Article
Engineering, Environmental
Weiwei Wang, Jie Zhang, Ze Li, Jie Gu, Jingyu Qin, Jiali Li, Xiaona Zhang, Shaoguo Ru
Summary: BPS exposure accelerates the progression of ASCVD, inducing characteristic symptoms in zebrafish embryo-larvae model, such as inflammation, macrophage recruitment, and oxLDL accumulation in blood vessels.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Pharmacology & Pharmacy
Jiarou Wang, Yifan Zhang, Xiaoteng Feng, Min Du, Sijin Li, Xindi Chang, Ping Liu
Summary: This study suggests that Tanshinone IIA (TIIA) may reduce lipid accumulation and treat atherosclerosis by enhancing macrophage efferocytosis.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Wesal Elgretli, Tianyan Chen, Nadine Kronfli, Giada Sebastiani
Summary: Hepatitis C virus (HCV) infection is the main cause of chronic liver disease and can lead to various hepatic diseases. It is also associated with extrahepatic manifestations such as immune-related disorders and metabolic abnormalities. HCV is dependent on the host's lipid metabolism for successful replication.
Review
Endocrinology & Metabolism
Ping Ling, Xueying Zheng, Sihui Luo, Junbo Ge, Suowen Xu, Jianping Weng
Summary: ASCVD is the largest cause of morbidity and mortality worldwide, with lipid-lowering therapies as the current major cornerstone of its management. However, some patients do not respond to standard therapies and remain at high risk of ASCVD.
DIABETES OBESITY & METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Xiaoqing Guo, Bowei Li, Cheng Wen, Feng Zhang, Xuying Xiang, Lei Nie, Jiaojiao Chen, Ling Mao
Summary: Disordered lipid accumulation in the arterial wall is a hallmark of atherosclerosis. This study investigated the role of triggering receptor expressed on myeloid cells 2 (TREM2) in atherosclerosis using animal models and cell cultures. The results showed that TREM2 promotes the development of atherosclerosis by promoting foam cell formation in vascular smooth muscle cells and macrophages through regulating the expression of the scavenger receptor CD36. These findings suggest that TREM2 may be a potential therapeutic target for the treatment of atherosclerosis.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Review
Endocrinology & Metabolism
Chunyu Li, Fei Wang, Lili Cui, Shaoxin Li, Junyu Zhao, Lin Liao
Summary: Metabolic reprogramming is a characteristic of tumors, with lipid metabolism playing a significant role. Abnormal lipid metabolism is associated with various diseases, and the number of people with such abnormalities is increasing. Lipid metabolism regulates oncogenic signaling pathways and is involved in the occurrence, development, invasion, and metastasis of tumors. Factors such as tumor origin, lipid metabolism pathway regulation, and diet contribute to the differences in lipid metabolism among different tumors. This article provides a review of lipid synthesis and regulatory pathways, highlighting the research progress on cholesterol, triglycerides, sphingolipids, lipid rafts, adipocytes, lipid droplets, and lipid-lowering drugs in relation to tumors and their drug resistance. It also identifies current research limitations and potential targets for tumor treatment within the lipid metabolism pathway. Studying and intervening in lipid metabolism abnormalities may offer new insights into tumor treatment and survival prognosis.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Hematology
Lilli Arndt, Ileana Hernandez-Resendiz, Doreen Moos, Janine Dokas, Silvana Mueller, Franziska Jeromin, Richard Wagner, Uta Ceglarek, Iris M. Heid, Marcus Hoering, Gerhard Liebisch, Sonja C. Stadler, Ralph Burkhardt
Summary: This study demonstrates that deficiency of Trib1 promotes the formation of atherosclerotic lesions and increases plasma cholesterol and triglyceride levels in Ldlr(-/-) mice. It also suggests that Trib1 deficiency alters hepatic lipid metabolism and induces inflammation.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Prakriti Gaba, Michelle L. O'Donoghue, Jeong-Gun Park, Stephen D. Wiviott, Dan Atar, Julia F. Kuder, KyungAh Im, Sabina A. Murphy, Gaetano M. De Ferrari, Zbigniew A. Gaciong, Kalman Toth, Ioanna Gouni-Berthold, Jose Lopez-Miranda, Francois Schiele, Francois Mach, Jose H. Flores-Arredondo, J. Antonio G. Lopez, Mary Elliott-Davey, Bei Wang, Maria Laura Monsalvo, Siddique Abbasi, Robert P. Giugliano, Marc S. Sabatine
Summary: This study found that long-term achievement of lower LDL-C levels (below 20 mg/dL) in patients with atherosclerotic cardiovascular disease was associated with a lower risk of cardiovascular events without significant safety concerns.
Article
Multidisciplinary Sciences
Xu Xiao, Youngjae Kim, Beatriz Romartinez-Alonso, Kristupas Sirvydis, Daniel S. Ory, John W. R. Schwabe, Michael E. Jung, Peter Tontonoz
Summary: Aster proteins mediate nonvesicular plasma membrane to endoplasmic reticulum cholesterol transport, with 20 alpha-hydroxycholesterol and U18666A identified as potential small molecule modulators. However, they target other sterol homeostatic proteins, limiting their utility.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Chemistry, Medicinal
Saba Soltani, Motahareh Boozari, Arrigo F. G. Cicero, Tannaz Jamialahmadi, Amirhossein Sahebkar
Summary: HDL plays a crucial role in cardiovascular diseases, while phytochemicals have the potential to enhance cholesterol efflux. Current research mostly focuses on preclinical studies, indicating a need for more clinical research to develop novel clinical applications.
PHYTOTHERAPY RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Hongyan Zhou, Peidong You, Hao Liu, Jialong Fan, Chunyi Tong, Anning Yang, Yideng Jiang, Bin Liu
Summary: The biomimetic membrane-coated Prussian blue nanoparticles (PB NPs) prepared in this study, incorporating Artemisinin (ART) and Procyanidins (PC), showed significant scavenging effect on ROS and NO, while inhibiting NF-kappa B/NLRP3 pathway, and enhancing AMPK/mTOR/autophagy pathway. The improved biocompatibility and immune-escape ability of nanocomplexes allowed high drug accumulation in the atherosclerotic plaque of ApoE-/- mice model, showing high efficacy against atherosclerosis with both low and high dosage treatment.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Biochemistry & Molecular Biology
Anastasia Poznyak, Larisa Litvinova, Paolo Poggio, Alexander N. Orekhov, Alexandra A. Melnichenko
Summary: Lipid metabolism alterations play a significant role in the development of atherosclerosis, and familial hypercholesterolaemia is a common cause associated with increased risk of atherosclerosis.
Article
Biochemistry & Molecular Biology
Maria Pia Adorni, Bianca Papotti, Maria Orietta Borghi, Elena Raschi, Francesca Zimetti, Franco Bernini, Pier Luigi Meroni, Nicoletta Ronda
Summary: This study investigates the direct effects of tofacitinib on macrophage cholesterol metabolism, finding that it can increase cholesterol efflux, decrease cholesterol uptake and synthesis, and have a favorable impact on macrophage cholesterol metabolism. These findings are important for understanding the impact of tofacitinib on cardiovascular risk.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Hematology
Jing Liu, Baiba K. Gillard, Dedipya Yelamanchili, Antonio M. Gotto, Corina Rosales, Henry J. Pownall
Summary: Mice lacking the HDL receptor Scarb1 exhibit increased bioavailability of FC in HDL, leading to elevated FC content in multiple tissue sites associated with female infertility, impaired cell maturation, cardiac dysfunction, and atherosclerosis. Sex-dependent differences in tissue-lipid composition and plasma FC clearance rates were also observed. Higher HDL-FC bioavailability may serve as a potential biomarker mechanistically linked to various pathologies.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Materials Science, Biomaterials
Shuangshuang Tu, Wenzhi Ren, Jinru Han, Haijing Cui, Ting Dai, Haoxuan Lu, Yanqing Xie, Wenming He, Aiguo Wu
Summary: Osteopontin-coupled polydopamine (PDA-OPN) nanoparticles were synthesized and applied for mild photothermal therapy (PTT) of atherosclerosis. These nanoparticles were specifically recognized and absorbed by foam cells, and under near-infrared laser irradiation, they generated mild photothermal effects that reduced intracellular lipid accumulation without inducing cell apoptosis. In vivo treatment showed that mild PTT substantially reduced plaque area and improved plaque stability in atherosclerotic mice.
REGENERATIVE BIOMATERIALS
(2023)
