Article
Environmental Sciences
Shahid Hussain, Jesse Nii Okai Amu-Darko, Mingsong Wang, Asma A. Alothman, Mohamed Ouladsmane, Samar A. Aldossari, Muhammad Shahzeb Khan, Guanjun Qiao, Guiwu Liu
Summary: Considering the significant risk of H2S gas to human life, research on H2S gas sensors has gained considerable interest. This study presents the fabrication of CuO/ZnO multifaceted nanostructures through heat treatment of Cu2+/ZIF-8 impregnation precursors, and evaluates their microstructure and gas sensing characteristics using various characterization techniques. The hollow CuO/ZnO nanostructures demonstrated high gas response, quick response and recovery times, low detection limit, good humidity resistance, and high selectivity towards H2S gas, which can be attributed to their porous hollow nanostructures, p-CuO/n-ZnO heterojunctions, and the spillover effect between CuO and H2S.
Article
Environmental Sciences
Jesse Nii Okai Amu-Darko, Shahid Hussain, Xiangzhao Zhang, Asma A. Alothman, Mohamed Ouladsmane, M. Tariq Nazir, Guanjun Qiao, Guiwu Liu
Summary: Through thermal treatment, a mixed heterostructures In2O3/ZnO hollow nanocages were prepared, which showed exceptional sensitivity and selectivity to hydrogen sulfide gas, greatly improving the gas sensing performance.
Article
Nanoscience & Nanotechnology
Mehdi Akbari-Saatlu, Marcin Procek, Claes Mattsson, Goran Thungstrom, Tobias Torndahl, Ben Li, Jiale Su, Wenjuan Xiong, Henry H. Radamson
Summary: Designing heterostructure materials at the nanoscale is a well-known method to enhance gas sensing performance. In this study, ZnO/SnO2 heterostructures were grown on alumina substrates using the ultrasonic spray pyrolysis method. The results showed that the sensitivity of the sensor to H2S gas can be altered by changing the zinc chloride content in the precursor, and the heterostructures with a 5:1 ratio of ZnCl2 to SnCl2·2H(2)O exhibited the highest response. The gas sensing mechanism of the ZnO/SnO2 heterostructures was analyzed and attributed to the formation of the heterostructure between ZnO and SnO2.
ACS APPLIED NANO MATERIALS
(2022)
Article
Chemistry, Analytical
Wenzhi Zhang, Liyue Song, Dan Zhao, Tongyu Liu, Huiye Jiang, Wanli Yang, Bin Zhao, Weiwei Huang, Ping Wang, Lili Sui
Summary: Novel flower-like ZnO nanomaterials were synthesized by a solvothermal method without using a template or surfactant. The resulting ZnO flowers had a hierarchical structure composed of nanorods that grew radially from the center. Gas sensors based on these ZnO flowers showed high sensitivity to H2S gas with a response of 157.3 and excellent selectivity at a low temperature of 92 degrees C. The porous hierarchical architecture of the ZnO flowers facilitated rapid gas adsorption and enhanced charge transfer, resulting in superior gas-sensing capabilities. The XPS technique was used to investigate the surface state of the ZnO flowers before and after exposure to H2S gas, and a possible sensing mechanism was proposed.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Analytical
Phan Hong Phuoc, Nguyen Ngoc Viet, Le Viet Thong, Chu Manh Hung, Nguyen Duc Hoa, Nguyen Van Duy, Hoang Si Hong, Nguyen Van Hieu
Summary: The study explored the gas-sensing performance of composite nanofibers with internal and external hetero-junctions of ZnO-SnO2, revealing enhanced response compared to mixed nanofibers. The gas-sensing mechanism of the hetero-nanojunctions was analyzed, attributing the remarkable gas sensing performance to the formation of internal heterojunctions.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Multidisciplinary
Kyu Seung Lee, Jaeho Shim, Joo Song Lee, Jaehyeon Lee, Hi Gyu Moon, Young Jae Park, Donghee Park, Dong Ick Son
Summary: This study demonstrates the sensing properties and adsorption mechanism of monolayer graphene and multilayer graphene encapsulated ZnO quantum dots for NO2 gas. The results show that the gas response value and surface potential change of multilayer graphene encapsulated ZnO quantum dots are significantly higher than those of monolayer graphene and ZnO quantum dots. The proposed adsorption mechanism provides insights for improving the detection behavior and enhancing the accuracy of gas sensor analysis.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2022)
Article
Chemistry, Analytical
Phan Hong Phuoc, Nguyen Van Hoang, Nguyen Manh Hung, Pham Tien Hung, Phung Dinh Hoat, Nguyen Van Hieu
Summary: xCuO-(1-x)Fe2O3 composite nanofibers for gas-sensing applications were investigated using on-chip electrospinning. The composite nanofibers showed improved sensor response compared to single metal oxides. The optimal composition of 0.5CuO-0.5Fe2O3 formed a complex oxide of copper ferrite (CuFe2O4) and exhibited the highest response to H2S and NO2 gases. The gas-sensing performance was attributed to the nanograin-based structure, formation of CuFe2O4 oxide, and heterojunctions in the composite nanofibers.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Analytical
Amit Kumar, Amit Kumar Shringi, Mahesh Kumar
Summary: To achieve good living standards, it is crucial to develop high-performance toxic gas sensing devices for various applications. Researchers have demonstrated CuO anchored SnO2 nanostructures for H2S gas sensors, which showed improved selectivity and sensitivity. These sensors exhibit good selectivity and response rate, making them promising for applications in sewer line detection and petroleum industry leak detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Analytical
Tao -Tao Wu, Li -Yuan Zhu, Xue-Yan Wu, Xiao-Yong Miao, Li-Wen Mao, Xuan-Hong Jin, Hong-Liang Lu
Summary: In this study, hierarchical Nb2O5@ZnO hetero-branched nanorods were synthesized for highly responsive, selective, and stable H2S sensors. These sensors showed excellent response at the optimal working temperature and maintained steady performance over a month, indicating their potential for sensitive and selective H2S detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Nanoscience & Nanotechnology
Lecheng Zhu, Qian Rong, Zheng Yang, Wei Zhang, Mingzhi Jiao, Jiming Song, Chunchang Wang, Youmin Guo
Summary: The development of MEMS-based sensors with ZnO nanoparticles as sensitive materials for detecting a low concentration of H2S has attracted extensive attention. Undecorated ZnO nanoparticles were synthesized and characterized for their gas sensing performances. The sensors showed good sensitivity, wide linear range, repeatability, and high selectivity. The enhanced sensing performance was attributed to the large surface area and high surface basicity of the ZnO nanoparticles.
ACS APPLIED NANO MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Ahmad Umar, Ahmed A. Ibrahim, Mohsen A. Alhamami, S. Hussain, Hassan Algadi, Faheem Ahmed, Hassan Fouad, Sheikh Akbar
Summary: In this study, ZnO nanoflowers were synthesized by a simple solution process and characterized for their gas sensing properties. The nanoflowers exhibited flower-shaped morphology with a wurtzite hexagonal crystal structure of ZnO. The fabricated gas sensor using ZnO nanoflowers as the electrode material displayed good response and recovery time towards H2S gas.
Article
Chemistry, Analytical
Hong Wang, Yuanyuan Luo, Bo Liu, Lei Gao, Guotao Duan
Summary: ZnO@CuO hierarchical heterostructures were prepared through template-assisted magnetron sputtering and annealing, showing sensitive and recoverable detection of H2S gas at low temperature. The structure exhibits enhanced sensing response and short response/recovery time, making it a promising platform for high-performance gas sensors.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Inorganic & Nuclear
Jiaying Liu, Tiezhu Xin, Zizhen Yang, Weixun Hao, You Wang, Juanyuan Hao
Summary: A Bi2S3/ZnS heterostructure has been developed as a sensing material with improved sensitivity towards H2S, especially in dark conditions. The sensor shows high response rate, excellent selectivity, and stability, making it suitable for practical applications in dark and humid environments.
INORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Chemistry, Physical
Maciej J. Szary
Summary: This study investigates doping of MoS2 for enhanced H2S detection, finding that phosphorus increases charge transfer during H2S adsorption compared to pristine MoS2, while Ge and Cl doping show no benefit. Doping does not hinder the recovery of adsorption sites, and H2S adsorption energy is significantly higher than O-2 and N-2.
APPLIED SURFACE SCIENCE
(2021)
Article
Nanoscience & Nanotechnology
Tingting Chen, Jianhai Sun, Ning Xue, Wen Wang, Zongchang Luo, Qinqin Liang, Tianye Zhou, Hao Quan, Haoyuan Cai, Kangsong Tang, Kaisheng Jiang
Summary: Cu-doped SnO2/rGO nanocomposites prepared by a solvothermal method show promising potential as H2S sensors due to their excellent selectivity, linear working range, response time, and detection ability at low concentrations. The superior sensing properties are attributed to catalytic sensitization by the Cu dopant and a synergistic effect of the Cu-SnO2 and rGO.
MICROSYSTEMS & NANOENGINEERING
(2023)
Article
Materials Science, Ceramics
Tao Chen, Qiuyun Fu, Dongxiang Zhou, Yunxiang Hu, Zhiping Zheng, Chao Gao, Yang Liu
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
(2016)
Article
Clinical Neurology
Zhen-hua Chen, Gao-hua Wang, Xiao-ping Wang, Ren-yun Chen, Hui-lin Wang, Ming-hua Yang, Yun-xiang Hu, Hong-bing Mei
HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL
(2008)
Article
Physics, Applied
Jun Zhao, Fajun Wang, Wen Li, Hui Li, Dongxiang Zhou, Shuping Gong, Yunxiang Hu, Qiuyun Fu
JOURNAL OF APPLIED PHYSICS
(2010)
Article
Medicine, Research & Experimental
Yunxiang Hu, Yufei Wang, Zhimin Yu, Xinxian Li
Summary: Percutaneous vertebroplasty (PVP) is an effective treatment for vertebral compression fractures, but may lead to severe complications such as cement-associated thrombotic embolism. Surgeons should be cautious and have a better understanding of the fracture pattern and anatomy of the vertebral venous net system to minimize risks during PVP.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2021)
Review
Medicine, General & Internal
Jun Han, Yunxiang Hu, Sanmao Liu, Zhenxin Hu, Wenzhong Liu, Hong Wang
Summary: This meta-analysis compared the efficacy and safety of PCV and VCV ventilation modes in spinal surgery in prone position. The results showed that PCV had better outcomes than VCV in terms of ventilation parameters, but there was no significant difference in hemodynamics variables.
ANNALS OF MEDICINE AND SURGERY
(2022)
Article
Oncology
Jun Han, Yunxiang Hu, Sanmao Liu, Jian Jiang, Hong Wang
Summary: This study aimed to determine the prognostic significance of cuproptosis-associated lncRNAs in soft tissue sarcomas (STSs) and their relationship to the tumor immune microenvironment. The study identified a signature of 5 cuproptosis-associated lncRNAs, classified STS patients into high-risk and low-risk groups, and found that high-risk patients had a worse prognosis. A nomogram combining clinical characteristics and risk scores was constructed and showed reliable predictive power. Functional enrichment and tumor immune microenvironment analysis suggested that high-risk STSs tend to be immunologically sensitive tumors.
JOURNAL OF ONCOLOGY
(2022)
Article
Endocrinology & Metabolism
Yunxiang Hu, Jun Han, Shengqiang Ding, Sanmao Liu, Hong Wang
Summary: Objective of this study was to identify significant ferroptosis-associated biomarkers for postmenopausal osteoporosis (PMOP) and establish a diagnostic and personalized treatment approach. The results showed that a ferroptosis-associated gene signature can be used for early diagnosis of PMOP and two different subtypes of PMOP were identified.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Yu-Fei Wang, Zhao-Yue Bian, Xin-Xian Li, Yun-Xiang Hu, Lin Jiang
Summary: Inadvertent intradural anesthesia during PVP is a rare and life-threatening complication, but successful resuscitation can lead to a smooth postoperative recovery for the patient.
WORLD JOURNAL OF CLINICAL CASES
(2022)
Review
Surgery
Yunxiang Hu, Jun Han, Lin Gao, Sanmao Liu, Hong Wang
Summary: This article reported a case of drug fever in a patient after cervical spine surgery, in which the patient's body temperature rapidly decreased after discontinuing the medication and there were no further complaints. For patients with persistent fever after surgery without infectious evidence, it is important to consider the possibility of drug-induced fever.
FRONTIERS IN SURGERY
(2023)
Review
Medicine, General & Internal
Yunxiang Hu, Yufei Wang, Sanmao Liu, Hong Wang
Summary: Ferroptosis, a form of cell death involving iron metabolism and lipid peroxidation, differs from other forms such as apoptosis, autophagy, pyroptosis, and cuproptosis. It plays a crucial role in various diseases including malignant tumors, neurodegenerative diseases, and cardiovascular diseases. Both iron overload and lipid peroxide accumulation contribute to musculoskeletal diseases, providing new opportunities for clinical diagnosis and treatment.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Chemistry, Medicinal
Yufei Wang, Ye Sun, Yunxiang Hu, Zhaoyang Xiao
Summary: This study conducted a bibliometric analysis of the present status, areas of focus, and upcoming developments in the research of anesthetic drugs and their impact on immune function. A total of 318 publications were analyzed to determine the publication output and key research areas related to anesthetic drugs and immune function.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Article
Medicine, General & Internal
Jianhe Wang, Yunxiang Hu, Hong Wang
Summary: This study reports a case of abdominal aorta injury during lumbar fusion surgery and discusses the diagnosis and treatment methods. Although vascular injury during lumbar fusion surgery is rare, it is often overlooked, so physicians should focus on prevention and timely intervention during the surgical process.
Review
Pharmacology & Pharmacy
Y-X Hu, Y-F Wang, J. Han, S-M Liu, H. Wang
Summary: With the advancement of minimally invasive techniques, percutaneously placed interspinous stabilization devices have been gradually recognized by doctors and patients as the future direction in this field. This paper reviews the current clinical research progress in this area and emphasizes the importance of conducting more clinical studies with long-term follow-up.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Article
Crystallography
Yunxiang Hu, Mohammad Afzaal, Mohammad A. Malik, Paul O'Brien
JOURNAL OF CRYSTAL GROWTH
(2006)
Article
Chemistry, Analytical
Mengmeng Guo, Na Luo, Yueling Bai, Zhenggang Xue, Qingmin Hu, Jiaqiang Xu
Summary: A porous heterostructure WO3-C/In2O3 was designed and prepared for a miniature H2 sensor, which showed higher response value, lower operating temperature, fast response-recovery speed, and low limit of detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Feng Hu, Hui Hu, Yuting Li, Xiaohui Wang, Xiaowen Shi
Summary: Arsenic contamination in water bodies is a significant health risk. This study developed a chitosan-catechol modified electrode for rapid and accurate detection of trace amounts of arsenic. The modified electrode demonstrated good detection capability and resistance to ionic interference, making it suitable for in situ detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Yantao Zhang, Qian Liu, Tao Tian, Chunhua Xu, Pengli Yang, Lianju Ma, Yi Hou, Hui Zhou, Yongjun Gan
Summary: In this study, a lysosome-targeting buffering fluorogenic probe (Lyso-BFP) was designed and synthesized, demonstrating excellent photostability, pH specificity, and responsiveness to lysosomal acidification in living cells. The performance of Lyso-BFP in pH sensing was attributed to the inhibition of the photo-induced electron transfer process. Lyso-BFP allowed for wash-free imaging and long-term real-time monitoring of lysosome pH changes based on its off-on fluorescence behavior and buffer strategy.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Wei Cai, Wenbo Sun, Jiayue Wang, Xiaokui Huo, Xudong Cao, Xiangge Tian, Xiaochi Ma, Lei Feng
Summary: In this study, a near-infrared fluorescent probe HCBG was developed for imaging of alpha-GLC. HCBG exhibited excellent selectivity and sensitivity towards alpha-GLC in complex bio-samples, and showed good cell permeability for in situ real-time imaging. Through the high-throughput screening system established by HCBG, a natural alpha-GLC inhibitor was successfully isolated and identified. This study provides a novel fluorescence visualization tool for discovering and exploring the biological functions of diabetes-related gut microbiota, and a high-throughput screening approach for alpha-GLC inhibitor.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Trey W. Pittman, Xi Zhang, Chamindie Punyadeera, Charles S. Henry
Summary: Heart failure is a growing epidemic and a significant clinical and public health problem. Researchers have developed a portable and affordable diagnostic device for heart failure that can be used at the point-of-care, providing a valid alternative to current diagnostics approaches.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Anders O. Tjell, Barbara Jud, Roland Schaller-Ammann, Torsten Mayr
Summary: An optical hydrogen peroxide sensor based on catalytic degradation and the detection of produced oxygen is presented. The sensor offers higher resolution and better sensitivity at lower H2O2 concentrations. By removing O2 from the sample solution, a more sensitive O2 sensor can be used for measurement. The sensor has been successfully applied in a flow-through cell to measure H2O2 concentration in different flow rates.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Seong Jae Kim, Ji-hun Jeong, Gaabhin Ryu, Yoon Sick Eom, Sanha Kim
Summary: Surface-enhanced Raman spectroscopy (SERS) is a high-sensitivity, label-free detection method with various analytical applications. Researchers have developed a hydrophobic SERS substrate based on engineered carbon nanotube arrays (CNT-SERS) and studied the role of structural design at both micro and nanoscales. The substrate demonstrated controlled self-enrichment capability and enhanced sensitivity, with a significant increase in the SERS signal. The study also proposed a theoretical model and a concentration strategy inspired by plants for analyte deposition on microarrays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Dan Zhao, Renjun Jiang, Xiaoqiang Liu, Subbiah Alwarappan
Summary: In this study, a novel ternary composite material was constructed by assembling cerium vanadate nanorods on reduced graphene oxide-microcrystalline cellulose nanosheets, and it was used for real-time monitoring of the concentration of superoxide anions in vivo. The ternary composite showed excellent conductivity, large surface area, and abundant active sites, leading to a wider linear range, high sensitivity, low detection limit, and fast response time for superoxide anion detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Tengfei Wang, Liwen Wang, Guang Wu, Dating Tian
Summary: In this study, a covalent organic framework material TaTp-COF with porous and uniform spheres was successfully prepared via hydrothermal reaction, and it was found to significantly enhance the aggregation-induced emission (AIE) of berberine. The unique emission properties of berberine on TaTp-COF were studied and utilized for the sensitive detection of berberine.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Lin Li, Yilei Ding, Lei Xu, Shuoran Chen, Guoliang Dai, Pengju Han, Lixin Lu, Changqing Ye, Yanlin Song
Summary: In this study, a novel TTI based on a ratiometric fluorescent nanosensor is designed, which has the advantages of high accuracy and low cost. Experimental and theoretical investigations confirm its pH responsiveness and demonstrate its good sensitivity and reliability. By monitoring the total volatile basic nitrogen, this TTI can accurately predict food spoilage and can be adaptively modified for different types of food. The TTI based on this nanosensor enables visual monitoring of food quality.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Fangju Chen, Xueting Wang, Wei Chen, Chenwen Shao, Yong Qian
Summary: Lung cancer is the second most common malignant tumor worldwide. Drug resistance in lung cancer leads to treatment failure and recurrence in majority of patients. This study developed a fluorescent prodrug that can be activated in cancer cells to release drugs, and its signal can be tracked by imaging. It shows a unique autophagy-driven ferroptosis effect, indicating its potential for targeting drug-resistant cancer cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Weichao Li, Qiming Yuan, Zhangcheng Xia, Xiaoxue Ma, Lifang He, Ling Jin, Xiangfeng Chu, Kui Zhang
Summary: This study developed a high-performance gas sensor for formaldehyde detection by modifying ZnSnO3 with ZnO QDs and SnO2 QDs. The modified sensor showed improved sensing response and lower working temperature. The presence of ZnO QDs formed rich heterojunctions, increased surface area, and provided oxygen deficiency for formaldehyde sensing reaction, thus enhancing the sensor performance. This research provides an alternative method to enhance the sensing properties of MOS by QDs modification.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Joung-Il Moon, Eun Jung Choi, Younju Joung, Jin-Woo Oh, Sang-Woo Joo, Jaebum Choo
Summary: A novel nanoplasmonic substrate was developed for biomedical applications, which showed strong hot spots for detecting biomarkers at low concentrations. The substrate, called AuNPs@M13, was made by immobilizing 60 nm gold nanoparticles onto the surface of an M13 bacteriophage scaffold. It demonstrated higher sensitivity and lower limit of detection compared to commercially available assays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Ning Li, Ya Zhang, Ying Xu, Xiaofang Liu, Jian Chen, Mei Yang, Changjun Hou, Danqun Huo
Summary: The molecular subtype of breast cancer guides treatment and drug selection. Invasive tests can promote cancer cell metastasis, so the development of high-performance, low-cost diagnostic tools for cancer prognosis is crucial. Liquid biopsy techniques enable noninvasive, real-time, dynamic, multicomponent, quantitative, and long-term observations at the cellular, genetic, and molecular levels. A Cu-Zr metal-organic framework (MOF) nanoenzyme with monatomic Cu attachment has been synthesized and proven to have high catalytic performance. The sensor constructed using this nanoenzyme shows potential for accurate classification of breast cancer serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Jeongmin Kim, Hyemin Kim, Seunghyun Park, Hyeonaug Hong, Yong Jae Kim, Jiyong Lee, Jaeho Kim, Seung-Woo Cho, Wonhyoung Ryu
Summary: This study presents a method to fabricate independently functioning microneedle (MN) electrodes with narrow intervals for high precision electrochemical sensing. The optimized mixture of photocurable polymer and single-wall carbon nanotubes was used to mold single composite MNs, which were then attached to pre-patterned electrodes. Plasma etching and electropolymerization were performed to enhance the electrochemical activity, and Prussian blue and glucose oxidase were electrodeposited on the MNs for glucose detection. The MN electrodes showed good sensitivity and linearity, and the feasibility of glucose detection was demonstrated in an in vivo mouse study.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)