期刊
STEROIDS
卷 114, 期 -, 页码 25-32出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.steroids.2016.05.012
关键词
Antenatal; Glucocorticoids; Preterm birth; Neurodevelopment
资金
- ACS grant [RSG-09-054-0 1-GMC]
- G. Harold and Leila Y. Mathers Charitable Foundation Award
- Nuclear Receptor Signaling Atlas (NURSA) Data Resource Project from an NIH U24 Grant [DK097748]
- NIH [T32-HD071834-01A1, K12 HD052892-09]
- Magee-Womens Clinical Trainee Research Award
- University of Pittsburgh Medical Center Department of Pediatrics Endowed Instructorship
Glucocorticoids (GCs) regulate distinct physiological processes in the developing fetus, in particular accelerating organ maturation that enables the fetus to survive outside the womb. In preterm birth, the developing fetus does not receive sufficient exposure to endogenous GCs in utero for proper organ development predisposing the neonate to complications including intraventricular hemorrhage, respiratory distress syndrome (RDS) and necrotizing enterocolitis (NEC). Synthetic GCs (sGCs) have proven useful in the prevention of these complications since they are able to promote the rapid maturation of underdeveloped organs present in the fetus. While these drugs have proven to be clinically effective in the prevention of IVH, RDS and NEC, they may also trigger adverse developmental side effects. This review will examine the current clinical use of antenatal sGC therapy in preterm birth, their placental metabolism, and their effects on the developing brain. Published by Elsevier Inc.
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