期刊
SEMINARS IN CANCER BIOLOGY
卷 36, 期 -, 页码 33-51出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcancer.2015.09.015
关键词
F-box; SCF; Ubiquitin; E3 ubiquitin ligases; Cancer
类别
资金
- National Institutes of Health (NIH) [CA009109]
- New Idea Award (NIA) from the leukemia and lymphoma society (LLS) [P-NIA-0214-13]
F-box proteins are substrate receptors of the SCF (SKP1-Cullin 1-F-box protein) E3 ubiquitin ligase that play important roles in a number of physiological processes and activities. Through their ability to assemble distinct E3 ubiquitin ligases and target key regulators of cellular activities for ubiquitylation and degradation, this versatile group of proteins is able to regulate the abundance of cellular proteins whose deregulated expression or activity contributes to disease. In this review, we describe the important roles of select F-box proteins in regulating cellular activities, the perturbation of which contributes to the initiation and progression of a number of human malignancies. (C) 2015 Elsevier Ltd. All rights reserved.
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