Prevention of atherosclerosis by bioactive palmitoleate through suppression of organelle stress and inflammasome activation

Lymphocytes in Atherosclerosis

(2015) C. C. Hedrick   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Anti-Inflammatory and Antiatherogenic Effects of the NLRP3 Inflammasome Inhibitor Arglabin in ApoE2.Ki Mice Fed a High-Fat Diet

(2015) A. Abderrazak et al.   CIRCULATION

Monounsaturated Fatty Acid–Enriched High-Fat Diets Impede Adipose NLRP3 Inflammasome–Mediated IL-1β Secretion and Insulin Resistance Despite Obesity

(2015) Orla M. Finucane et al.   DIABETES

Palmitoleate Reverses High Fat-induced Proinflammatory Macrophage Polarization via AMP-activated Protein Kinase (AMPK)

(2015) Kenny L. Chan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

(2015) Rebecca C Coll et al.   NATURE MEDICINE

Inflammasomes: mechanism of action, role in disease and therapeutics

(2015) Haitao Guo et al.   NATURE MEDICINE

Metabolic functions of FABPs—mechanisms and therapeutic implications

(2015) Gökhan S. Hotamisligil et al.   Nature Reviews Endocrinology

De novo lipogenesis in metabolic homeostasis: More friend than foe?

(2015) Giovanni Solinas et al.   Molecular Metabolism

NLRP3 inflammasome: From a danger signal sensor to a regulatory node of oxidative stress and inflammatory diseases

(2015) Amna Abderrazak et al.   Redox Biology

Discovery of a Class of Endogenous Mammalian Lipids with Anti-Diabetic and Anti-inflammatory Effects

(2014) Mark M. Yore et al.   CELL

Purified palmitoleic acid for the reduction of high-sensitivity C-reactive protein and serum lipids: A double-blinded, randomized, placebo controlled study

(2014) Adam M. Bernstein et al.   Journal of Clinical Lipidology

Palmitoleic Acid (N-7) Attenuates the Immunometabolic Disturbances Caused by a High-Fat Diet Independently of PPARα

(2014) Camila O. Souza et al.   MEDIATORS OF INFLAMMATION

Palmitoleic acid prevents palmitic acid-induced macrophage activation and consequent p38 MAPK-mediated skeletal muscle insulin resistance

(2014) Nicola A. Talbot et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Lipid metabolites as metabolic messengers in inter-organ communication

(2014) Sihao Liu et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Calcium signaling and mitochondrial destabilization in the triggering of the NLRP3 inflammasome

(2014) Tiffany Horng   TRENDS IN IMMUNOLOGY

Palmitoleic acid reduces intramuscular lipid and restores insulin sensitivity in obese sheep

(2014) Susan Duckett et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

Oral administration of omega-7 palmitoleic acid induces satiety and the release of appetite-related hormones in male rats

(2013) Zhi-Hong Yang et al.   APPETITE

Macrophage Mitochondrial Oxidative Stress Promotes Atherosclerosis and Nuclear Factor-κB–Mediated Inflammation in Macrophages

(2013) Ying Wang et al.   CIRCULATION RESEARCH

Is there something special about palmitoleate?

(2013) Leanne Hodson et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Muscle lipogenesis balances insulin sensitivity and strength through calcium signaling

(2013) Katsuhiko Funai et al.   JOURNAL OF CLINICAL INVESTIGATION

Unsaturated fatty acids prevent activation of NLRP3 inflammasome in human monocytes/macrophages

(2013) Laurent L'homme et al.   JOURNAL OF LIPID RESEARCH

A diurnal serum lipid integrates hepatic lipogenesis and peripheral fatty acid use

(2013) Sihao Liu et al.   NATURE

CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation

(2013) Frederick J Sheedy et al.   NATURE IMMUNOLOGY

Membrane lipid saturation activates endoplasmic reticulum unfolded protein response transducers through their transmembrane domains

(2013) R. Volmer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The UPR in atherosclerosis

(2013) Alex X. Zhou et al.   Seminars in Immunopathology

De novo lipogenesis in human fat and liver is linked to ChREBP-β and metabolic health

(2013) Leah Eissing et al.   Nature Communications

The Role of Endoplasmic Reticulum in Hepatic Lipid Homeostasis and Stress Signaling

(2012) Suneng Fu et al.   Cell Metabolism

Inhibiting Adipose Tissue Lipogenesis Reprograms Thermogenesis and PPARγ Activation to Decrease Diet-Induced Obesity

(2012) Irfan J. Lodhi et al.   Cell Metabolism

IRE1α Induces Thioredoxin-Interacting Protein to Activate the NLRP3 Inflammasome and Promote Programmed Cell Death under Irremediable ER Stress

(2012) Alana G. Lerner et al.   Cell Metabolism

Gluteofemoral Adipose Tissue Plays a Major Role in Production of the Lipokine Palmitoleate in Humans

(2012) K. E. Pinnick et al.   DIABETES

Inflammasomes in health and disease

(2012) Till Strowig et al.   NATURE

Palmitoleate Induces Hepatic Steatosis but Suppresses Liver Inflammatory Response in Mice

(2012) Xin Guo et al.   PLoS One

ER stress activates the NLRP3 inflammasome via an UPR-independent pathway

(2012) P Menu et al.   Cell Death & Disease

Inflammatory Mechanisms in Obesity

(2011) Margaret F. Gregor et al.   Annual Review of Immunology

Role of lipids in the control of food intake

(2011) Marc Fantino   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Silica Crystals and Aluminum Salts Regulate the Production of Prostaglandin in Macrophages via NALP3 Inflammasome-Independent Mechanisms

(2011) Etsushi Kuroda et al.   IMMUNITY

Chitosan microparticles for the controlled delivery of fluoride

(2011) Gemma M. Keegan et al.   JOURNAL OF DENTISTRY

Pannexin-1 Is Required for ATP Release during Apoptosis but Not for Inflammasome Activation

(2011) Y. Qu et al.   JOURNAL OF IMMUNOLOGY

Chronic administration of palmitoleic acid reduces insulin resistance and hepatic lipid accumulation in KK-Ay Mice with genetic type 2 diabetes

(2011) Zhi-Hong Yang et al.   Lipids in Health and Disease

A nuclear-receptor-dependent phosphatidylcholine pathway with antidiabetic effects

(2011) Jae Man Lee et al.   NATURE

Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity

(2011) Suneng Fu et al.   NATURE

Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling

(2011) Haitao Wen et al.   NATURE IMMUNOLOGY

Atherosclerosis: current pathogenesis and therapeutic options

(2011) Christian Weber et al.   NATURE MEDICINE

Fatty Acids Identified in the Burmese Python Promote Beneficial Cardiac Growth

(2011) C. A. Riquelme et al.   SCIENCE

InterfERing with endoplasmic reticulum stress

(2011) Honorata Kraskiewicz et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Circulating palmitoleic acid and risk of metabolic abnormalities and new-onset diabetes

(2010) Dariush Mozaffarian et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Double-Stranded RNA-Dependent Protein Kinase Links Pathogen Sensing with Stress and Metabolic Homeostasis

(2010) Takahisa Nakamura et al.   CELL

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Endoplasmic Reticulum Stress and Inflammation in Obesity and Diabetes

(2010) Sarah Hummasti et al.   CIRCULATION RESEARCH

Restoring endoplasmic reticulum function by chemical chaperones: an emerging therapeutic approach for metabolic diseases

(2010) F. Engin et al.   DIABETES OBESITY & METABOLISM

Western diet changes cardiac acyl-CoA composition in obese rats: a potential role for hepatic lipogenesis

(2010) Romain Harmancey et al.   JOURNAL OF LIPID RESEARCH

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses

(2010) Vijay A K Rathinam et al.   NATURE IMMUNOLOGY

Therapeutic targeting of chemokine interactions in atherosclerosis

(2010) Rory R. Koenen et al.   NATURE REVIEWS DRUG DISCOVERY

Mammalian endoplasmic reticulum stress sensor IRE1 signals by dynamic clustering

(2010) H. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of a Physiologically Relevant Endogenous Ligand for PPARα in Liver

(2009) Manu V. Chakravarthy et al.   CELL

Circulating Palmitoleate Strongly and Independently Predicts Insulin Sensitivity in Humans

(2009) N. Stefan et al.   DIABETES CARE

Markers of de novo lipogenesis in adipose tissue: associations with small adipocytes and insulin sensitivity in humans

(2009) R. Roberts et al.   DIABETOLOGIA

The plasma lipidomic signature of nonalcoholic steatohepatitis

(2009) Puneet Puri et al.   HEPATOLOGY

Disrupting functional interactions between platelet chemokines inhibits atherosclerosis in hyperlipidemic mice

(2009) Rory R Koenen et al.   NATURE MEDICINE

Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosis

(2009) Ebru Erbay et al.   NATURE MEDICINE

Valproate Attenuates Accelerated Atherosclerosis in Hyperglycemic ApoE-Deficient Mice

(2008) Anna J. Bowes et al.   AMERICAN JOURNAL OF PATHOLOGY

Differential regulation of the ER stress response by long-chain fatty acids in the pancreatic β-cell

(2008) Eleftheria Diakogiannaki et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Differential requirement for the activation of the inflammasome for processing and release of IL-1  in monocytes and macrophages

(2008) M. G. Netea et al.   BLOOD

Identification of a Lipokine, a Lipid Hormone Linking Adipose Tissue to Systemic Metabolism

(2008) Haiming Cao et al.   CELL

Mechanisms and consequences of macrophage apoptosis in atherosclerosis

(2008) Tracie Seimon et al.   JOURNAL OF LIPID RESEARCH

The unfolded protein response signals through high-order assembly of Ire1

(2008) Alexei V. Korennykh et al.   NATURE

Plasma palmitoleic acid, a product of stearoyl-coA desaturase activity, is an independent marker of triglyceridemia and abdominal adiposity

(2008) François Paillard et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Fatty acid composition of adipose tissue and blood in humans and its use as a biomarker of dietary intake

(2008) Leanne Hodson et al.   PROGRESS IN LIPID RESEARCH