期刊
SEMINARS IN IMMUNOPATHOLOGY
卷 38, 期 5, 页码 623-629出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00281-016-0566-0
关键词
Mast cell; Rejection; Graft-versus-host disease; Contact hypersensitivity; Innate-type allergic airway inflammation
资金
- Ministry of Education, Culture, Sports, Science, and Technology, Japan
- Precursory Research for Embryonic Science and Technology
- Health Labour Sciences Research Grant from the Ministry of Health, Labour and Welfare, Japan
- Banyu Life Science Foundation International
- Japan Science and Technology Agency
- Grants-in-Aid for Scientific Research [15H04866, 16K15515] Funding Source: KAKEN
Mast cells are important immune cells for host defense through activation of innate immunity (via toll-like receptors or complement receptors) and acquired immunity (via Fc epsilon RI). Conversely, mast cells also act as effector cells that exacerbate development of allergic or autoimmune disorders. Yet, several lines of evidence show that mast cells act as regulatory cells to suppress certain inflammatory diseases. Here, we review the mechanisms by which mast cells suppress diseases.
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