Article
Computer Science, Information Systems
Yongkui Tang, Leng-Ying Chen, Ailin Zhang, Chun-Peng Liao, Mitchell Eric Gross, Eun Sok Kim
Summary: The study evaluated the therapeutic effects of a new pulsed high-frequency medium-intensity focused ultrasound in selective cancer treatment with promising results, demonstrating reduced tumor size without thermal damage for potentially safer cancer treatment.
Article
Chemistry, Multidisciplinary
Xiaojing Wang, Gun Kim, James L. Chu, Tingjie Song, Zhenglin Yang, Weijie Guo, Xiangli Shao, Michael L. Oelze, King C. Li, Yi Lu
Summary: This study presents a novel method for detecting metal ions in vivo by combining high-intensity focused ultrasound with DNAzyme sensors. The thermal energy delivered by HIFU can activate the DNAzyme sensors, enabling the recognition of metal ions.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Xiaojing Wang, Gun Kim, James L. Chu, Tingjie Song, Zhenglin Yang, Weijie Guo, Xiangli Shao, Michael L. Oelze, King C. Li, Yi Lu
Summary: In this study, high-intensity focused ultrasound (HIFU) was successfully used to remotely activate DNAzyme sensors for high spatiotemporal resolution detection of metal ions in both in vitro and in vivo settings. The effectiveness of this approach was demonstrated by Zn2+-specific fluorescent resonance energy transfer (FRET) imaging in HeLa cells and mice. These findings offer new possibilities for in vivo imaging and medical diagnosis.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Review
Biochemistry & Molecular Biology
Loreto B. Feril, Rodney L. Fernan, Katsuro Tachibana
Summary: High-intensity focused ultrasound (HIFU) is a non-invasive method of ablating malignant tumors, with growing interest in its clinical application for breast cancer treatment. Despite technical challenges and limited clinical studies, HIFU is considered safe and potentially the preferred treatment option for most breast cancer patients in the future.
CURRENT MEDICINAL CHEMISTRY
(2021)
Review
Oncology
Rajneesh Mungur, Jiesheng Zheng, Ben Wang, Xinhua Chen, Renya Zhan, Ying Tong
Summary: The use of LIFU+MBs in drug delivery for glioblastoma has shown to be a safe and effective method, with improved drug uptake and tumor control without causing harm to brain structures.
FRONTIERS IN ONCOLOGY
(2022)
Article
Acoustics
Shaojian Mo, Jinyun Chen, Rong Zhang, Chao Yang, Ting Wang, Li Chen, Wenzhi Chen
Summary: This study aimed to evaluate the feasibility, safety, and therapeutic effects of high-intensity focused ultrasound ablation (HIFUA) in the treatment of post-operative recurrent desmoid tumors. The results showed that HIFUA can be used as an effective minimally invasive therapy for the local control of post-operative recurrent desmoid tumors.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2022)
Article
Acoustics
Ryo Takagi, Yoshihiko Koseki, Shin Yoshizawa, Shin-ichiro Umemura
Summary: A new filtering method was proposed to selectively eliminate HIFU noise while monitoring tissue changes in high-intensity focused ultrasound (HIFU) treatment, especially in the presence of cavitation bubbles. Experimental results showed the efficiency of the proposed method in ex-vivo studies.
Review
Medicine, General & Internal
Yun-Xiao Zhong, Jin-Chi Liao, Xv Liu, Hao Tian, Li-Ren Deng, Ling Long
Summary: Parkinson's disease is a chronic and progressive neurodegenerative disease that lacks effective and safe targeted drug therapy. Low-intensity focused ultrasound (LIFU), a non-invasive method to stimulate the brain and open the blood-brain barrier (BBB), has gained attention as a potential treatment for Parkinson's disease.
ANNALS OF MEDICINE
(2023)
Article
Chemistry, Analytical
Yufeng Zhou, Wei Chun Daniel Lim
Summary: High-intensity focused ultrasound (HIFU) was used to ablate solid tumors and cancers in this study. The interaction between HIFU bursts and blood vessels in hypervascular tumors was investigated to ensure efficiency and safety. Results showed that the presence of the artery led to a decrease in lesion size, with characteristics dependent on focus alignment. Acoustic and hydrodynamic cavitation played important roles in lesion production and interaction with the artery, with both thermal and mechanical effects found on the artery wall after HIFU ablation, but no vessel rupture was observed in this ex vivo study.
Article
Oncology
Yiran Wang, Yonghua Xu, Felix Wong, Yi Wang, Yu Cheng, Lixia Yang
Summary: The study demonstrated that ultrasound-guided high-intensity focused ultrasound ablation is feasible, effective, and safe for treating broad ligament fibroids, with significant reduction in fibroid volume and improvement in related symptoms.
INTERNATIONAL JOURNAL OF HYPERTHERMIA
(2021)
Article
Acoustics
Gengxi Lu, Xuejun Qian, Johnny Castillo, Runze Li, Laiming Jiang, Haotian Lu, K. Kirk Shung, Mark S. Humayun, Biju B. Thomas, Qifa Zhou
Summary: Ultrasonic neuromodulation, particularly with transcranial focused ultrasound, shows potential for the development of noninvasive cortical visual prostheses. The study found that blind rats had stronger responses to ultrasound stimulation compared to normal rats, with different ultrasound waveforms leading to varied cortical activities. Acoustic radiation force was identified as the primary physical mechanism behind ultrasound neuromodulation based on observed cortical activities.
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL
(2021)
Article
Automation & Control Systems
Jonas Lussi, Simone Gervasoni, Michelle Mattille, Roland Dreyfus, Quentin Boehler, Michael Reinehr, Nicole Ochsenbein, Bradley J. Nelson, Ueli Moehrlen
Summary: A robotic platform using remote magnetic navigation for fetoscopic surgery is proposed in this study, which can effectively treat twin-to-twin transfusion syndrome with flexibility, dexterity, safety, and precision.
ADVANCED INTELLIGENT SYSTEMS
(2022)
Editorial Material
Behavioral Sciences
Sadaf Afif, Syeda Tayyaba Rehan, Hassan ul Hussain, Md. Saiful Islam
Summary: Approximately 80% of epilepsy patients are in poor resource settings, and despite advancements in treatment options, epilepsy remains a major health problem in developing countries. Low-intensity, pulsed-focused ultrasound (FUS) could potentially be a new noninvasive treatment option for epilepsy, which would be particularly beneficial in areas where surgical therapies are not feasible. Improved understanding of epilepsy in developing countries and continuous evaluation of new therapeutic options are needed to reduce the burden of epilepsy and the treatment gap.
BRAIN AND BEHAVIOR
(2023)
Article
Dermatology
Ying-Xin Zhao, Xiao-Ye Hu, Xian Zhong, Hong Shen, Ying Yuan
Summary: This study investigated the treatment of myxofibrosarcoma in a 35-year-old female patient, who remained disease-free for more than 30 months after HIFU treatment, indicating a promising novel therapy for recurrent myxofibrosarcoma.
DERMATOLOGIC THERAPY
(2021)
Article
Acoustics
Nicole Ochsenbein-Koelble
Summary: Twin pregnancies, accounting for 2-3% of all deliveries, require specialized care and monitoring, including accurate dating of pregnancy and assessment of chorionicity/amnionicity in the first trimester, as well as regular ultrasound examinations to observe fetal growth and amniotic fluid levels. An intertwin weight discordance > 20% is indicative of pregnancies at increased risk of adverse outcomes.
ULTRASCHALL IN DER MEDIZIN
(2021)
Article
Pediatrics
Erin McGillick, Sandra Orgeig, Beth J. Allison, Kirsty L. Brain, Youguo Niu, Nozomi Itani, Katie L. Skeffington, Andrew D. Kane, Emilio A. Herrera, Janna L. Morrison, Dino A. Giussani
Summary: Maternal vitamin C treatment in late gestation in sheep enhances the expression of genes important for fetal lung maturation at a molecular level. However, it does not affect protein markers or the number of surfactant-producing cells in fetal lung tissue.
PEDIATRIC RESEARCH
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Allison Payne, Rajiv Chopra, Nicholas Ellens, Lili Chen, Pejman Ghanouni, Steffen Sammet, Chris Diederich, Gail Ter Haar, Dennis Parker, Chrit Moonen, Jason Stafford, Eduardo Moros, David Schlesinger, Stanley Benedict, Keith Wear, Ari Partanen, Keyvan Farahani
Summary: The report provides background information on MRgFUS technology, focusing on clinical body MRgFUS systems, and offers recommendations for successfully implementing and maintaining a clinical MRgFUS program.
Article
Acoustics
Ragnar Sande, Klaus-Vitold Jenderka, Carmel M. Moran, Susana Marques, J. F. Jimenez Diaz, Gail Ter Haar, Karel Marsal, Christoph Lees, Jacques S. Abramowicz, Kjell Asmund Salvesen, Piero Miloro, Andrea Dall'Asta, Christoph Brezinka, Christian Kollmann
Summary: Ultrasound safety is crucial in fetal and neonatal scanning due to vulnerable tissues and incomplete investigation of potential biological effects. Balancing clinical benefits with safety considerations is essential. The perinatal period appears to be less vulnerable, making ultrasound a safer alternative to other imaging modalities.
ULTRASCHALL IN DER MEDIZIN
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Rory Geoghegan, Gail ter Haar, Kathryn Nightingale, Leonard Marks, Shyam Natarajan
Summary: Thermal ablation is a method of tumor control by briefly raising tissue temperature, which can reduce complications compared to traditional cancer therapies. Monitoring the progress of ablation treatment is crucial for clinical success, and there are many promising technologies under development.
Review
Oncology
Petros X. E. Mouratidis, Gail ter Haar
Summary: Pancreatic cancer, with its low survival rates, presents a significant challenge in terms of treatment. Immunotherapy has shown promise in cancer treatment, but its effectiveness for pancreatic cancer patients is limited. Alternative treatment approaches to enhance the effectiveness of immunotherapy are needed. Therapeutic focused ultrasound, a non-invasive physical modality, can kill cancer cells and induce an anti-cancer immune response. Studies have shown that therapeutic focused ultrasound is a safe and effective technique for treating pancreatic cancer patients, improving survival rates.
Article
Acoustics
Lisa Braunstein, Sarah C. Brueningk, Ian Rivens, John Civale, Gail ter Haar
Summary: In this study, PVA cellulose composite hydrogels were characterized for their acoustic, cavitation, and thermal properties. The results showed that these materials have the potential to serve as mimics of soft tissue for therapeutic ultrasound applications.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2022)
Article
Peripheral Vascular Disease
Wen Tong, Beth J. Allison, Kirsty L. Brain, Olga Patey, Youguo Niu, Kimberley J. Botting, Sage G. Ford, Tessa A. Garrud, Peter F. B. Wooding, Caroline J. Shaw, Qiang Lyu, Lin Zhang, Jin Ma, Tereza Cindrova-Davies, Hong Wa Yung, Graham J. Burton, Dino A. Giussani
Summary: This study investigated the inter-relationship between chronic hypoxia during pregnancy and maternal, placental, and fetal outcomes, common in preeclampsia. The results showed that chronic hypoxia in ovine pregnancy promoted fetal growth restriction and activated placental stress response pathways. It also led to changes in maternal blood pressure and angiogenic balance. These findings demonstrate that chronic hypoxia recapitulates physiological and molecular features of preeclampsia in the mother, placenta, and offspring.
Review
Biochemistry & Molecular Biology
Carolin Brombach, Wen Tong, Dino A. Giussani
Summary: The prevalence of maternal obesity is increasing rapidly, posing a major challenge for obstetric practice. Adverse effects on maternal and fetal health are mediated by complex interactions in the placenta. Endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) may be key mediators in the pathogenesis of placental dysfunction. This article summarizes the current literature on placental changes in obese women, with a special focus on ER stress in obese pregnancy.
TRENDS IN MOLECULAR MEDICINE
(2022)
Article
Acoustics
Frederic Padilla, Gail Ter Haar
Summary: The recommendations aim to provide guidance and promote best practices in reporting therapeutic ultrasound treatment parameters. Detailed uniform reporting enables testing of therapy ultrasound systems and protocols, comparison of studies using different systems, and validation of therapeutic bio-effects. The recommendations are divided into clinical and preclinical studies, taking into account disparities in expertise and equipment access. They are intended to be useful for clinicians, researchers, ethical and funding review boards, as well as scientific journal editors and reviewers.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2022)
Article
Obstetrics & Gynecology
Wen Tong, Esha Ganguly, Roberto Villalobos-Labra, Anita Quon, Floor Spaans, Dino A. A. Giussani, Sandra T. T. Davidge
Summary: Gestational hypoxia is associated with fetal growth restriction and perinatal morbidity and mortality. This study found that chronic hypoxia promotes sexually dimorphic activation of the unfolded protein response (UPR) in the placenta, with increased GRP78 expression in male placentae and increased ATF6 activation in female placentae. Additionally, gestational hypoxia reduced fetal weight only in males and ATF6 activation correlated with an increase in the fetal crown-rump-length/body weight ratio only in females.
REPRODUCTIVE SCIENCES
(2023)
Article
Oncology
Diana Andres, Ian Rivens, Petros Mouratidis, Noe Jimenez, Francisco Camarena, Gail ter Haar
Summary: Acoustic holograms can deliver controlled ultrasound hyperthermia to multiple tumor spheroids simultaneously. By designing holographic lenses to deliver a uniform thermal dose, rather than a uniform acoustic field, the natural focus of a transducer can be tuned, enabling the exposure of several tumor spheroids to ultrasound-mediated hyperthermia at the same time. Preliminary in-vitro findings suggest that ultrasound-induced hyperthermia has a greater lethal effect on tumor spheroids compared to PCR heating at the same thermal dose.
Article
Neurosciences
Mitchell C. Lock, Kimberley J. Botting, Beth J. Allison, Youguo Niu, Sage G. Ford, Michael P. Murphy, Sandra Orgeig, Dino A. Giussani, Janna L. Morrison
Summary: Chronic fetal hypoxemia increases the risk of respiratory complications at birth. Maternal antioxidant therapy has been shown to be protective for fetal growth and cardiovascular development. This study investigated the effects of maternal antenatal treatment with MitoQ on lung development in hypoxic pregnancy in sheep, and found that it promoted fetal pulmonary surfactant maturation and increased expression of key genes involved in lung development.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Oncology
Georgios Imseeh, Sharon L. Giles, Alexandra Taylor, Matthew R. D. Brown, Ian Rivens, Richard Gordon-Williams, Gail ter Haar, Nandita M. deSouza
Summary: The study documented longitudinal symptoms, quality-of-life, and imaging responses in patients with recurrent gynecological tumors treated with MRgHIFU. It found that patients with extra-pelvic tumors responded better than those with intra-pelvic tumors, showing immediate swelling and reduction in perfused volume by day 30.
INTERNATIONAL JOURNAL OF HYPERTHERMIA
(2021)
Review
Chemistry, Medicinal
Nahid S. Awad, Vinod Paul, Nour M. AlSawaftah, Gail ter Haar, Theresa M. Allen, William G. Pitt, Ghaleb A. Husseini
Summary: Nano-sized carriers designed for selective delivery of anticancer drugs and genes to tumors can achieve enhanced therapeutic effects by triggering the release of therapeutic drugs through stimuli. Recent research has focused on the application of various stimuli-responsive nanocarriers, showing promising prospects for cancer treatment.
ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Stephanie F. Smith, Piero Miloro, Richard Axell, Gail ter Haar, Christoph Lees
Summary: This study measured temperature changes in a simulator of the maternal-fetal environment using clinically relevant ultrasound equipment. Results showed that the highest temperature increase occurred at the transducer-skin interface, with most heating happening within the first 3 minutes of exposure. The power setting had a proportional effect on maximum temperature increase.
