Restoration of Mitochondrial NAD+Levels Delays Stem Cell Senescence and Facilitates Reprogramming of Aged Somatic Cells

Mitofusins deficiency elicits mitochondrial metabolic reprogramming to pluripotency

(2015) M J Son et al.   CELL DEATH AND DIFFERENTIATION

Redox Modulation by Reversal of the Mitochondrial Nicotinamide Nucleotide Transhydrogenase

(2015) Michael P. Murphy   Cell Metabolism

Human adipose tissue-derived stem cells cultured in xeno-free culture condition enhance c-MYC expression increasing proliferation but bypassing spontaneous cell transformation

(2015) Ana CC Paula et al.   Stem Cell Research & Therapy

New Strategies for Overcoming Limitations of Mesenchymal Stem Cell-Based Immune Modulation

(2015) Nayoun Kim et al.   International Journal of Stem Cells

Mitochondrial effectors of cellular senescence: beyond the free radical theory of aging

(2014) Dorian V. Ziegler et al.   AGING CELL

Enhanced ex vivo expansion of adult mesenchymal stem cells by fetal mesenchymal stem cell ECM

(2014) Chee Ping Ng et al.   BIOMATERIALS

Geroncogenesis: Metabolic Changes during Aging as a Driver of Tumorigenesis

(2014) Lindsay E. Wu et al.   CANCER CELL

Defective Mitophagy in XPA via PARP-1 Hyperactivation and NAD+/SIRT1 Reduction

(2014) Evandro Fei Fang et al.   CELL

NAD+ Deficiency in Age-Related Mitochondrial Dysfunction

(2014) Tomas A. Prolla et al.   Cell Metabolism

A High-Fat Diet and NAD + Activate Sirt1 to Rescue Premature Aging in Cockayne Syndrome

(2014) Morten Scheibye-Knudsen et al.   Cell Metabolism

Deficiency of Nicotinamide Mononucleotide Adenylyltransferase 3 (Nmnat3) Causes Hemolytic Anemia by Altering the Glycolytic Flow in Mature Erythrocytes

(2014) Keisuke Hikosaka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nicotinamide Nucleotide Transhydrogenase (Nnt) Links the Substrate Requirement in Brain Mitochondria for Hydrogen Peroxide Removal to the Thioredoxin/Peroxiredoxin (Trx/Prx) System

(2014) Pamela Lopert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Geriatric muscle stem cells switch reversible quiescence into senescence

(2014) Pedro Sousa-Victor et al.   NATURE

The role of senescent cells in ageing

(2014) Jan M. van Deursen   NATURE

Ageing as developmental decay: insights from p16INK4a

(2014) Nadine Martin et al.   TRENDS IN MOLECULAR MEDICINE

Characterization of Human Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium Cell Sheets Aiming for Clinical Application

(2014) Hiroyuki Kamao et al.   Stem Cell Reports

Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging

(2013) Ana P. Gomes et al.   CELL

The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

(2013) Laurent Mouchiroud et al.   CELL

Interference with the mitochondrial bioenergetics fuels reprogramming to pluripotency via facilitation of the glycolytic transition

(2013) Myung Jin Son et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence

(2013) Joanna Kaplon et al.   NATURE

Nicotinamide Overcomes Pluripotency Deficits and Reprogramming Barriers

(2013) Myung Jin Son et al.   STEM CELLS

An acetylome peptide microarray reveals specificities and deacetylation substrates for all human sirtuin isoforms

(2013) David Rauh et al.   Nature Communications

SIRT3 regulation of mitochondrial oxidative stress

(2012) Alexandra S. Bause et al.   EXPERIMENTAL GERONTOLOGY

Axis of ageing: telomeres, p53 and mitochondria

(2012) Ergün Sahin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondrial Metabolism, Sirtuins, and Aging

(2012) M. N. Sack et al.   Cold Spring Harbor Perspectives in Biology

Rejuvenating senescent and centenarian human cells by reprogramming through the pluripotent state

(2011) L. Lapasset et al.   GENES & DEVELOPMENT

p16INK4a Suppression by Glucose Restriction Contributes to Human Cellular Lifespan Extension through SIRT1-Mediated Epigenetic and Genetic Mechanisms

(2011) Yuanyuan Li et al.   PLoS One

SIRT3 Is a Mitochondria-Localized Tumor Suppressor Required for Maintenance of Mitochondrial Integrity and Metabolism during Stress

(2010) Hyun-Seok Kim et al.   CANCER CELL

Sirt3 Mediates Reduction of Oxidative Damage and Prevention of Age-Related Hearing Loss under Caloric Restriction

(2010) Shinichi Someya et al.   CELL

Induced pluripotent stem cells and senescence: learning the biology to improve the technology

(2010) Ana Banito et al.   EMBO REPORTS

Senescence impairs successful reprogramming to pluripotent stem cells

(2009) A. Banito et al.   GENES & DEVELOPMENT

Aging impairs the angiogenic response to ischemic injury and the activity of implanted cells: Combined consequences for cell therapy in older recipients

(2009) Yufeng Zhuo et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

The Ink4/Arf locus is a barrier for iPS cell reprogramming

(2009) Han Li et al.   NATURE

NAMPT is essential for the G-CSF–induced myeloid differentiation via a NAD+–sirtuin-1–dependent pathway

(2009) Julia Skokowa et al.   NATURE MEDICINE