期刊
STEROIDS
卷 115, 期 -, 页码 147-153出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.steroids.2016.09.005
关键词
Solvent-free; Steroidal pyridines; Synthesis; Enaminonitrile
资金
- Natural Science Foundation of China [21372206]
- Development Foundation of Priority, Ministry of Education [20134101130001]
The synthesis of novel steroidal 3-cyano-2-aminopyridines using enaminonitrile and various primary amines was established under solvent-free condition. Structures of the new compounds were characterized by MS,H-1 and C-13 NMR data and the structure of 2-aminopyridine of the product 5b was further confirmed by X-ray analysis. The reaction mechanism was proposed on the basis of the key intermediate obtained. The adjacent amine and nitrile groups existed in the final products have the potential for late stage functionalization, which would provide efficient access to steroidal compound collections with structural diversity and complexity. (C) 2016 Elsevier Inc. All rights reserved.
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