Review
Nursing
Caitlin E. Mayhew, Kristin R. Simonson, Esther R. Ellsworth Bowers
Summary: Maternal thyroid hormones play a critical role in fetal growth and development during pregnancy. This review aims to provide clinicians with current evidence on the adverse effects of hypothyroidism in pregnancy, including recurrent pregnancy loss. It also discusses clinical presentation, evidence-based screening guidelines, and treatments for hypothyroidism during pregnancy.
JOURNAL OF MIDWIFERY & WOMENS HEALTH
(2022)
Article
Pediatrics
Riddhi Patel, Chetankumar Dave, Sajili Mehta, Hemangkumar Mendpara, Rishi Shukla, Anurag Bajpai
Summary: Obesity-related subclinical hypothyroidism is associated with increased fat percentage, android to gynoid ratio, and alanine aminotransferase (ALT) levels, predisposing to non-alcoholic steatohepatitis. The impact of thyroid supplementation in this setting needs further exploration.
INDIAN JOURNAL OF PEDIATRICS
(2021)
Article
Endocrinology & Metabolism
Zhekun Zhao, Huanqiang Zhao, Yu Xiong, Qiongjie Zhou, Xiaotian Li
Summary: Children born to mothers with subclinical hypothyroidism (SCH) have slightly lower neuropsychological scores at 6 months to 2 years of age compared to those born to mothers with overt hypothyroidism (OH) in clinical practice. The therapeutic effect of maternal SCH on child neurodevelopment requires further exploration.
CLINICAL ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Biao Wang, Yajuan Xu, Xiaofeng Hou, Jingjing Li, Yanjun Cai, Yingqi Hao, Qian Ouyang, Bo Wu, Zongzong Sun, Miao Zhang, Yanjie Ban
Summary: The study found that the prevalence of small intestinal bacterial overgrowth (SIBO) is higher in pregnant women with subclinical hypothyroidism compared to those with normal thyroid function. SIBO-positive patients are more likely to experience abdominal distension and constipation, and have lower body mass index. Additionally, SIBO-positive patients have higher levels of inflammatory markers and thyroid function indicators.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Medicine, General & Internal
Fatima Tarboush, Mohammad Alsultan, Zaynab Alourfi
Summary: This study investigated the relationship between hypothyroidism and lipid profile disturbance. The findings revealed a significant association between hypothyroidism and dyslipidemia, with hypothyroidism patients showing higher levels of blood lipids compared to the general population.
Article
Immunology
Jingjing Li, Yajuan Xu, Yanjun Cai, Miao Zhang, Zongzong Sun, Yanjie Ban, Shanshan Zhai, Yingqi Hao, Qian Ouyang, Bo Wu, Mengqi Wang, Wentao Wang
Summary: The study investigates the association between differential metabolites, small intestinal microflora, and maternal outcomes in subclinical hypothyroidism (SCH) during pregnancy. The results suggest that differential metabolites in the SCH group are associated with small intestinal bacterial overgrowth (SIBO) and may affect pregnancy outcomes. Bile acids and cholesterol are identified as potential biomarkers.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Luyang Han, Yan Ma, Zhaoxia Liang, Danqing Chen
Summary: Compared to the euthyroid group, pregnant women with subclinical hypothyroidism (SCH) displayed higher rates of inadequate gestational weight gain, premature delivery, low birth weight offspring, and infants small for their gestational age. After levothyroxine treatment, the SCH group showed improvements in cholesterol levels but still exhibited adverse pregnancy outcomes. Regular monitoring of blood sugar, lipid, and homocysteine levels, along with interventions to promote gestational weight gain, may help mitigate the negative effects of SCH on pregnancy outcomes.
Review
Endocrinology & Metabolism
Zheng Ding, Yindi Liu, Spyridoula Maraka, Nadia Abdelouahab, He-Feng Huang, William D. Fraser, Jianxia Fan
Summary: This study aimed to evaluate the effects of levothyroxine (LT4) treatment on pregnancy and neonatal outcomes among pregnant women with subclinical hypothyroidism (SCH) based on the 2017 American Thyroid Association diagnostic criteria. The results indicated that pregnant women with SCH treated with LT4 had a lower risk of pregnancy loss, preterm birth, and gestational hypertension compared to those in the control group.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
A. Amouzegar, M. Dehghani, H. Abdi, L. Mehran, S. Masoumi, F. Azizi
Summary: This study aimed to clarify the natural history of subclinical hypothyroidism (SCH) and the predictive factors for its progression. The results showed that TPOAb and TSH levels were predictors for the development of overt hypothyroidism (OH) in individuals with SCH.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2022)
Article
Endocrinology & Metabolism
Balsam Bohlega, Afshan Zahedi, George Tomlinson, Denice S. Feig
Summary: The study found that using a weight-based dosing method of starting thyroxine for women newly diagnosed with subclinical hypothyroidism during pregnancy increased the odds of reaching the target TSH range within 4-8 weeks. This approach should be considered by clinicians when initiating treatment during pregnancy.
CLINICAL ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Jiaxi Luo, Jialing Yuan
Summary: LT4 therapy can reduce the risk of premature delivery and amniotic fluid abnormalities in pregnant women with SCH and TPOAb+.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2022)
Article
Otorhinolaryngology
Ceren Ersoz Unlu, Ceren Karacayli, F. Ceyda Akin Ocal
Summary: This study aimed to evaluate and compare the acoustic and perceptual parameters of voice in patients newly diagnosed with subclinical and overt hypothyroidism. The results showed that overt hypothyroidism significantly affected the frequency parameters and patients' subjective assessment of voice, while subclinical hypothyroidism did not have a significant impact on voice parameters.
AURIS NASUS LARYNX
(2022)
Article
Endocrinology & Metabolism
Kamila Szeliga, Aleksandra Antosz, Karolina Skrzynska, Barbara Kalina-Faska, Aleksandra Januszek-Trzciakowska, Aneta Gawlik
Summary: This retrospective study aimed to investigate the course of subclinical hypothyroidism (SH) in children with Down's syndrome (DS), evaluate the risk of developing overt thyroid disease and autoimmunity, and identify characteristics of patients prescribed L-T4 therapy. The results showed that SH is the most common thyroid dysfunction in DS children, and a small percentage of patients develop overt hypothyroidism.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Jiajia Chen, Jing Zhu, Xianping Huang, Shenzhi Zhao, Huiqiu Xiang, Panpan Zhou, Tong Zhou, Zhangye Xu
Summary: This study aimed to evaluate the intellectual development of offspring born to mothers with SCH-TPOAb(-). The results showed that TSH levels were correlated with the intellectual development of offspring, and early treatment in SCH-TPOAb(-) pregnant women with TSH levels between 4.0 and 10.0 mIU/L significantly improved the intellectual development levels of the approximately two-year-old offspring.
Review
Endocrinology & Metabolism
Yue Han, Jun Wang, Xiaoying Wang, Ling Ouyang, Yan Li
Summary: This study conducted a systematic review and meta-analysis to evaluate the relationship between subclinical hypothyroidism in pregnancy and hypertensive disorders of pregnancy (HDP). The results indicated that pregnant women with subclinical hypothyroidism had an increased risk of developing HDP, regardless of the gestational period. However, the available evidence does not support the benefit of thyroxine intervention for these patients.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Medicine, General & Internal
Eng Loon Tng
SINGAPORE MEDICAL JOURNAL
(2015)
Review
Endocrinology & Metabolism
Eng-Loon Tng, Jeanne May-May Tan
Summary: The diagnostic accuracy of the dexamethasone suppression test and selective venous sampling in identifying virilizing tumors in postmenopausal hyperandrogenism is high, with both tests showing a sensitivity of 100%. The dexamethasone suppression test has a specificity of 89.2%, while selective venous sampling has a specificity of 100%. Limited evidence supports the use of these tests in clinical practice.
GYNECOLOGICAL ENDOCRINOLOGY
(2021)
Review
Endocrinology & Metabolism
Eng-Loon Tng, Aye Thida Aung, Nicole Chong
Summary: This article reports a case of myxedema coma after iohexol administration. The patient had pre-existing primary hypothyroidism but had stopped treatment. The results suggest that iodine-based contrast media may worsen primary hypothyroidism and can potentially precipitate myxedema coma. Patients with thyroid disorders should monitor for worsening symptoms after iodine-based contrast media administration, and long-term follow-up of thyroid function may be necessary for patients who fail to escape from the Wolff-Chaikoff effect.
Review
Endocrinology & Metabolism
Eng-Loon Tng, Yee Sian Tiong, Aye Thida Aung, Nicole Ya Yuan Chong, Zhemin Wang
Summary: This study evaluated the efficacy and safety of anticoagulation in patients with thyrotoxic atrial fibrillation. The results showed that anticoagulation can reduce the risk of ischemic stroke and systemic thromboembolism in these patients, and direct oral anticoagulants may be associated with fewer bleeding events.
ENDOCRINE CONNECTIONS
(2022)
Article
Endocrinology & Metabolism
Eng-Loon Tng, Jeanne May May Tan
Summary: Postmenopausal hyperandrogenism can be caused by either neoplastic or nonneoplastic conditions, leading to excessive secretion of androgens. Accurately diagnosing the etiology of this condition is challenging due to limited accuracy of current diagnostic tests. Studies comparing the diagnostic accuracy of GnRH analogue stimulation test and selective venous sampling in distinguishing neoplastic from nonneoplastic causes in postmenopausal women showed limited evidence for either test in identifying virilizing tumors.
JOURNAL OF THE ENDOCRINE SOCIETY
(2021)
Review
Medicine, General & Internal
Lawrence M. J. Best, Suzanne C. Freeman, Alex J. Sutton, Nicola J. Cooper, Eng-Loon Tng, Mario Csenar, Neil Hawkins, Chavdar S. Pavlov, Brian R. Davidson, Douglas Thorburn, Maxine Cowlin, Elisabeth Jane Milne, Emmanuel Tsochatzis, Kurinchi Selvan Gurusamy
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2019)
