Article
Pharmacology & Pharmacy
Valeriya Gushchina, Nadja Kupper, Michael Schwarzkopf, Gitta Frisch, Karina Piatek, Cornelia Aigner, Alexandra Michel, Hemma Schueffl, Luca Iamartino, Taha Elajnaf, Teresa Manhardt, Andrea Vlasaty, Petra Heffeter, Marcella Bassetto, Enikoe Kallay, Martin Schepelmann
Summary: The activation of CaSR induces the activation of the PGE(2) pathway, but with different effects in vitro and in vivo. This may be due to the different microenvironment in vivo compared to in vitro, specifically the presence of a CaSR-responsive immune system. Calcilytics, which inhibit ligand-mediated CaSR signaling, could be considered for novel therapies against inflammatory bowel disease.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Sheng Yin, Chao Sun, Yi Ji, Hamid Abdolmaleky, Jin-Rong Zhou
Summary: The study found that WSBCW has positive effects on gastrointestinal health, including increased overall gut motility, improved intestinal permeability, and alleviation of diarrhea symptoms, achieved through the regulation of intestinal junction proteins and gut microbiota composition.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Food Science & Technology
Yanjun Tong, Qinyue Wang, Jieyu Zhang, Ruijin Yang
Summary: This study found that xylo-oligosaccharides (XOS) can alleviate diarrhea symptoms by regulating gut microbiota, reducing pro-inflammatory factors, increasing anti-inflammatory factors, and suppressing intestinal permeability in colon tissues. Dietary supplementation of XOS may be an effective choice for preventing and alleviating diarrhea.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Microbiology
Jing Liu, Bo Qiao, Ying Cai, Zhoujin Tan, Na Deng
Summary: This study investigated the association between the intestinal mucosal microbiota and the intestinal mucosal barrier under fatigue combined with a high-fat diet. The results showed that this combination led to diarrhea symptoms and structural damage to the small intestine in mice. Additionally, Limosilactobacillus reuteri was found to be involved in intestinal inflammation and impairment of the mucosal barrier.
Review
Microbiology
Mihaela Adela Iancu, Monica Profir, Oana Alexandra Rosu, Ruxandra Florentina Ionescu, Sanda Maria Cretoiu, Bogdan Severus Gaspar
Summary: The gut microbiota plays a crucial role in gut health and immune metabolism. Probiotics have the potential to modulate the gut microbiome, strengthen the intestinal barrier, and regulate the immune system, thus offering benefits in treating diarrhea and constipation.
Article
Immunology
Rosie Shrout, Annelise A. Madison, Megan E. Renna, Catherine M. Alfano, Stephen P. Povoski, Adele M. Lipari, Doreen M. Agnese, William E. Carson, William B. Malarkey, Michael T. Bailey, Janice K. Kiecolt-Glaser
Summary: Satisfying relationships among breast cancer survivors are associated with lower gut permeability and inflammation levels, leading to improved physiological health. This type of relationship can help reduce disease risks and enhance quality of life.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Biochemistry & Molecular Biology
Annette Brandt, Anja Baumann, Angelica Hernandez-Arriaga, Finn Jung, Anika Nier, Raphaela Staltner, Dragana Rajcic, Christian Schmeer, Otto W. Witte, Barbara Wessner, Bernhard Franzke, Karl-Heinz Wagner, Amelia Camarinha-Silva, Ina Bergheim
Summary: Aging is associated with low grade inflammation, called "inflammaging". Maintaining intestinal homeostasis may help extend the healthy status of older adults. In this study, it was found that even in healthy older men, low grade bacterial endotoxemia is common. Additionally, while intestinal microbiota composition changes significantly during aging, fecal microbiota transplantation does not protect against aging-associated intestinal barrier dysfunction in mice.
Article
Immunology
Yu-Chen Wang, Yang Cao, Calvin Pan, Zhiqiang Zhou, Lili Yang, Aldons J. Lusis
Summary: This study utilized single-cell RNA sequencing and statistical modeling to investigate the dynamic properties and underlying cellular mechanisms of intestinal cells. It identified new cell subsets and developmental trajectories in different layers of intestinal cells. The high-fat high-sucrose Western diet led to changes in immune cell populations and nutrient absorption function in enterocytes, as well as revealed novel interactions and communication hubs among intestinal cells.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Agriculture, Multidisciplinary
Qi-Le Zuo, Xue Cai, Xiao-Yang Zheng, De-Shui Chen, Mian Li, Zhi-Qiang Liu, Kai-Qian Chen, Fei-Fei Han, Xuan Zhu
Summary: The study found that rats experienced diarrhea after consuming medium and high doses of xylitol, with higher immune responses observed in the high-dose group. Significant changes in gut microbiota composition were observed in the high-dose group rats.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Immunology
Andong Zha, Bie Tan, Jing Wang, Ming Qi, Yuankun Deng, Rui Li, Peng Liao
Summary: The study aimed to investigate the beneficial effect of modified attapulgites on piglet diarrhea. The results showed that dietary supplementation with 1.5 mg/kg modified attapulgites significantly reduced the severity and frequency of diarrhea, and improved survival rate. This effect was achieved through regulating the intestinal microbial community composition and alleviating intestinal epithelial barrier.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Oncology
Yu Wang, Huan He, Jingwen Chen, Zijing Song, Xuediao Pan, Tian Lan, Guixiang Wang
Summary: Studies on colorectal cancer tumor growth and tumor polyamine metabolism have found that the expression level of HIF1α affects the growth rate of tumors and intestinal mucosal permeability, with higher HIF1α expression promoting tumor growth and increasing intestinal mucosal permeability.
FRONTIERS IN ONCOLOGY
(2022)
Article
Immunology
Linglian Kong, Zhenhua Wang, Chuanpi Xiao, Qidong Zhu, Zhigang Song
Summary: The study demonstrated that appropriate doses of glycerol monolaurate (GML) enhanced growth performance and immunity, improved intestinal morphology and barrier function in broiler chicks, and modulated the composition of cecal microbiota.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Microbiology
Vijay K. K. Singh, Marianna Almpani, Kelsey M. M. Wheeler, Laurence G. G. Rahme
Summary: Pseudomonas aeruginosa is a common multidrug-resistant bacterial pathogen that poses a serious threat to critically ill and immunocompromised patients. Intestinal colonization by this pathogen is associated with increased mortality rates. In this study, the role of the three major communication systems in P. aeruginosa was investigated, and it was found that the MvfR system plays a key role in intestinal inflammation while the other systems have relatively minor effects. This study reveals the interrelationships of the quorum sensing systems during infection and provides important insights for developing effective antivirulence strategies.
Article
Nutrition & Dietetics
Shafaque Rahman, Mark Davids, Patricia H. P. van Hamersveld, Olaf Welting, Hakim Rahaoui, Frank Schuren, Sybren L. Meijer, Rene M. van den Wijngaard, Theodorus B. M. Hakvoort, Wouter J. de Jonge, Sigrid E. M. Heinsbroek
Summary: This study found that intake of curdlan can reduce weight loss and colonic inflammation in mice, without inducing general microbiota community changes, but can increase a specific type of Bifidobacterium. Additionally, curdlan can also induce global changes in the healthy human intestinal microbiota.
Article
Veterinary Sciences
Yongdi Zeng, Zirui Wang, Tiande Zou, Jun Chen, Guanhong Li, Liuzhen Zheng, Shuo Li, Jinming You
Summary: This study found that dietary supplementation of 400mg/kg bacteriophage can improve the growth performance, intestinal morphology, barrier function, and gut microbiota of weaned piglets, serving as an antibiotic alternative. The underlying mechanism involves a positive effect on intestinal inflammation, barrier function, and gut microbiota.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Yaima L. Lightfoot, Kurt Selle, Tao Yang, Yong Jun Goh, Bikash Sahay, Mojgan Zadeh, Jennifer L. Owen, Natacha Colliou, Eric Li, Timo Johannssen, Bernd Lepenies, Todd R. Klaenhammer, Mansour Mohamadzadeh
Article
Peripheral Vascular Disease
Tao Yang, Monica M. Santisteban, Vermali Rodriguez, Eric Li, Niousha Ahmari, Jessica Marulanda Carvajal, Mojgan Zadeh, Minghao Gong, Yanfei Qi, Jasenka Zubcevic, Bikash Sahay, Carl J. Pepine, Mohan K. Raizada, Mansour Mohamadzadeh
Article
Food Science & Technology
Natacha Colliou, Bikash Sahay, Mojgan Zadeh, Jennifer L. Owen, Mansour Mohamadzadeh
Article
Medicine, Research & Experimental
Natacha Colliou, Yong Ge, Bikash Sahay, Minghao Gong, Mojgan Zadeh, Jennifer L. Owen, Josef Neu, William G. Farmerie, Francis Alonzo, Ken Liu, Dean P. Jones, Shuzhao Li, Mansour Mohamadzadeh
JOURNAL OF CLINICAL INVESTIGATION
(2017)
Article
Immunology
Bikash Sahay, Kathleen Bashant, Nicole L. J. Nelson, Rebeca L. Patsey, Shiva Kumar Gadila, Rebecca Boohaker, Ashutosh Verma, Klemen Strle, Timothy J. Sellati
INFECTION AND IMMUNITY
(2018)
Article
Immunology
Bikash Sahay, Natacha Colliou, Mojgan Zadeh, Yong Ge, Minghao Gong, Jennifer L. Owen, Melissa Valletti, Christian Jobin, Mansour Mohamadzadeh
Review
Virology
Bikash Sahay, Janet K. Yamamoto
Article
Biochemistry & Molecular Biology
Sam X. Cheng, Yaima L. Lightfoot, Tao Yang, Mojgan Zadeh, Lieqi Tang, Bikash Sahay, Gary P. Wang, Jennifer L. Owen, Mansour Mohamadzadeh
Article
Immunology
Bikash Sahay, Jennifer L. Owen, Mojgan Zadeh, Tao Yang, Yaia L. Lightfoot, Firas Abed, Mansour Mohamadzadeh
JOURNAL OF INFECTIOUS DISEASES
(2014)
Article
Multidisciplinary Sciences
Mahesh Kathania, Mojgan Zadeh, Yaima L. Lightfoot, Robert M. Roman, Bikash Sahay, Jeffrey R. Abbott, Mansour Mohamadzadeh
Article
Multidisciplinary Sciences
Yaima L. Lightfoot, Tao Yang, Bikash Sahay, Mojgan Zadeh, Sam X. Cheng, Gary P. Wang, Jennifer L. Owen, Mansour Mohamadzadeh
Article
Biochemistry & Molecular Biology
Bikash Sahay, Jennifer L. Owen, Tao Yang, Mojgan Zadeh, Yaima L. Lightfoot, Jun-Wei Ge, Mansour Mohamadzadeh
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
(2013)
Article
Gastroenterology & Hepatology
Bikash Sahay, Yong Ge, Natacha Colliou, Mojgan Zadeh, Chelsea Weiner, Ashley Mila, Jennifer L. Owen, Mansour Mohamadzadeh
Article
Gastroenterology & Hepatology
Yaima L. Lightfoot, Tao Yang, Bikash Sahay, Mansour Mohamadzadeh
Review
Cell Biology
Alyssa Kearly, Andrew D. L. Nelson, Aleksandra Skirycz, Monika Chodasiewicz
Summary: Stress Granules (SGs) and Processing-bodies (P-bodies) are important biomolecular condensates that play crucial roles in maintaining mRNA balance and regulating stress responses. They are composed of proteins and RNAs involved in translation, protein folding, and energy metabolism.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
P. Lemonnier, T. Lawson
Summary: Stomatal conductance plays a crucial role in determining CO2 uptake and water loss in plants, affecting overall water status and productivity. However, the signals coordinating mesophyll demands for CO2, the role of chloroplasts in stomatal function, and other GC metabolic processes in stomatal function remain poorly understood.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Matteo Gionfriddo, Timothy Rhodes, Spencer M. Whitney
Summary: Rubisco is a key enzyme that facilitates the entry of CO2 into the biosphere, but its catalytic properties are slow and error-prone. More effective Rubisco variants have been discovered in certain algae, offering the potential to significantly improve crop productivity. However, incompatibilities in protein folding have hindered the transplantation of these variants into plants. Directed evolution is now being explored to enhance Rubisco catalysis.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Vittoria Clapero, Stephanie Arrivault, Mark Stitt
Summary: The Calvin-Benson cycle has undergone massive selection and co-evolution with carbon-concentrating mechanisms due to changing environmental factors. Metabolite profiling reveals species-specific variations in the operation of the cycle, indicating the influence of different modes of photosynthesis. Connectivity analysis identifies constraints and driving factors for cross-species diversity in the cycle.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Sukhbir Kaur, David D. Roberts
Summary: Thrombospondin-1 modulates cell behavior by interacting with components of the extracellular matrix and cell surface receptors. Its release and expression are influenced by injuries and various diseases, while its sustained presence in the extracellular space is regulated by receptor-mediated clearance. Thrombospondin-1 plays important roles in immune responses.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Richard P. Tucker, Josephine C. Adams
Summary: Thrombospondins (TSPs) play diverse roles in animals and have been found to belong to a superfamily that includes different subgroups such as mega-TSPs, sushi-TSPs, and poriferan-TSPs. Invertebrates encode a greater diversity of TSP superfamily members than vertebrates.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
James Petrik, Sylvia Lauks, Bianca Garlisi, Jack Lawler
Summary: Many cancers start with a small nest of transformed cells that can remain dormant. Thrombospondin-1 (TSP-1) initially promotes dormancy by suppressing angiogenesis, but over time, factors promoting angiogenesis become dominant and recruit various cells to form a complex tumor microenvironment. TSPs play a role in the proliferation, migration, and invasion of cells in the tumor microenvironment, as well as influencing the immune characteristics and phenotype of tumor-associated macrophages.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Hana Fakim, Christine Vande Velde
Summary: There has been increasing attention to the role of phase-separated biomolecular condensates, specifically stress granules, in neurodegenerative diseases like ALS. ALS-associated mutations in genes involved in stress granule assembly have been found, and stress granule proteins have been detected in pathological inclusions in ALS patient neurons. However, protein components of stress granules are also present in other physiological biomolecular condensates, which have not been adequately discussed in relation to ALS. This review explores the functions of TDP-43 and FUS in physiological condensates occurring in the nucleus and neurites beyond stress granules, and discusses the impact of ALS-linked mutations on their ability to phase separate and perform their functions in stress-independent biomolecular condensates.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Alexander Lin, Yogambha Ramaswamy, Ashish Misra
Summary: Smooth muscle cells, endothelial cells, and macrophages in blood vessels display remarkable heterogeneity, and their developmental origins may influence their plasticity. Unbiased single cell whole transcriptome analysis techniques are revolutionizing the understanding of cellular diversity and plasticity, providing insights for therapeutic research.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Elton P. Hudson
Summary: The Calvin Benson cycle plays a crucial role in the ecological and biotechnological aspects of bacteria. Recent studies have shed light on the regulation of this cycle in bacteria, with post-transcriptional and post-translational regulation being important in phototrophic bacteria, and transcriptional regulation being prominent in chemolithoautotrophic bacteria. Understanding the regulation of the Calvin Benson cycle has implications for enhancing CO2 fixation and improving the synthesis of desired products. Non-canonical cycles may offer potential benefits for industrial applications.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Xin-Guang Zhu, Haim Treves, Honglong Zhao
Summary: This paper discusses the major regulatory mechanisms over the Calvin Benson Cycle (CBC) that maintain homeostasis of metabolite levels. These mechanisms include redox regulation of enzymes, metabolite regulations (especially allosteric regulations), and balanced activities of enzymes. These regulatory mechanisms are crucial for maintaining high flux and photosynthetic efficiency in CBC.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Hunter C. Herriage, Yi-Ting Huang, Brian R. Calvi
Summary: Apoptosis prevents the inappropriate acquisition of extra copies of the genome, known as polyploidy, but the polyploid state can suppress apoptosis. The mechanisms linking apoptosis and polyploid cell cycles are still largely unknown, and studying the regulation of apoptosis in development and cancer could lead to more effective therapies.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Daniel Campbell, Steven Zuryn
Summary: Mitochondrial dynamics play a crucial role in regulating cellular and organismal homeostasis, impacting various aspects of an organism's healthspan. By studying the nematode Caenorhabditis elegans, a comprehensive understanding of the impact of mitochondrial dynamics on homeostasis over a lifetime can be obtained.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Diba Borgmann, Henning Fenselau
Summary: Maintaining blood glucose at an appropriate physiological level requires coordination of multiple organs and tissues, with the vagus nerve playing a key role in central control. Recent studies have revealed the cellular identity, neuroanatomical organization, and functional contributions of vagal neurons in the regulation of systemic glucose metabolism. These findings provide new insights into the precise roles of vagal neurons in coordinating glucose levels and offer potential avenues for treating glucose metabolism disorders.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Tatiana C. Coverdell, Stephen B. G. Abbott, John N. Campbell
Summary: In this article, we review how genetic technology and single-cell genomics are revealing the organizational principles of the efferent vagus in unprecedented detail.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)