Article
Biochemistry & Molecular Biology
Anna Danielewicz, Magdalena Wojciak, Ireneusz Sowa, Monika Kusz, Joanna Wessely-Szponder, Slawomir Dresler, Michal Latalski
Summary: This study investigated the concentrations of bone remodeling-related agents in adolescent idiopathic scoliosis (AIS) patients, and found that the levels of vitamin D, N-terminal propeptide of type I procollagen, and fibroblast growth factor-23 were altered in these patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Luca Marin, Adam Kawczynski, Vittoria Carnevale Pellino, Massimiliano Febbi, Dario Silvestri, Luisella Pedrotti, Nicola Lovecchio, Matteo Vandoni
Summary: The study found that self-elongation correction helps to improve COP symmetry in AIS patients, with a positive impact on balance management.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Pediatrics
Jin-Xu Wen, Hui-Hui Yang, Shu-Man Han, Lei Cao, Hui-Zhao Wu, Chen Yang, Han Li, Lin-Lin Chen, Nuan-Nuan Li, Bao-Hai Yu, Bu-Lang Gao, Wen-Juan Wu
Summary: This study investigated the relationship of trunk balance with head posture and plantar pressure in patients with Adolescent Idiopathic Scoliosis (AIS). The findings showed that most AIS patients have trunk imbalance, with the coronal plane imbalance being more severe than the sagittal plane imbalance. AIS patients with trunk imbalance also exhibited more significant local deformities, greater head offset, larger center of pressure (COP) sway area, and decreased head and standing stability.
FRONTIERS IN PEDIATRICS
(2022)
Article
Nutrition & Dietetics
RuTong Wang, Weijing Wang, Ping Hu, Ronghui Zhang, Xue Dong, Dongfeng Zhang
Summary: This study aimed to evaluate the association between dietary vitamin D intake and serum vitamin D concentrations with cognitive performance in older Americans. The results showed a positive association between dietary vitamin D intake, serum total 25-hydroxyvitamin D, and cognitive performance, with no significant gender differences in the associations. Further research is needed to clarify the effects of dietary vitamin D intake and specific serum D concentrations on cognitive performance.
Article
Biotechnology & Applied Microbiology
Yanan Liu, Xianglan Li, Xiaoran Dou, Zhiguan Huang, Jun Wang, Bagen Liao, Xiaohui Zhang
Summary: The standing balance and gait characteristics of AIS patients are different from those of healthy subjects, as reflected in their three-dimensional spinopelvic radiographic parameters.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Clinical Neurology
Cesare Faldini, Francesca Barile, Fabrizio Perna, Stefano Pasini, Michele Fiore, Giovanni Viroli, Alberto Di Martino, Alberto Ruffilli
Summary: This article presents an original surgical technique for the treatment of rigid Adult Idiopathic Scoliosis (AdIS) and evaluates the results in a cohort of 40 patients. The surgical technique, Hi-PoAD, proved to be safe and effective in correcting spinal deformity and improving clinical outcomes.
EUROPEAN SPINE JOURNAL
(2021)
Review
Genetics & Heredity
Duan Sun, Zihao Ding, Yong Hai, Yunzhong Cheng
Summary: Scoliosis, a three-dimensional deformity of the spine, is closely related to genetic, hormonal, and environmental factors. Epigenetic alterations in scoliosis have been studied but a comprehensive review is lacking. We analyzed 25 studies on DNA methylation, non-coding RNAs, histone modifications, and chromatin remodeling in scoliosis. DNA methylation and non-coding RNAs are well-researched, providing insights into prevention and treatment strategies. However, there is limited research on histone modifications and chromatin remodeling in scoliosis. Further exploration is needed to understand the overall effects of epigenetics in scoliosis.
FRONTIERS IN GENETICS
(2023)
Article
Endocrinology & Metabolism
Jiao Zuo, Ahmed A. Hasan, Carl-Friedrich Hocher, Philipp Kalk, Burkhard Kleuser, Bernhard K. Kraemer, Berthold Hocher
Summary: This study investigated the relationship between 25(OH)D and 1,25(OH)2D with PTH. The results showed a negative correlation between all forms of PTH and 25(OH)D, while there was no significant correlation between 1,25(OH)2D and PTH. This finding suggests an inhibitory effect of 25(OH)D on the synthesis of all forms of PTH in the chief cells of the parathyroid gland.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Engineering, Biomedical
Luo Yi, Lin Houwei, Wang Lin, Zhao Lihua, Chen Mengjie, Wang Sun, Rao Zejiang, Ma Qichao
Summary: The study found that lumbar lordosis was positively correlated with pelvic tilt and sacral slope; on the major curve side, pelvic tilt showed positive correlation with all baropodometric parameters; while thoracic kyphosis showed negative correlations with contact surface and weight percentage of the forefoot.
CLINICAL BIOMECHANICS
(2021)
Article
Clinical Neurology
Jean-Francois Catanzariti, Alexandre Rimetz, Florence Genevieve, Gemma Renaud, Natacha Mounet
Summary: This study aims to verify the link between obesity and adolescent idiopathic scoliosis (AIS). By conducting X-ray measurements on obese adolescents, it was found that the prevalence of AIS in this population is twice as high as in the general population.
EUROPEAN SPINE JOURNAL
(2023)
Article
Clinical Neurology
Scott L. Zuckerman, Meghan Cerpa, Griffin R. Baum, Eduardo C. Beauchamp, J. Alex Sielatycki, Joseph Osorio, Joseph M. Lombardi, Takayoshi Shimizu, Lawrence G. Lenke
Summary: The study found that spine surgeons had higher intraobserver reliability in assessing preoperative shoulder balance in AIS and AdIS patients, while interobserver reliability was only fair to moderate. Combined measures are needed for UIV selection.
EUROPEAN SPINE JOURNAL
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Chao Wu, Gedong Meng, Jie Lian, Jingxu Xu, Mingjie Gao, Chencui Huang, Shu Zhang, Yunfeng Zhang, Yizhou Yu, Haiyan Wang, Yujie He, Xiaohe Li, Zhijun Li
Summary: This study developed a deep learning algorithm to automatically evaluate and diagnose scoliosis on full spinal X-ray images. The model achieved high sensitivity and accuracy for parameters such as the Cobb angle, apical vertebrae, and demonstrated potential to improve diagnostic efficiency for radiologists.
EUROPEAN RADIOLOGY
(2022)
Article
Clinical Neurology
Sabri Batin, Ahmet Payas, Emre Bal, Yakup Ekinci, Erdal Kurtoglu, Ilyas Ucar, Mustafa Arik, Turgut Seber, Buesra Kepenek Varol, Ersin Kasim Ulusoy, Ayse Kacar Bayram, Duygu Ekinci, Erdogan Unur
Summary: The study found that balance problems in patients with adolescent idiopathic scoliosis are correlated with decreased cerebellum volume and increased trunk oscillation velocity.
EUROPEAN SPINE JOURNAL
(2023)
Article
Orthopedics
Zhipeng Deng, Liang Wang, Linnan Wang, Xi Yang, Lei Wang, Limin Liu, Yueming Song
Summary: This study aimed to determine the incidence and independent risk factors of medial shoulder imbalance (MSI) with lateral shoulder balance (LSB) in Lenke 2 adolescent idiopathic scoliosis (AIS) patients after corrective surgery. It found that up to 69.2% of patients suffered from MSI despite achieving LSB after surgery. Postoperative upper instrumented vertebra tilt, proximal thoracic curve, ratio of proximal thoracic curve to main thoracic curve, and T2 vertebra rotation ratio were significant predictors for MSI. Sufficient correction of these variables may facilitate the achievement of medial shoulder balance.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Article
Clinical Neurology
Seung Woo Suh, Woo Sub Kim
Summary: This study aimed to investigate the characteristics of mechanical work during gait in adolescent idiopathic scoliosis (AIS) patients. The results showed that AIS patients had increased lower limb joint burden and limited trunk function during walking. Understanding the mechanical work during gait provides insights into the biomechanical characteristics of AIS.
Article
Biochemistry & Molecular Biology
Karolina Bukowska-Strakova, Joanna Wlodek, Ewelina Pitera, Magdalena Kozakowska, Anna Konturek-Ciesla, Maciej Ciesla, Monika Gonka, Witold Nowak, Aleksandra Wieczorek, Katarzyna Pawinska-Wasikowska, Alicja Jozkowicz, Maciej Siedlar
Summary: While survival rates for childhood acute lymphoblastic leukemia (ALL) have improved over recent decades, the overexpression of heme oxygenase-1 (HO-1) and specific polymorphisms in the HO-1 gene have been linked to chemoresistance and treatment failure in ALL patients. Targeting HO-1 may be a potential strategy to overcome treatment failure in ALL patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Malgorzata Pasek, Lilia Suchocka, Grazyna Osuch-Pecak, Konrad Muzykiewicz, Ewa Iwanska, Helena Kaducakowa, Anna Gozdzialska, Magdalena Gozdzialska
Summary: This study examined the quality of life in cervical cancer patients undergoing radiotherapy through four stages of assessment. The results showed that physical functioning was highest before treatment and decreased over time, emotional functioning was lowest before treatment and showed a decreasing trend, while global quality of life was lowest in the fourth stage. Overall, patients rated their general health and quality of life slightly above average, but slightly below average five years after treatment.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Maciej Ciesla, Phuong Cao Thi Ngoc, Eugenia Cordero, Alvaro Sejas Martinez, Mikkel Morsing, Sowndarya Muthukumar, Giulia Beneventi, Magdalena Madej, Roberto Munita, Terese Jonsson, Kristina Lovgren, Anna Ebbesson, Bjorn Nodin, Ingrid Hedenfalk, Karin Jirstrom, Johan Vallon-Christersson, Gabriella Honeth, Johan Staaf, Danny Incarnato, Kristian Pietras, Ana Bosch, Cristian Bellodi
Summary: The study uncovers the central role of the core splice factor SF3A3 in rewiring splicing during malignant transformation, particularly in the context of MYC hyperactivation. SF3A3 levels are modulated through translation in an elF3D-dependent manner, leading to metabolic reprogramming and stem-like properties that fuel MYC tumorigenic potential. Overall, these findings reveal a post-transcriptional interplay between splicing and translation that governs critical facets of MYC-driven oncogenesis.
Meeting Abstract
Oncology
A. Bosch, M. Ciesla, P. Cao Thi Ngoc, S. Mutukumar, G. Honeth, J. Staaf, D. Incarnato, K. Pietras, C. Bellodi
ANNALS OF ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jagoda Drag, Malgorzata Knapik-Czajka, Anna Gawedzka, Joanna Gdula-Argasinska, Jerzy Jaskiewicz
Summary: High-sucrose diet influences the mRNA levels and enzyme activities of elongases and desaturases in rat adipose tissue, leading to changes in fatty acid composition. Specifically, Elovl5, Elovl6, Fads1, and Scd mRNA levels were higher in HSD rats, while Fads2 mRNA level was lower. Monounsaturated fatty acids were also decreased in the AT of HSD rats compared to the ST group.
BIOCHEMISTRY-MOSCOW
(2021)
Review
Music
Felicity A. Baker, Jonathan Pool, Kjersti Johansson, Thomas Wosch, Anna A. Bukowska, Aleksandra Kulis, Laura Blauth, Karette Stensaeth, Imogen N. Clark, Helen Odell-Miller
Summary: Positive effects of music therapy for people with dementia and their family carers are reported in studies, but more adequately powered evidence-based studies are needed. Recruitment in dementia trials is complex and challenging and needs thorough planning. Future studies should include reporting of recruitment strategies and related aspects to aid in better design and resource estimation.
JOURNAL OF MUSIC THERAPY
(2021)
Article
Public, Environmental & Occupational Health
Helena Kaducakova, Gabriela Nowak, Lilia Suchocka, Anna Gozdzialska, Malgorzata Pasek
Summary: After completion of cancer treatment, patients experience positive emotions, not necessarily related to healing but rather to the relief of finishing therapeutic procedures. Chronic fatigue is a common complaint, mainly in terms of mental fatigue related to anxiety about relapse, functional losses, and feelings of loss due to aggressive treatment.
CLINICAL SOCIAL WORK AND HEALTH INTERVENTION
(2021)
Article
Biochemistry & Molecular Biology
Anna Kusienicka, Karolina Bukowska-Strakova, Maciej Ciesla, Witold Norbert Nowak, Iwona Bronisz-Budzynska, Agnieszka Seretny, Monika Zukowska, Mateusz Jez, Roscislaw Krutyholowa, Hevidar Taha, Neli Kachamakova-Trojanowska, Halina Was, Claudine Kieda, Alicja Jozkowicz
Summary: It has been found that the expression of MIC markers does not select CSC-like cells in the B16-F10 murine melanoma cell line.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Nicola Guzzi, Sowndarya Muthukumar, Maciej Ciesla, Gabriele Todisco, Phuong Cao Thi Ngoc, Magdalena Madej, Roberto Munita, Serena Fazio, Simon Ekstrom, Teresa Mortera-Blanco, Monika Jansson, Yasuhito Nannya, Mario Cazzola, Seishi Ogawa, Luca Malcovati, Eva Hellstrom-Lindberg, Marios Dimitriou, Cristian Bellodi
Summary: This study demonstrates that pseudouridylation of a stem cell-enriched tRF subtype, mini tRFs containing a 5' terminal oligoguanine (mTOG), selectively inhibits aberrant protein synthesis programs, thereby promoting engraftment and differentiation of hematopoietic stem and progenitor cells in MDS patients. The mechanism involves hindering the recruitment of translational co-activator PAIP1 and repressing translation of transcripts sharing pyrimidine-enriched sequences at the 5' UTR, including TOP sequences frequently altered in cancer. Dysregulation of mTOG leads to increased translation of 5' PES mRNA in malignant MDS-HSPCs, which is associated with leukaemic transformation and reduced patient survival.
NATURE CELL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Gabriela Mazur, Katarzyna Panczyk-Straszak, Anna Rapacz, Jan Kiszela, Magdalena Smolik, Maciej Gawlik, Maria Walczak, Joanna Czekajewska, Celina Poloczek, Elzbieta Karczewska, Ewa Zeslawska, Wojciech Nitek, Anna Niedbal, Joanna Lesniak, Katarzyna Ciapala, Katarzyna Pawlik, Joanna Mika, Anna M. Waszkielewicz
Summary: A series of 10 aminoalkanol derivatives of 5-chloro-2- or 5-chloro-4-methylxanthone were synthesized and evaluated for their anticonvulsant properties. The compound 5-chloro-2-([4-hydroxypiperidin-1-yl]methyl)-9H-xanthen-9-one hydrochloride showed the best results in terms of anticonvulsant activity and protective index value. The compounds exhibited rapid absorption, good bioavailability, and the ability to penetrate the blood-brain barrier.
CHEMICAL BIOLOGY & DRUG DESIGN
(2023)
Editorial Material
Medical Laboratory Technology
Leslie M. Shaw, Hugo Vanderstichele, Malgorzata Knapik-Czajka, Kaj Blennow, John Q. Trojanowski
CLINICAL CHEMISTRY
(2022)
Review
Oncology
Malgorzata Pasek, Anna Gozdzialska, Malgorzata Jochymek, Rosario Caruso
Summary: This scoping review aimed to investigate the impact of social support on the patient-informal caregiver relationship during cancer treatment. The findings suggested that social support can enhance the quality of life, hope, and resilience of both patients and informal caregivers. However, the current studies have some limitations, and future research should be more robustly powered and designed.
Article
Health Care Sciences & Services
Ewa Wojtyna, Malgorzata Pasek, Aleksandra Nowakowska, Anna Gozdzialska, Malgorzata Jochymek
Summary: Self-esteem is an important factor affecting the quality of life (QoL) for cancer patients undergoing surgical procedures for bodily deformities. However, little data exists on which aspects of self-esteem are most closely associated with QoL. This article presents two studies aimed at addressing this gap. Study 1 focuses on changes in global self-esteem and QoL in oral cancer patients (n = 35) treated surgically, while Study 2 examines changes in explicit and implicit self-esteem and QoL in women with breast cancer undergoing mastectomy (n = 96). Both studies used the EORTC QLQ-C30 and Rosenberg's SES questionnaires, with Study 2 also including the Implicit Association Test (IAT). Results showed that patients experienced a decline in global QoL and self-esteem after surgery. Study 1 revealed that patients with higher initial self-esteem experienced a greater decrease in self-esteem and QoL compared to those with lower initial self-esteem. In Study 2, women with fragile self-esteem exhibited the largest decreases in various dimensions of QoL and explicit self-esteem. Conversely, women with high explicit and implicit self-esteem had the best QoL after mastectomy. These findings highlight the need for special psycho-oncological care for cancer patients with high, fragile self-esteem.
Meeting Abstract
Hematology
Gladys Telliam Dushime, Ouyang Yuan, Olga Kotova, Maciej Ciesla, Henrik Lilljebjorn, Jonas Ungerback, Thoas Fioretos, Cristian Bellodi, David Bryder, Ewa Sitnicka
EXPERIMENTAL HEMATOLOGY
(2022)
Article
Sport Sciences
Aneta Bac, Aleksandra Kulis, Katarzyna Filar-Mierzwa, Anna Scislowska-Czarnecka
Summary: This study compared the repeatability and diagnostic objectivity of two methods of measuring the range of motion, showing that the goniometric test had smaller measurement error compared to the Hippocrates Sensor test. Both methods demonstrated high repeatability, but results showed statistically significant differences in measuring the range of motion in the joints when using different methods by the same therapist. The universal goniometer test exhibited greater measurement precision in accordance with ISOM standards.
ACTA KINESIOLOGICA
(2021)