Article
Biochemistry & Molecular Biology
Ping-Hsun Lu, Tzu-Hsien Liao, Yau-Hung Chen, Yeng-Ling Hsu, Chan-Yen Kuo, Chuan-Chi Chan, Lu-Kai Wang, Ching-Yuh Chern, Fu-Ming Tsai
Summary: This study found that six coumarin derivatives can inhibit platelet aggregation induced by ADP, with 7-hydroxyflavone having the most severe effect. In addition, these derivatives also affect the downstream signal transduction of the ADP receptor by inhibiting the release of calcium ions and the regulation of cAMP.
Article
Biochemistry & Molecular Biology
Aldona Siennicka, Magdalena Klysz, Monika Adamska, Kornel Chelstowski, Andrzej Biskupski, Maria Jastrzebska
Summary: The study found that diosmin did not enhance the anti-aggregation effect of ASA at any assessment time, but there was a stronger diosmin-independent anti-aggregation effect 30 days after surgery. Increased levels of inflammatory markers in the late postoperative period may be an unfavorable prognostic factor in long-term follow-up.
Article
Biotechnology & Applied Microbiology
Brian Schnoor, Anne-Laure Papa
Summary: Lyophilized platelets, as a potential hemostatic agent, have long-term ambient storage capabilities and high biocompatibility, which make them a promising platform for drug delivery. The interactions between lyophilized platelets and fresh platelets have paradoxical effects on platelet adhesion and aggregation, which could have an impact for clinical applications.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Environmental Sciences
Sandra Hernandez-Garcia, Mirthala Flores-Garcia, Maria Maldonado-Vega, Gerardo Hernandez, Facundo Meneses-Melo, Nadia-Cristina Lopez-Vanegas, Jose-Victor Calderon-Salinas
Summary: Chronic lead exposure leads to pro-oxidative and pro-inflammatory conditions in the blood, affecting platelet activation and aggregation. Our study found that platelet aggregation was lower in lead-exposed workers compared to non-exposed workers. ADP-activated platelets from lead-exposed workers showed decreased superoxide release and NADPH concentration, increased hydrogen peroxide concentration, and higher plasma PGE2 concentration. These findings suggest that platelets may adapt to the oxidative environment in chronic lead exposure to prevent thrombotic problems.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Jinmi Zou, Frauke Swieringa, Bas de Laat, Philip G. de Groot, Mark Roest, Johan W. M. Heemskerk
Summary: This paper reviews the functional reversibility of integrin alpha IIb beta 3 activation and transient aggregation and discusses the signaling pathways involved. The study finds that ADP P2Y(1) and P2Y(12) receptor signaling via phosphoinositide 3-kinases and Akt are the principal pathways linked to reversible integrin activation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Bernadeta Chyrchel, Olga Kruszelnicka, Andrzej Surdacki
Summary: This study compared the effects of ticagrelor and clopidogrel on endothelial biomarkers and platelet reactivity in patients with acute coronary syndrome (ACS). The results showed that ticagrelor users had decreased platelet aggregation and soluble P-selectin levels compared to clopidogrel users. In addition, T2DM patients on ticagrelor had lower levels of soluble vascular cell adhesion molecule-1 compared to those on clopidogrel.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Hematology
Alessandro Aliotta, Debora Bertaggia Calderara, Maxime G. Zermatten, Lorenzo Alberio
Summary: In this study, the role of epinephrine in the generation of procoagulant platelets was investigated. Epinephrine was found to increase platelet aggregation induced by all agonist combinations tested while dose-dependently reducing the formation of procoagulant COAT platelets. The addition of increasing concentrations of epinephrine modulated platelet response by reducing cytosolic calcium mobilization, decreasing procoagulant activity, and enhancing platelet aggregation when platelets were activated with CVX and THR.
THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Biochemistry & Molecular Biology
Alvaro Petersen-Uribe, Marcel Kremser, Anne-Katrin Rohlfing, Tatsiana Castor, Kyra Kolb, Valerie Dicenta, Frederic Emschermann, Bo Li, Oliver Borst, Dominik Rath, Karin Anne Lydia Mueller, Meinrad Paul Gawaz
Summary: Platelets play a significant role in atherothrombosis, and this study found that they are a major source of PCSK9 in coronary artery disease (CAD). PCSK9 released by platelets contributes to platelet activation and thrombo-inflammation, with inhibition of PCSK9 showing beneficial effects in reducing these processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Karolina Siewiera, Magdalena Labieniec-Watala, Hassan Kassassir, Nina Wolska, Dawid Polak, Cezary Watala
Summary: The study found that prolonged exposure of blood platelets to high concentrations of glucose in diabetes can lead to increased mitochondrial respiration, but this is not the main reason for abnormal platelet functioning. Additionally, metformin was not able to inhibit platelet activation under in vitro conditions, indicating that its beneficial effect on the coagulation system in vivo may be related to other mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
David J. Schneider, Heidi S. Taatjes-Sommer, Jayne Prats, Efthymios N. Deliargyris
Summary: The study showed that the pharmaceutical lipid excipients used in a novel oral formulation with aspirin do not impair the pharmacodynamic effects of aspirin or alter platelet function. Additionally, when the inhibition of platelet aggregation by aspirin was limited, the excipients tended to enhance its pharmacodynamic effects.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Arthur Shiyovich, Liat Sasson, Eli Lev, Alejandro Solodky, Ran Kornowski, Leor Perl
Summary: This study found a significant association between MV-CAD and HAPR, with a dose-response relationship between the number of stenotic coronary arteries and the rate of HAPR.
CARDIOVASCULAR DRUGS AND THERAPY
(2022)
Article
Hematology
Marie-Christine Alessi, Carmen Coxon, Manal Ibrahim-Kosta, Monica Bacci, Sophie Voisin, Jose Rivera, Andreas Greinacher, Johannes Raster, Fabio Pulcinelli, Katrien M. J. Devreese, Francois Mullier, Aine N. Mccormick, Juan Pablo Frontroth, Claire Pouplard, Ulrich J. Sachs, Isabelle Diaz, Nuria Bermejo, Marina Camera, Pierre Fontana, Anne Bauters, Alain Stepanian, Maria R. Cozzi, Anastasia N. Sveshnikova, Dorothee Faille, Wendy Hollon, Meera Chitlur, Alessandra Casonato, Dominique Lasne, Cecile Lavenu-Bombled, Mathieu Fiore, Bello Hamidou, Marie-Francoise Hurtaud-Roux, Paul Saultier, Louisa Goumidi, Paolo Gresele, Marie Lordkipanidze
Summary: This international study evaluated the impact of activators on light transmission aggregation (LTA) and found that they have a significant effect on the reproducibility of LTA results. The study results showed significant concentration differences and interindividual variability for certain activators, therefore caution is needed when interpreting results before reporting them as abnormal. The establishment and adoption of simple standardization principles can help mitigate variability caused by activator sources.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Medicine, Research & Experimental
Lieve Mees van Zijverden, Moya Henriette Schutte, Milou Cecilia Madsen, Tobias Nicolaas Bonten, Yvo Michiel Smulders, Chantal Maria Wiepjes, Jeske Joanna Katarina van Diemen, Abel Thijs
Summary: Patients with severe infection have an increased risk of cardiovascular events. A possible underlying mechanism is inflammation-induced platelet aggregation. This study investigated whether hyperaggregation occurs during infection, and whether aspirin inhibits this.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Hasan Imam, Thanh H. Nguyen, Irene Stafford, Saifei Liu, Tamila Heresztyn, Yuliy Y. Chirkov, John D. Horowitz
Summary: Coronary artery spasm (CAS) is poorly understood and treatment is often ineffective. Platelet reactivity is abnormal in CAS patients, with increased resistance to NO during symptomatic crises. High-dose N-acetylcysteine (NAC) reverses platelet resistance to NO and prevents glycocalyx shedding during symptomatic crises, suggesting that H2S donors may correct the pathophysiological anomalies underlying CAS.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Gastroenterology & Hepatology
Alberto Zanetto, Elena Campello, Cristiana Bulato, Sabrina Gavasso, Fabio Farinati, Francesco Paolo Russo, Daniela Tormene, Patrizia Burra, Marco Senzolo, Paolo Simioni
Summary: Platelet aggregation in patients with cirrhosis is significantly increased, particularly in decompensated patients, and is associated with a higher risk of further complications and death.
JOURNAL OF HEPATOLOGY
(2022)