Revisiting protein kinase–substrate interactions: Toward therapeutic development

Protein kinase CK2 potentiates translation efficiency by phosphorylating eIF3j at Ser127

(2015) Christian Borgo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Cancer-Associated Protein Kinase C Mutations Reveal Kinase’s Role as Tumor Suppressor

(2015) Corina E. Antal et al.   CELL

A Docking Interface in the Cyclin Cln2 Promotes Multi-site Phosphorylation of Substrates and Timely Cell-Cycle Entry

(2015) Samyabrata Bhaduri et al.   CURRENT BIOLOGY

Kinase-interacting substrate screening is a novel method to identify kinase substrates

(2015) Mutsuki Amano et al.   JOURNAL OF CELL BIOLOGY

Phosphoproteomic Analysis Identifies Focal Adhesion Kinase 2 (FAK2) as a Potential Therapeutic Target for Tamoxifen Resistance in Breast Cancer

(2015) Xinyan Wu et al.   MOLECULAR & CELLULAR PROTEOMICS

Aurora-A-Dependent Control of TACC3 Influences the Rate of Mitotic Spindle Assembly

(2015) Selena G. Burgess et al.   PLoS Genetics

Small Molecule Substrate Phosphorylation Site Inhibitors of Protein Kinases: Approaches and Challenges

(2014) Meghan E. Breen et al.   ACS Chemical Biology

Substrate Activity Screening with Kinases: Discovery of Small-Molecule Substrate-Competitive c-Src Inhibitors

(2014) Meghan E. Breen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Design, Synthesis, and Evaluation of Non-ATP-Competitive Small-Molecule Polo-Like Kinase 1 (Plk1) Inhibitors

(2014) Dong-Xing Chen et al.   ARCHIV DER PHARMAZIE

Novel benzothiazinones (BTOs) as allosteric modulator or substrate competitive inhibitor of glycogen synthase kinase 3β (GSK-3β) with cellular activity of promoting glucose uptake

(2014) Peng Zhang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Characterization of the Human NEK7 Interactome Suggests Catalytic and Regulatory Properties Distinct from Those of NEK6

(2014) Edmarcia Elisa de Souza et al.   JOURNAL OF PROTEOME RESEARCH

Identification of Extracellular Signal-regulated Kinase 1 (ERK1) Direct Substrates using Stable Isotope Labeled Kinase Assay-Linked Phosphoproteomics

(2014) Liang Xue et al.   MOLECULAR & CELLULAR PROTEOMICS

Modulation of the Chromatin Phosphoproteome by the Haspin Protein Kinase

(2014) Alessio Maiolica et al.   MOLECULAR & CELLULAR PROTEOMICS

Kinases and Pseudokinases: Lessons from RAF

(2014) A. S. Shaw et al.   MOLECULAR AND CELLULAR BIOLOGY

Identification of a Major Determinant for Serine-Threonine Kinase Phosphoacceptor Specificity

(2014) Catherine Chen et al.   MOLECULAR CELL

Allosteric enhancement of MAP kinase p38α's activity and substrate selectivity by docking interactions

(2014) Yuji Tokunaga et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Protein folding creates structure-based, noncontiguous consensus phosphorylation motifs recognized by kinases

(2014) M. L. Duarte et al.   Science Signaling

Discovery of a Type III Inhibitor of LIM Kinase 2 That Binds in a DFG-Out Conformation

(2014) Nicole C. Goodwin et al.   ACS Medicinal Chemistry Letters

PSEA: Kinase-specific prediction and analysis of human phosphorylation substrates

(2014) Sheng-Bao Suo et al.   Scientific Reports

Fragment based discovery of arginine isosteres through REPLACE: Towards non-ATP competitive CDK inhibitors

(2013) Padmavathy Nandha Premnath et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Optimization of allosteric MEK inhibitors. Part 1: Venturing into underexplored SAR territories

(2013) Ingo V. Hartung et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Incorporating substrate sequence motifs and spatial amino acid composition to identify kinase-specific phosphorylation sites on protein three-dimensional structures

(2013) Min-Gang Su et al.   BMC BIOINFORMATICS

A Neo-Substrate that Amplifies Catalytic Activity of Parkinson’s-Disease-Related Kinase PINK1

(2013) Nicholas T. Hertz et al.   CELL

Identification of Direct Tyrosine Kinase Substrates Based on Protein Kinase Assay-Linked Phosphoproteomics

(2013) Liang Xue et al.   MOLECULAR & CELLULAR PROTEOMICS

Effective Identification of Akt Interacting Proteins by Two-Step Chemical Crosslinking, Co-Immunoprecipitation and Mass Spectrometry

(2013) Bill X. Huang et al.   PLoS One

Molecular basis of MAP kinase regulation

(2013) Wolfgang Peti et al.   PROTEIN SCIENCE

AKAP signaling complexes: pointing towards the next generation of therapeutic targets?

(2013) Jessica L. Esseltine et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Global analysis of protein phosphorylation networks in insulin signaling by sequential enrichment of phosphoproteins and phosphopeptides

(2012) Michael Fedjaev et al.   Molecular BioSystems

Targeting Subcellular Localization through the Polo-Box Domain: Non-ATP Competitive Inhibitors Recapitulate a PLK1 Phenotype

(2012) C. McInnes et al.   MOLECULAR CANCER THERAPEUTICS

Protein–protein interaction inhibitors get into the groove

(2012) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

Evolution of the eukaryotic protein kinases as dynamic molecular switches

(2012) S. S. Taylor et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Sensitive kinase assay linked with phosphoproteomics for identifying direct kinase substrates

(2012) L. Xue et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Specificity of Linear Motifs That Bind to a Common Mitogen-Activated Protein Kinase Docking Groove

(2012) A. Garai et al.   Science Signaling

Substrate Recognition Mechanism of Atypical Protein Kinase Cs Revealed by the Structure of PKCι in Complex with a Substrate Peptide from Par-3

(2012) Chihao Wang et al.   STRUCTURE

Structural biology and drug discovery for protein–protein interactions

(2012) Harry Jubb et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Computational prediction of eukaryotic phosphorylation sites

(2011) B. Trost et al.   BIOINFORMATICS

Chemical and structural lessons from recent successes in protein–protein interaction inhibition (2P2I)

(2011) Xavier Morelli et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Chemical strategies for tagging and imaging the proteome

(2011) Kimberly E. Beatty   Molecular BioSystems

Identification of kinase substrates by bimolecular complementation assays

(2011) Stefan Pusch et al.   PLANT JOURNAL

Predicting Protein Kinase Specificity: Predikin Update and Performance in the DREAM4 Challenge

(2011) Jonathan J. Ellis et al.   PLoS One

Substrates of Mitotic Kinases

(2011) L. N. Johnson   Science Signaling

Spatial Exclusivity Combined with Positive and Negative Selection of Phosphorylation Motifs Is the Basis for Context-Dependent Mitotic Signaling

(2011) J. Alexander et al.   Science Signaling

A Distinct Interaction Mode Revealed by the Crystal Structure of the Kinase p38  with the MAPK Binding Domain of the Phosphatase MKP5

(2011) Y.-Y. Zhang et al.   Science Signaling

Quantitative Phosphoproteomics Identifies Substrates and Functional Modules of Aurora and Polo-Like Kinase Activities in Mitotic Cells

(2011) A. N. Kettenbach et al.   Science Signaling

Non-ATP Competitive Protein Kinase Inhibitors

(2010) L. Garuti et al.   CURRENT MEDICINAL CHEMISTRY

New potent dual inhibitors of CK2 and Pim kinases: discovery and structural insights

(2010) Miriam López-Ramos et al.   FASEB JOURNAL

Phosphoproteomics Profiling Suggests a Role for Nuclear βΙPKC in Transcription Processes of Undifferentiated Murine Embryonic Stem Cells

(2010) Helio Miranda Costa-Junior et al.   JOURNAL OF PROTEOME RESEARCH

An overlapping kinase and phosphatase docking site regulates activity of the retinoblastoma protein

(2010) Alexander Hirschi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Phospho3D 2.0: an enhanced database of three-dimensional structures of phosphorylation sites

(2010) A. Zanzoni et al.   NUCLEIC ACIDS RESEARCH

The three-dimensional structure of MAP kinase p38β: different features of the ATP-binding site in p38β compared with p38α

(2009) Sangita B. Patel et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Detection and characterization of 3D-signature phosphorylation site motifs and their contribution towards improved phosphorylation site prediction in proteins

(2009) Pawel Durek et al.   BMC BIOINFORMATICS

The nuts and bolts of AGC protein kinases

(2009) Laura R. Pearce et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Comparative surface geometry of the protein kinase family

(2009) Elaine E. Thompson et al.   PROTEIN SCIENCE

Structural Basis of Substrate Recognition by Hematopoietic Tyrosine Phosphatase†,‡

(2008) David A. Critton et al.   BIOCHEMISTRY

Synthesis and structure based optimization of novel Akt inhibitors

(2008) Blaise Lippa et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Understanding and exploiting substrate recognition by protein kinases

(2008) Benjamin E Turk   CURRENT OPINION IN CHEMICAL BIOLOGY

Mapping the Integrin-Linked Kinase Interactome Using SILAC

(2008) Iveta Dobreva et al.   JOURNAL OF PROTEOME RESEARCH

Linking the kinome and phosphorylome—a comprehensive review of approaches to find kinase targets

(2008) Richelle Sopko et al.   Molecular BioSystems

A Sliding Docking Interaction Is Essential for Sequential and Processive Phosphorylation of an SR Protein by SRPK1

(2008) Jacky Chi Ki Ngo et al.   MOLECULAR CELL

Activation of tyrosine kinases by mutation of the gatekeeper threonine

(2008) Mohammad Azam et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Predikin webserver: improved prediction of protein kinase peptide specificity using structural information

(2008) N. F. W. Saunders et al.   NUCLEIC ACIDS RESEARCH

Covalent capture of kinase-specific phosphopeptides reveals Cdk1-cyclin B substrates

(2008) J. D. Blethrow et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Specific modulation of protein kinase activity via small peptides

(2008) Helio Miranda Costa-Junior et al.   REGULATORY PEPTIDES

Activation of Aldehyde Dehydrogenase-2 Reduces Ischemic Damage to the Heart

(2008) Che-Hong Chen et al.   SCIENCE

A specific immunoprecipitation method for isolating isoforms of insulin-like growth factor binding protein-3 from serum

(2007) Judith A.P. Bons et al.   CLINICA CHIMICA ACTA