal disease.
FRONTIERS IN MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Li-Fang Chou, Huang-Yu Yang, Cheng-Chieh Hung, Ya-Chung Tian, Shen-Hsing Hsu, Chih-Wei Yang
Summary: Leptospirosis is a neglected bacterial disease caused by leptospiral infection, which has a high mortality risk. It has been found that leptospiral infections, including acute, chronic, and asymptomatic infections, are closely linked to acute and chronic kidney disease (CKD) and renal fibrosis. Leptospires infiltrate kidney cells and survive in the kidney by evading the immune system. The binding of bacterial outer membrane protein LipL32 to toll-like receptor-2 in renal tubular epithelial cells (TECs) is the most well-known pathogenic mechanism of renal tubular damage caused by leptospiral infection.
BIOMEDICAL JOURNAL
(2023)
Article
Medicine, Research & Experimental
Chih-Hung Chiang, Ching Chen, Shih-Ying Fang, Su-Chu Lin, Jaw-Wen Chen, Ting-Ting Chang
Summary: Water hydralazine protects renal proximal tubular epithelial cells against ischemia-reperfusion injury through XO/NADPH oxidase inhibition and prevents kidney damage in AKI and AKI-to-CKD mouse models. It exerts antioxidant, anti-inflammatory, and anti-fibrotic effects both in vitro and in vivo.
Article
Urology & Nephrology
George Vasquez-Rios, Wonsuk Oh, Samuel Lee, Pavan Bhatraju, Sherry G. Mansour, Dennis G. Moledina, Faris F. Gulamali, Edward D. Siew, Amit X. Garg, Pinaki Sarder, Vernon M. Chinchilli, James S. Kaufman, Chi-yuan Hsu, Kathleen D. Liu, Paul L. Kimmel, Alan S. Go, Mark M. Wurfel, Jonathan Himmelfarb, Chirag R. Parikh, Steven G. Coca, Girish N. Nadkarni
Summary: This study identified four subphenotypes of acute kidney injury (AKI) with different clinical features and biomarker profiles, which were associated with longitudinal clinical outcomes.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Review
Biochemistry & Molecular Biology
Xiaoyu Zhang, Jing Wang, Jing Zhang, Yuwei Tan, Yiming Li, Zhiyong Peng
Summary: This review discusses the mechanisms of action of exosomes derived from different cell sources in acute kidney injury (AKI). It highlights the potential of exosomes in promoting renal tubular cell regeneration and angiogenesis, regulating autophagy, suppressing inflammatory responses and oxidative stress, and preventing fibrosis. It also emphasizes the role of exosomes as potential biomarkers for diagnosing AKI and the development of exosome engineering for clinical use. However, further research is needed to fully understand the specific mechanisms of exosome actions, their delivery pathways to renal tubular cells, and the application of multi-omics research in studying AKI.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Physiology
Xue Hong, Yanni Zhou, Dedong Wang, Fuping Lyu, Tianjun Guan, Youhua Liu, Liangxiang Xiao
Summary: The study found that in vivo expression of exogenous Wnt1 before ischemia/reperfusion injury (IRI) protected mice against acute kidney injury (AKI) and impeded its progression to chronic kidney disease (CKD. In contrast, pretreatment with ICG-001 had no effect on renal Wnt/beta-catenin signaling or the progression of AKI to CKD. Exogenous Wnt1 suppressed proapoptotic proteins and reduced inflammatory responses in AKI and CKD mice.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Anesthesiology
K. Karkouti, P. Yip, C. Chan, L. Chawla, V. Rao
Review
Urology & Nephrology
Eric A. J. Hoste, John A. Kellum, Nicholas M. Selby, Alexander Zarbock, Paul M. Palevsky, Sean M. Bagshaw, Stuart L. Goldstein, Jorge Cerda, Lakhmir S. Chawla
NATURE REVIEWS NEPHROLOGY
(2018)
Letter
Critical Care Medicine
Jacob C. Jentzer, Saraschandra Vallabhajosyula, Ashish K. Khanna, Lakhmir S. Chawla, Laurence W. Busse, Kianoush B. Kashani
Letter
Critical Care Medicine
Rinaldo Bellomo, Stew Kroll, Lakhmir S. Chawla, George F. Tidmarsh
CRITICAL CARE MEDICINE
(2019)
Article
Critical Care Medicine
Lakhmir S. Chawla, Blaire Beers-Mulroy, George F. Tidmarsh
CRITICAL CARE CLINICS
(2019)
Article
Critical Care Medicine
Michael Joannidis, Lui G. Forni, Michael Haase, Jay Koyner, Jing Shi, Kianoush Kashani, Lakhmir S. Chawla, John A. Kellum
CRITICAL CARE MEDICINE
(2019)
Article
Critical Care Medicine
Kealy R. Ham, David W. Boldt, Michael T. McCurdy, Laurence W. Busse, Raphael Favory, Michelle N. Gong, Ashish K. Khanna, Stefan N. Chock, Feng Zeng, Lakhmir S. Chawla, George F. Tidmarsh, Marlies Ostermann
ANNALS OF INTENSIVE CARE
(2019)
Article
Critical Care Medicine
O. G. Rewa, S. M. Bagshaw, X. Wang, R. Wald, O. Smith, J. Shapiro, B. McMahon, K. D. Liu, S. A. Trevino, L. S. Chawla, J. L. Koyner
JOURNAL OF CRITICAL CARE
(2019)
Article
Critical Care Medicine
Eric Hoste, Azra Bihorac, Ali Al-Khafaji, Luis M. Ortega, Marlies Ostermann, Michael Haase, Kai Zacharowski, Richard Wunderink, Michael Heung, Matthew Lissauer, Wesley H. Self, Jay L. Koyner, Patrick M. Honore, John R. Prowle, Michael Joannidis, Lui G. Forni, J. Patrick Kampf, Paul McPherson, John A. Kellum, Lakhmir S. Chawla
INTENSIVE CARE MEDICINE
(2020)
Article
Urology & Nephrology
Jesus Rivero, Francisco Rodriguez, Virgilia Soto, Etienne Macedo, Lakhmir S. Chawla, Ravindra L. Mehta, Sucheta Vaingankar, Pranav S. Garimella, Carlos Garza, Magdalena Madero
Article
Urology & Nephrology
Lakhmir S. Chawla
Article
Critical Care Medicine
Rinaldo Bellomo, Richard G. Wunderink, Harold Szerlip, Shane W. English, Laurence W. Busse, Adam M. Deane, Ashish K. Khanna, Michael T. McCurdy, Marlies Ostermann, Paul J. Young, Damian R. Handisides, Lakhmir S. Chawla, George F. Tidmarsh, Timothy E. Albertson
Article
Cardiac & Cardiovascular Systems
Peter A. McCullough, Marlies Ostermann, Lui G. Forni, Azra Bihorac, Jay L. Koyner, Lakhmir S. Chawla, Jing Shi, J. Patrick Kampf, Paul McPherson, John A. Kellum
CARDIORENAL MEDICINE
(2019)
Article
Pharmacology & Pharmacy
Marlies Ostermann, Lakhmir S. Chawla, Lui G. Forni, Sandra L. Kane-Gill, John A. Kellum, Jay Koyner, Patrick T. Murray, Claudio Ronco, Stuart L. Goldstein
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2018)
Article
Biotechnology & Applied Microbiology
Blaithin A. McMahon, Jay L. Koyner, Tessa Novick, Steve Menez, Robert A. Moran, Bonnie E. Lonze, Niraj Desai, Sami Alasfar, Marvin Borja, William T. Merritt, Promise Ariyo, Lakhmir S. Chawla, Edward Kraus
Article
Medical Laboratory Technology
Jiansheng Lin, Weihua Lin, Yiming Lin, Weilin Peng, Zhenzhu Zheng
Summary: This study retrospectively analyzed the cases of Chinese infants with NICCD and identified multiple genetic mutations. The study also found comorbidity of NICCD and other inborn errors of metabolism in some patients.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Lihua Guan, Wei Su, Jian Zhong, Ling Qiu
Summary: Multiple myeloma is characterized by excessive production of monoclonal immunoglobulins. Routine screening methods are insufficient for detecting low levels of M proteins, but advances in mass spectrometry enable reliable detection of low abundance serum biomarkers for minimal residual disease assessment in multiple myeloma.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Liya Zhu, Chao Zhu, Jialie Jin, Jinxin Wang, Xiaojing Zhao, Rongxi Yang
Summary: This study found an association between blood-based ITGB2 methylation and coronary heart disease (CHD), with hypomethylation of ITGB2 being a risk factor for CHD. Additionally, the combination of ITGB2 methylation and conventional CHD risk factors could efficiently discriminate CHD patients from controls.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
H. Al Habobe, E. B. Haverkort, K. Nazmi, A. P. Van Splunter, R. H. H. Pieters, F. J. Bikker
Summary: Saliva diagnostics have become popular due to their non-invasive nature and patient-friendly collection process. However, the choice of saliva collection method can affect the measured levels of various biomarkers.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Abdurrahman Coskun, Anna Carobene, Ozlem Demirelce, Michele Mussap, Federica Braga, Ebru Sezer, Aasne Karine Aarsand, Sverre Sandberg, Pilar Fernandez Calle, Jorge Diaz-Garzon, Metincan Erkaya, Cihan Coskun, Esila Nur Erol, Hunkar Dag, Bill Bartlett, Mustafa Serteser, Niels Jonker, Ibrahim Unsal
Summary: In this study, BV estimates for 22 AAs were provided based on a large sample size, and it was found that there are differences in CVI estimates between males and females for most AAs, which has implications for the clinical interpretation and use of AAs.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Valentinus Besin, Farizky Martriano Humardani, Trilis Yulianti, Matthew Justyn
Summary: The study of Parkinson's Disease in Asian populations has revealed the impact of genetic variants on multiple biological pathways and highlighted shared genetic susceptibility with other diseases. These findings emphasize the importance of personalized treatment based on individual genetic profiles.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Simona Ferraro, Sara Benedetti, Savina Mannarino, Santica Marcovina, Elia Mario Biganzoli, Gianvincenzo Zuccotti
Summary: Risk stratification for cardio-vascular disease should be implemented in childhood to promote early prevention strategies, as atherosclerotic lesions can be present even in very young individuals. Evaluating pediatric CV risk factors/clinical conditions and conducting lipid profile and genetic testing can help identify children at risk of future CV events and guide appropriate therapeutic options.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Ahmad Mobed, Bita Abdi, Sajjad Masoumi, Mohammad Mikaeili, Elham Shaterian, Hamed Shaterian, Esmat Sadat Kazemi, Mahdiye Shirafkan
Summary: Reproductive biomarkers play important regulatory roles in women. The discovery and quantification of these biomarkers are clinically significant. Various detection strategies, including nanotechnology-based methods, have been developed. This article provides an in-depth introduction to the latest advances in biosensor and nanosensor research for detecting and quantitatively identifying reproductive biomarkers.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Chengfang Tang, Fang Tang, Yanna Cai, Minyi Tan, Sichi Liu, Ting Xie, Xiang Jiang, Yonglan Huang
Summary: This study proposes an effective method for screening X-ALD and evaluates the performance of newborn screening for X-ALD in Guangzhou. The LC-MS/MS method can accurately identify X-ALD through analysis of C26:0-LPC.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Lan Liu, Jiamin Wang, Xijing Liu, Jing Wang, Lin Chen, Hongmei Zhu, Jingqun Mai, Ting Hu, Shanling Liu
Summary: The 16p11.2 deletion is a common genetic cause of neurodevelopmental disorders, with prenatal and postnatal presentations including vertebral malformations and language impairment. The majority of deletions are de novo and may be associated with MAPK3 and histidine-associated metabolism.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Sneha Venkatesalu, Shanmugapriya Dilliyappan, Avanthika Satish Kumar, Thirunavukkarasu Palaniyandi, Gomathy Baskar, Maddaly Ravi, Asha Sivaji
Summary: Microfluidics is a science and technology that deals with less sample-to-more precision in vitro analysis. It has wide applications in cancer theranostics, enabling precise diagnosis and personalized treatment.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Yuanqin Zhao, Wei Deng, Zhaoyue Wang, Yanxia Wang, Hongyu Zheng, Kun Zhou, Qian Xu, Le Bai, Huiting Liu, Zhong Ren, Zhisheng Jiang
Summary: The cardiovascular system and the central nervous system exhibit a coordinated developmental process during embryonic development. Congenital heart disease (CHD) is the most common congenital disorder, and neurodevelopmental disorders (NDD) are common complications in CHD patients. Both genetic and non-genetic factors contribute to the co-occurrence of CHD and NDD. Further research should focus on identifying common molecular mechanisms underlying this co-occurrence and promoting the research and treatment of developmental disorders related to the cardiovascular and central nervous systems.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Karol Gostomczyk, Ewelina Lukaszewska, Jedrzej Borowczak, Anita Bator, Marek Zdrenka, Magdalena Bodnar, Lukasz Szylberg
Summary: Flow cytometry improves the detection of epithelial cancer cells in peritoneal and pleural fluids compared to conventional cytology. Due to similar speciflcity and higher sensitivity, flow cytometry offers a promising alternative to cytology for patient screening.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Heping Tian, Genghuan Wang, Qi Zhong, Haihang Zhou
Summary: This study found that the decline of serum ITIH4 concentrations during the early phase after aneurysmal subarachnoid hemorrhage (aSAH) was closely related to the severity and poor prognosis of the disease. Serum ITIH4 may represent a promising prognostic biomarker of aSAH.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Xueting Zhu, Yang Yu, Jun Zhang, Yuxia Zhan, Guanghua Luo, Lu Zheng
Summary: This study successfully established a 2D-PCR method for identifying HLA-B*15:02 through a two-tube reaction. This method can distinguish HLA-B*15:02 from 16 highly homologous HLA-B*15 alleles. Among 1830 samples from the clinical general population, 3 HLA-B*15:02 homozygotes and 84 HLA-B*15:02 heterozygotes were detected.
CLINICA CHIMICA ACTA
(2024)