期刊
SEMINARS IN IMMUNOPATHOLOGY
卷 39, 期 1, 页码 47-54出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00281-016-0607-8
关键词
Interleukin 9; IL-9; T helper cells; T helper cell subsets; T helper type 9 cells; Th9 cells; Skin; Cutaneous; Inflammation; Skin resident; Skin homing; Atopic dermatitis; Candida albicans; Allergic contact dermatitis; Psoriasis; Cutaneous T cell lymphoma
资金
- NCI NIH HHS [R01 CA203721] Funding Source: Medline
- NIAID NIH HHS [R01 AI127654] Funding Source: Medline
Interleukin 9 secreting T(H)9 cells have been proposed as the latest addition to the family of T helper cell subsets. While a growing body of evidence from animal models points to important roles for these cells in allergic inflammation of the lung, autoinflammation of the gastrointestinal tract, and tumor immunity, their role in skin immunity and skin immunopathology remains poorly defined. Interestingly, studies of T helper cells from healthy humans suggest that T(H)9 cells are predominantly skin-homing and skin-resident and that they are involved in protection against extracellular pathogens. Thus, T(H)9 cells have entered the stage as potential mediators of cutaneous pathology. However, under which conditions and by which mechanisms these cells contribute to skin immunity and disease still has to be investigated. Here, we review our current understanding of T(H)9 cells as skin-tropic T helper cells and their involvement in skin pathology. Further, we discuss open questions with regard to the intricate nature of interleukin 9 producing T helper cells.
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