Review
Chemistry, Multidisciplinary
Lu-Lu Chen, Liang Zhao, Zhi-Gang Wang, Shu-Lin Liu, Dai-Wen Pang
Summary: NIR-II imaging breakthrough imaging limitations in deep tissues, while NIR-II quantum dots exhibit excellent optical properties and have become promising fluorescent biomarkers in in vivo fluorescence imaging.
Article
Chemistry, Analytical
Yuefang Hu, Liangliang Zhang, Li Hou, Tianran Lin, Yulong Bai, Shulin Zhao
Summary: AFP is an embryonic glycoprotein that is closely related to liver cell proliferation, cirrhosis, chronic hepatitis and other diseases. It has been widely used as a tumor marker in the research and diagnosis of diseases such as liver cancer. In this study, a near-infrared fluorescent carbon quantum dots were synthesized and a turn-on fluorescent nanosensor was constructed. The proposed nanosensor showed high sensitivity with a detection limit of 3.0 pg/mL for AFP, enabling accurate quantification and imaging of AFP for early-stage liver cancer diagnosis.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Multidisciplinary
Shu-Lan Li, Peng Jiang, Siyu Hua, Feng-Lei Jiang, Yi Liu
Summary: This study reported a simple one-step synthesis method for ultrasmall Zn-doped Cu2S QDs with high CDT activity and fluorescence imaging capability. The QDs were able to specifically inhibit cancer cell growth and induce apoptosis via a Fenton-like reaction, showing potential as multi-functional theranostic agents.
Article
Nanoscience & Nanotechnology
Connor Riahin, Adam Meares, Nopondo N. Esemoto, Marcin Ptaszek, Michael LaScola, Narendra Pandala, Erin Lavik, Mengran Yang, Gary Stacey, Dehong Hu, Jeremiah C. Traeger, Galya Orr, Zeev Rosenzweig
Summary: This paper presents a method for synthesizing near-infrared emitting polymer dots (Pdots) with tunable emission peak wavelength by doping chlorins and bacteriochlorins. The doped Pdots show nearly spherical morphology with narrow emission bands. The paper demonstrates the utility of this synthesis approach and showcases the potential applications of Pdots in various fields.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Materials Science, Multidisciplinary
Md Tanvir Hasan, Bong Han Lee, Ching-Wei Lin, Ainsley McDonald-Boyer, Roberto Gonzalez-Rodriguez, Satvik Vasireddy, Uyanga Tsedev, Jeffery Coffer, Angela M. Belcher, Anton Naumov
Summary: RGQDs, synthesized for the first time, are nanometer-sized graphene quantum dots derived from reduced graphene oxide, with NIR emission and high biocompatibility, suitable for bioimaging and therapeutic delivery. Through a high-yield synthetic process, RGQDs exhibit efficient internalization in cells and fluorescence tracking in live mice, presenting a new potential for NIR imaging in live animal models.
Article
Chemistry, Multidisciplinary
Alexander M. Saeboe, Alexey Y. Nikiforov, Reyhaneh Toufanian, Joshua C. Kays, Margaret Chern, J. Paolo Casas, Keyi Han, Andrei Piryatinski, Dennis Jones, Allison M. Dennis
Summary: This report showcases the reddest emitting indium phosphide quantum dots to date, demonstrating tunable near-infrared photoluminescence and PL multiplexing in the first optical tissue window while avoiding toxic constituents. By utilizing an inverted QD heterostructure, the synthesis overcomes the growth bottleneck and extends the emission peak of the nanoparticles into the deeper optical tissue window.
Article
Multidisciplinary Sciences
Zhuoran Ma, Feifei Wang, Weizhi Wang, Yeteng Zhong, Hongjie Dai
Summary: This study utilized artificial neural networks to transform fluorescence images in the shorter-wavelength NIR window to images resembling NIR-IIb window, achieving high signal-to-background ratio in vivo lymph node imaging with human-approved molecular probes. Translation of PD-L1 or EGFR imaging greatly enhanced tumor-to-normal tissue ratio and improved tumor margin localization, showcasing the potential of deep learning in enhancing noninvasive NIR imaging and microscopy. Deep learning equipped NIR imaging could facilitate basic biomedical research and clinical diagnostics and imaging-guided surgery.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Nanoscience & Nanotechnology
Song Chen, Tao Tang, Biao Huang, Feng Liu, Ran Cui, Mingxi Zhang, Taolei Sun
Summary: A thiolate etching strategy was proposed for the synthesis of high-quality Ag2Te QDs emitting in the NIR-II window, showing great potential for biomedical imaging.
ACS APPLIED NANO MATERIALS
(2022)
Article
Chemistry, Analytical
Jing Yang, Hao Liu, Yan Huang, Li Li, Xiaoli Zhu, Yaping Ding
Summary: In this paper, near-infrared carbon quantum dots (NIR-CQDs) were prepared and applied for fluorescence sensing of cortisol. NIR-CQDs-Apt can adsorb on the surface of graphene oxide (GO) and exhibit an inner filter effect (IFE). The presence of cortisol disrupts the IFE process, resulting in the recovery of NIR-CQDs-Apt fluorescence. This sensor shows excellent selectivity and a low detection limit, making it suitable for intracellular cortisol detection.
Article
Chemistry, Multidisciplinary
Fei Wang, Xiaoju Men, Haobin Chen, Feixue Mi, Mengze Xu, Xiaoxiao Men, Zhen Yuan, Pik Kwan Lo
Summary: A novel organic NIR-II conjugated polymer nanoparticles were developed for effective cancer photoacoustic imaging and photothermal therapy, showing high photothermal conversion efficiency, good photostability, and excellent biocompatibility. In vitro and in vivo tests demonstrated efficient photothermal therapy effect in ablating cancer cells and inhibiting tumor growth under laser irradiation, with rapid clearance capability and negligible systematic toxicity.
Article
Chemistry, Multidisciplinary
Wei Lian, Datao Tu, Xukeng Weng, Kaiyu Yang, Fushan Li, Decai Huang, Haomiao Zhu, Zhi Xie, Xueyuan Chen
Summary: In this study, highly efficient near-infrared nanophosphors based on copper indium selenide quantum dots (CISe QDs) were developed for portable micro and mini converted light-emitting diodes (pc-LEDs). By adjusting the stoichiometry and doping, the peak wavelength of the QDs' photoluminescence can be controlled within a wide range from 750 to 1150 nm. The use of a ZnSe shell significantly improves the photoluminescence quantum yield. The resulting NIR pc-LEDs exhibit remarkable photostability and the highest radiant flux among lead and cadmium-free NIR pc-LEDs. Additionally, the QDs-based nanophosphors show excellent luminescence conversion properties for micro-LEDs with resolutions exceeding current commercial inkjet display pixels.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Applied
Muzhou Teng, Yunlong Chen, Yili Xie, Zhijia Li, Qing Wan, Zhiming Wang, Jian Yang
Summary: The bright organic luminescent dots prepared in this study have desirable biocompatibility, great water dispersibility, high photoluminescent quantum efficiency, large Stokes shift, anti-background interference and great photostability. These dots can be used for long-term cell tracking studies on hepatocarcinoma cells.
Article
Chemistry, Multidisciplinary
Yuichi Ueya, Masakazu Umezawa, Eiji Takamoto, Moe Yoshida, Hisanori Kobayashi, Masao Kamimura, Kohei Soga
Summary: The polarity of PSt NPs can be adjusted to obtain highly emissive OTN-PSt-PEG NPs, which exhibit excellent dispersion stability and biocompatibility with the use of PEG. This approach is expected to facilitate the design of high emissivity OTN-NIR fluorescent imaging probes.
Article
Engineering, Biomedical
Zeng Xu, Huabei Huang, Xiang Xiong, Xiaoqing Wei, Xing Guo, Jingya Zhao, Shaobing Zhou
Summary: Developed a near-infrared light-responsive extracellular vesicle nanoplatform that can deeply penetrate tumor tissues and be rapidly eliminated from the body post-treatment, enhancing therapeutic efficacy. Similar to a Trojan horse, the nanoplatform hides anti-tumor agents in macrophage cell-secreted vesicles and utilizes NIR fluorescence imaging for in vivo biodistribution monitoring.
Article
Chemistry, Analytical
Huan Zhang, Zhenzhen Li, Huaying Huang, Si Ouyang, Yiqing Deng, Qiang Zhao
Summary: The study synthesized NIR core-shell CdSeTe/CdS quantum dots modified with l-cysteine, and successfully prepared an NIR nanosensor for the quantitative detection of Cu2+. The results showed a good linear relationship and detection accuracy in both water samples and cells.
Article
Chemistry, Analytical
Yishan Fang, Haiqiang Deng, Xinjian Huang, Lishi Wang
Summary: The novel approach utilizes FT-SC-SV combined with ITIES interface for selective determination of cations or anions, providing a simple and sensitive platform for detection of a wide range of ions and neutral molecules. The method demonstrates feasibility and reliability in discriminating and quantifying apparently indistinguishable ion transfer, suggesting a new way for analytical detection of redox inactive ions.
ANALYTICAL CHEMISTRY
(2021)
Article
Nanoscience & Nanotechnology
Xiaolin Zhong, Jianzhi Huang, Min Wang, Lishi Wang
Summary: The novel conducting polymer/metal/metal oxide composite as HER catalyst shows enhanced electrocatalytic activity, with an overpotential of 168 mV at 10 mA . cm(-2) and low Tafel slope of 79 mV. dec(-1) in 0.5 M H2SO4, which is significantly better than traditional Au/Co3O4 catalyst. The multifunctionality of polythionine in boosting the HER performance of nano electrocatalysts is also demonstrated by the enhanced performance of N-doped reduced graphene (N-rGO) with polythionine layers.
Article
Chemistry, Analytical
Jie Yang, Qiang Zeng, Lishi Wang
Summary: A new strategy has been developed for direct chirality fixation of macrocyclic hosts pillar[5]arene using electrochemical polymerization. The resulting chiral nanofiber-like crystalline pillar[5]arene-based polymers show significant circular dichroism signals and have been used as a photoelectrochemical chiral sensor for identifying and determining L- and D-ascorbic acid. This work provides a promotional strategy for building a PEC chiral recognition platform based on pillararenes, demonstrating a broad chiral detection range for L-AA.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Silan Bai, Cheng Liu, Lishi Wang
Summary: By electrochemically synthesizing silver wire within a nanopipette using a liquid-liquid interface, the i-t curve characterizes the growth state of the silver wire, with a higher rate of current increase indicating faster growth. The shape of the nanopipette also influences the growth of the silver wire, with larger diameters leading to multibranched structures and smaller diameters resulting in fewer branches.
Article
Chemistry, Analytical
Yamin Ma, Cheng Liu, Lishi Wang
Summary: A strategy for fast analysis of ion transfer/facilitated ion transfer in femtoliter water-in-oil droplets has been established. The study demonstrates that the half-wave potential is directly related to the transfer Gibbs free energy and logarithmic concentration of ions. The behavior of protamine transfer inside a single droplet has been thoroughly investigated, revealing significant differences under different conditions.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Rui Zhang, Xuye Liu, Qiang Zeng, Huanhuan Shen, Lishi Wang
Summary: This study reports a nanopore-based strategy to evaluate and compare the catalytic ability of single MnO2 catalyst particles with different morphologies by monitoring the generated O-2 bubbles from the catalytic decomposition of H2O2.
Article
Chemistry, Multidisciplinary
Zhimin Gao, Qiang Zeng, Min Wang, Lishi Wang
Summary: In this study, 8-hydroxyquinoline (8-HQ) was successfully detected using a poly(tannic acid) (PTA) modified electrode, which exhibited excellent electrocatalytic activity and stability. The sensor showed satisfactory results when applied to real hair conditioner samples.
Article
Nanoscience & Nanotechnology
Xinrong Guo, Jie Yang, Yubo Wei, Lishi Wang, Jiang Pi
Summary: Graphitic carbon nitride quantum dots (g-C3N4 QDs) are synthesized and used for trace analysis of Ag(I) and cysteine in a dual-mode fluorescence switching platform. A high selectivity and sensitivity dual-mode fluorescence switching sensor is developed based on the interesting reaction mechanism, and it shows excellent analytical performance in natural samples.
ACS APPLIED NANO MATERIALS
(2022)
Article
Electrochemistry
Yongtao You, Silan Bai, Yamin Ma, Cheng Liu, Lishi Wang
Summary: This study introduces a nanoscale soft sensor constructed using the interface between two immiscible electrolyte solutions for detecting chlorpromazine and promethazine drugs. The results show that this sensor method has good accuracy and reliability, and can be applied in drug determination and kinetics studies.
ELECTROCHIMICA ACTA
(2022)
Article
Chemistry, Analytical
Silan Bai, Yongtao You, Xiangping Chen, Cheng Liu, Lishi Wang
Summary: In this study, an approach to track the process of autorepeating bipolar reactions and hydrogen evolution reaction (HER) on a micro gold bipolar electrode (BPE) is established. The current response shows a periodic behavior with three regions: the bubble generation region (I), the bubble rupture/generation region (II), and the channel opening region (III). Finite element simulations are used to reveal the underlying thermodynamic mechanism. This research provides insights into the physicochemical mechanism in nanoscale confinement and offers a potential candidate for studying catalytic capability at the single particle level.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Physical
Cheng Liu, Yamin Ma, Zhidan Xu, Yongtao You, Silan Bai, Junmin Nan, Lishi Wang
Summary: A new subtype of nano-impacts by emulsion droplets via reorganization of the electric double layer (EDL) at the liquid/ liquid interface (LLI) is reported. This subtype shows anodic, bipolar, and cathodic transient currents with a potential of zero charge (PZC) dependence, revealing the non-faradic characteristic of single fusion impacts. In addition, the absolute integrated mean charge is proportional to the Galvani potential at the ITIES, indicating that the EDL at the LLI may obey the discrete Helmholtz model. The exact PZC point is interpolated from the fitting curve, and the droplet size distribution is estimated from the integrated charge distribution. Moreover, the different values of Epzc between single fusion impacts of MgCl2 droplets and pure water droplets is due to the specific absorption between Mg2+ and antagonistic anion in the organic phase. The influence of the concentration of the supporting electrolyte is also investigated. The above work gives physicochemical insights into the EDL at the micropipette-supported LLI and provides potential application to measure micro/nanoscale heterogeneous media without catalytic, reactive, or charge-transfer activity via impact experiments at LLI.
JOURNAL OF PHYSICAL CHEMISTRY B
(2022)
Article
Chemistry, Multidisciplinary
Rui Zhang, Qiang Zeng, Xuye Liu, Lishi Wang
Summary: Construction of nanoporous arrays is crucial for their development in sensing, energy conversion, and nanofluidic devices. In this study, an inorganic and non-crystalline mesoporous silica SBA-15 was synthesized in situ to construct a multichannel array structure, GP-SBA-15, and its ion transport properties were characterized using electrochemical methods. The results showed rapid ion accumulation and slow redistribution in the surface-charged nanochannels, and the high/low currents were attributed to ion accumulation/depletion in the channels. Finite element simulation was used to investigate the effects of surface charge and pore size on ion rectification and concentration distribution. The study also demonstrated the presence of short straight channels and long bending channels in GP-SBA-15 using voltage-independent resistance pulse signals during BSA translocation. Overall, this study provides important insights into ion transport, structure description, and sensing potential of GP-SBA-15.
Article
Materials Science, Biomaterials
Junhui Xiao, Siqi Qiu, Qiufeng Ma, Silan Bai, Xinrong Guo, Lishi Wang
Summary: In this study, a near-infrared II fluorescent probe targeting HER-2-positive breast cancer was constructed and compared with a similar structure probe. The results showed that the constructed probe had stronger fluorescence, better targeting ability, and comparatively faster metabolism, highlighting its potential in intraoperative breast cancer navigation.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Chemistry, Analytical
Xiongtao Yu, Bowen Jiang, Lishi Wang
Summary: In this study, we constructed a signal-on electrochemical platform for detecting the MnSOD gene using DNA electrochemical detection technology. The sensor showed excellent specificity and sensitivity, allowing for fast and simple detection of different DNA sequences. This research has significant implications for disease outbreaks and early clinical diagnosis of gene-related diseases.
ANALYTICAL METHODS
(2022)
Article
Chemistry, Analytical
Qiong Hu, Yishan Fang, Xiongtao Yu, Jianzhi Huang, Lishi Wang
Summary: The novel ferrocene-linked metal-covalent organic polymer (MCOP-NFC) synthesized in this study acts as an efficient artificial enzyme for mimicking peroxidase, with good stability in harsh chemical environments. A highly sensitive dual channel detection method for hydrogen peroxide was developed based on the peroxidase-like activity of MCOP-NFC, with a colorimetric detection limit of 2.1 μM and an electrochemical detection limit as low as 0.08 μM.
Article
Chemistry, Analytical
Mengmeng Guo, Na Luo, Yueling Bai, Zhenggang Xue, Qingmin Hu, Jiaqiang Xu
Summary: A porous heterostructure WO3-C/In2O3 was designed and prepared for a miniature H2 sensor, which showed higher response value, lower operating temperature, fast response-recovery speed, and low limit of detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Feng Hu, Hui Hu, Yuting Li, Xiaohui Wang, Xiaowen Shi
Summary: Arsenic contamination in water bodies is a significant health risk. This study developed a chitosan-catechol modified electrode for rapid and accurate detection of trace amounts of arsenic. The modified electrode demonstrated good detection capability and resistance to ionic interference, making it suitable for in situ detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Yantao Zhang, Qian Liu, Tao Tian, Chunhua Xu, Pengli Yang, Lianju Ma, Yi Hou, Hui Zhou, Yongjun Gan
Summary: In this study, a lysosome-targeting buffering fluorogenic probe (Lyso-BFP) was designed and synthesized, demonstrating excellent photostability, pH specificity, and responsiveness to lysosomal acidification in living cells. The performance of Lyso-BFP in pH sensing was attributed to the inhibition of the photo-induced electron transfer process. Lyso-BFP allowed for wash-free imaging and long-term real-time monitoring of lysosome pH changes based on its off-on fluorescence behavior and buffer strategy.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Wei Cai, Wenbo Sun, Jiayue Wang, Xiaokui Huo, Xudong Cao, Xiangge Tian, Xiaochi Ma, Lei Feng
Summary: In this study, a near-infrared fluorescent probe HCBG was developed for imaging of alpha-GLC. HCBG exhibited excellent selectivity and sensitivity towards alpha-GLC in complex bio-samples, and showed good cell permeability for in situ real-time imaging. Through the high-throughput screening system established by HCBG, a natural alpha-GLC inhibitor was successfully isolated and identified. This study provides a novel fluorescence visualization tool for discovering and exploring the biological functions of diabetes-related gut microbiota, and a high-throughput screening approach for alpha-GLC inhibitor.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Trey W. Pittman, Xi Zhang, Chamindie Punyadeera, Charles S. Henry
Summary: Heart failure is a growing epidemic and a significant clinical and public health problem. Researchers have developed a portable and affordable diagnostic device for heart failure that can be used at the point-of-care, providing a valid alternative to current diagnostics approaches.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Anders O. Tjell, Barbara Jud, Roland Schaller-Ammann, Torsten Mayr
Summary: An optical hydrogen peroxide sensor based on catalytic degradation and the detection of produced oxygen is presented. The sensor offers higher resolution and better sensitivity at lower H2O2 concentrations. By removing O2 from the sample solution, a more sensitive O2 sensor can be used for measurement. The sensor has been successfully applied in a flow-through cell to measure H2O2 concentration in different flow rates.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Seong Jae Kim, Ji-hun Jeong, Gaabhin Ryu, Yoon Sick Eom, Sanha Kim
Summary: Surface-enhanced Raman spectroscopy (SERS) is a high-sensitivity, label-free detection method with various analytical applications. Researchers have developed a hydrophobic SERS substrate based on engineered carbon nanotube arrays (CNT-SERS) and studied the role of structural design at both micro and nanoscales. The substrate demonstrated controlled self-enrichment capability and enhanced sensitivity, with a significant increase in the SERS signal. The study also proposed a theoretical model and a concentration strategy inspired by plants for analyte deposition on microarrays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Dan Zhao, Renjun Jiang, Xiaoqiang Liu, Subbiah Alwarappan
Summary: In this study, a novel ternary composite material was constructed by assembling cerium vanadate nanorods on reduced graphene oxide-microcrystalline cellulose nanosheets, and it was used for real-time monitoring of the concentration of superoxide anions in vivo. The ternary composite showed excellent conductivity, large surface area, and abundant active sites, leading to a wider linear range, high sensitivity, low detection limit, and fast response time for superoxide anion detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Tengfei Wang, Liwen Wang, Guang Wu, Dating Tian
Summary: In this study, a covalent organic framework material TaTp-COF with porous and uniform spheres was successfully prepared via hydrothermal reaction, and it was found to significantly enhance the aggregation-induced emission (AIE) of berberine. The unique emission properties of berberine on TaTp-COF were studied and utilized for the sensitive detection of berberine.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Lin Li, Yilei Ding, Lei Xu, Shuoran Chen, Guoliang Dai, Pengju Han, Lixin Lu, Changqing Ye, Yanlin Song
Summary: In this study, a novel TTI based on a ratiometric fluorescent nanosensor is designed, which has the advantages of high accuracy and low cost. Experimental and theoretical investigations confirm its pH responsiveness and demonstrate its good sensitivity and reliability. By monitoring the total volatile basic nitrogen, this TTI can accurately predict food spoilage and can be adaptively modified for different types of food. The TTI based on this nanosensor enables visual monitoring of food quality.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Fangju Chen, Xueting Wang, Wei Chen, Chenwen Shao, Yong Qian
Summary: Lung cancer is the second most common malignant tumor worldwide. Drug resistance in lung cancer leads to treatment failure and recurrence in majority of patients. This study developed a fluorescent prodrug that can be activated in cancer cells to release drugs, and its signal can be tracked by imaging. It shows a unique autophagy-driven ferroptosis effect, indicating its potential for targeting drug-resistant cancer cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Weichao Li, Qiming Yuan, Zhangcheng Xia, Xiaoxue Ma, Lifang He, Ling Jin, Xiangfeng Chu, Kui Zhang
Summary: This study developed a high-performance gas sensor for formaldehyde detection by modifying ZnSnO3 with ZnO QDs and SnO2 QDs. The modified sensor showed improved sensing response and lower working temperature. The presence of ZnO QDs formed rich heterojunctions, increased surface area, and provided oxygen deficiency for formaldehyde sensing reaction, thus enhancing the sensor performance. This research provides an alternative method to enhance the sensing properties of MOS by QDs modification.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Joung-Il Moon, Eun Jung Choi, Younju Joung, Jin-Woo Oh, Sang-Woo Joo, Jaebum Choo
Summary: A novel nanoplasmonic substrate was developed for biomedical applications, which showed strong hot spots for detecting biomarkers at low concentrations. The substrate, called AuNPs@M13, was made by immobilizing 60 nm gold nanoparticles onto the surface of an M13 bacteriophage scaffold. It demonstrated higher sensitivity and lower limit of detection compared to commercially available assays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Ning Li, Ya Zhang, Ying Xu, Xiaofang Liu, Jian Chen, Mei Yang, Changjun Hou, Danqun Huo
Summary: The molecular subtype of breast cancer guides treatment and drug selection. Invasive tests can promote cancer cell metastasis, so the development of high-performance, low-cost diagnostic tools for cancer prognosis is crucial. Liquid biopsy techniques enable noninvasive, real-time, dynamic, multicomponent, quantitative, and long-term observations at the cellular, genetic, and molecular levels. A Cu-Zr metal-organic framework (MOF) nanoenzyme with monatomic Cu attachment has been synthesized and proven to have high catalytic performance. The sensor constructed using this nanoenzyme shows potential for accurate classification of breast cancer serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Jeongmin Kim, Hyemin Kim, Seunghyun Park, Hyeonaug Hong, Yong Jae Kim, Jiyong Lee, Jaeho Kim, Seung-Woo Cho, Wonhyoung Ryu
Summary: This study presents a method to fabricate independently functioning microneedle (MN) electrodes with narrow intervals for high precision electrochemical sensing. The optimized mixture of photocurable polymer and single-wall carbon nanotubes was used to mold single composite MNs, which were then attached to pre-patterned electrodes. Plasma etching and electropolymerization were performed to enhance the electrochemical activity, and Prussian blue and glucose oxidase were electrodeposited on the MNs for glucose detection. The MN electrodes showed good sensitivity and linearity, and the feasibility of glucose detection was demonstrated in an in vivo mouse study.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
