Article
Chemistry, Analytical
Raviraj Thakur, Felix P. Aplin, Gene Y. Fridman
Summary: The study developed a silicone-based nerve cuff lead for stimulating and recording nerves, providing greater spatial separation and reversible nerve block through the delivery of direct current. Unlike most metallic electrodes, this cuff was manufactured using consumer-grade equipment, making it a cost-effective solution for neuro modulation experiments.
Article
Chemistry, Multidisciplinary
Jing Wang, Qing Li, Kuncai Li, Xu Sun, Yizhuo Wang, Tiantian Zhuang, Junjie Yan, Hong Wang
Summary: This study reports highly conductive PEDOT:PSS hydrogels without any conductive filler, which exhibit about 8 times higher conductivity than polymeric hydrogels without conductive filler in literature. These hydrogels not only show enhanced thermoelectric output power and electromagnetic interference shielding efficiency, but also have stretchable, self-healing, and shape/size-tunable properties, which are desirable for hydrogel bioelectronics and wearable organic devices.
ADVANCED MATERIALS
(2022)
Article
Engineering, Biomedical
Tao Sun, Tea Tsaava, Joanne Peragine, Christine Crosfield, Maria Fernanda Lopez, Romil Modi, Rohit Sharma, Chunyan Li, Harbaljit Sohal, Eric H. Chang, Loren Rieth
Summary: This study developed a microfabricated cuff electrode (MouseFlex) for vagus nerve stimulation in mice, which showed good stimulation stability and electrochemical properties. The electrode was safe and effective in inducing physiological responses in mice and tolerated surgical handling.
ACTA BIOMATERIALIA
(2023)
Article
Materials Science, Multidisciplinary
Francisco Zurita, Leroy Grob, Amelie Erben, Fulvia Del Duca, Hauke Clausen-Schaumann, Stefanie Sudhop, Oliver Hayden, Bernhard Wolfrum
Summary: Interfacing with the peripheral nervous system is an effective method for diagnosing and treating a variety of diseases. Targeting large nerves allows for selective stimulation, while targeting small nerves presents challenges in electrode fabrication and implantation.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Article
Otorhinolaryngology
James T. Heaton, James B. Kobler, Mark P. Ottensmeyer, Robert H. Petrillo, Monica A. Tynan, Robert E. Hillman, Steven M. Zeitels
Summary: A new method for tracking recovery after nerve injury was studied, using subcutaneous electrical connection ports to repeatedly connect to nerve cuff or intramuscular electrodes for periodic assessments of nerve and muscle function over long periods.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2021)
Article
Biotechnology & Applied Microbiology
Laura M. Ferrari, Bruno Rodriguez-Meana, Alberto Bonisoli, Annarita Cutrone, Silvestro Micera, Xavier Navarro, Francesco Greco, Jaume del Valle
Summary: A new regenerative nerve cuff electrode based on a novel fabrication strategy combining conducting and heat-shrinkable polymers showed promising results in animal models for functional recovery and axonal regeneration support. The electrodes were able to stimulate regenerated motor axons and induce muscular response three months post-implantation, paving the way for cost-effective manufacturing of transparent nerve interfaces with polymeric microelectrodes in the field of neuroprosthetics.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Qi Zeng, Shoujun Yu, Zihui Fan, Yubin Huang, Bing Song, Tian Zhou
Summary: In this study, a nanocone-shaped Pt-IrOx neural microelectrode is proposed, with a uniform nanocone-shaped Pt created through controlling the ratio of ions in the electrolyte. The coated microelectrode exhibits low impedance, high charge storage capacity, and excellent stability and biocompatibility.
Article
Chemistry, Analytical
Mengting Dai, Jinfeng Xia, Zhenhai Xue, Guohong Zhou, Danyu Jiang, Yuerong Heng, Cuiyan Yu, Jiayan Miao, Qiang Li
Summary: pH measurement is widely studied in various fields. Iridium/iridium oxide electrodes are considered as the most promising candidate for pH detection due to their stability and preparation process. In this study, the electrodes were fabricated and improved through supercritical treatment, resulting in better performance.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2022)
Article
Materials Science, Coatings & Films
Wei-Chiang Huang, Sheng-Po Wang, Meng-Ting Lee, Te-Yi Wang, Wen-Liang Chen, Po-Chun Chen
Summary: This study develops a wet chemical approach to fabricate space-controllable TiO2@IrO2 core@shell nanotube arrays. The nanotube arrays exhibit large charge storage capacity, good crystallinity, and stability, making them suitable for neural activity applications.
SURFACE & COATINGS TECHNOLOGY
(2022)
Article
Chemistry, Physical
Natalia Festinger, Aneta Kisielewska, Barbara Burnat, Katarzyna Ranoszek-Soliwoda, Jaroslaw Grobelny, Kamila Koszelska, Dariusz Guziejewski, Sylwia Smarzewska
Summary: The present study investigates the impact of two different oxygen content graphene oxides on the electrochemical and structural properties of noble metal disk electrodes. The chemistry and structural properties of the modifier layers were analyzed using various techniques, and comparative electrochemical studies were conducted using cyclic voltammetry.
Article
Chemistry, Analytical
Vincenzo Mazzaracchio, Luca Fiore, Simone Nappi, Gaetano Marrocco, Fabiana Arduini
Summary: Wearable sensors play a key role in reliable health state monitoring, although wearable and epidermal sensors for chemical biomarker monitoring are not yet fully developed. In this study, a wireless and flexible epidermal device for pH monitoring in sweat was fabricated, showing promising results in real-time monitoring of pH levels during physical activities.
Article
Chemistry, Physical
Guoqiang Zhao, Zhouxin Luo, Baohua Zhang, Yaping Chen, Xiangzhi Cui, Jian Chen, Yongfeng Liu, Mingxia Gao, Hongge Pan, Wenping Sun
Summary: In this study, highly active iridium dioxide (IrO2) nanoparticles (NPs) were anchored on the surface of exfoliated h-boron nitride (BN) nanosheets (NSs) to achieve efficient catalysis for the oxygen evolution reaction (OER) in acid media. The stabilizing effect of the epitaxial interface between IrO2 and h-BN allowed the IrO2/BN catalyst to maintain stable performance at high working potentials, while the activity of bare IrO2 NPs rapidly decreased. The compressive strain induced by the smaller lattice spacing of h-BN also contributed to the improved activity of IrO2. These findings suggest the potential of constructing robust interfaces for stabilizing highly active Ir(V) species and designing advanced heterostructured electrocatalysts.
Article
Chemistry, Multidisciplinary
Xiaojing Wang, Peng Liu, Boonkar Yap, Ruidong Xia, Wai-Yeung Wong, Zhicai He
Summary: Liquid-exfoliated 2D transition metal disulfides can be potential substitutes for PEDOT:PSS as hole transport layers in Organic Solar Cells. By optimizing the preparation conditions of WS2 layers, the device performance and power conversion efficiency can be improved.
Article
Chemistry, Physical
Tita Labi, Francois Van Schalkwyk, Shuang Ma Andersen, Per Morgen, Sekhar Chandra Ray, Jessica Chamier
Summary: Adding an oxygen evolution reaction (OER) catalyst to the anode of a membrane electrode assembly (MEA) can mitigate the potential reversal impacts caused by fuel starvation. The performance of intermittently starved MEAs can be recovered up to over 95%, with a significant 4% performance loss after the first event. The increased ohmic resistance is mainly attributed to membrane deformation, contraction, and ionomer reconfiguration, impacting proton conductive pathways.
JOURNAL OF POWER SOURCES
(2021)
Article
Orthopedics
Tingmo Huang, Liyang Wan, Yang Chen, Yinghong Xiong, Feifei Yuan, Shansha Xie, Jianjun Huang, Hongbin Lu
Summary: This study aimed to explore the effect of local sympatholysis (LS) on bone-tendon interface (BTI) healing in a murine rotator cuff repair model. The results indicated that LS was beneficial for BTI healing outcomes. This study found that sympathetic innervation played a role in the healing process of injured BTI, and local sympathetic denervation using guanethidine could improve BTI healing.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2023)
Article
Chemistry, Multidisciplinary
Junmin Lee, Yonggang Wang, Chengbin Xue, Yi Chen, Moyuan Qu, Jai Thakor, Xingwu Zhou, Natan Roberto Barros, Natashya Falcone, Patric Young, Floor W. van den Dolder, KangJu Lee, Yangzhi Zhu, Hyun-Jong Cho, Wujin Sun, Bo Zhao, Samad Ahadian, Vadim Jucaud, Mehmet R. Dokmeci, Ali Khademhosseini, Han-Jun Kim
Summary: Injectable shear-thinning biomaterials, specifically gelatin/LAPONITE (R) nanocomposites, have shown promising potential for efficiently delivering molecules like doxorubicin in response to different pH values. Among different compositions tested, STBs with lower LAPONITE (R) content (6NC25) demonstrated enhanced pH-responsiveness and localized drug release in acidic tumor microenvironments. Additionally, 6NC25 exhibited lower storage modulus and required lower injection forces, improving ease of administration.
Article
Engineering, Biomedical
Junmin Lee, Aly Ung, Hanjun Kim, KangJu Lee, Hyun-Jong Cho, Praveen Bandaru, Samad Ahadian, Mehmet R. Dokmeci, Ali Khademhosseini
Summary: Increasing evidence suggests that fusion of cancer cells with different cell types in the tumor microenvironment may contribute to the generation of metastasis-initiating cells. The role of human mesenchymal stem cells (hMSCs) in fusion with cancer cells is still controversial. In this study, a liver-on-a-chip platform was used to investigate the fusion of liver hepatocellular cells (HepG2) with hMSCs and their invasive potential. It was found that hMSCs may play dual roles in HepG2 spheroids, preventing HepG2 growth while also leading to the generation of highly invasive HepG2-hMSC hybrid cells. These hybrid cells expressed markers associated with stemness, proliferation, epithelial to mesenchymal transition, and matrix deposition, and were responsible for collective invasion following HepG2.
Review
Engineering, Biomedical
Gita Kiaee, Nikolaos Dimitrakakis, Shabnam Sharifzadeh, Han-Jun Kim, Reginald K. Avery, Kamyar Mollozadeh Moghaddam, Reihaneh Haghniaz, Ezgi Pinar Yalcintas, Natan Roberto de Barros, Solmaz Karamikamkar, Alberto Libanori, Ali Khademhosseini, Parastoo Khoshakhlagh
Summary: Laponite is a clay-based material with highly ionic and large surface area, which allows for intercalation and dissolution of biomolecules for drug delivery. Its properties and architecture also enable the development of tunable pH-responsive drug delivery systems for sustained drug release.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Chemistry, Physical
Yangzhi Zhu, Martin C. Hartel, Ning Yu, Pamela Rosario Garrido, Sanggon Kim, Junmin Lee, Praveen Bandaru, Shenghan Guan, Haisong Lin, Sam Emaminejad, Natan Roberto de Barros, Samad Ahadian, Han-Jun Kim, Wujin Sun, Vadim Jucaud, Mehmet R. Dokmeci, Paul S. Weiss, Ruoxue Yan, Ali Khademhosseini
Summary: A low-cost, scalable, and high-performance piezoresistive sensor has been developed with high sensitivity, extensive sensing range, fast response time, and excellent long-term stability. The sensor's piezoresistive functionality is achieved through a flexible transparent electrode using stable reduced graphene oxide self-wrapped copper nanowire network. The developed sensor is suitable for wearable electronics applications.
Article
Engineering, Biomedical
Sevana Baghdasarian, Bahram Saleh, Avijit Baidya, Hanjun Kim, Mahsa Ghovvati, Ehsan Shirzaei Sani, Reihaneh Haghniaz, Shashank Madhu, Maria Kanelli, Iman Noshadi, Nasim Annabi
Summary: A double-crosslinked sealant called Gelatin Methacryloyl-Catechol (GelMAC) was engineered, demonstrating excellent hemostatic property without compromising tissue adhesion. The GelMAC hydrogel controls bleeding through wound-sealing capability and chemical activity. It showed significantly reduced clotting time compared to existing commercial hemostats in blood clotting assays and closed incisions rapidly in an in vivo liver bleeding test.
MATERIALS TODAY BIO
(2022)
Article
Chemistry, Multidisciplinary
Gunhyu Bae, Myeong Soo Kim, Ramar Thangam, Thomas Myeongseok Koo, Woo Young Jang, Jinho Yoon, Seong-Beom Han, Letao Yang, Seong Yeol Kim, Nayeon Kang, Sunhong Min, Hyunsik Hong, Hong En Fu, Min Jun Ko, Dong-Hwee Kim, Woong Kyo Jeong, Dong-Hyun Kim, Tae-Hyung Kim, Jeong-Woo Choi, Ki-Bum Lee, Ramasamy Paulmurugan, Yangzhi Zhu, Han-Jun Kim, Junmin Lee, Jong Seung Kim, Ali Khademhosseini, Young Keun Kim, Heemin Kang
Summary: The study focuses on tuning the diameter and interdistance of RGD-bearing AuNPs on Fe3O4 nanotemplates to regulate stem cell differentiation and adhesion functions.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Fatemeh Zehtabi, Hossein Montazerian, Reihaneh Haghniaz, Kaylee Tseng, Neda Mohaghegh, Kalpana Mandal, Behnam Zamanian, Mehmet Remzi Dokmeci, Mohsen Akbari, Alireza Hassani Najafabadi, Han-Jun Kim, Ali Khademhosseini
Summary: Shear-thinning biomaterials based on gelatin-silicate nanoplatelets are being explored as an alternative treatment for vascular anomalies. The addition of sodium phytate additives improves the mechanical properties and injectability of the biomaterials while reducing immune responses. The optimized biomaterials show enhanced storage modulus and reduced injection force, making them suitable for minimally invasive therapies. Furthermore, the incorporation of phytate leads to accelerated blood coagulation, contributing to the prolonged durability of the biomaterials in coagulopathic patients.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Shin Hyung Lee, Dongjae Baek, Whibeom Cho, Nohyun Lee, Kwangjin Kim, Jae-Hun Kim, Han-Jun Kim, Hyeon Ho Kim, Hyo Jin Kim, Seungwoo Lee, Sung-Min Lee
Summary: A new type of multi-junction LSC photovoltaic system is developed in this study, which successfully improves the power conversion efficiency of the module through transfer printing and design of luminescent waveguide arrays. The experimental results show that the optimal LSC configuration increases the efficiency of the flexible module by about 0.55%, indicating the significant potential of this approach for practical applications.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Ramar Thangam, Seong Yeol Kim, Nayeon Kang, Hyunsik Hong, Hyun-Jeong Lee, Sungkyu Lee, Daun Jeong, Kyong-Ryol Tag, Kanghyeon Kim, Yangzhi Zhu, Wujin Sun, Han-Jun Kim, Seung-Woo Cho, Jae-Pyoung Ahn, Woo Young Jang, Jong Seung Kim, Ramasamy Paulmurugan, Ali Khademhosseini, Hong-Kyu Kim, Heemin Kang
Summary: Materials with movably couplable ligands are developed by grafting liganded gold nanoparticles (AuNPs) to a substrate and flexibly grafting liganded movable linear nanomaterials (MLNs) to the substrate via a bendable linker, creating a decoupled state. Magnetic control of the MLNs decreases the space between MLNs and AuNPs, coupling them together. Remote control of ligand coupling stimulates integrin recruitment, facilitating stem cell focal adhesion, mechanosensing, and potential differentiation, while ligand decoupling suppresses these processes. Versatile tuning of MLNs can help advance regenerative therapies by studying ligand-coupling-dependent stem cell fate.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Correction
Biology
Seong Yeong An, Hyo-Sung Kim, So Yeon Kim, Se Young Van, Han Jun Kim, Jae-Hyung Lee, Song Wook Han, Il Keun Kwon, Chul-Kyu Lee, Sun Hee Do, Yu-Shik Hwang
COMMUNICATIONS BIOLOGY
(2022)
Article
Biology
Seong Yeong An, Hyo-Sung Kim, So Yeon Kim, Se Young Van, Han Jun Kim, Jae-Hyung Lee, Song Wook Han, Il Keun Kwon, Chul-Kyu Lee, Sun Hee Do, Yu-Shik Hwang
Summary: Injecting human hair-derived keratin into mice skin promotes hair growth and formation, due to the extracellular interaction of keratin with hair forming cells. Keratin induces condensation of dermal papilla cells and the formation of hair germ. Keratin plays a critical role in hair growth.
COMMUNICATIONS BIOLOGY
(2022)
Correction
Biology
Seong Yeong An, Hyo-Sung Kim, So Yeon Kim, Se Young Van, Han Jun Kim, Jae-Hyung Lee, Song Wook Han, Il Keun Kwon, Chul-Kyu Lee, Sun Hee Do, Yu-Shik Hwang
COMMUNICATIONS BIOLOGY
(2022)
Article
Engineering, Biomedical
Seung Hyeon Kim, Jae Seo Lee, Sang Jin Lee, Haram Nah, Sung Jun Min, Ho Jin Moon, Jae Beum Bang, Han-Jun Kim, Won Jong Kim, Il Keun Kwon, Dong Nyoung Heo
Summary: In this study, plasma treatment was used to enhance the biocompatibility of 3D-printed scaffolds. The wettability, roughness, and protein adsorption capability of the scaffolds significantly increased with the plasma treatment. The plasma-treated scaffolds exhibited enhanced cell adhesion and proliferation in vitro, as well as higher tissue infiltration and lower collagen encapsulation in vivo.
Article
Engineering, Biomedical
Reihaneh Haghniaz, Han -Jun Kim, Hossein Montazerian, Avijit Baidya, Maryam Tavafoghi, Yi Chen, Yangzhi Zhu, Solmaz Karamikamkar, Amir Sheikhi, Ali Khademhosseini
Summary: Blood loss from hemorrhaging wounds is a major cause of trauma fatalities, resulting in millions of deaths each year. This study developed biocompatible and biodegradable microneedle arrays (MNAs) that promote rapid blood coagulation for hemorrhage control. By combining gelatin meth-acryloyl (GelMA) biomaterial with silicate nanoplatelets (SNs), these MNAs effectively reduced bleeding by 92% compared to untreated injuries in a rat liver bleeding model. The micro and nanoengineering features of the SN-containing MNAs outperformed needle-free patches and a commercial hemostat, making them suitable for rapid hemorrhage control.
BIOACTIVE MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Junmin Lee, Oju Jeon, Jaekyung Koh, Han-Jun Kim, Sang Jin Lee, Yangzhi Zhu, Jihyeon Song, Yeji Lee, Rohollah Nasiri, KangJu Lee, Praveen Bandaru, Hyun-Jong Cho, Shiming Zhang, Natan R. Barros, Samad Ahadian, Heemin Kang, Mehmet R. Dokmeci, Joanna Lee, Dino Di Carlo, Eben Alsberg, Ali Khademhosseini
Summary: We developed a biomaterial-based engineering strategy to create cartilage-tissue equivalents with microarchitecture similar to native cartilage. The mechanical property mismatch between soft pericellular matrix and stiff extracellular matrix regulates the behavior of human mesenchymal stem cells (hMSCs) during cartilage repair. Our findings highlight the importance of the pericellular-extracellular matrix mechanical property mismatch in hMSC-based cartilage repair under dynamic compression.
Article
Chemistry, Analytical
Mengmeng Guo, Na Luo, Yueling Bai, Zhenggang Xue, Qingmin Hu, Jiaqiang Xu
Summary: A porous heterostructure WO3-C/In2O3 was designed and prepared for a miniature H2 sensor, which showed higher response value, lower operating temperature, fast response-recovery speed, and low limit of detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Feng Hu, Hui Hu, Yuting Li, Xiaohui Wang, Xiaowen Shi
Summary: Arsenic contamination in water bodies is a significant health risk. This study developed a chitosan-catechol modified electrode for rapid and accurate detection of trace amounts of arsenic. The modified electrode demonstrated good detection capability and resistance to ionic interference, making it suitable for in situ detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Yantao Zhang, Qian Liu, Tao Tian, Chunhua Xu, Pengli Yang, Lianju Ma, Yi Hou, Hui Zhou, Yongjun Gan
Summary: In this study, a lysosome-targeting buffering fluorogenic probe (Lyso-BFP) was designed and synthesized, demonstrating excellent photostability, pH specificity, and responsiveness to lysosomal acidification in living cells. The performance of Lyso-BFP in pH sensing was attributed to the inhibition of the photo-induced electron transfer process. Lyso-BFP allowed for wash-free imaging and long-term real-time monitoring of lysosome pH changes based on its off-on fluorescence behavior and buffer strategy.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Wei Cai, Wenbo Sun, Jiayue Wang, Xiaokui Huo, Xudong Cao, Xiangge Tian, Xiaochi Ma, Lei Feng
Summary: In this study, a near-infrared fluorescent probe HCBG was developed for imaging of alpha-GLC. HCBG exhibited excellent selectivity and sensitivity towards alpha-GLC in complex bio-samples, and showed good cell permeability for in situ real-time imaging. Through the high-throughput screening system established by HCBG, a natural alpha-GLC inhibitor was successfully isolated and identified. This study provides a novel fluorescence visualization tool for discovering and exploring the biological functions of diabetes-related gut microbiota, and a high-throughput screening approach for alpha-GLC inhibitor.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Trey W. Pittman, Xi Zhang, Chamindie Punyadeera, Charles S. Henry
Summary: Heart failure is a growing epidemic and a significant clinical and public health problem. Researchers have developed a portable and affordable diagnostic device for heart failure that can be used at the point-of-care, providing a valid alternative to current diagnostics approaches.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Anders O. Tjell, Barbara Jud, Roland Schaller-Ammann, Torsten Mayr
Summary: An optical hydrogen peroxide sensor based on catalytic degradation and the detection of produced oxygen is presented. The sensor offers higher resolution and better sensitivity at lower H2O2 concentrations. By removing O2 from the sample solution, a more sensitive O2 sensor can be used for measurement. The sensor has been successfully applied in a flow-through cell to measure H2O2 concentration in different flow rates.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Seong Jae Kim, Ji-hun Jeong, Gaabhin Ryu, Yoon Sick Eom, Sanha Kim
Summary: Surface-enhanced Raman spectroscopy (SERS) is a high-sensitivity, label-free detection method with various analytical applications. Researchers have developed a hydrophobic SERS substrate based on engineered carbon nanotube arrays (CNT-SERS) and studied the role of structural design at both micro and nanoscales. The substrate demonstrated controlled self-enrichment capability and enhanced sensitivity, with a significant increase in the SERS signal. The study also proposed a theoretical model and a concentration strategy inspired by plants for analyte deposition on microarrays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Dan Zhao, Renjun Jiang, Xiaoqiang Liu, Subbiah Alwarappan
Summary: In this study, a novel ternary composite material was constructed by assembling cerium vanadate nanorods on reduced graphene oxide-microcrystalline cellulose nanosheets, and it was used for real-time monitoring of the concentration of superoxide anions in vivo. The ternary composite showed excellent conductivity, large surface area, and abundant active sites, leading to a wider linear range, high sensitivity, low detection limit, and fast response time for superoxide anion detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Tengfei Wang, Liwen Wang, Guang Wu, Dating Tian
Summary: In this study, a covalent organic framework material TaTp-COF with porous and uniform spheres was successfully prepared via hydrothermal reaction, and it was found to significantly enhance the aggregation-induced emission (AIE) of berberine. The unique emission properties of berberine on TaTp-COF were studied and utilized for the sensitive detection of berberine.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Lin Li, Yilei Ding, Lei Xu, Shuoran Chen, Guoliang Dai, Pengju Han, Lixin Lu, Changqing Ye, Yanlin Song
Summary: In this study, a novel TTI based on a ratiometric fluorescent nanosensor is designed, which has the advantages of high accuracy and low cost. Experimental and theoretical investigations confirm its pH responsiveness and demonstrate its good sensitivity and reliability. By monitoring the total volatile basic nitrogen, this TTI can accurately predict food spoilage and can be adaptively modified for different types of food. The TTI based on this nanosensor enables visual monitoring of food quality.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Fangju Chen, Xueting Wang, Wei Chen, Chenwen Shao, Yong Qian
Summary: Lung cancer is the second most common malignant tumor worldwide. Drug resistance in lung cancer leads to treatment failure and recurrence in majority of patients. This study developed a fluorescent prodrug that can be activated in cancer cells to release drugs, and its signal can be tracked by imaging. It shows a unique autophagy-driven ferroptosis effect, indicating its potential for targeting drug-resistant cancer cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Weichao Li, Qiming Yuan, Zhangcheng Xia, Xiaoxue Ma, Lifang He, Ling Jin, Xiangfeng Chu, Kui Zhang
Summary: This study developed a high-performance gas sensor for formaldehyde detection by modifying ZnSnO3 with ZnO QDs and SnO2 QDs. The modified sensor showed improved sensing response and lower working temperature. The presence of ZnO QDs formed rich heterojunctions, increased surface area, and provided oxygen deficiency for formaldehyde sensing reaction, thus enhancing the sensor performance. This research provides an alternative method to enhance the sensing properties of MOS by QDs modification.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Joung-Il Moon, Eun Jung Choi, Younju Joung, Jin-Woo Oh, Sang-Woo Joo, Jaebum Choo
Summary: A novel nanoplasmonic substrate was developed for biomedical applications, which showed strong hot spots for detecting biomarkers at low concentrations. The substrate, called AuNPs@M13, was made by immobilizing 60 nm gold nanoparticles onto the surface of an M13 bacteriophage scaffold. It demonstrated higher sensitivity and lower limit of detection compared to commercially available assays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Ning Li, Ya Zhang, Ying Xu, Xiaofang Liu, Jian Chen, Mei Yang, Changjun Hou, Danqun Huo
Summary: The molecular subtype of breast cancer guides treatment and drug selection. Invasive tests can promote cancer cell metastasis, so the development of high-performance, low-cost diagnostic tools for cancer prognosis is crucial. Liquid biopsy techniques enable noninvasive, real-time, dynamic, multicomponent, quantitative, and long-term observations at the cellular, genetic, and molecular levels. A Cu-Zr metal-organic framework (MOF) nanoenzyme with monatomic Cu attachment has been synthesized and proven to have high catalytic performance. The sensor constructed using this nanoenzyme shows potential for accurate classification of breast cancer serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Jeongmin Kim, Hyemin Kim, Seunghyun Park, Hyeonaug Hong, Yong Jae Kim, Jiyong Lee, Jaeho Kim, Seung-Woo Cho, Wonhyoung Ryu
Summary: This study presents a method to fabricate independently functioning microneedle (MN) electrodes with narrow intervals for high precision electrochemical sensing. The optimized mixture of photocurable polymer and single-wall carbon nanotubes was used to mold single composite MNs, which were then attached to pre-patterned electrodes. Plasma etching and electropolymerization were performed to enhance the electrochemical activity, and Prussian blue and glucose oxidase were electrodeposited on the MNs for glucose detection. The MN electrodes showed good sensitivity and linearity, and the feasibility of glucose detection was demonstrated in an in vivo mouse study.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
