Article
Biochemistry & Molecular Biology
Xiaoyan Gao, Xiaoting Liang, Baojuan Liu, Yimei Hong, Haiwei He, Ying Shen, Jiaqi Chen, Xinran Huang, Bei Hu, Weifeng Li, Xin Li, Yuelin Zhang
Summary: In this study, the role of ALKBH5 in regulating the senescence of mesenchymal stem cells (MSCs) was investigated. ALKBH5 was found to accelerate MSC senescence through the regulation of m6A modification and stability of CDKN1C mRNA. Knockdown of ALKBH5 rejuvenated aged MSCs and improved their therapeutic efficacy for myocardial infarction.
Article
Cell Biology
Hao Zhang, Chengling Zhao, Guojun Jiang, Bei Hu, Huifeng Zheng, Yimei Hong, Zhen Cui, Linli Shi, Xin Li, Fang Lin, Yue Ding, Lu Wei, Mimi Li, Xiaoting Liang, Yuelin Zhang
Summary: The study found that Apelin rejuvenated AMSCs by activating AMPK, promoting autophagy, and enhancing cardiac protection following myocardial infarction in mice.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Hsuan Peng, Kazuhiro Shindo, Renee R. Donahue, Ahmed Abdel-Latif
Summary: Stem cell-based cardiac therapies present challenges in cell delivery, engraftment, and differentiation, but still lead to sustained cardiac benefits. Current research focuses on exploring the mechanisms of stem cell-mediated cardiac immunomodulation, with efforts to improve current strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Gentaro Ikeda, Michelle R. Santoso, Yuko Tada, Albert M. Li, Evgeniya Vaskova, Ji-Hye Jung, Connor O'Brien, Elizabeth Egan, Jiangbin Ye, Phillip C. Yang
Summary: This study demonstrated that extracellular vesicle-mediated transfer of autologous mitochondria can enhance cardiac function by restoring myocardial bioenergetics. The therapy shows potential as a precision therapeutic for mitochondria-related diseases such as heart failure.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Weihua Bian, Wangping Chen, Thanh Nguyen, Yang Zhou, Jianyi Zhang
Summary: The study demonstrates that miR-199a-overexpressing hiPSC-CMs can increase cell proliferation in a heart infarction model, improving cardiac function and fibrosis. While the treatment may lead to lethal arrhythmia, there was no evidence of sudden death in the mouse model. Future investigations on miR-199a-overexpressing hiPSC-CMs in larger animals are supported by these results.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Lin Chen, Guangjin Luo, Yameng Liu, Hairuo Lin, Cankun Zheng, Dongxiao Xie, Yingqi Zhu, Lu Chen, Xiaoxia Huang, Donghong Hu, Jiahe Xie, Zhenhuan Chen, Wangjun Liao, Jianping Bin, Qiancheng Wang, Yulin Liao
Summary: Research suggests that GDF11 may alleviate myocardial IR injury by activating telomerase, leading to enhanced mitochondrial biogenesis and suppression of cardiomyocyte apoptosis.
CELL DEATH & DISEASE
(2021)
Review
Biochemistry & Molecular Biology
Maria Csobonyeiova, Nikoleta Beerova, Martin Klein, Michaela Debreova-Cehakova, L'ubos Danisovic
Summary: Heart failure is a major cause of morbidity and mortality in modern society due to cardiomyocyte death or dysfunction caused by myocardial infarction. Current therapies for heart failure or myocardial infarction are limited and non-curative. Therefore, research has focused on developing cell-based approaches, such as multipotent stem cells and induced pluripotent stem cells, for myocardial regeneration. Other potential sources for cardiac regeneration include telocytes and cell-free approaches, such as gene therapy and exosomes released from stem cells. This review provides insights into the novel strategies for myocardial repair based on different cell types and cell-free approaches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Huifeng Zheng, Xiaoting Liang, Qian Han, Zhuang Shao, Yuxiao Zhang, Linli Shi, Yimei Hong, Weifeng Li, Cong Mai, Qingwen Mo, Qingling Fu, Xiaoxue Ma, Fang Lin, Mimi Li, Bei Hu, Xin Li, Yuelin Zhang
Summary: The study demonstrates that Hemin-pretreated MSC-derived exosomes are more effective in treating myocardial infarction compared to regular MSC-derived exosomes, with exosomal miR-183-5p playing a key role in inhibiting cardiomyocyte senescence through regulation of the HMGB1/ERK pathway.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Jianyi Zhang, Roberto Bolli, Daniel J. Garry, Eduardo Marban, Philippe Menasche, Wolfram-Hubertus Zimmermann, Timothy J. Kamp, Joseph C. Wu, Victor J. Dzau
Summary: This paper provides an update on the recent preclinical and clinical trials using cell therapy and engineered heart tissues for postinfarction left ventricular remodeling and heart failure. The authors discuss novel approaches for cardiac remuscularization through activating proliferative mechanisms or direct reprogramming, aiming to facilitate the translation of discoveries in regenerative myocardial therapies to the clinic.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Jiacheng Sun, Lu Wang, Rachel C. Matthews, Gregory P. Walcott, Yu-An Lu, Yuhua Wei, Yang Zhou, Lior Zangi, Jianyi Zhang
Summary: The specific modified mRNA translation system (SMRTs) can induce CCND2 expression in cardiomyocytes, promoting cardiomyocyte proliferation, reducing infarct size, and improving cardiac performance in mammalian hearts with myocardial infarction.
CIRCULATION RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Tripti Rastogi, Frederick K. Ho, Patrick Rossignol, Thomas Merkling, Javed Butler, Andrew Clark, Timothy Collier, Christian Delles, J. Wouter Jukema, Stephane Heymans, Roberto Latini, Alexandre Mebazaa, Pierpaolo Pellicori, Peter Sever, Jan A. Staessen, Lutgarde Thijs, John G. Cleland, Naveed Sattar, Faiez Zannad, Nicolas Girerd
Summary: This study compares the clinical characteristics associated with the progression to heart failure (HF) in patients with and without a prior history of myocardial infarction (MI). The results show that the importance of risk factors for HF onset is dependent on whether the patient has had a prior MI. Lower renal function is strongly associated with HF onset in patients with prior MI, while higher body mass index (BMI), systolic blood pressure, and blood glucose are significantly associated with HF onset only in patients without prior MI.
EUROPEAN JOURNAL OF HEART FAILURE
(2022)
Review
Physiology
Florian Weinberger, Thomas Eschenhagen
Summary: The regenerative capacity of the heart is minimal due to the lack of progenitor cell population and the inability of cardiomyocytes to re-enter the cell cycle after birth. Loss of cardiomyocytes can lead to irreversible damage and exacerbate heart failure. Advances in understanding signaling pathways and stem cell technology have provided strategies for potential generation of new myocytes, fulfilling a central criterion for heart repair.
ANNUAL REVIEW OF PHYSIOLOGY, VOL 83
(2021)
Review
Pharmacology & Pharmacy
Pooi-Fong Wong, Murugan Dharmani, Thamil Selvee Ramasamy
Summary: This review discusses the role of senotherapeutics in MSC senescence, rejuvenation, and transplantation, with examples of some tested compounds in vitro. Senotherapeutics target cellular senescence through senolytic and senomorphic functions to induce apoptosis and suppress chronic inflammation caused by the senescence-associated secreted phenotype (SASP). They could delay aging-associated degeneration and be used to eliminate senescent MSCs during in vitro expansion or bioprocessing for transplantation. The prospects, challenges, and the way forward in clinical applications of senotherapeutics in cell-based therapeutics are also discussed.
DRUG DISCOVERY TODAY
(2023)
Article
Cardiac & Cardiovascular Systems
Amil. M. M. Shah, Brian Claggett, Narayana Prasad, Guichu Li, Mayra Volquez, Karola Jering, Maja Cikes, Attila Kovacs, Wilfried Mullens, Jose C. Nicolau, Lars Kober, Peter Van der Meer, Pardeep. S. S. Jhund, Ghionul Ibram, Martin Lefkowitz, Yinong Zhou, Scott. D. D. Solomon, Marc A. Pfeffer
Summary: This study compared the effects of sacubitril/valsartan and ramipril on left ventricular function and adverse remodeling after acute myocardial infarction (AMI). The results showed that patients randomized to sacubitril/valsartan had better improvements in filling pressure, left ventricular volume changes, and other aspects compared to those randomized to ramipril.
Article
Biotechnology & Applied Microbiology
Xiaoting Liang, Yuelin Zhang, Fang Lin, Mimi Li, Xin Li, Yu Chen, Jing Liu, Qingshu Meng, Xiaoxue Ma, Enhao Wang, Lu Wei, Zhiying He, Huimin Fan, Xiaohui Zhou, Yue Ding, Zhongmin Liu
Summary: Direct transplantation of mitochondria derived from mesenchymal stem cells (MSC-mt) can enhance blood vessel density, inhibit cardiac remodeling and apoptosis, thus improving heart function. MSC-mt also has protective effects on endothelial cells.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)