Direct measurement of T cell receptor affinity and sequence from naïve antiviral T cells

Heightened self-reactivity associated with selective survival, but not expansion, of naïve virus-specific CD8+T cells in aged mice

(2016) Kylie M. Quinn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clonal Deletion Prunes but Does Not Eliminate Self-Specific αβ CD8+ T Lymphocytes

(2015) Wong Yu et al.   IMMUNITY

Cutting Edge: Resident Memory CD8 T Cells Express High-Affinity TCRs

(2015) Elizabeth L. Frost et al.   JOURNAL OF IMMUNOLOGY

Specific Roles of Each TCR Hemichain in Generating Functional Chain-Centric TCR

(2015) Munehide Nakatsugawa et al.   JOURNAL OF IMMUNOLOGY

CMV-specific T cells generated from naïve T cells recognize atypical epitopes and may be protective in vivo

(2015) Patrick J. Hanley et al.   Science Translational Medicine

Linking T-cell receptor sequence to functional phenotype at the single-cell level

(2014) Arnold Han et al.   NATURE BIOTECHNOLOGY

Towards error-free profiling of immune repertoires

(2014) Mikhail Shugay et al.   NATURE METHODS

T-cell receptor affinity and avidity defines antitumor response and autoimmunity in T-cell immunotherapy

(2013) S. Zhong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TCR-Ligand koff Rate Correlates with the Protective Capacity of Antigen-Specific CD8+ T Cells for Adoptive Transfer

(2013) M. Nauerth et al.   Science Translational Medicine

T Cell Affinity Regulates Asymmetric Division, Effector Cell Differentiation, and Tissue Pathology

(2012) Carolyn G. King et al.   IMMUNITY

Two-Stage Cooperative T Cell Receptor-Peptide Major Histocompatibility Complex-CD8 Trimolecular Interactions Amplify Antigen Discrimination

(2011) Ning Jiang et al.   IMMUNITY

Tumor Regression in Patients With Metastatic Synovial Cell Sarcoma and Melanoma Using Genetically Engineered Lymphocytes Reactive With NY-ESO-1

(2011) Paul F. Robbins et al.   JOURNAL OF CLINICAL ONCOLOGY

Dependence of T Cell Antigen Recognition on T Cell Receptor-Peptide MHC Confinement Time

(2010) Milos Aleksic et al.   IMMUNITY

Ca 2+ Release from the Endoplasmic Reticulum of NY-ESO-1–Specific T Cells Is Modulated by the Affinity of TCR and by the Use of the CD8 Coreceptor

(2010) Ji-Li Chen et al.   JOURNAL OF IMMUNOLOGY

The kinetics of two-dimensional TCR and pMHC interactions determine T-cell responsiveness

(2010) Jun Huang et al.   NATURE

TCR–peptide–MHC interactions in situ show accelerated kinetics and increased affinity

(2010) Johannes B. Huppa et al.   NATURE

Complete but curtailed T-cell response to very low-affinity antigen

(2009) Dietmar Zehn et al.   NATURE

T-cell receptor binding affinities and kinetics: impact on T-cell activity and specificity

(2008) Jennifer D. Stone et al.   IMMUNOLOGY

Age-associated decline in T cell repertoire diversity leads to holes in the repertoire and impaired immunity to influenza virus

(2008) Eric J. Yager et al.   JOURNAL OF EXPERIMENTAL MEDICINE