Article
Hematology
Osamu Baba, Li-Hao Huang, Andrew Elvington, Martyna Szpakowska, Deborah Sultan, Gyu Seong Heo, Xiaohui Zhang, Hannah Luehmann, Lisa Detering, Andy Chevigne, Yongjian Liu, Gwendalyn J. Randolph
Summary: The accumulation of Cu-64-DOTA-vMIP-II tracer at atherosclerotic lesions in mice was found to be associated with the expression of chemokine receptor CXCR4 on endothelial cells, indicating that it is not solely targeting monocytes and macrophages. This suggests that endothelial cell expression of CXCR4 is a key target for Cu-64-DOTA-vMIP-II imaging.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Immunology
Hui Zhou, Xiyan Liao, Qin Zeng, Haowei Zhang, Jianfeng Song, Wanyu Hu, Xiaoxiao Sun, Yujin Ding, Dandan Wang, Yalun Xiao, Tuo Deng
Summary: Accumulation and activation of immunocytes in adipose tissues are important in obesity-induced inflammation and insulin resistance. Chemokines, especially CCL5, play a crucial role in recruiting immunocytes to adipose tissue during obesity. CCL5 deficiency exacerbates adipose inflammation and impairs insulin sensitivity in obese mice. This study provides insights into the role of CCL5 in obesity-induced adipose inflammation.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Adele Ruder, Suzan M. W. Wetzels, Lieve Temmerman, Erik A. L. Biessen, Pieter Goossens
Summary: Monocytes differentiate into macrophages at sites of inflammation and contribute to the development of cardiovascular disease. Different subtypes of monocytes, characterized by the expression of CD14 and CD16, have been identified. The middle subtype has been found to be associated with atherosclerosis, myocardial infarction, and heart failure. However, more research is needed to understand their exact role and predictive value in cardiovascular disease.
CARDIOVASCULAR RESEARCH
(2023)
Review
Neurosciences
Meiling Bai, Ruize Sun, Bin Cao, Juan Feng, Jue Wang
Summary: Ischemic stroke is a leading cause of death worldwide and the most common cause of disability in Western countries. Inflammation plays a vital role in the development and progression of ischemic stroke, and peripheral blood immune cells, particularly monocytes, are involved in the immune cascade after stroke.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Medicine, Research & Experimental
Jie Lin, Ya Xu, Peiwen Guo, Yu-Jie Chen, Jiru Zhou, Min Xia, Binbin Tan, Xin Liu, Hua Feng, Yujie Chen
Summary: Due to metabolic disequilibrium and immune suppression, intracerebral hemorrhage patients are prone to infections. The intrinsic mechanisms underlying the effects of infection-related peripheral inflammation after ICH remain unclear.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Christina Kassiteridi, Jennifer E. Cole, Thibault Griseri, Mika Falck-Hansen, Michael E. Goddard, Anusha N. Seneviratne, Patricia A. Green, Inhye Park, Annelie G. Shami, Tanyaporn Pattarabanjird, Aditi Upadhye, Angela M. Taylor, Ashok Handa, Keith M. Channon, Esther Lutgens, Coleen A. McNamara, Richard O. Williams, Claudia Monaco
Summary: The study demonstrates the significant role of CD200 in atherosclerosis, where CD200 deficiency increases atherosclerotic lesion formation. The CD200/CD200R pathway restrains macrophage activation and monocyte recruitment, limiting the progression of atherosclerosis.
CIRCULATION RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Ariane Schumski, Almudena Ortega-Gomez, Kanin Wichapong, Carla Winter, Patricia Lemnitzer, Joana R. Viola, Mayra Pinilla-Vera, Eduardo Folco, Victor Solis-Mezarino, Moritz Volker-Albert, Sanne L. Maas, Chang Pan, Laura Perez Olivares, Janine Winter, Tilman Hackeng, Mikael C. Karlsson, Tanja Zeller, Axel Imhof, Rebecca M. Baron, Gerry A. F. Nicolaes, Peter Libby, Lars Maegdefessel, Frits Kamp, Martin Benoit, Yvonne Doring, Oliver Soehnlein
Summary: Acute infection increases the risk of cardiovascular complications, with lipopolysaccharide playing a role in accelerating vascular inflammation through the activation of circulating immune cells. Histone H2a associated with NETs is shown to mediate charge-dependent monocyte adhesion and accelerate atherosclerosis during endotoxinemia.
Article
Immunology
Danielle Borges Germano, Steffany Bernardo Oliveira, Andre Luis Lacerda Bachi, Yara Juliano, Neil Ferreira Novo, Jonatas Bussador do Amaral, Carolina Nunes Franca
Summary: Chemokine receptors play a fundamental role in various processes related to cardiovascular diseases, but the translation of experimental studies to clinical applications remains challenging. This review explores promising results and discusses obstacles that need to be overcome before utilizing chemokine receptor blockade as a therapeutic target in cardiovascular disease treatment.
IMMUNOLOGY LETTERS
(2023)
Article
Biochemistry & Molecular Biology
Albert Frank Magnusen, Reena Rani, Mary Ashley McKay, Shelby Loraine Hatton, Tsitsi Carol Nyamajenjere, Daniel Nii Aryee Magnusen, Joerg Koehl, Gregory Alex Grabowski, Manoj Kumar Pandey
Summary: Gaucher disease is a lysosomal storage disease caused by mutations in GBA1/Gba1. Deficiency of lysosomal acid beta-glucosidase enzyme leads to abnormal accumulation of glucosylceramide, resulting in altered function of immune cells and tissue damage. The study reveals the role of CXCR3 receptor and CXCL9 chemokine in increased recruitment of T cells in Gaucher disease, suggesting potential therapeutic targets for inflammation treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Hematology
Luka Zivkovic, Yaw Asare, Jurgen Bernhagen, Martin Dichgans, Marios K. Georgakis
Summary: This study systematically reviewed and meta-analyzed studies on the use of CCL2/CCR2 blockade in atheroprone mice. The results showed that CCL2/CCR2 blockade can attenuate atherosclerotic lesion size and improve lesion morphology. However, the majority of existing studies have major quality issues, highlighting the need for additional high-quality research.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Mathilde Mura, Michele Weiss-Gayet, Nellie Della-Schiava, Erica Chirico, Patrick Lermusiaux, Marie Chambion-Diaz, Camille Faes, Anaelle Boreau, Benedicte Chazaud, Antoine Millon, Vincent Pialoux
Summary: Atherosclerosis is associated with chronic inflammation involving circulating monocytes. Physical activity has been shown to decrease inflammation and the risk of stroke. This study found that moderately active patients had a lower percentage of classical and intermediate monocytes compared to non-active and highly active patients. In contrast, the percentage of non-classical monocytes increased in moderately active patients. These findings suggest that physical activity can be beneficial for patients by reducing the risk of ischemic stroke and promoting lesion healing.
Review
Cell Biology
Ki-Wook Kim, Stoyan Ivanov, Jesse W. Williams
Summary: Atherosclerotic lesions progress due to the recruitment and differentiation of circulating monocytes into macrophages within plaques, forming foam cells. Recent studies have used single-cell gene expression profiling to investigate the roles of macrophages and monocytes in inflammatory mechanisms, motility, and proliferation within lesions, but questions remain about tissue-specific regulation and the contribution of recruited monocytes during disease progression. Further research is needed to advance therapeutic strategies for cardiovascular disease based on these findings.
Article
Biology
Xing Feng, Ruifeng Sun, Moonyoung Lee, Xinyue Chen, Shangqin Guo, Huimin Geng, Marcus Muschen, Jungmin Choi, Joao Pedro Pereira
Summary: Acute lymphoblastic and myeloblastic leukemias (ALL and AML) modify the bone marrow microenvironment and disrupt non-malignant hematopoiesis. Leukemic cells express lymphotoxin alpha 1 beta 2 and activate lymphotoxin beta receptor (LT beta R) signaling in mesenchymal stem cells (MSCs), which turns off IL7 production and prevents non-malignant lymphopoiesis. Genetic or pharmacological disruption of LT beta R signaling in MSCs restores lymphopoiesis but not erythropoiesis, reduces leukemic cell growth, and extends the survival of transplant recipients.
Article
Cell Biology
Jianrui Song, Diana Farris, Paola Ariza, Smriti Moorjani, Mita Varghese, Muriel Blin, Judy Chen, Daniel Tyrrell, Min Zhang, Kanakadurga Singer, Morgan Salmon, Daniel R. Goldstein
Summary: This study reveals that aging enhances atherosclerosis through the increased inflammation of visceral fat. The transplantation of aged fat onto the carotid artery of mice resulted in larger atherosclerotic plaques with increased macrophage numbers. Inflammatory factors secreted by adipose tissue macrophages, including TNF alpha, CXCL2, and CCL2, were found to contribute to the enhancement of atherosclerosis in aging fat transplants.
Article
Biology
Magdalena Makarewicz-Wujec, Jan Henzel, Mariusz Kruk, Cezary Kepka, Lukasz Wardziak, Piotr Trochimiuk, Andrzej Parzonko, Marcin Demkow, Zofia Dzielinska, Malgorzata Kozlowska-Wojciechowska
Summary: The study found that the DASH diet can lower the levels of inflammatory markers, which may have potential benefits for patients with atherosclerosis.
Article
Biotechnology & Applied Microbiology
Tobias Beer, Sebastian Haensch, Klaus Pfeffer, Sander H. J. Smits, Stefanie Weidtkamp-Peters, Lutz Schmitt
Summary: Secretion systems play a vital role in Gram-negative bacteria by allowing communication with the outside world. This study focused on the hemolysin A (HlyA) type I secretion system (T1SS) in Escherichia coli and analyzed its localization and clustering. The results showed that the amount of ToIC, a component of the T1SS, was not affected by overexpression of the HlyBD complex. Superresolution microscopy revealed that the HlyA T1SS did not exhibit polarization and the size of T1SS clusters did not correlate with outer membrane islands.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2022)
Article
Surgery
Andreas Kyriakou, Alexander Oberhuber, Lia Friesen, Lioba Franziska Huelsboemer, Johannes F. Schaefers
Summary: This study presents an endovascular management technique for treating a specific type of endoleak occurring after branched aortic aneurysm repair. The misalignment of the stent graft is resolved through retrograde cannulation of the superior mesenteric artery, allowing for successful repair of the endoleak.
JOURNAL OF ENDOVASCULAR THERAPY
(2023)
Article
Surgery
Johannes Frederik Schaefers, Ahmed Murtaja, Alexander Oberhuber
Summary: The application of precannulated branches and a femoral approach for bridging stent graft deployment in branched endovascular aneurysm repair is a feasible and quick method for complex procedures, ensuring safe and efficient completion of the implantation.
JOURNAL OF ENDOVASCULAR THERAPY
(2022)
Article
Surgery
Lia Friesen, Giuseppe Asciutto, Johannes Frederik Schaefers, Alexander Oberhuber
Summary: This report describes the use of a double-branched custom-made iliac branch device (IBD) for the endovascular repair of an aorto-bi-iliac aneurysm with concomitant bilateral hypogastric aneurysms.
JOURNAL OF ENDOVASCULAR THERAPY
(2023)
Letter
Dermatology
Sarah Janssen, Bernhard Homey, Stephan Meller
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Oliver H. Weiergraeber, Dusan Petrovic, Andreas Kislat, Martin Pattky, Judith Fabig, Renu Batra-Safferling, Jan Schulte Am Esch, Karen Haenel, Carolin Huhn, Birgit Strodel, Bernhard Homey, Dieter Willbold
Summary: CCL16 is primarily synthesized by hepatocytes, circulates in the blood as a full-length protein, and the C-terminal extension may impair its biological activity modulation.
Article
Dermatology
Elke Weisshaar, Philipp Bentz, Christian Apfelbacher, Eva Haufe, Luise Heinrich, Annice Heratizadeh, Susanne Abraham, Inken Harder, Andreas Kleinheinz, Andreas Wollenberg, Knut Schaekel, Franca Wiemers, Julia Ertner, Matthias Augustin, Julia Wildberger, Ralph von Kiedrowski, Margitta Worm, Alexander Zink, Isaak Effendy, Andrea Asmussen, Mario Pawlak, Michael Sticherling, Melanie Hilgers, Christiane Handrick, Sven Quist, Beate Schwarz, Magnus Bell, Petra Staubach-Renz, Sung-Hei Hong-Weldemann, Bernhard Homey, Jens-Joachim Bruecher, Stephan Weidinger, Thomas Werfel, Jochen Schmitt
Summary: TREATgermany is a disease registry that investigates the severity, symptoms, treatment, and quality of life in patients with moderate to severe atopic dermatitis. The results show that 97.2% of patients experienced itch, and the severity of itch is correlated with the patient's self-reported disease severity.
ACTA DERMATO-VENEREOLOGICA
(2023)
Article
Surgery
Peter Arne Gerber, Bettina A. Buhren, Edwin Boelke, Wolfgang G. Philipp-Dormston, Bernhard Homey, Holger Schrumpf
Summary: This study found that almost all hyaluronic acid fillers can be dissolved by hyaluronidase in a dose- and time-dependent manner. The technology and degree of cross-linking of the fillers seem to have a stronger effect on degradability by hyaluronidase compared to the concentration of hyaluronic acid.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2023)
Article
Medicine, Research & Experimental
Alessio Mylonas, Heike C. Hawerkamp, Yichen Wang, Jiaqi Chen, Francesco Messina, Olivier Demaria, Stephan Meller, Bernhard Homey, Jeremy Di Domizio, Lucia Mazzolai, Alain Hovnanian, Michel Gilliet, Curdin Conrad
Summary: Rosacea is a chronic inflammatory skin disease characterized by excessive inflammation and neovascularization. Bacillus oleronius and kallikrein 5 have been identified as key triggers in the development of rosacea. This study reveals that plasmacytoid dendritic cells produce type I interferons, linking microbial dysbiosis, immune response abnormalities, and neovascularization. The excessive expression of type I interferons leads to neoangiogenesis through IL-22 induction and upregulation of the IL-22 receptor on endothelial cells.
Article
Biochemistry & Molecular Biology
Andreas Kislat, Peter Olah, Marcus Kuchner, Peter Arne Gerber, Juergen Schrader, Stephan Meller, Bernhard Homey
Summary: Alitretinoin, a dual RAR and RXR agonist, targets skin dysregulation and exerts strong immunomodulatory effects on antigen presenting cells, leading to the treatment of chronic hand eczema with remarkable efficacy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Paolo Calo, Alexander Oberhuber, Hartmut Goertz
Summary: The results of this retrospective analysis suggest that CAS can be performed with very low complication rates through strict patient selection based on anatomical and clinical criteria. Standardization of the materials and the procedure itself is crucial.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Polymer Science
Waseem Garabet, Polina Shabes, Katharina Henrika Wolters, Julian-Dario Rembe, Wiebke Ibing, Markus Udo Wagenhauser, Florian Simon, Hubert Schelzig, Alexander Oberhuber
Summary: Compared to cellulose-based hemostats, gelatin-based hemostats have shown advantageous effects on central aspects of wound healing. However, the influence of gelatin-based hemostats on wound healing has not been fully explored yet. Fibroblast cell counts decreased significantly at 7 and 14 days after exposure to the gelatin-based hemostat, while the extracellular matrix contraction was not affected. Vascular endothelial growth factor significantly increased after a prolonged 24-hour application of the gelatin-based hemostat. Gelatin-based hemostats seem to be compatible with wound healing, but further animal and human studies are needed for clinical assessment.
Article
Medicine, General & Internal
Joscha Mulorz, Franziska Garcon, Amir Arnautovic, Casper De Somer, Artis Knapsis, Hug Aubin, Felix Fleissner, Julian-Dario Rembe, Malwina Vockel, Alexander Oberhuber, Artur Lichtenberg, Hubert Schelzig, Markus Udo Wagenhaeuser
Summary: This study examines the geometric architecture of the aortic arch and supra-aortic branches in patients with type B aortic dissection (TBAD) compared to non-TBAD patients. The results show significant differences in aortic arch configuration, angles, and inter-vessel distance between TBAD and non-TBAD patients, providing insights into potential risk factors for TBAD development.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Joscha Mulorz, Wiebke Ibing, Melanie Cappallo, Soenke Maximilian Brass, Kiku Takeuchi, Uwe Raaz, Isabel Nahal Schellinger, Kim Jurgen Krott, Hubert Schelzig, Hug Aubin, Alexander Oberhuber, Margitta Elvers, Markus Udo Wagenhaeuser
Summary: This experimental study investigates the effects of nicotine, angiotensin II, and ethanol on human aortic endothelial cells. It reveals that these substances can reduce metabolic viability, enhance cell adherence, and decrease cell migration capacity. These findings suggest a potential mechanism for developing an endothelial entry tear due to increased mechanical rigidity.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Danny Jazmati, Balint Tamaskovics, Norman-Philipp Hoff, Bernhard Homey, Edwin Boelke, Belebenie Boyomo, Waseem Garabet, Jan Haussmann, Wilfried Budach, Judith Neuwahl, Hubert Schelzig, Stefanie Corradini, Martijn van Griensven, Johannes Fischer, Wolfram Trudo Knoefel, John Pegani, Alessia Pedoto, Gerald Antoch, Julian Kirchner, Tom Luedde, Noemi F. Freise, Torsten Feldt, Bjoern-Erik Ole Jensen, Verena Keitel, Christiane Matuschek
Summary: Low-dose irradiation is an effective treatment option for persistent lymphatic fistulas after inguinal vascular surgery, preventing infection, sepsis, bleeding, and possible leg amputation. The recommended dose ranges from 0.3-0.5 to 1-12 Gy. In this study, every patient experienced resolution of the lymphatic fistula without major complications.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
