期刊
STEM CELLS AND DEVELOPMENT
卷 25, 期 14, 页码 1050-1059出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/scd.2016.0062
关键词
-
资金
- National Natural Science Foundation of China [NSFC 81371173, 81321002]
The discovery of mammalian N-6-methyladenosine (m(6)A) methyltransferases and demethylases has enriched our knowledge of the dynamic regulation of the most prevalent posttranscriptional RNA modification, m(6)A methylation. This reversible methylation process of adding and removing m(6)A marks on RNA has been shown to have broad biological functions in fine tuning cellular processes and gene expression. Recent studies have revealed a critical role for the currently known m(6)A methyltransferases and demethylases in regulating the pluripotency and differentiation of stem cells. These data establish a novel dimension in epigenetic regulation at the RNA level to affect mammalian cell fate.
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