期刊
SEMINARS IN CANCER BIOLOGY
卷 36, 期 -, 页码 62-70出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcancer.2015.09.005
关键词
Fbw7; SCF ubiquitin ligase; Protein degradation; Tumor suppressor; Oncogene
类别
资金
- German Science Foundation [PO1458/4-1]
- institutional grant of the Deutsche Krebshilfe
The F-box protein Fbw7 targets for degradation critical cellular regulators, thereby controlling essential processes in cellular homeostasis, including cell cycle, differentiation and apoptosis. Most Fbw7 substrates are strongly associated with tumorigenesis and Fbw7 can either suppress or promote tumor development in mouse models. Fbw7 activity is controlled at different levels, resulting in specific and tunable regulation of the abundance and activity of its substrates. Here we highlight recent studies on the role of Fbw7 in controlling tumorigenesis and on the mechanisms that modulate Fbw7 function. (C) 2015 Elsevier Ltd. All rights reserved.
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