Article
Food Science & Technology
Fatemeh Mahdavi Abhari, Maryam Niyyati, Hamid Assadzadeh Aghdaei, Hamed Mirjalali
Summary: The increasing demands for food, lack of arable land, and limited water resources pose important challenges for humanity in the century ahead. Food-related diseases have been on the rise and have significant impacts on the global economy. Therefore, ensuring food safety is essential and should be taken into consideration by health policy makers. In recent decades, there have been significant improvements in laboratory diagnosis of foodborne pathogens, aiming to increase accuracy, sensitivity, and decrease the time and facilities required for diagnostic tests. Loop-isothermal mediated amplification (LAMP) is a simple and sensitive rapid test that reduces the dependency on current facilities required for conventional molecular methods. The incorporation of laboratory sciences with engineering has also led to the development of a new approach called lab-on-a-chip, known as a point of care (POC) diagnostic method. Here, we provide a state-of-the-art review on available diagnostic techniques from conventional PCR to microfluidic LAMP for the detection of foodborne parasites.
Article
Chemistry, Analytical
Eadaoin Carthy, Brian Hughes, Eimear Higgins, Phil Early, Cian Merne, Darren Walsh, Anne Parle-McDermott, David J. Kinahan
Summary: The challenge of integrating effective valving mechanisms in the design and manufacture of LoaD devices highlights the need for improved processes. A LoaD device without integrated valving system successfully automated biological workflows and reagent actuation. The optimized LoaD platform demonstrated superior DNA yield at higher cell concentrations.
ANALYTICA CHIMICA ACTA
(2023)
Review
Biophysics
Vahid Kordzadeh-Kermani, Masoud Madadelahi, Seyed Nezameddin Ashrafizadeh, Lawrence Kulinsky, Sergio O. Martinez-Chapa, Marc J. Madou
Summary: This review introduces the on-board power supply and electrokinetic applications of electrified-LOD (eLOD) devices. By utilizing electrokinetic phenomena, different microfluids can be propelled, separated, and manipulated. While extensive research exists on stationary platforms, the applications on rotating platforms are still underdeveloped.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Engineering, Environmental
Yang Sylvia Liu, Yanlin Deng, Chun Kwan Chen, Bee Luan Khoo, Song Lin Chua
Summary: Inadequate access to clean water can negatively impact human health and aquatic industries. Monitoring microbial pathogens and assessing their infection risk on a large scale is crucial for environmental agencies and research laboratories. The TelM platform, which is based on microfluidics, offers a portable and cost-effective solution for monitoring waterborne pathogens and their infection potential. It allows direct access to the animal and provides clear observation of sensor readouts, making it an effective tool for assessing microbial and chemical risk in resource-constrained aquatic bodies.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Engineering, Chemical
Niamh A. Kilcawley, Toni C. Voebel, Philip L. Early, Niamh A. McArdle, Marine Renou, Jeanne Rio, Godefroi Saint-Martin, Macdara T. Glynn, Daniel Zontar, Christian Brecher, Jens Ducree, David J. Kinahan
Summary: A multi-step assay was automated using Lab-on-a-Disc (LoaD) technology, combining buoyancy pumping and dissolvable film. The technology allows tasks like blood centrifugation to be located in less valuable areas with higher centrifugal forces. A mathematical model and simulation were used to estimate volume errors caused by manufacturing deviations.
Article
Engineering, Electrical & Electronic
Jens Ducree
Summary: Non-genuine medical products, including diagnostic devices, have become a lucrative business for fraudsters, causing significant damage to revenues and reputation of companies, as well as posing a significant risk to the health of people and societies.
SENSORS AND ACTUATORS A-PHYSICAL
(2023)
Article
Food Science & Technology
Yining Luo, Shan Shan, Shuanglong Wang, Jinlin Li, Daofeng Liu, Weihua Lai
Summary: A microfluidic chip was developed to detect Salmonella by combining LAMP and CRISPR/Cas12a system. The method showed high sensitivity and was successfully used on real samples.
Article
Food Science & Technology
Andrea Zendrini, Valentina Carta, Virginia Filipello, Laura Ragni, Elena Cosciani-Cunico, Sara Arnaboldi, Barbara Bertasi, Niccolo Franceschi, Paolo Ajmone-Marsan, Dario De Medici, Marina Nadia Losio
Summary: Salmonella and Campylobacter screening in poultry meat can be efficiently conducted using real-time PCR even after shorter enrichment times, providing timely detection of these pathogens. Additionally, colorimetric LAMP is a valid alternative to real-time PCR when one-day results are needed, enabling quick identification of positive meat batches without the need for specialized instrumentation.
Review
Chemistry, Multidisciplinary
Carla Spatola Rossi, Frederic Coulon, Shaohua Ma, Yu Shrike Zhang, Zhugen Yang
Summary: Rapid, sensitive, and selective detection of live pathogens is crucial for quality control and risk assessment. Conventional methods are often complex, expensive, time-consuming, and not suitable for field testing or low-resource settings. Microfluidic devices that integrate laboratory functions in a miniaturized manner have emerged as a promising tool for rapid and sensitive pathogen detection.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Akansha Prasad, Shadman Khan, Jonathan K. Monteiro, Jiuxing Li, Fatima Arshad, Liane Ladouceur, Lei Tian, Amid Shakeri, Carlos D. M. Filipe, Yingfu Li, Tohid F. Didar
Summary: Lab-in-a-Package is a novel food packaging platform that allows sampling, concentration, and detection of pathogenic bacteria within closed food packaging without opening it. The platform utilizes an inclined food packaging tray and a reagent-infused membrane to maximize fluid localization and serve as a reagent-immobilizing matrix and an antifouling barrier for the sensor. It is validated using a newly discovered Salmonella-responsive nucleic acid probe, enabling hands-free detection of target pathogens at a level of 10(3) colony forming units (CFU) g(-1) in packaged chicken. Real-world in situ detection is simulated using a handheld fluorescence scanner with smartphone connectivity.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Analytical
Brian D. Henderson, David J. Kinahan, Jeanne Rio, Rohit Mishra, Damien King, Sarai M. Torres-Delgado, Dario Mager, Jan G. Korvink, Jens Ducree
Summary: The centrifugal microfluidic Lab-on-a-Disc platform combines event-triggered dissolvable film valves with a centrifugo-pneumatic siphon structure to control and time the release and incubations of samples/reagents/wash buffers through changes in disc spin-speed. This platform is suitable for integrating and automating chemiluminescent immunoassay for detection of C-reactive protein marker, with a limit of detection of 44.87 ng mL(-1) and limit of quantitation of 135.87 ng mL(-1).
Article
Food Science & Technology
Antonia Kreitlow, Andre Becker, Ulrich Schotte, Burkhard Malorny, Madeleine Ploetz, Amir Abdulmawjood
Summary: The study established a specific and rapid LAMP assay for detecting Salmonella in various food matrices. The results showed that the method can complete sample screening within 24 hours and accurately identify Salmonella, making it suitable for official applications.
Article
Microbiology
Weiwei Jiang, Dongying Hu, Yanyan Xu, Yang Chen, Xiaoyang Zhu, Zhao Han, Xin Ye, Xiaojing Li
Summary: In this study, LAMP primers for Trichophyton were designed and a LAMP-Microfluidic chip detection system was developed. The system exhibited high specificity and sensitivity, enabling the detection of six common species of Trichophyton without cross-reactivity with other dermatophytes. The system has the potential for clinical application, offering a simple and efficient way to detect Trichophyton infections.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Chemistry, Analytical
Danbi Lee, Eunsuk Kim, Kyung Won Lee, Ka Ram Kim, Hyeong Jin Chun, Hyunjin Yoon, Hyun C. Yoon
Summary: Loop-mediated isothermal amplification (LAMP) is a rapid, specific, and sensitive method for molecular diagnostics, although it requires a sophisticated optical setup. This study developed a novel sensing method that can quantify target analytes using simple equipment, successfully applied to quantitative analysis of Salmonella. The results suggest the potential application of this method in pathogen detection in contaminated food sources.
Article
Chemistry, Analytical
Xinlian Zhang, Xi Chen, Yuhan Yao, Xiaona Shang, Huijun Lu, Wang Zhao, Sixiu Liu, Jianmin Chen, Guodong Sui
Summary: A novel acute toxicity detection system using smartphones with high-performance cameras has been successfully developed, replacing the expensive PMT methods, and can be widely used in environmental monitoring scenarios.
Article
Chemistry, Analytical
Shah Mukim Uddin, Abkar Sayad, Jianxiong Chan, Duc Hau Huynh, Efstratios Skafidas, Patrick Kwan
Summary: A heater-integrated lab-on-a-chip device was developed for rapid detection of HLA-B alleles, showing complete concurrence with the traditional tube assay.
Article
Nutrition & Dietetics
Sumaiyah Mat, Maw Pin Tan, Mas Sahidayana Mohktar, Shahrul Bahyah Kamaruzzaman, Fatimah Ibrahim
Summary: The study evaluated the role of PhA in diabetes in older adults and found that men with PhA <= 4.9 were more likely to have diabetes, which was associated with oral hypoglycaemic agents. No significant relationship between PhA and diabetes was found in women. Further research is needed to determine the potential of PhA as a prognostic tool for diabetes.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Chemistry, Analytical
Shah Mukim Uddin, Abkar Sayad, Jianxiong Chan, Efstratios Skafidas, Patrick Kwan
Summary: The magnetic bead detection-based immunoassay has potential applications in point-of-care testing. In this study, a single-layered magnetic biosensor was evaluated to overcome the limitations of expensive multilayered sensors. By optimizing the sensor design, effective detection of magnetic bead concentrations was achieved.
Article
Engineering, Electrical & Electronic
Wan Nurlina Wan Yahya, Fatimah Ibrahim, Aung Thiha, Nurul Fauzani Jamaluddin, Marc Madou
Summary: The study presents the development of a 3D carbon DEP microfluidic chip for cell patterning in liver tissue engineering. The design of a new electrode and microfabrication approach were utilized to improve the efficiency of cell patterning. The results show that the 3D carbon DEP microfluidic chip has the potential for applications in 3D hepatic cells patterning.
JOURNAL OF MICROMECHANICS AND MICROENGINEERING
(2022)
Article
Chemistry, Analytical
Mohamed Osman Baloola, Fatimah Ibrahim, Mas S. Mohktar
Summary: This paper presents an optimization method for medication delivery drones using the Internet of Things (IoT)-Guidance Landing System. The IoT-GLS assists the drone in selecting the best landing angles based on the direction and intensity of light. The results show significant improvements in detection distance and face recognition distance, achieved by the IoT-GLS.
Review
Cell & Tissue Engineering
Vieralynda Vitus, Fatimah Ibrahim, Wan Safwani Wan Kamarul Zaman
Summary: Human hair has been recognized as a potential biomaterial for biomedical applications due to its advantageous characteristics. Utilizing human hair as a biomaterial for tissue engineering applications can reduce hair waste accumulation and promote the production of sustainable, environmentally friendly, and non-toxic materials.
TISSUE ENGINEERING PART C-METHODS
(2022)
Article
Environmental Sciences
Eva Bezak, Kristin V. Carson-Chahhoud, Loredana G. Marcu, Magdalena Stoeva, Lenka Lhotska, Gilda A. Barabino, Fatimah Ibrahim, Eleni Kaldoudi, Sierin Lim, Ana Maria Marques da Silva, Peck Ha Tan, Virginia Tsapaki, Monique Frize
Summary: This study analyzes the challenges faced by STEM professionals during remote working under COVID-19 lockdowns. Participants reported challenges within the immediate family, such as school responsibilities and loss of social interactions. They also mentioned increased domestic duties, connectivity issues, concentration difficulties, and concerns about COVID-19. The study also highlights gender, relationship status, and ethnic-related pressure points. However, some benefits were identified, including increased productivity and improved relationships with family.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Medical Informatics
Monique Frize, Virginia Tsapaki, Lenka Lhotska, Ana Maria Marques da Silva, Fatimah Ibrahim, Eva Bezak, Magdalena Stoeva, Gilda Barabino, Sierin Lim, Eleni Kaldoudi, Peck Ha Tan, Loredana G. Marcu
Summary: WiMPBME is a Task Group established under IUPESM in 2014, focusing on coordinating tasks and projects related to women's needs and roles in medical physics and biomedical engineering globally. The group has summarized past, present, and future goals and activities, aiming to support the professional development of women in these fields. Additionally, the article outlines the historical path of women's groups and subcommittees since 2004 and sets out future aims for promoting gender balance in these professions.
HEALTH AND TECHNOLOGY
(2022)
Article
Polymer Science
Vieralynda Vitus, Fatimah Ibrahim, Shamsul Azlin Ahmad Shamsuddin, Nuguelis Razali, Noor Anastasha Balqis Noor Azlan, Wan Safwani Wan Kamarul Zaman
Summary: The usage of carbon derived from biomass waste is increasing in various fields due to its availability, cost-effectiveness, and sustainability, but its application in tissue engineering is still limited. In this study, carbon derived from human hair waste was used to fabricate a carbon-based bioscaffold, which showed potential for tissue engineering applications based on its properties and compatibility with stem cells.
Review
Chemistry, Multidisciplinary
Elyana Kosri, Fatimah Ibrahim, Aung Thiha, Marc Madou
Summary: This paper reviews the use of mu/n-IDEA configurations as working electrodes in four-electrode electrochemical sensors, focusing on the two-dimensional and three-dimensional IDEA configurations and methods to expand the surface area. Compared to traditional electrochemical sensors, IDEAs show improved performance and face several challenges in future development.
Review
Chemistry, Multidisciplinary
Nuraina Anisa Dahlan, Aung Thiha, Fatimah Ibrahim, Lazar Milic, Shalini Muniandy, Nurul Fauzani Jamaluddin, Bojan Petrovic, Sanja Kojic, Goran M. Stojanovic
Summary: bioNEMS/MEMS is an innovative technology for miniaturizing biomedical devices. Various organic and inorganic nanomaterials have driven the development of high-throughput and sensitive bioNEMS/MEMS-based biosensors, actuators, drug delivery systems, and implantable/wearable sensors. Converting food waste into nanomaterials is a groundbreaking research in this field.
Article
Medicine, Research & Experimental
Syarifah Aisyah Syed Ibrahim, Fatimah Ibrahim, Nur Aishah Mohd Taib, Jongman Cho
Summary: The researchers developed a low-cost, portable, mobile-based bioimpedance lymphedema monitoring system (Mobilymph) for continuous monitoring of lymphedema. Validation tests showed that the bioimpedance measurements obtained from Mobilymph were comparable to those obtained from the Quadscan 4000. The Mobilymph system offers a feasible solution for early lymphedema diagnosis and treatment monitoring.
LYMPHATIC RESEARCH AND BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Aung Thiha, Fatimah Ibrahim, Karunan Joseph, Bojan Petrovic, Sanja Kojic, Nuraina Anisa Dahlan, Nurul Fauzani Jamaluddin, Saima Qureshi, Goran M. Stojanovic
Summary: This study presents a systematic design of a microfluidic compact disc (CD) with six unique chambers for simultaneous analysis of different types of saliva and mouthwashes. Electrical impedance analysis was used to investigate the electrochemical property changes between real saliva and artificial saliva mixed with three different types of mouthwashes. The findings suggest that the microfluidic CD platform has the potential for future research on salivary theranostics using point-of-care devices.
Article
Multidisciplinary Sciences
Nurul Farhah Shamsuddin, Mas Sahidayana Mohktar, Reena Rajasuriar, Safwani Wan Kamarul Zaman, Fatimah Ibrahim, Adeeba Kamarulzaman
Summary: The purpose of this study is to analyze the relationship between fat mass and inflammation marker interleukin-6, clinical, and metabolic data in HIV-positive male patients. The study found that factors such as weight, waist-hip ratio, BMI, triglycerides, high-density lipoprotein, and HIV viral load were significantly associated with body fat mass in male HIV patients. In addition, an artificial neural network model was used to predict fat mass with high accuracy.
ACTA SCIENTIARUM-TECHNOLOGY
(2022)
Article
Chemistry, Analytical
Mengmeng Guo, Na Luo, Yueling Bai, Zhenggang Xue, Qingmin Hu, Jiaqiang Xu
Summary: A porous heterostructure WO3-C/In2O3 was designed and prepared for a miniature H2 sensor, which showed higher response value, lower operating temperature, fast response-recovery speed, and low limit of detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Feng Hu, Hui Hu, Yuting Li, Xiaohui Wang, Xiaowen Shi
Summary: Arsenic contamination in water bodies is a significant health risk. This study developed a chitosan-catechol modified electrode for rapid and accurate detection of trace amounts of arsenic. The modified electrode demonstrated good detection capability and resistance to ionic interference, making it suitable for in situ detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Yantao Zhang, Qian Liu, Tao Tian, Chunhua Xu, Pengli Yang, Lianju Ma, Yi Hou, Hui Zhou, Yongjun Gan
Summary: In this study, a lysosome-targeting buffering fluorogenic probe (Lyso-BFP) was designed and synthesized, demonstrating excellent photostability, pH specificity, and responsiveness to lysosomal acidification in living cells. The performance of Lyso-BFP in pH sensing was attributed to the inhibition of the photo-induced electron transfer process. Lyso-BFP allowed for wash-free imaging and long-term real-time monitoring of lysosome pH changes based on its off-on fluorescence behavior and buffer strategy.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Wei Cai, Wenbo Sun, Jiayue Wang, Xiaokui Huo, Xudong Cao, Xiangge Tian, Xiaochi Ma, Lei Feng
Summary: In this study, a near-infrared fluorescent probe HCBG was developed for imaging of alpha-GLC. HCBG exhibited excellent selectivity and sensitivity towards alpha-GLC in complex bio-samples, and showed good cell permeability for in situ real-time imaging. Through the high-throughput screening system established by HCBG, a natural alpha-GLC inhibitor was successfully isolated and identified. This study provides a novel fluorescence visualization tool for discovering and exploring the biological functions of diabetes-related gut microbiota, and a high-throughput screening approach for alpha-GLC inhibitor.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Trey W. Pittman, Xi Zhang, Chamindie Punyadeera, Charles S. Henry
Summary: Heart failure is a growing epidemic and a significant clinical and public health problem. Researchers have developed a portable and affordable diagnostic device for heart failure that can be used at the point-of-care, providing a valid alternative to current diagnostics approaches.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Anders O. Tjell, Barbara Jud, Roland Schaller-Ammann, Torsten Mayr
Summary: An optical hydrogen peroxide sensor based on catalytic degradation and the detection of produced oxygen is presented. The sensor offers higher resolution and better sensitivity at lower H2O2 concentrations. By removing O2 from the sample solution, a more sensitive O2 sensor can be used for measurement. The sensor has been successfully applied in a flow-through cell to measure H2O2 concentration in different flow rates.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Seong Jae Kim, Ji-hun Jeong, Gaabhin Ryu, Yoon Sick Eom, Sanha Kim
Summary: Surface-enhanced Raman spectroscopy (SERS) is a high-sensitivity, label-free detection method with various analytical applications. Researchers have developed a hydrophobic SERS substrate based on engineered carbon nanotube arrays (CNT-SERS) and studied the role of structural design at both micro and nanoscales. The substrate demonstrated controlled self-enrichment capability and enhanced sensitivity, with a significant increase in the SERS signal. The study also proposed a theoretical model and a concentration strategy inspired by plants for analyte deposition on microarrays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Dan Zhao, Renjun Jiang, Xiaoqiang Liu, Subbiah Alwarappan
Summary: In this study, a novel ternary composite material was constructed by assembling cerium vanadate nanorods on reduced graphene oxide-microcrystalline cellulose nanosheets, and it was used for real-time monitoring of the concentration of superoxide anions in vivo. The ternary composite showed excellent conductivity, large surface area, and abundant active sites, leading to a wider linear range, high sensitivity, low detection limit, and fast response time for superoxide anion detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Tengfei Wang, Liwen Wang, Guang Wu, Dating Tian
Summary: In this study, a covalent organic framework material TaTp-COF with porous and uniform spheres was successfully prepared via hydrothermal reaction, and it was found to significantly enhance the aggregation-induced emission (AIE) of berberine. The unique emission properties of berberine on TaTp-COF were studied and utilized for the sensitive detection of berberine.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Lin Li, Yilei Ding, Lei Xu, Shuoran Chen, Guoliang Dai, Pengju Han, Lixin Lu, Changqing Ye, Yanlin Song
Summary: In this study, a novel TTI based on a ratiometric fluorescent nanosensor is designed, which has the advantages of high accuracy and low cost. Experimental and theoretical investigations confirm its pH responsiveness and demonstrate its good sensitivity and reliability. By monitoring the total volatile basic nitrogen, this TTI can accurately predict food spoilage and can be adaptively modified for different types of food. The TTI based on this nanosensor enables visual monitoring of food quality.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Fangju Chen, Xueting Wang, Wei Chen, Chenwen Shao, Yong Qian
Summary: Lung cancer is the second most common malignant tumor worldwide. Drug resistance in lung cancer leads to treatment failure and recurrence in majority of patients. This study developed a fluorescent prodrug that can be activated in cancer cells to release drugs, and its signal can be tracked by imaging. It shows a unique autophagy-driven ferroptosis effect, indicating its potential for targeting drug-resistant cancer cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Weichao Li, Qiming Yuan, Zhangcheng Xia, Xiaoxue Ma, Lifang He, Ling Jin, Xiangfeng Chu, Kui Zhang
Summary: This study developed a high-performance gas sensor for formaldehyde detection by modifying ZnSnO3 with ZnO QDs and SnO2 QDs. The modified sensor showed improved sensing response and lower working temperature. The presence of ZnO QDs formed rich heterojunctions, increased surface area, and provided oxygen deficiency for formaldehyde sensing reaction, thus enhancing the sensor performance. This research provides an alternative method to enhance the sensing properties of MOS by QDs modification.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Joung-Il Moon, Eun Jung Choi, Younju Joung, Jin-Woo Oh, Sang-Woo Joo, Jaebum Choo
Summary: A novel nanoplasmonic substrate was developed for biomedical applications, which showed strong hot spots for detecting biomarkers at low concentrations. The substrate, called AuNPs@M13, was made by immobilizing 60 nm gold nanoparticles onto the surface of an M13 bacteriophage scaffold. It demonstrated higher sensitivity and lower limit of detection compared to commercially available assays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Ning Li, Ya Zhang, Ying Xu, Xiaofang Liu, Jian Chen, Mei Yang, Changjun Hou, Danqun Huo
Summary: The molecular subtype of breast cancer guides treatment and drug selection. Invasive tests can promote cancer cell metastasis, so the development of high-performance, low-cost diagnostic tools for cancer prognosis is crucial. Liquid biopsy techniques enable noninvasive, real-time, dynamic, multicomponent, quantitative, and long-term observations at the cellular, genetic, and molecular levels. A Cu-Zr metal-organic framework (MOF) nanoenzyme with monatomic Cu attachment has been synthesized and proven to have high catalytic performance. The sensor constructed using this nanoenzyme shows potential for accurate classification of breast cancer serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Jeongmin Kim, Hyemin Kim, Seunghyun Park, Hyeonaug Hong, Yong Jae Kim, Jiyong Lee, Jaeho Kim, Seung-Woo Cho, Wonhyoung Ryu
Summary: This study presents a method to fabricate independently functioning microneedle (MN) electrodes with narrow intervals for high precision electrochemical sensing. The optimized mixture of photocurable polymer and single-wall carbon nanotubes was used to mold single composite MNs, which were then attached to pre-patterned electrodes. Plasma etching and electropolymerization were performed to enhance the electrochemical activity, and Prussian blue and glucose oxidase were electrodeposited on the MNs for glucose detection. The MN electrodes showed good sensitivity and linearity, and the feasibility of glucose detection was demonstrated in an in vivo mouse study.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
