Article
Nanoscience & Nanotechnology
Juan Yue, Qian Mei, Panyong Wang, Peng Miao, Wen-Fei Dong, Li Li
Summary: The yellow fluorescent carbon dots (CDs) for detecting GSSG through a fluorescence off-on process show linear correlation with GSSG concentration and a detection limit of 0.18mu M. Additionally, the CDs can also be used for fluorescence imaging in living cells and zebrafish.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Applied
Hong-Mei Zhao, Tao Sun, Jiang Wang, Ai-Ju Xu, Mei-Lin Jia, Bin Xue
Summary: A novel phosphorus-doped carbon nitride oligomer-based fluorescence sensor with needle-like nanostructures and terminal amino and hydroxyl functional groups was synthesized via hydrothermal reaction, showing selective quenching towards mercury (II) ions. The sensor achieved a minimum detection limit of 0.35 nmol L-1 in the range of 1-100 nmol L-1 and demonstrated sensitivity and accuracy in detecting mercury (II) ions in actual shrimp samples.
Article
Spectroscopy
Nayomi Camilus, Stephanie Gao, Musonda Mitti, Jun-Ray Macairan, Rafik Naccache, Sanela Martic
Summary: The post-translational modification of amino acids plays a critical role in normal and diseased biological states. This study achieved selective detection of nitrotyrosine (nTyr) using dual-fluorescent carbon dots (CDs), even in the presence of common biological interferences. These findings highlight the potential of CDs as viable sensors for key biological modifications.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Chemistry, Multidisciplinary
Fahad A. Alharthi, Hend Khalid Aldubeikl, Hamdah S. Alanazi, Wedyan Saud Al-Nafaei, Imran Hasan
Summary: In this study, a Ni-doped ZnWO4 mixed metal tungstate nanocomposite material was synthesized by the hydrothermal method and used as a sensor for the fluorometric determination of p-nitroaniline (p-NA). The results showed that ZnNiWO4 exhibited higher sensitivity towards p-NA, with a concentration range of 25-1000 μM and a detection limit of 1.93 x 10(-8) M. The detection limits for ZnWO4 and NiWO4 were 2.17 x 10(-8) M and 2.98 x 10(-8) M, respectively.
Article
Food Science & Technology
Wenshuo Zhang, Hongda Zhong, Pingping Zhao, Aiguo Shen, Houbin Li, Xinghai Liu
Summary: Carbon quantum dots (CDs) show great potential in detecting food ingredients and contaminants due to their easy preparation, good biocompatibility, and adjustable modification. The design of probes for CDs can be categorized into three types, with the introduction of functional groups on the surface being a key factor. The intermolecular interactions of different target substances play a role in determining the choice of carbon source and synthesis method.
Review
Chemistry, Analytical
Muthaiah Shellaiah, Kien Wen Sun
Summary: Biothiols, such as cysteine, homocysteine, and glutathione, play a crucial role in various biological processes, but abnormal levels can lead to serious diseases. Carbon-dots (CDs) have emerged as a promising tool for biothiols quantification due to their easy synthesis, nanosize, low toxicity, and real-time applicability. However, a comprehensive review on fluorescent CDs-based biothiols detection is lacking. This review provides valuable information on the assays, mechanisms, applications, selection of probes/CDs, sensory requirements, merits, limitations, and future prospects.
Article
Chemistry, Analytical
Farah Noun, Evelyne Anastasia Jury, Rafik Naccache
Summary: Carbon dots prepared using glutathione and formamide as dual fluorescent metal sensing probes show selective behavior towards Pb2+ and Hg2+ ions, leading to the development of a robust ratiometric sensor with low-ppb detection sensitivity in water. Characterization techniques and acid-base theory reveal insights into the nature of metal-carbon dot interactions, which can be used to tailor properties for targeting specific metal ions and applicable to other fluorescent nanoparticle systems for metal sensing applications.
Article
Chemistry, Inorganic & Nuclear
Hema Sindhuja George, Hosimin Selvaraj, Andivelu Ilangovan, Karthikeyan Chandrasekaran, Velu Rajesh Kannan, Punniyakotti Parthipan, Bader O. Almutairi, Ranjith Balu
Summary: Heavy metal ions pose a serious threat to the environment and human health, making their detection and removal crucial. This study demonstrates the successful conversion of papaya seeds into water-soluble carbon dots, which show excellent sensitivity and detection capabilities for Fe3+ ions.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Article
Chemistry, Inorganic & Nuclear
Salar Khaledian, Ali Noroozi-Aghideh, Danial Kahrizi, Sajad Moradi, Mohadese Abdoli, Akbar Haji Ghasemalian, Mohammad Foad Heidari
Summary: A simple, rapid, and inexpensive nanosensor based on fluorescence carbon dots (CDs) has been reported for the detection of diazinon in real samples. The synthesized CDs showed high sensitivity and specificity, with a low detection limit and a wide linear range.
INORGANIC CHEMISTRY COMMUNICATIONS
(2021)
Article
Chemistry, Physical
Raji Atchudan, Thomas Nesakumar Jebakumar Immanuel Edison, Suguna Perumal, Rajangam Vinodh, Ashok K. Sundramoorthy, Rajendran Suresh Babu, Yong Rok Lee
Summary: The synthesized Mortis nigra carbon dots exhibit strong fluorescence, monodispersity, and emit bright cyan-blue light under ultraviolet light. With a high quantum yield, they can be used as potential fluorescent sensors for sensitive detection of Fe3+ ions. Additionally, Mortis nigra CDs labeled colon cancer cells emit multicolor light when excited through different wavelength filters, providing potential applications in biomedical imaging.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Review
Chemistry, Multidisciplinary
Alejandro Lopez-Beltran, Claudia Iriarte-Mesa, Clarissa Murru, Frank J. Chao-Mujica, Angel Luis Corcho-Valdes, Lisandra Morales-Alvarez, Luis Felipe Desdin-Garcia, Johnny Deschamps, Manuel Antuch
Summary: The review summarizes the pollution caused by heavy metals through natural processes and human activities, and its occurrence in complex media. It aims to provide a systematic summary of the state-of-the-art fluorescent CDs and their sensing applications. The review also addresses the origin of observed selectivity in chemiluminescence sensors, offering explanations for trends and providing guidelines for the design of CDs targeting ions in solution.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Spectroscopy
Baoqiang Liu, Shanshan Wei, Enqi Liu, Hongyuan Zhang, Pengju Lu, Jiali Wang, Guoying Sun
Summary: A simple and convenient approach was designed to prepare fluorescent N-doped carbon dots for folic acid (FA) detection. The N-CDs showed excellent hydrophilicity, high photostability, and outstanding biocompatibility, making them a reliable quantitative probe for FA analysis in the field of biosensing. Cell experiments confirmed low toxicity and good cell imaging performance of the N-CDs, indicating their potential for practical applications in FA detection.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Food Science & Technology
Haoyang He, Da-Wen Sun, Zhihui Wu, Hongbin Pu, Qingyi Wei
Summary: On-off-on fluorescent sensors based on nanomaterials have gained much attention in food analysis due to their high sensitivity, wide detection range, strong anti-interference ability, and flexible design. This review introduces common nanomaterials and elaborates the main detection strategies of on-off-on fluorescent sensors. It also summarizes recent applications of these sensors for trace level detection of various analytes in food. However, the commercial and industrial applications of these sensors are still limited, and future research should focus on developing high-throughput detection techniques and portable or visual fluorescent sensors.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2022)
Article
Chemistry, Applied
Jiannan Chen, Xiuhua Xia, Peizhen Li, Hang Yu, Yunfei Xie, Yahui Guo, Weirong Yao, He Qian, Yuliang Cheng
Summary: In this study, crayfish shells were used as precursors to prepare a new type of carbon dots through the hydrothermal method. The synthesized carbon dots showed strong blue fluorescence emission and were sensitive to quenching effect by 4-nitrophenol. Based on this, a facile and rapid fluorescence sensor was developed to detect 4-nitrophenol with a detection limit of 0.16 μM. The sensor was successfully applied for the detection of 4-nitrophenol in fresh crayfish meat and aquatic water samples.
FOOD AND AGRICULTURAL IMMUNOLOGY
(2023)
Review
Chemistry, Analytical
H. K. Melvin Ng, G. K. Lim, C. P. Leo
Summary: Carbon dots (CDs) are nanomaterials with photoluminescence properties useful for detecting hazardous materials, synthesized from biowaste and chemicals through methods like hydrothermal and microwave-assisted synthesis. Additional dopants like nitrogen and sulfur can enhance their performance, and immobilization into a solid substrate allows for reuse. Interaction with heavy metals enables quantification of heavy metal concentrations in water samples.
MICROCHEMICAL JOURNAL
(2021)
Article
Biophysics
Jhili Mishra, Ashok Kumar Mishra
COLLOIDS AND SURFACES B-BIOINTERFACES
(2020)
Article
Chemistry, Physical
Swayam Prakash, Ashok Kumar Mishra
JOURNAL OF PHYSICAL CHEMISTRY A
(2020)
Article
Chemistry, Multidisciplinary
Swayam Prakash, Saugata Sahu, Shubhayan Bhattacharya, Prem B. Bisht, Ashok Kumar Mishra
Summary: Phosphor materials with broad spectral range and an average emission lifetime have been achieved from carbon dots-NaCl crystals, with fructose as the precursor showing the most intense emission. Utilizing ripe banana peel as the precursor, white-light emission with specific CIE index has been achieved from the single source of CDs-NaCl crystals, which also function as Fabry-Perot resonators for lasing with low laser threshold value and high Q-factor. This approach offers a new method for F-P lasing and white light emission from a non-toxic green source with a quick and low-cost synthesis procedure.
CHEMISTRY-AN ASIAN JOURNAL
(2021)
Article
Environmental Sciences
Swayam Prakash, Suraj Kumar Panigrahi, Rebecca Paulina Dorner, Martin Wagner, Wido Schmidt, Ashok Kumar Mishra
Summary: A detailed photophysical study was conducted on two faecal pigments (UB and SB) and their zinc complexes, revealing that the fluorescence of UB and SB can be enhanced by the formation of Zn(II) complexes. The physicochemical environments play a significant role in influencing the fluorescence behavior of the Zn(II) complexes. Molecular orbital calculations provided insights into the geometry of the complexes and rationalized the fluorescence enhancement after complexation.
Article
Chemistry, Multidisciplinary
Saugata Sahu, Pulak Karan, Ashok Kumar Mishra
Summary: FDAPT is an efficient environment-sensitive fluorescent probe that can sense the alteration of its microenvironment with six different fluorescent parameters. The study investigates the saccharide-induced dehydration of a F127 polymeric micelle using multiparametric fluorescence approach, revealing that saccharide molecules not only decrease the critical micellization temperature of the F127 solution but also strongly alter the physical properties inside the micellar structures. The dehydration efficiency order of different saccharide molecules is found to be trisaccharide (raffinose) > disaccharide (sucrose) > monosaccharide (glucose and fructose), with dehydration occurring more significantly in the core region than in the corona region.
Article
Chemistry, Multidisciplinary
Anand Kumar Sahu, Ashok Kumar Mishra
Summary: Curcumin is the main bioactive component of turmeric, with various pharmacological benefits including antioxidant and anti-inflammatory effects. The exact mechanism of its action is still unclear.
Article
Chemistry, Multidisciplinary
Anand Kumar Sahu, Ashok Kumar Mishra
Summary: This report investigates the interaction of dopamine with different types of membranes using DSC and intrinsic fluorescence techniques. The results indicate a strong specific interaction between dopamine and the anionic DMPS membrane, while a weaker interaction is observed with the zwitterionic DMPC membrane.
Article
Chemistry, Physical
Anand Kumar Sahu, Ashok Kumar Mishra
Summary: This study investigated the photophysical behavior of structurally related flavonols in different solvents and a model membrane. The results showed that the behavior of flavonols varied in different solvent environments and membranes. The number of B-ring hydroxy groups and membrane fluidity affected the binding of flavonols with the membrane. Additionally, flavonols exhibited antioxidant activity in the membrane.
JOURNAL OF PHYSICAL CHEMISTRY B
(2022)
Article
Chemistry, Physical
Sonali Sahu, Venkatakrishnan Parthasarathy, Ashok Kumar Mishra
Summary: Organic push-pull molecules with donor and acceptor moieties connected via pi-linkages exhibit interesting photophysical properties due to intramolecular electron charge transfer. This study investigated basic phenylethynylanthracene derivatives to demonstrate that their photophysical properties can be dramatically changed by substituents. The emission properties and ICT abilities of these molecules were compared with different electron donating and withdrawing substituents. The study also showed the sensitivity of these compounds towards microviscosity and demonstrated the application of a white light emitting gel in a commercial UV LED.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)
Article
Chemistry, Physical
Asit Kumar Pradhan, Manaswini Ray, Venkatakrishnan Parthasarathy, Ashok Kumar Mishra
Summary: This study explores the photophysical, electrochemical, and fluorescence polarization properties of a group of pi-conjugated phenylethynyl-2,1,3-benzothiadiazole derivatives. It is found that derivatives with strong electron-donating substituents exhibit pronounced solvatochromic behavior and a strong ICT character in the excited state. Different types of BTDs show different fluorescence quantum yields in different solvent media.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)
Article
Chemistry, Analytical
Swayam Prakash, Ashok Kumar Mishra
Summary: This study developed a simple, low-cost, and rapid fluorescence-based analytical method for real-time detection of trace faecal pigments, which is of great significance for water quality monitoring.
ANALYTICAL METHODS
(2022)
Article
Chemistry, Analytical
Swayam Prakash, Ashok Kumar Mishra
Summary: This study introduces a new analytical paradigm for high sensitivity detection of fecal pigments (FPs) by fluorescence enhancement and background fluorescence minimization. The use of 1-hexanol as an efficient extraction medium for FPs is proposed, along with the complexation of FP-Zn(ii) in alcohol media to enhance fluorescence emission intensity and reduce interference, enabling the detection of FPs at picomolar to sub-picomolar concentrations. The study also examines the complexation behavior of FPs with various metal salts and validates the proposed analytical method using real water samples.
ANALYTICAL METHODS
(2021)
Article
Chemistry, Multidisciplinary
Jhili Mishra, Ashok Kumar Mishra, Jitendriya Swain
Summary: 3-Pentadecylphenol is a phenolic lipid that can modify the properties of the dipalmitoylphosphatidylcholine bilayer, leading to physico-chemical changes at higher concentrations. Fisetin, a sensitive membrane probe, shows variation in fluorescence properties with changes in PDP concentration. Overall, the study demonstrates that the alteration of bilayer properties is primarily caused by the abundance of the large phenolic headgroup.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Food Science & Technology
Jhili Mishra, Ashok Kumar Mishra
Summary: The study revealed the mechanism of solubilization of bioactive compounds Cap and I3C in sodium taurocholate (NaTC) bile salt aggregates, which is related to the increase in nonpolarity of the NaTC micellar environment. Through fluorescence study and dynamic light scattering analysis, the binding location of both bioactive molecules in NaTC micelles and their effects on micelle size were determined.
ACS FOOD SCIENCE & TECHNOLOGY
(2021)
Article
Chemistry, Physical
Anand Kumar Sahu, Jhili Mishra, Ashok Kumar Mishra
Article
Chemistry, Analytical
Mengmeng Guo, Na Luo, Yueling Bai, Zhenggang Xue, Qingmin Hu, Jiaqiang Xu
Summary: A porous heterostructure WO3-C/In2O3 was designed and prepared for a miniature H2 sensor, which showed higher response value, lower operating temperature, fast response-recovery speed, and low limit of detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Feng Hu, Hui Hu, Yuting Li, Xiaohui Wang, Xiaowen Shi
Summary: Arsenic contamination in water bodies is a significant health risk. This study developed a chitosan-catechol modified electrode for rapid and accurate detection of trace amounts of arsenic. The modified electrode demonstrated good detection capability and resistance to ionic interference, making it suitable for in situ detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Yantao Zhang, Qian Liu, Tao Tian, Chunhua Xu, Pengli Yang, Lianju Ma, Yi Hou, Hui Zhou, Yongjun Gan
Summary: In this study, a lysosome-targeting buffering fluorogenic probe (Lyso-BFP) was designed and synthesized, demonstrating excellent photostability, pH specificity, and responsiveness to lysosomal acidification in living cells. The performance of Lyso-BFP in pH sensing was attributed to the inhibition of the photo-induced electron transfer process. Lyso-BFP allowed for wash-free imaging and long-term real-time monitoring of lysosome pH changes based on its off-on fluorescence behavior and buffer strategy.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Wei Cai, Wenbo Sun, Jiayue Wang, Xiaokui Huo, Xudong Cao, Xiangge Tian, Xiaochi Ma, Lei Feng
Summary: In this study, a near-infrared fluorescent probe HCBG was developed for imaging of alpha-GLC. HCBG exhibited excellent selectivity and sensitivity towards alpha-GLC in complex bio-samples, and showed good cell permeability for in situ real-time imaging. Through the high-throughput screening system established by HCBG, a natural alpha-GLC inhibitor was successfully isolated and identified. This study provides a novel fluorescence visualization tool for discovering and exploring the biological functions of diabetes-related gut microbiota, and a high-throughput screening approach for alpha-GLC inhibitor.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Trey W. Pittman, Xi Zhang, Chamindie Punyadeera, Charles S. Henry
Summary: Heart failure is a growing epidemic and a significant clinical and public health problem. Researchers have developed a portable and affordable diagnostic device for heart failure that can be used at the point-of-care, providing a valid alternative to current diagnostics approaches.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Anders O. Tjell, Barbara Jud, Roland Schaller-Ammann, Torsten Mayr
Summary: An optical hydrogen peroxide sensor based on catalytic degradation and the detection of produced oxygen is presented. The sensor offers higher resolution and better sensitivity at lower H2O2 concentrations. By removing O2 from the sample solution, a more sensitive O2 sensor can be used for measurement. The sensor has been successfully applied in a flow-through cell to measure H2O2 concentration in different flow rates.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Seong Jae Kim, Ji-hun Jeong, Gaabhin Ryu, Yoon Sick Eom, Sanha Kim
Summary: Surface-enhanced Raman spectroscopy (SERS) is a high-sensitivity, label-free detection method with various analytical applications. Researchers have developed a hydrophobic SERS substrate based on engineered carbon nanotube arrays (CNT-SERS) and studied the role of structural design at both micro and nanoscales. The substrate demonstrated controlled self-enrichment capability and enhanced sensitivity, with a significant increase in the SERS signal. The study also proposed a theoretical model and a concentration strategy inspired by plants for analyte deposition on microarrays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Dan Zhao, Renjun Jiang, Xiaoqiang Liu, Subbiah Alwarappan
Summary: In this study, a novel ternary composite material was constructed by assembling cerium vanadate nanorods on reduced graphene oxide-microcrystalline cellulose nanosheets, and it was used for real-time monitoring of the concentration of superoxide anions in vivo. The ternary composite showed excellent conductivity, large surface area, and abundant active sites, leading to a wider linear range, high sensitivity, low detection limit, and fast response time for superoxide anion detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Tengfei Wang, Liwen Wang, Guang Wu, Dating Tian
Summary: In this study, a covalent organic framework material TaTp-COF with porous and uniform spheres was successfully prepared via hydrothermal reaction, and it was found to significantly enhance the aggregation-induced emission (AIE) of berberine. The unique emission properties of berberine on TaTp-COF were studied and utilized for the sensitive detection of berberine.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Lin Li, Yilei Ding, Lei Xu, Shuoran Chen, Guoliang Dai, Pengju Han, Lixin Lu, Changqing Ye, Yanlin Song
Summary: In this study, a novel TTI based on a ratiometric fluorescent nanosensor is designed, which has the advantages of high accuracy and low cost. Experimental and theoretical investigations confirm its pH responsiveness and demonstrate its good sensitivity and reliability. By monitoring the total volatile basic nitrogen, this TTI can accurately predict food spoilage and can be adaptively modified for different types of food. The TTI based on this nanosensor enables visual monitoring of food quality.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Fangju Chen, Xueting Wang, Wei Chen, Chenwen Shao, Yong Qian
Summary: Lung cancer is the second most common malignant tumor worldwide. Drug resistance in lung cancer leads to treatment failure and recurrence in majority of patients. This study developed a fluorescent prodrug that can be activated in cancer cells to release drugs, and its signal can be tracked by imaging. It shows a unique autophagy-driven ferroptosis effect, indicating its potential for targeting drug-resistant cancer cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Weichao Li, Qiming Yuan, Zhangcheng Xia, Xiaoxue Ma, Lifang He, Ling Jin, Xiangfeng Chu, Kui Zhang
Summary: This study developed a high-performance gas sensor for formaldehyde detection by modifying ZnSnO3 with ZnO QDs and SnO2 QDs. The modified sensor showed improved sensing response and lower working temperature. The presence of ZnO QDs formed rich heterojunctions, increased surface area, and provided oxygen deficiency for formaldehyde sensing reaction, thus enhancing the sensor performance. This research provides an alternative method to enhance the sensing properties of MOS by QDs modification.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Joung-Il Moon, Eun Jung Choi, Younju Joung, Jin-Woo Oh, Sang-Woo Joo, Jaebum Choo
Summary: A novel nanoplasmonic substrate was developed for biomedical applications, which showed strong hot spots for detecting biomarkers at low concentrations. The substrate, called AuNPs@M13, was made by immobilizing 60 nm gold nanoparticles onto the surface of an M13 bacteriophage scaffold. It demonstrated higher sensitivity and lower limit of detection compared to commercially available assays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Ning Li, Ya Zhang, Ying Xu, Xiaofang Liu, Jian Chen, Mei Yang, Changjun Hou, Danqun Huo
Summary: The molecular subtype of breast cancer guides treatment and drug selection. Invasive tests can promote cancer cell metastasis, so the development of high-performance, low-cost diagnostic tools for cancer prognosis is crucial. Liquid biopsy techniques enable noninvasive, real-time, dynamic, multicomponent, quantitative, and long-term observations at the cellular, genetic, and molecular levels. A Cu-Zr metal-organic framework (MOF) nanoenzyme with monatomic Cu attachment has been synthesized and proven to have high catalytic performance. The sensor constructed using this nanoenzyme shows potential for accurate classification of breast cancer serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Jeongmin Kim, Hyemin Kim, Seunghyun Park, Hyeonaug Hong, Yong Jae Kim, Jiyong Lee, Jaeho Kim, Seung-Woo Cho, Wonhyoung Ryu
Summary: This study presents a method to fabricate independently functioning microneedle (MN) electrodes with narrow intervals for high precision electrochemical sensing. The optimized mixture of photocurable polymer and single-wall carbon nanotubes was used to mold single composite MNs, which were then attached to pre-patterned electrodes. Plasma etching and electropolymerization were performed to enhance the electrochemical activity, and Prussian blue and glucose oxidase were electrodeposited on the MNs for glucose detection. The MN electrodes showed good sensitivity and linearity, and the feasibility of glucose detection was demonstrated in an in vivo mouse study.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)