Article
Engineering, Chemical
Chen Wang, Myoung Jun Park, Ralph Rolly Gonzales, Hideto Matsuyama, Enrico Drioli, Ho Kyong Shon
Summary: The study presented the preparation of cross-linked multilayer PEI/GO nanofiltration membrane using inkjet printing assisted layer-by-layer assembly. The (PEI/GO)3 membrane showed the optimal separation performances with high permeability and selectivity. The membrane exhibited excellent rejection rates for different dyes and selectivity for different salts. Furthermore, (PEI/GO)3 membrane demonstrated desirable stability and long-term filtration stability.
Article
Nanoscience & Nanotechnology
Changwoo Kim, Siyuan An, Junseok Lee, Anushree Ghosh, Mingjiang Zhong, John D. Fortner
Summary: The application of positively charged polymers, such as polyethylenimine (PEI), has shown significant potential for the sorption and reduction of hexavalent chromium Cr(VI). The study demonstrates that the photoactive nature of PEI enhances Cr(VI) photoreduction, with the efficiency being dependent on the density of amine groups. When combined with graphene oxide (GO) as a stabilizing scaffold, the performance for Cr(VI) treatment is influenced by the mass loading of PEI, its molecular weight, and the oxidation extent of GO. Furthermore, combining PEI with magnetic nanomaterials allows for low-energy, high-efficiency separation and reuse, showing excellent performance over multiple cycles.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Multidisciplinary
George Paterakis, Eoghan Vaughan, Dinesh R. Gawade, Richard Murray, George Gorgolis, Stefanos Matsalis, George Anagnostopoulos, John L. Buckley, Brendan O'Flynn, Aidan J. Quinn, Daniela Iacopino, Costas Galiotis
Summary: Ultra-sensitive and responsive humidity sensors were fabricated by depositing graphene oxide on laser-induced graphene electrodes. The sensors exhibited high sensitivity, stability, and fast response/recovery times, and showed comparable performance to commercial humidity sensors.
Article
Polymer Science
Alejandro Borras, Bruno Henriques, Gil Goncalves, Julio Fraile, Eduarda Pereira, Ana M. Lopez-Periago, Concepcion Domingo
Summary: This article reports the synthesis and potential application of a rGO/PEI aerogel as an effective sorbent to treat Hg(II) contaminated water. The designed aerogel exhibited a high Hg(II) sorption capacity and was able to eliminate almost all of the metal from the water phase.
Article
Chemistry, Multidisciplinary
Yue Yin, Xiaoyang Li, Haixia Ma, Jie Zhang, Di Yu, Ruifang Zhao, Shengji Yu, Guangjun Nie, Hai Wang
Summary: The research team developed a transformable hydrogel that can generate nanovaccines for up to 30 days after injection, showing promising potential for effective cancer immunotherapy.
Article
Chemistry, Applied
Lin Shi, Guodong Hong, Chuntao Chen, Xueqian Li, Heng Zhang, Renjie Chai, Dongping Sun
Summary: Researchers have developed a new form of bioactive hydrogel, incorporating topological graphene oxide (GO) and TEMPO-oxidized bacterial cellulose (GO/TOBC hydrogel), which provides a favorable microenvironment for spiral ganglion neurons (SGNs) to promote their growth and potentially improve hearing loss.
CARBOHYDRATE POLYMERS
(2023)
Article
Engineering, Environmental
Giannis-Florjan Norra, Luis Baptista-Pires, Elisabeth Cuervo Lumbaque, Carles M. Borrego, Jelena Radjenovic
Summary: Graphene sponge electrodes were utilized for chlorine-free inactivation of Escherichia coli from low conductivity water, achieving complete E. coli inactivation through electrosorption and electroporation, with additional killing of bacteria due to damaged cell membranes in stored electrochemically treated samples. The use of intermittent current significantly reduced energy consumption for E. coli removal in tap water, showcasing the potential of graphene for efficient electro-disinfection without the formation of toxic byproducts.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Physical
Renbo Zhu, Yanzhe Zhu, Fandi Chen, Robert Patterson, Yingze Zhou, Tao Wan, Long Hu, Tom Wu, Rakesh Joshi, Mengyao Li, Claudio Cazorla, Yuerui Lu, Zhaojun Han, Dewei Chu
Summary: This article reports a simple strategy to modify graphene oxide and improve the electric output of moisture-electric generators. By assembling multiple generator units in series or parallel, the electric output can be further improved. This technology has great commercial potential for flexible and wearable applications.
Article
Pharmacology & Pharmacy
Monika Matiyani, Anita Rana, Neha Karki, Kamal Garwal, Mintu Pal, Nanda Gopal Sahoo
Summary: Cancer is a serious global threat to human health caused by uncontrolled proliferation of malignant cells. Traditional cancer treatments have adverse side effects and high mortality rates, so novel drug delivery systems are urgently needed.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Analytical
Tasnima Alam Asa, Young Jun Seo
Summary: In this study, we present a novel method for recognizing multiple genes using ligation-double transcription mediated fluorometric profiling. By combining this approach with a selective fluorophore probe-RNA hybridization/graphene oxide quenching system, we successfully identified potential multi-gene classifiers for diagnostic use. The system is efficient, with a total experimentation time of only 45 minutes, and offers high sensitivity and specificity for the detection of RNA viruses.
Article
Biochemistry & Molecular Biology
Jun-Sung Oh, Jeong-Sun Park, Eun-Jung Lee
Summary: Statin derivatives have been traditionally used to treat hyperlipidemia, but recent studies have shown their potential in regulating bone metabolism and promoting bone growth. By combining simvastatin with graphene oxide, a compound effective for bone regeneration was produced, showing excellent osteogenic differentiation properties.
Article
Chemistry, Physical
Souvik Pandit, Soma Seth (Duley), Aloke Bapli, Sanyukta Bhattacharjee, Debabrata Seth
Summary: Graphene oxide (GO) has gained attention in the laboratory due to its diverse applications, although most studies have reported fluorescence quenching induced by GO. This study demonstrates the enhancement of fluorescence induced by GO and reveals its promotion of prototropism in various solvents, which is not well documented in the literature. The oxygen-containing functional groups on the surface of GO play a significant role in promoting prototropism.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Chemistry, Analytical
Guangyuan Wang, Jiayi Chen, Lu Huang, Yiting Chen, Yanxia Li
Summary: A label-free CEA electrochemical immunosensor was developed based on the surface engineering of laser-induced graphene (LIG)/Au electrode, showing high sensitivity and selectivity, suitable for liquid samples without the need for sample labeling and pretreatment.
Article
Chemistry, Physical
Paulina Bolibok, Stanislaw Koter, Anna Kaczmarek-Kedziera, Piotr Kowalczyk, Bogna Lukomska, Olga Lukomska, Slawomir Boncel, Marek Wisniewski, Katsumi Kaneko, Artur P. Terzyk
Summary: It has been found that graphene oxide (GO) undergoes transformation from micro to nanoscale and forms nanoscale GO (nanoGO) when subjected to adsorbed particular organic molecules. A new model is proposed to take nanosizing into account, and DFT calculations explain the selective adsorption behavior of different adsorbates on GO. The GO-nanoGO transformation is supported by marked changes in the surface area of GO during liquid phase adsorption of organic molecules.
Article
Optics
Hongtao Wang, Chenglong Hao, Han Lin, Yongtian Wang, Tian Lan, Chengwei Qiu, Baohua Jia
Summary: Graphene-based metalenses offer new opportunities for precisely controlling phase and amplitude modulations, leading to unprecedented possibilities in lens design and applications. The conversion of graphene oxide into graphene materials allows for simultaneous modulation at a single position, enabling the demonstration of ultra-long optical needles and axial multifocal spots in graphene oxide metalenses.
OPTO-ELECTRONIC ADVANCES
(2021)
Article
Medicine, Research & Experimental
Danbi Jo, Gwangho Yoon, Oh Yoen Kim, Juhyun Song
Summary: Sarcopenia, characterized by reduced skeletal muscle mass and decreased muscle strength, is becoming more prevalent globally. The pathophysiology of sarcopenia is related to various factors including hormonal imbalance, increased intracellular oxidative stress, reduction of food intake, advanced age, low body mass index, and low physical activity. Recent studies have found an association between sarcopenia and cognitive decline, with common risk factors observed between sarcopenia and memory loss.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Medicine, Research & Experimental
Jae-ho Jeong, Dong Hoon Lee, Juhyun Song
Summary: Diabetes is related to various diseases, including cancer and cardiovascular and neurodegenerative diseases. The interplay between high mobility group box1 (HMGB1), receptor for advanced glycation end-products (RAGE), and toll-like receptor 4 (TLR4) has been found to play an important role in diabetes-related dementia.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Hee Kyung Kim, Juhyun Song
Summary: The incidence of dementia is increasing worldwide, including diabetes-related dementia. Hypothyroidism is considered a critical cause of neurological problems in the central nervous system, contributing to the development of diabetes-related dementia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Archana Arjunan, Dhiraj Kumar Sah, Young Do Jung, Juhyun Song
Summary: Hepatic encephalopathy is a severe metabolic syndrome associated with liver disorders, with limited treatment options available. The disease is a neuropsychiatric complication linked with cognitive decline, coma, and death, and its pathogenesis remains unclear. Melatonin, as the sole endogenous hormone related to HE, has neuroprotective effects by crossing the blood-brain barrier.
Article
Biochemistry & Molecular Biology
Young-Kook Kim, Yoon Seok Jung, Juhyun Song
Summary: Hepatic encephalopathy (HE) is a chronic metabolic disease with neurological and psychiatric symptoms, and recent studies suggest a positive correlation with Alzheimer's disease (AD). Our study compares the gene expression in an HE mouse model and an AD mouse model, revealing a potential link between HE-associated genes and neuronal dysfunction in AD mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Polash Kumar Biswas, Sang Rok Park, Jongyub An, Kyung Min Lim, Ahmed Abdal Dayem, Kwonwoo Song, Hye Yeon Choi, Yujin Choi, Kyoung Sik Park, Hyun Jin Shin, Aram Kim, Minchan Gil, Subbroto Kumar Saha, Ssang-Goo Cho
Summary: In this study, the expression of GPR50 in CSLC and breast cancer cell lines was evaluated, and its role in CSLC progression was investigated. Knockdown of GPR50 in CSLC resulted in decreased cancer properties and stemness. GPR50 was found to regulate NF-kB and NOTCH signaling pathways, as well as ADAM-17 activity, in CSLC. Overall, this study provided novel insights into GPR50-mediated regulation of the NF-kappa B-Notch signaling pathway in CSLC and its implications for treatment strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Archana Arjunan, Dhiraj Kumar Sah, Minna Woo, Juhyun Song
Summary: Neurodegenerative disorders are characterized by neuronal degeneration and glial dysfunction, leading to impairments in cognition, psychomotor function, and behavior. Metabolic syndrome has been linked to these disorders, and insulin growth factor-1 (IGF-1) deficiency has been associated with MetS-related pathologies. IGF-1 plays a crucial role in neurogenesis, plasticity, angiogenesis, and metabolic function in the brain, making it a potential therapeutic target for MetS-related neurodegenerative diseases. This review highlights the evidence for the potential therapeutic effects of IGF-1 and its involvement in molecular signaling defects in MetS-related neurodegeneration.
CELL AND BIOSCIENCE
(2023)
Article
Medicine, Research & Experimental
Ahmed Abdal Dayem, Soo Bin Lee, Kyung Min Lim, Aram Kim, Hyun Jin Shin, Balachandar Vellingiri, Young Bong Kim, Ssang-Goo Cho
Summary: Peptides, which are short protein fragments, have the ability to mimic full-length proteins and have become a promising alternative to recombinant proteins due to their specificity, stability, low cost, and customization capabilities. They can enhance stem cell adhesion, proliferation, and differentiation and can be immobilized on culture plates or integrated into scaffolds. This review evaluates the applications of various peptides in stem cell culture and discusses the challenges and future directions for advancing peptide applications in tissue regeneration and clinical settings.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Sehee Kim, Yeokyung Shin, Yujin Choi, Kyung-Min Lim, Yeojin Jeong, Ahmed Abdal Dayem, Yoonjoo Lee, Jongyub An, Kwonwoo Song, Soo Bin Jang, Ssang-Goo Cho
Summary: Flavonoids enhance the therapeutic potential of mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) by promoting their production and improving their anti-inflammatory and wound-healing effects. This study provides a strategy for the efficient production of MSC-EVs with superior therapeutic potential using flavonoids, which shows significant improvement in wound closure compared to traditional flavonoid-only treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Danbi Jo, Gwangho Yoon, Yeonghwan Lim, Youngkook Kim, Juhyun Song
Summary: Recent evidence suggests that neurodegenerative diseases, such as Alzheimer's disease, are associated with metabolic disorders like diabetes and obesity. Studies have shown that circular RNAs (circRNAs) are involved in neuropathological mechanisms in the brain, but their role in metabolic imbalance-related neuropathology has not been explored. In this study, researchers profiled and analyzed circRNAs in mouse brain cell lines exposed to obesity-related conditions and found that these circRNAs regulate genes related to inflammatory responses and fatty acid metabolism, which may contribute to the development of neurodegenerative diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Jaekwon Seok, Hee Jeong Kwak, Yeonjoo Kwak, Moonjung Lee, Kyoung Sik Park, Aram Kim, Ssang-Goo Cho
Summary: This study investigates the effects of androgen suppression therapy on bladder cancer progression and identifies potential therapeutic targets. It is found that dutasteride, a 5 alpha-reductase inhibitor, can inhibit cell proliferation and migration of bladder cancer cells by regulating the expression of cancer progression proteins. Additionally, the study reveals the role of the target gene SRD5A1 in bladder cancer and its correlation with patient survival.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Biology
Sejong Kim, Geun-Ho Kang, Kyung Min Lim, Yeokyung Shin, Kwonwoo Song, Sangrok Park, Jongyub An, Dae Young Kim, Hang-Cheol Shin, Ssang-Goo Cho
Summary: Human pluripotent stem cells are a valuable resource for cell therapy products due to their ability to differentiate into various tissues. However, culturing these stem cells requires the presence of basic fibroblast growth factor (bFGF) to maintain their stemness. Unfortunately, bFGF has a short half-life and needs continuous supply, posing challenges for high-quality stem cell culture. To address this issue, a thermostable bFGF was developed, which showed better proliferation, stemness, morphology, and differentiation of human embryonic stem cells. This thermostable bFGF can play a critical role in securing high-quality stem cells during cultivation.
Article
Nutrition & Dietetics
Jihyun Park, Mi Ri Ha, Juhyun Song, Oh Yoen Kim
Summary: The study found that cigarette smoking and dietary acid load are associated with an increased risk of chronic obstructive pulmonary disease in healthy, middle-aged Korean men, particularly among current smokers and individuals with higher DAL levels.
Article
Genetics & Heredity
Eun Gyung Park, Du Hyeong Lee, Woo Ryung Kim, Yun Ju Lee, Woo Hyeon Bae, Jung-min Kim, Hae Jin Shin, Hongseok Ha, Joo Mi Yi, Ssang Goo Cho, Yung Hyun Choi, Sun Hee Leem, Hee Jae Cha, Sang Woo Kim, Heui Soo Kim
Summary: Although most HERVs have lost their function due to accumulated mutations, they still contribute to human biology, especially in cancer. In this study, 29 miRNAs derived from HERV sequences were identified in the human genome, and miR-4454, a HERV-H-derived miRNA, was found to be upregulated in NMIBC cells. Two target genes, DNAJB4 and SASH1, were confirmed to be negatively regulated by miR-4454 through the dual-luciferase assay. These findings suggest that the upregulation of miR-4454 derived from HERV-H promotes NMIBC progression by suppressing tumor suppressor genes.
Article
Biochemistry & Molecular Biology
Sangrok Park, Sejong Kim, Kyungmin Lim, Yeokyung Shin, Kwonwoo Song, Geun-Ho Kang, Dae Young Kim, Hang-Cheol Shin, Ssang-Goo Cho
Summary: In this study, we evaluated the utilization of thermostable basic fibroblast growth factor (TS-bFGF) for MSC culture and exosome production. The results showed that MSCs cultured with TS-bFGF had superior proliferation and produced a greater quantity of exosomes. These exosomes displayed anti-inflammatory and wound-healing effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)