Article
Endocrinology & Metabolism
Na Li, Chunhua Lu, Yuhang Ma, Xuejiao Wang, Yunxia Ling, Yanhua Yin, Shumei Li, Jiao Huang, Lihua Yu, Weiping Dong, Huichen He, Mei Kang, Lei Ma, Mingyu Gu, Li Zhao, Yunhong Huang, Fang Liu, Yufan Wang, Xianying Gai, Junyi Jiang, Yongde Peng, Xiaoying Ding
Summary: This study aims to examine the predictive factors associated with the progression from different prediabetic status to diabetes. The results showed that individuals with combined IFG and IGT were at a higher risk of progressing to diabetes compared to those with IFG alone. Males, obese individuals, higher BMI and WHR, and hypertension were positively associated with the progression to diabetes, while HOMA-b was negatively associated with the progression to diabetes.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2022)
Article
Endocrinology & Metabolism
Kosuke Inoue, Eriko Semba, Tadashi Yamakawa, Yasuo Terauchi
Summary: This study found a higher risk of all-cause mortality among individuals with diabetes in the American population, as well as those with impaired glucose tolerance who have sleep disorders or short sleep duration.
BMJ OPEN DIABETES RESEARCH & CARE
(2021)
Article
Medicine, General & Internal
Lore Raets, Kim Van Hoorenbeeck, Toon Maes, Chris Vercammen, Christophe De Block, Eveline Dirinck, Inge Van Pottelbergh, Katrien Wierckx, Annouschka Laenen, Annick Bogaerts, Chantal Mathieu, Katrien Benhalima
Summary: The Belgian Diabetes in Pregnancy follow-up study (BEDIP-FUS) aims to investigate the impact of BMI, adiposity, and glucose intolerance on the metabolic profile and future risk for T2D in women and offspring after a five-year period. The study involves recruiting 375 women-offspring pairs based on the results of glucose challenge and oral glucose tolerance tests during pregnancy. The primary outcomes measured are glucose intolerance in mothers and BMI z-score in offspring. The study is important for individualizing follow-up care for women with different degrees of hyperglycemia during pregnancy and their offspring.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Miki Kakutani-Hatayama, Manabu Kadoya, Akiko Morimoto, Akio Miyoshi, Kae Kosaka-Hamamoto, Akinori Kanzaki, Kosuke Konishi, Yoshiki Kusunoki, Takuhito Syoji, Hidenori Koyama
Summary: This study found that long daytime napping may lead to decreased insulin sensitivity, particularly in individuals with shorter nighttime sleep.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Zhuofan Yang, Zhuyu Li, Yunjiu Cheng, Peisong Chen, Dongyu Wang, Haitian Chen, Wei Chen, Zilian Wang
Summary: This study aimed to assess the relationship between lipid trajectories during pregnancy and early postpartum glucose intolerance in women with GDM. The results showed that GDM women with lower LDL-c trajectories had a higher risk of postpartum glucose intolerance. On the other hand, high LDL-c trajectory may play a protective role in preventing postpartum glucose intolerance. Additionally, participants with different LDL-c trajectories showed significant differences in insulin sensitivity.
ACTA DIABETOLOGICA
(2022)
Article
Clinical Neurology
Andrea M. Spaeth, Risha Khetarpal, Daohai Yu, Grace W. Pien, Sharon J. Herring
Summary: The study found that breastfeeding, having a bedtime after midnight, and being employed were associated with shorter sleep duration, while multiparity, being unmarried, being employed, breastfeeding, bedsharing, and responding to infant awakenings by getting up immediately were significant determinants of sleeping less than 7 hours per night. Bedsharing was the only variable identified from the multiple regression model that associated with poorer sleep efficiency.
Article
Endocrinology & Metabolism
Rui Zhang, Xiangjin Gao, Ting Sun, Huan Li, Qing Yang, Bin Li, Dongshan Zhu, Ruiping Wang
Summary: This study aimed to investigate the relationship between the duration of daily physical exercise (PE) and the frequency of abnormal plasma glucose (PG) occurrences in women with gestational diabetes mellitus (GDM). The results showed that the duration of moderate-intensity PE was negatively associated with the number of abnormal fasting PG occurrences, but not with the number of PG occurrences 2 hours after a standard diet.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Huapeng Lu, Qinling Yang, Fang Tian, Yi Lyu, Hairong He, Xia Xin, Xuemei Zheng
Summary: Short or long sleep duration can increase the risk of type 2 diabetes mellitus.
JOURNAL OF DIABETES RESEARCH
(2021)
Article
Endocrinology & Metabolism
Yi Zeng, Zhen Zhang, SiTing Liang, XinMiao Chang, RuiJie Qin, Hong Chen, LiXin Guo
Summary: Sleep insufficiency may lead to metabolic dysregulation and increase the risk of diabetes. Research has found that paternal sleep deprivation can affect the metabolic phenotype of offspring, and this is believed to be due to epigenetic inheritance. Male offspring of sleep-deprived fathers show glucose intolerance, insulin resistance, and impaired insulin secretion.
JOURNAL OF PINEAL RESEARCH
(2023)
Article
Multidisciplinary Sciences
Khalid Abdul Basit, Asher Fawwad, Nida Mustafa, Thomas Davey, Bilal Tahir, Abdul Basit
Summary: This study aimed to observe trends of diabetes and its associated risk factors in rural areas of Baluchistan-Pakistan through health surveys conducted between 2002-2017. The results showed a continuous increase in the prevalence of early-onset diabetes in the rural population, with central obesity and dyslipidemia being the major risk factors. This poses a major public health challenge.
Article
Endocrinology & Metabolism
Nina M. T. Meyer, Stefan Kabisch, Ulrike Dambeck, Caroline Honsek, Margrit Kemper, Christiana Gerbracht, Ayman M. Arafat, Andreas L. Birkenfeld, Peter E. H. Schwarz, Juergen Machann, Martin A. Osterhoff, Martin O. Weickert, Andreas F. H. Pfeiffer
Summary: This study examined whether insulin growth factor 1 (IGF1) and its binding proteins 1 and 2 can predict the onset of type 2 diabetes mellitus (T2DM) in prediabetes patients and determine their metabolic regeneration capacity. The findings suggest that lower levels of IGF1 and higher levels of IGFBP1 in prediabetes patients are associated with an increased risk of developing T2DM.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Chiara Lopez, Chiara Bima, Martina Bollati, Fabio Bioletto, Matteo Procopio, Stefano Arata, Daniele Giuseppe Candela, Guglielmo Beccuti, Ezio Ghigo, Mauro Maccario, Mirko Parasiliti-Caprino
Summary: Glycemic alterations are common in patients with PPGL, but the incidence of secondary DM is uncertain due to lack of prospective multicenter studies. The main mechanisms of glucose homeostasis alterations in PPGL are impaired insulin and GLP-1 secretion and increased insulin resistance. Different pathways leading to glucose intolerance may be related to the secretory phenotype of the tumor. Predictive factors for glucose intolerance in PPGL patients include higher age, more anti-hypertensive drugs, and secreting neoplasms. Tumor resection is strongly associated with resolution of DM and improved glycemic control.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Public, Environmental & Occupational Health
Zhihan Zhai, Xiaotian Liu, Haiqing Zhang, Xiaokang Dong, Yaling He, Miaomiao Niu, Mingming Pan, Chongjian Wang, Xiaoqiong Wang, Yuqian Li
Summary: The study found that late midpoint of sleep, early midpoint of sleep, and long night sleep duration were all associated with a higher prevalence of T2DM. The combination of a late midpoint of sleep and long night sleep duration further increased the prevalence of T2DM, particularly more pronounced in women.
Article
Oncology
Young Hyo Choi, Yong-Moon Park, Kyung Jae Hur, U-Syn Ha, Sung-Hoo Hong, Ji Youl Lee, Sae Woong Kim, Kyungdo Han, Seung Hyun Ko, Yong Hyun Park
Summary: The study suggests that the duration of diabetes mellitus is associated with an increased risk of kidney and bladder cancer. Individuals with impaired fasting glucose and longer duration of diabetes have a higher likelihood of developing these cancers compared to those without diabetes.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Zuzana Lattova, Lucie Slovakova, Andrea Plihalova, Jan Gojda, Moustafa Elkalaf, Katerina Westlake, Jan Polak
Summary: This study investigated the effect of obstructive sleep apnea (OSA) on skeletal muscle lipid oxidation in nondiabetic controls and type 2 diabetes (T2DM) patients. The results showed that severe OSA is not associated with reduced muscle lipid oxidation and that metabolic derangements in OSA are not mediated through impaired muscle lipid oxidation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Sara Schramm, Isabell Tenhagen, Boerge Schmidt, Dagny Holle-Lee, Steffen Naegel, Zaza Katsarava, Karl-Heinz Joeckel, Susanne Moebus
Summary: Headaches and migraines are not uncommon in the elderly population, and they are associated with mood and sleep disturbances, as well as potentially linked to lower levels of physical activity. The use of antihypertensive medications may be related to headache remission.
Article
Environmental Sciences
Simone Ohlwein, Frauke Hennig, Sarah Lucht, Boerge Schmidt, Lewin Eisele, Marina Arendt, Ulrich Duehrsen, Jan Duerig, Karl-Heinz Joeckel, Susanne Moebus, Barbara Hoffmann
Summary: Residential exposure to air pollution is positively associated with activation of the adaptive immune system, particularly with middle-term exposures showing strongest associations. Traffic-related PM, PNAM, and NO2 were found to have the strongest associations with polyclonal free light chains produced by plasma cells.
ENVIRONMENTAL HEALTH PERSPECTIVES
(2021)
Article
Clinical Neurology
Sara Schramm, Lea Schliephake, Heiko Himpfen, Svenja Caspers, Raimund Erbel, Karl-Heinz Joeckel, Susanne Moebus
Summary: This study found an inverse association between serum 25-hydroxyvitamin D (25OHD) levels and white matter hyperintensities (WMHs), suggesting that low 25OHD levels may be a risk factor for the occurrence of WMHs.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Lingyao Zeng, Sylvain Moser, Nazanin Mirza-Schreiber, Claudia Lamina, Stefan Coassin, Christopher P. Nelson, Tarmo Annilo, Oscar Franzen, Marcus E. Kleber, Salome Mack, Till F. M. Andlauer, Beibei Jiang, Barbara Stiller, Ling Li, Christina Willenborg, Matthias Munz, Thorsten Kessler, Adnan Kastrati, Karl-Ludwig Laugwitz, Jeanette Erdmann, Susanne Moebus, Markus M. Noethen, Annette Peters, Konstantin Strauch, Martina Mueller-Nurasyid, Christian Gieger, Thomas Meitinger, Elisabeth Steinhagen-Thiessen, Winfried Maerz, Andres Metspalu, Johan L. M. Bjoerkegren, Nilesh J. Samani, Florian Kronenberg, Bertram Mueller-Myhsok, Heribert Schunkert
Summary: This study attempts to identify non-additive genetic effects associated with CAD, specifically epistatic interactions. A SNP pair located in cis at the LPA locus was found to be jointly associated with risk for CAD, peripheral arterial disease, aortic stenosis, hepatic lipoprotein(a) levels, and Lp(a) serum levels, while individual SNPs displayed no association. Further exploration revealed a strong dependency on a rare variant influencing risk through additive genetic as well as epistatic effects.
CARDIOVASCULAR RESEARCH
(2022)
Article
Acoustics
Bryce T. Lawrence, Jonas Hornberg, Timo Haselhoff, Robynne Sutcliffe, Salman Ahmed, Susanne Moebus, Dietwald Gruehn
Summary: This study used ecoacoustic indices to analyze the acoustic characteristics of urban and forest environments, revealing the complexity and richness of urban acoustic environments through multiple acoustic indices.
Article
Acoustics
Timo Haselhoff, Bryce Lawrence, Jonas Hornberg, Salman Ahmed, Robynne Sutcliffe, Dietwald Gruehn, Susanne Moebus
Summary: Sound pressure levels are commonly used to describe the urban acoustic environment, but further concepts are needed to analyze its effects on human health. The soundscape ecology approach has gained traction, but high-quality sound recordings are essential for applying it to cities. The SALVE project aims to establish a high-resolution dataset of the urban AE and connect it to human health and the built environment.
Article
Public, Environmental & Occupational Health
Jan Hovanec, Tobias Weiss, Holger Koch, Beate Pesch, Thomas Behrens, Benjamin Kendzia, Marina Arendt, Nico Dragano, Susanne Moebus, Boerge Schmidt, Thomas Bruening, Karl-Heinz Joeckel
Summary: The study findings show that there is a lack of accuracy in self-reported smoking intensity among individuals with lower socioeconomic status (SES) in both men and women. Although there is some correlation, the relationship between smoking intensity and urinary nicotine metabolites is weaker in the low SES group.
Article
Peripheral Vascular Disease
Janine Gronewold, Martha Jokisch, Sara Schramm, Christiane Jockwitz, Tatiana Miller, Nils Lehmann, Susanne Moebus, Karl-Heinz Jockel, Raimund Erbel, Svenja Caspers, Dirk M. Hermann
Summary: White matter hyperintensities (WMHs) of presumed vascular origin are common in older people's cerebral magnetic resonance imaging and are linked to cognitive decline. Hypertension, as well as other vascular risk factors, are associated with larger WMH volume. Early treatment of hypertension may help prevent the formation of WMHs.
Article
Public, Environmental & Occupational Health
Sarah Lucht, Lina Glaubitz, Susanne Moebus, Sara Schramm, Christiane Jockwitz, Svenja Caspers, Barbara Hoffmann
Summary: The study found that long-term exposure to air pollution and noise may not consistently affect the structural parameters of the brain's Default Mode Network (DMN). While some participants experienced outdoor noise levels above European recommendations, the exposure did not significantly alter the structure of DMN.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2022)
Article
Multidisciplinary Sciences
Nora Bittner, Horst-Werner Korf, Johanna Stumme, Christiane Jockwitz, Susanne Moebus, Boerge Schmidt, Nico Dragano, Svenja Caspers
Summary: This study investigated the relationship between night shift work and brain structure and functional connectivity. The results suggest that night shift work does not cause widespread changes in brain networks and has limited effects on the brain.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Nicola Hornung, Mirjam Frank, Nico Dragano, Jan Duerig, Ulrich Duehrsen, Susanne Moebus, Raimund Erbel, Andreas Stang, Karl-Heinz Joeckel, Boerge Schmidt
Summary: Register-based studies have shown a possible association between MGUS and PCa. The present study found that MGUS was associated with PCa, with IgM-MGUS showing the strongest association. There was no indication that the observed association is due to shared risk factors.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Dennis Schmiege, Timo Falkenbergm, Susanne Moebus, Thomas Kistemann, Mariele Evers
Summary: This study examined the associations between socio-spatially diverse urban areas and knowledge, attitudes, practices, and antibiotic use. The findings revealed distinct differences in knowledge, attitudes, and practices around antibiotics and antibiotic resistance in different areas within the metropolitan city of Dortmund, Germany. The study emphasizes the need for tailored interventions and increased efforts to educate the population about the proper use and handling of antibiotics.
Article
Public, Environmental & Occupational Health
D. Djeudeu, S. Moebus, K. Ickstadt
Summary: This study further develops multilevel models to explain spatial effects in epidemiological studies, and provides a comprehensive decision tree for analyzing data with spatially nested structure. Simulation studies show that multilevel conditional autoregressive models perform better than classical multilevel growth models.
SPATIAL AND SPATIO-TEMPORAL EPIDEMIOLOGY
(2022)
Article
Environmental Sciences
Timo Haselhoff, Tobias Braun, Jonas Hornberg, Bryce T. Lawrence, Salman Ahmed, Dietwald Gruehn, Susanne Moebus
Summary: Understanding the urban acoustic environment is crucial for the sustainable development of metropolitan regions. However, comprehensive datasets and established research methods for the urban acoustic environment are lacking. This study contributes to a better understanding of the urban acoustic environment by analyzing automatic audio recordings from nine urban settings over a ten-month period. The results reveal site-dependent patterns in frequency dynamics and demonstrate the use of frequency correlation matrices as a novel approach to access large audio datasets.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Genetics & Heredity
Jan Gehlen, Ann-Sophie Giel, Ricarda Koellges, Stephan L. Haas, Rong Zhang, Jiri Trcka, Ayse O. Sungur, Florian Renziehausen, Dorothea Bornholdt, Daphne Jung, Paul D. Hoyer, Agneta Nordenskjold, Dick Tibboel, John Vlot, Manon C. W. Spaander, Robert Smigiel, Dariusz Patkowski, Nel Roeleveld, Iris Alm van Rooij, Ivo de Blaauw, Alice Hoelscher, Marcus Pauly, Andreas Leutner, Joerg Fuchs, Joel Niethammer, Maria-Theodora Melissari, Ekkehart Jenetzky, Nadine Zwink, Holger Thiele, Alina Christine Hilger, Timo Hess, Jessica Trautmann, Matthias Marks, Martin Baumgarten, Gaby Blaess, Mikael Landen, Bengt Fundin, Cynthia M. Bulik, Tracie Pennimpede, Michael Ludwig, Kerstin U. Ludwig, Elisabeth Mangold, Stefanie Heilmann-Heimbach, Susanne Moebus, Bernhard G. Herrmann, Kristina Alsabeah, Carmen M. Burgos, Helene E. Lilja, Sahar Azodi, Pernilla Stenstrom, Einar Arnbjornsson, Barbora Frybova, Dariusz M. Lebensztejn, Wojciech Debek, Elwira Kolodziejczyk, Katarzyna Kozera, Jaroslaw Kierkus, Piotr Kalicinski, Marek Stefanowicz, Anna Socha-Banasiak, Michal Kolejwa, Anna Piaseczna-Piotrowska, Elzbieta Czkwianianc, Markus M. Noethen, Phillip Grote, Michal Rygl, Konrad Reinshagen, Nicole Spychalski, Barbara Ludwikowski, Jochen Hubertus, Andreas Heydweiller, Benno Ure, Oliver J. Muensterer, Ophelia Aubert, Jan-Hendrik Gosemann, Martin Lacher, Petra Degenhardt, Thomas M. Boemers, Anna Mokrowiecka, Ewa Malecka-Panas, Markus Woehr, Michael Knapp, Guido Seitz, Annelies de Klein, Grzegorz Oracz, Erwin Brosens, Heiko Reutter, Johannes Schumacher
Summary: This study identifies three risk loci and candidate genes associated with esophageal atresia with or without tracheoesophageal fistula (EA/TEF) through a genome-wide association study (GWAS), providing insights into the genetic architecture of EA/TEF.
HUMAN GENETICS AND GENOMICS ADVANCES
(2022)
Article
Clinical Neurology
Melanie Strauss, Lucie Griffon, Maxime Elbaz, Isabelle Arnulf, Mounir Chennaoui, Damien Leger
Summary: This study examines decision-making impairments in individuals with central disorders of hypersomnolence (CDH), specifically narcolepsy type 1 (NT1). The results suggest that both NT1 and other CDH patients have decreased learning abilities to avoid losses, which is associated with alterations in vigilance. The study provides new insights into the nature of decision-making impairments in CDH and suggests the potential for minimizing these alterations by restoring adequate vigilance.
Article
Clinical Neurology
Kyriakos Dimitriadis, Christina Stathakopoulou, Nikolaos Pyrpyris, Eirini Beneki, Elena Adamopoulou, Stergios Soulaidopoulos, Ioannis Leontsinis, Alexandros Kasiakogias, Aggelos Papanikolaou, Panagiotis Tsioufis, Konstantinos Aznaouridis, Dimitris Tsiachris, Konstantina Aggeli, Konstantinos Tsioufis
Summary: This review provides a comprehensive analysis of the common pathophysiology between sleep disordered breathing (SDB) and mitral regurgitation (MR), and discusses the effects of SDB treatment on MR and the effects of mitral valve surgery or transcatheter repair on obstructive and central sleep apnea (OSA and CSA).
Article
Clinical Neurology
Szu-Yu Hou, Ching-Ju Chiu, Jeanne Laraine Shea, Chih-Liang Wang, Hsiao-Han Tang, Po-Ching Kuo, Yi-Chieh Yang, Chih-Hsing Wu
Summary: The study aimed to examine the effects of age, menopausal status, and symptoms on sleep patterns and circadian rhythms in midlife women. Premenopausal women had the most unstable day-to-day rhythms, and women with more severe symptoms experienced greater sleep problems. Psychological symptoms were the strongest predictors for all sleep parameters.
Article
Clinical Neurology
Ya-Wen Hsiao, Wei-Lun Lin, Yu-Hui Chou, Shin-Huei Liu, Ting-Wei Ernie Liao, Shih-Ann Chen, Li-Wei Lo
Summary: This study aimed to investigate the effects of RDN on heart inflammation associated with COSA. The results suggest that RDN treatment may prevent COSA-associated heart inflammation through the JAK2-STAT3 signaling pathway.
Article
Clinical Neurology
Amy C. Reynolds, Kelly A. Loffler, Nicole Grivell, Brandon W. J. Brown, Robert J. Adams
Summary: This study aimed to understand the experience of sleep disorder diagnosis and treatment in shift workers and propose patient-informed solutions to improve access to health services. The findings showed that there were varied experiences with diagnosis and management, often taking a long time to seek help from healthcare providers after noticing symptoms. The study also identified the need for education and awareness initiatives, convenient screening and referral pathways, and tailored models of care.
Article
Clinical Neurology
Hsi -Chung Chen, Nai-Wei Hsu, Ching-Heng Lin
Summary: This study found a relationship between daytime sleepiness and mortality risk among older adults. The moderating effects of sex and physical function were examined. Specifically, the passive factor predicted mortality risk in women with good muscle power, while the active factor predicted mortality risk in men with good muscle power.
Article
Clinical Neurology
Sean P. A. Drummond, Bei Bei
Summary: This study proposes a parsimonious two-stage model for defining stages of Cognitive Behavioural Therapy for Insomnia (CBT-I) based on Sleep Restriction Therapy (SRT). Using data from a randomized clinical trial, the model helps identify patterns of treatment progression and their association with baseline insomnia severity. The model holds potential for further research on various CBT-I processes that are currently not fully understood.
Article
Clinical Neurology
Janet Jezkova, Karel Sonka, Jakub Kreisinger, Petra Prochazkova, Helena Tlaskalova-Hogenova, Sona Nevsimalova, Jitka Buskova, Radana Merkova, Tereza Dvorakova, Iva Prihodova, Simona Dostalova, Radka Roubalova
Summary: In recent years, there has been a growing interest in the influence of gut microbiota on sleep physiology. The gut microbiota affects the central nervous system and circadian rhythms, and can be associated with sleep disorders. This study observed the gut microbiota composition of patients with different types of narcolepsy and idiopathic hypersomnia, and found changes in beta diversity in these patient groups compared to healthy controls. However, after adjusting for confounding factors, the differences were no longer statistically significant. The study suggests that using metabolomics and proteomics approaches to study the role of microbiota in sleep disorders may be beneficial.
Article
Clinical Neurology
Mauro Manconi, Linda C. van der Gaag, Francesca Mangili, Corrado Garbazza, Silvia Riccardi, Christian Cajochen, Susanna Mondini, Francesca Furia, Elena Zambrelli, Simone Baiardi, Alessandra Giordano, Nicola Rizzo, Cristina Fonti, Elsa Viora, Armando D'Agostino, Alessandro Cicolin, Fabio Cirignotta, Daniele Aquilino, Alessandra Barassi, Renata del Giudice, Giulia Fior, Orsola Gambini, Barbara Giordano, Alma Martini, Chiara Serrati, Rossana Stefanelli, Silvio Scarone, Mariapaola Canevini, Valentina Fanti, Hans-Christian Stein, Anna Maria Marconi, Erica Raimondo, Emanuela Viglietta, Rossella Santoro, Giuliana Simonazzi, Alessandra Bianconcini, Francesco Meani, Nicoletta Piazza, Filippos Filippakos, Thomas Gyr
Summary: The Life-ON study provides the largest polysomnographic dataset coupled with longitudinal subjective assessments of sleep quality in pregnant women to date. Sleep disorders are highly frequent and distributed differently during pregnancy and postpartum. Routine assessment of sleep disturbances in the perinatal period is necessary to improve early detection and clinical management.
Article
Clinical Neurology
Zhihua Huang, Anqi Duan, Zhihui Zhao, Qing Zhao, Yi Zhang, Xin Li, Sicheng Zhang, Luyang Gao, Chenhong An, Qin Luo, Zhihong Liu
Summary: This study aims to investigate pulmonary arterial hypertension (PAH) phenotypes and their prognostic implications by clustering overnight cardiorespiratory signals in PAH patients. Three distinct clusters were identified, with patients in Cluster 3 exhibiting worse clinical outcomes. The presence of nocturnal hypoxemia and obstructive sleep apnea (OSA) in PAH patients was associated with increased risk of clinical worsening. Tailored management strategies addressing both PAH and nocturnal hypoxemia may improve clinical outcomes.
Article
Clinical Neurology
Yudan Lv, Yujun Wen, Ramalingam Vetrivelan, Jun Lu
Summary: This study demonstrated that the projections from the pontine parabrachial nucleus (PB) to the basal forebrain (BF) and medial septum (MS) can activate the cerebral cortex and hippocampus, providing important insights into the activities of these brain regions during the sleep-wake cycle.
Article
Clinical Neurology
Annika M. Myers, Megan E. Rech, Bengi Baran, Cara Palmer, Dimitrios Mylonas, Candice A. Alfano
Summary: This study found that N2 sleep spindles are associated with emotional functioning in school-aged children. Higher spindle density is related to decreased state-based emotional arousal towards negative affective images, and higher spindle peak frequency is associated with greater use of the positive emotion regulatory strategy of savoring.
Article
Clinical Neurology
Hung Youl Seok, Yong Won Cho
Summary: This study investigated the long-term impact of dopamine agonist treatment on altered central sensory processing in restless legs syndrome (RLS) patients. The results showed that dopamine agonist treatment effectively reduced RLS symptoms but did not reverse the altered central sensory processing observed on testing. These findings suggest that RLS pathophysiology is multifactorial and not solely driven by dopaminergic dysfunction.