Review
Endocrinology & Metabolism
Yan Yan, Fengjun Guo, Kexin Liu, Rixin Ding, Yichao Wang
Summary: Endocrine-disrupting chemicals (EDCs) are naturally occurring or artificial substances released into the environment. Humans are exposed to EDCs through ingestion, inhalation, and skin contact, and they are found in everyday household items. EDCs have negative effects on health, including cancer, cardiovascular risk, and reproductive disorders, and the placenta is particularly sensitive to their impact. This review evaluates the effects of various EDCs on placental development and function, identifies knowledge gaps, and guides future research.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Changhwan Ahn, Eui-Bae Jeung
Summary: Endocrine-disrupting chemicals (EDCs) have significant impacts on biological systems, especially by disrupting hormone balance, affecting reproductive, neurological, and metabolic development and function, and even stimulating tumor growth. EDC exposure during development can disrupt normal development patterns and alter susceptibility to disease. Many chemicals, including bisphenol A, organochlorines, polybrominated flame retardants, alkylphenols, and phthalates, have been identified as risk factors for reproductive, neural, metabolic diseases, and cancers. Endocrine disruption has spread to wildlife and species connected to the food chains. Dietary uptake is an important source of EDC exposure. The relationship and specific mechanism between EDCs and diseases remain unclear. This review focuses on the disease-EDC relationship and disease endpoints associated with endocrine disruption to better understand the EDC-disease relationship, and explores the development of new prevention/treatment opportunities and screening methods.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Dongling Liu, Qianhan Shi, Cuiqing Liu, Qinghua Sun, Xiang Zeng
Summary: Heavy metals play an important endocrine-disrupting role in health consequences, but the mechanisms behind this disruption are unclear. Animal models exposed to high doses of heavy metals may not provide relevant information for understanding human diseases. This review collects current knowledge on the endocrine-disrupting effects of heavy metals like lead, cadmium, arsenic, mercury, nickel, copper, zinc, and manganese. It also summarizes the potential molecular mechanisms of these endocrine-disrupting chemicals and their toxic effects on animals and humans.
Article
Environmental Sciences
Yuanji Li, Geovanny Genaro Reivan Ortiz, Pham Thi Minh Uyen, Phan The Cong, Sarah I. Othman, Ahmed A. Allam, Ahsanullah Unar, Hassan Imran Afridi
Summary: Exposure to endocrine disrupting chemicals (EDCs) or heavy metals can have negative effects on health, including immune and endocrine system disruption, respiratory problems, metabolic issues, diabetes, obesity, cardiovascular problems, growth impairment, neurological and learning disabilities, and cancer. Petrochemical industry drilling wastes, which contain varying levels of EDCs, pose a significant risk to human health. This study investigated toxic element levels in biological samples from petrochemical drilling workers and highlights the importance of adopting better practices to protect worker and environmental health.
ENVIRONMENTAL RESEARCH
(2023)
Article
Chemistry, Physical
Mingyu Liu, Xiaoting Zhang, Runping Han, Lingbo Qu
Summary: The novel PEI/PAN blend membrane synthesized via crosslinking technology showed high adsorption efficiency for multiple heavy metals and EDCs, making it suitable for wastewater treatment with good reusability and antibacterial properties.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Environmental Sciences
Xiaoqian Jia, Le Zhang, Jing Zhao, Mengyuan Ren, Zewu Li, Jiamei Wang, Shuo Wang, Yingying Liu, Hang An, Yuhuan Li, Lailai Yan, Zhiwen Li, Xiaohong Liu, Bo Pan, Rongwei Ye
Summary: The study revealed that high concentrations of endocrine-disrupting heavy metals (EDHMs) in maternal hair, particularly tin and mercury, may promote the development of gestational diabetes mellitus (GDM). Specifically, tin and mercury were found to have the largest contributions to the risk of GDM, especially among women with a body mass index below 24 kg/m^2.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Endocrinology & Metabolism
Margaret Banker, Muraly Puttabyatappa, Patrick O'Day, Jaclyn M. Goodrich, Angela S. Kelley, Steven E. Domino, Yolanda R. Smith, Dana C. Dolinoy, Peter X. K. Song, Richard J. Auchus, Vasantha Padmanabhan
Summary: This study demonstrates the association of steroids with pregnancy outcomes depending on maternal age, pre-pregnancy BMI, and fetal sex, with the effects of EDCs differing when considered individually or as mixtures. Steroidal hormonal measures have the potential to serve as biomarkers of the impact of EDC exposures and pregnancy outcomes.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Environmental Sciences
Sofia Macedo, Elisabete Teixeira, Tiago Bordeira Gaspar, Paula Boaventura, Mariana Alves Soares, Leandro Miranda-Alves, Paula Soares
Summary: The aim of this study was to investigate the association between human exposure to endocrine disrupting chemicals (EDCs) and the risk of endocrine-related tumors. A systematic review of observational studies published between 1980 and 2020 was conducted, and it was found that exposure to different types of EDCs, such as phthalates, heavy metals, and pesticides, was associated with increased cancer risk. However, there is a limited amount of research on the effects of EDCs, and further multinational and multicentric human studies are needed to obtain stronger and more consistent evidence.
ENVIRONMENTAL RESEARCH
(2023)
Article
Obstetrics & Gynecology
N. Spinder, J. E. H. Bergman, M. van Tongeren, H. M. Boezen, H. Kromhout, H. E. K. de Walle
Summary: Maternal occupational exposure to specific EDCs early in pregnancy may increase the risk of CAKUT in offspring. No association was observed between EDC exposure and hypospadias.
HUMAN REPRODUCTION
(2022)
Article
Environmental Sciences
Anna R. Smith, Pi-I D. Lin, Sheryl L. Rifas-Shiman, Mohammad L. Rahman, Diane R. Gold, Andrea A. Baccarelli, Birgit Claus Henn, Chitra Amarasiriwardena, Robert O. Wright, Brent Coull, Marie-France Hivert, Emily Oken, Andres Cardenas
Summary: This study evaluated the individual and joint associations of prenatal metals with mitochondrial DNA copy number and telomere length in maternal and cord blood. The results showed that maternal magnesium was associated with lower mtDNAcn, lead was associated with higher maternal mtDNAcn, and selenium was linked to longer cord blood TL. Nonlinear relationships and interactions were also observed among certain metals and biomarkers.
ENVIRONMENTAL HEALTH PERSPECTIVES
(2021)
Article
Environmental Sciences
Alyssa K. Merrill, Timothy Anderson, Katherine Conrad, Elena Marvin, Tamarra James-Todd, Deborah A. Cory-Slechta, Marissa Sobolewski
Summary: Exposure to multiple EDCs during pregnancy may exacerbate metabolic health issues for women in later life, as indicated by this pilot study.
Review
Biotechnology & Applied Microbiology
Muhammad Musaddiq Shah, Khurshid Ahmad, Sonia Boota, Tor Jensen, Michael R. La Frano, Joseph Irudayaraj
Summary: Endocrine-disrupting chemicals (EDCs) are man-made substances that can disrupt the standard function of the endocrine system. They are widespread in the environment and pose a potential threat to human health, aquatics, and wildlife. Traditional instrument-based analytical techniques are not suitable for onsite detection, while sensor/biosensor-based approaches are more attractive due to their rapid, portable, equally sensitive, and eco-friendly characteristics.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Environmental Sciences
Yuhao Wu, Junke Wang, Yuexin Wei, Jiadong Chen, Lian Kang, Chunlan Long, Shengde Wu, Lianju Shen, Guanghui Wei
Summary: Based on current evidence, maternal exposure to metals and phthalates may increase the risk for preterm birth.
ENVIRONMENTAL POLLUTION
(2022)
Review
Environmental Sciences
ZhiChao Dang, Maria Arena, Aude Kienzler
Summary: This study summarized and evaluated the effects of TDCs on fish thyroid sensitive endpoints, including thyroid hormones, gene expression, and other aspects. The findings suggest that changes in thyroid sensitive endpoints may be influenced by various factors, such as the balance of different processes and environmental factors.
ENVIRONMENTAL POLLUTION
(2021)
Article
Environmental Sciences
Ting Ding, Wei Yan, Ting Zhou, Wei Shen, Tian Wang, Milu Li, Su Zhou, Meng Wu, Jun Dai, Kecheng Huang, Jinjin Zhang, Jiang Chang, Shixuan Wang
Summary: This review study examines the impacts of endocrine-disrupting chemicals (EDCs) on ovarian aging and identifies potential mechanisms. It highlights inconsistent results and knowledge gaps in related research.
ENVIRONMENTAL POLLUTION
(2022)
Review
Neurosciences
Mona Hersi, Pauline Quach, Ming-Dong Wang, James Gomes, Janet Gaskin, Daniel Krewski
Review
Neurosciences
Ming-Dong Wang, Julian Little, James Gomes, Neil R. Cashman, Daniel Krewski
Review
Environmental Sciences
Nancy Edwards, Joshun Dulai, Alvi Rahman
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2019)
Review
Medicine, General & Internal
Faizan Khan, Alvi Rahman, Marc Carrier, Clive Kearon, Jeffrey I. Weitz, Sam Schulman, Francis Couturaud, Sabine Eichinger, Paul A. Kyrle, Cecilia Becattini, Giancarlo Agnelli, Timothy A. Brighton, Anthonie W. A. Lensing, Martin H. Prins, Elham Sabri, Brian Hutton, Laurent Pinede, Mary Cushman, Gualtiero Palareti, George A. Wells, Paolo Prandoni, Harry R. Buller, Marc A. Rodger
BMJ-BRITISH MEDICAL JOURNAL
(2019)
Review
Toxicology
J. Gomes, F. Au, A. Basak, S. Cakmak, R. Vincent, P. Kumarathasan
CRITICAL REVIEWS IN TOXICOLOGY
(2019)
Review
Genetics & Heredity
Michael Pugliese, Kylie Tingley, Andrea Chow, Nicole Pallone, Maureen Smith, Alvi Rahman, Pranesh Chakraborty, Michael T. Geraghty, Julie Irwin, Laure Tessier, Stuart G. Nicholls, Martin Offringa, Nancy J. Butcher, Ryan Iverson, Tammy J. Clifford, Sylvia Stockler, Brian Hutton, Karen Paik, Jessica Tao, Becky Skidmore, Doug Coyle, Kathleen Duddy, Sarah Dyack, Cheryl R. Greenberg, Shailly Jain Ghai, Natalya Karp, Lawrence Korngut, Jonathan Kronick, Alex MacKenzie, Jennifer MacKenzie, Bruno Maranda, John J. Mitchell, Murray Potter, Chitra Prasad, Andreas Schulze, Rebecca Sparkes, Monica Taljaard, Yannis Trakadis, Jagdeep Walia, Beth K. Potter
ORPHANET JOURNAL OF RARE DISEASES
(2020)
Article
Pharmacology & Pharmacy
Alvi Rahman, Joseph Kane, Francois Montastruc, Christel Renoux
Summary: The study found distinct trends in gabapentin and pregabalin prescription rates in Northern Ireland, possibly due to a high burden of anxiety disorders. Further exploration of reasons for discrepancies in gabapentinoid prescribing between UK nations is necessary.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Pediatrics
Michael Pugliese, Kylie Tingley, Andrea Chow, Nicole Pallone, Maureen Smith, Pranesh Chakraborty, Michael T. Geraghty, Julie K. Irwin, John J. Mitchell, Sylvia Stockler, Stuart G. Nicholls, Martin Offringa, Alvi Rahman, Laure A. Tessier, Nancy J. Butcher, Ryan Iverson, Monica Lamoureux, Tammy J. Clifford, Brian Hutton, Karen Paik, Jessica Tao, Becky Skidmore, Doug Coyle, Kathleen Duddy, Sarah Dyack, Cheryl R. Greenberg, Shailly Jain Ghai, Natalya Karp, Lawrence Korngut, Jonathan Kronick, Alex MacKenzie, Jennifer MacKenzie, Bruno Maranda, Murray Potter, Chitra Prasad, Andreas Schulze, Rebecca Sparkes, Monica Taljaard, Yannis Trakadis, Jagdeep Walia, Beth K. Potter
Summary: Core outcome sets (COSs) for pediatric medium-chain acyl-coenzyme A dehydrogenase (MCAD) deficiency and phenylketonuria (PKU) were developed through Delphi survey and consensus workshop, with 8 and 9 core outcomes identified for each disease along with measurement recommendations. Adoption of these COSs in future studies is expected to optimize research resources for improving care in children with these rare diseases.
Review
Medicine, General & Internal
Alex Lee, Ben Tipney, Alexandra Finstad, Alvi Rahman, Kirsten Devenny, Jad Abou Khalil, Craig Kuziemsky, Fady Balaa
Summary: This scoping review aims to evaluate the application of human factors in the operating room environment, focusing on education and training for healthcare professionals. Various databases were searched to identify relevant studies, and information on training characteristics will be summarized with key themes in human factors training being identified. The findings will be disseminated through conferences and publication in a peer-reviewed journal.
Review
Hematology
Faizan Khan, Alvi Rahman, Tobias Tritschler, Marc Carrier, Clive Kearon, Jeffrey Weitz, Sam Schulman, Francis Couturaud, Cecilia Becattini, Giancarlo Agnelli, Timothy A. Brighton, Anthonie W. A. Lensing, Laurent Pinede, Sameer Parpia, Geert-Jan Geersing, Toshihiko Takada, Charlotte A. Bradbury, Giuseppe M. Andreozzi, Gualtiero Palareti, Paolo Prandoni, Harry R. Buller, Ranjeeta Mallick, Brian Hutton, Kednapa Thavorn, Gregoire Le Gal, Marc A. Rodger, Dean A. Fergusson
Summary: The risk of major bleeding after discontinuing anticoagulant therapy for a first unprovoked venous thromboembolism is not zero, and a portion of these bleeding events may be fatal.
THROMBOSIS AND HAEMOSTASIS
(2022)
Review
Surgery
Alex Lee, Alexandra Finstad, Ben Tipney, Tyler Lamb, Alvi Rahman, Kirsten Devenny, Jad Abou Khalil, Craig Kuziemsky, Fady Balaa
Summary: This study explores the content of human factors training in the operating room and finds that the current training focuses on teaching behavioral and non-technical skills, but may not fully address the sociotechnical factors that impact operating room safety. The study suggests that future training should expand its scope to include the contributions of the work environment, technology, and organizational culture to a wider range of stakeholders.
Review
Hematology
Alvi A. Rahman, Na He, Soham Rej, Robert W. Platt, Christel Renoux
Summary: The concomitant use of SSRIs and OACs is associated with an increased risk of major bleeding. Physicians may need to adjust treatment based on individual patient risk factors for bleeding when prescribing SSRIs to patients using OACs.
THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Clinical Neurology
Alvi A. Rahman, Jonathan Michaud, Sophie Dell'Aniello, Erica E. M. Moodie, James M. Brophy, Madeleine Durand, Jason R. Guertin, Jean-Francois Boivin, Christel Renoux
Summary: In patients with nonvalvular atrial fibrillation (NVAF), the use of oral anticoagulants (OACs) is associated with a decreased risk of dementia, particularly in elderly individuals.
Article
Public, Environmental & Occupational Health
Selim M. Khan, Daniel Krewski, James Gomes, Raywat Deonandan
CANADIAN JOURNAL OF PUBLIC HEALTH-REVUE CANADIENNE DE SANTE PUBLIQUE
(2019)
Meeting Abstract
Oncology
Bernard Kadio, Sanni Hashimi Yaya, Ajoy Basak, James Gomes, Koffi Dje, Christian Mesenge
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2018)
Article
Environmental Sciences
Toshimi Nakajima, Mao Kuragano, Makoto Yamada, Ryo Sugimoto
Summary: This study compared the contribution of submarine groundwater discharge (SGD) to river nutrient budgets at nearshore and embayment scales, and found that SGD-derived nutrients become more important at larger spatial scales.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Fan Liu, Lei Zhang, Chongyang Zhang, Ziguang Chen, Jingguang Li
Summary: NO2 emissions from wall-mounted gas stoves used for household heating have become a significant source of indoor pollution in Chinese urban areas. The high indoor concentration of NO2 poses potential health risks to residents. It is urgently necessary to establish relevant regulations and implement emission reduction technologies to reduce NO2 emissions from wall-mounted gas stoves.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Letter
Environmental Sciences
Hans Peter H. Arp, Raoul Wolf, Sarah E. Hale, Sivani Baskaran, Juliane Gluege, Martin Scheringer, Xenia Trier, Ian T. Cousins, Harrie Timmer, Roberta Hofman-Caris, Anna Lennquist, Andre D. Bannink, Gerard J. Stroomberg, Rosa M. A. Sjerps, Rosa Montes, Rosario Rodil, Jose Benito Quintana, Daniel Zahn, Herve Gallard, Tobias Mohr, Ivo Schliebner, Michael Neumann
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Philomina Onyedikachi Peter, Binessi Edouard Ifon, Francois Nkinahamira, Kayode Hassan Lasisi, Jiangwei Li, Anyi Hu, Chang-Ping Yu
Summary: This study investigates the relationship between dissolved organic matter (DOM) and Rare Earth Elements (REEs) in sediments from Yundang Lagoon, China. The results show four distinct fluorescent components, with protein-like substances being the most prevalent. Additionally, the total fluorescence intensity and LREE concentrations exhibit a synchronized increase from Outer to Inner to Songbai Lake core sediments. The findings demonstrate a strong correlation between DOM content and pollution levels.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Surya Gupta, Pasquale Borrelli, Panos Panagos, Christine Alewell
Summary: The objective of this study is to incorporate soil hydraulic properties into the erodibility factor (K) of USLE-type models. By modifying and improving the existing equations for soil texture and permeability, the study successfully included information on saturated hydraulic conductivity (Ksat) into the calculation of K factor. Using the Random Forest machine learning algorithm, two independent K factor maps with different spatial resolutions were generated. The results show that the decrease in K factor values has a positive impact on the modeling of soil erosion rates.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Jesmin Akter, Wendy J. M. Smith, Yawen Liu, Ilho Kim, Stuart L. Simpson, Phong Thai, Asja Korajkic, Warish Ahmed
Summary: The choice of workflow in wastewater surveillance has a significant impact on SARS-CoV-2 concentrations, while having minimal effects on HF183 and no effect on HAdV 40/41 concentrations. Certain components in the workflow can be interchangeable, but factors such as buffer type, chloroform, and homogenization speed can affect the recovery of viruses and bacteria.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Yu Luo, Xueting Yang, Diwei Wang, Hongmei Xu, Hongai Zhang, Shasha Huang, Qiyuan Wang, Ningning Zhang, Junji Cao, Zhenxing Shen
Summary: Atmospheric PM2.5, which can generate reactive oxygen species (ROS), is associated with cardiorespiratory morbidity and mortality. The study found that both the mass concentration of PM2.5 and the DTT activity were higher during the heating season than during the nonheating season. Combustion sources were the primary contributors to DTT activity during the heating season, while secondary formation dominated during the nonheating season. The study also revealed that biomass burning had the highest inherent oxidation potential among all sources investigated.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Erin L. Murphy, Leah R. Gerber, Chelsea M. Rochman, Beth Polidoro
Summary: Plastic pollution has devastating consequences for marine organisms. This study uses a trait-based framework to develop a vulnerability index for marine mammals, seabirds, and sea turtles in Hawai'i. The index ranks 63 study species based on their vulnerability to macroplastic pollution, providing valuable information for species monitoring and management priorities.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Kenji Maurice, Amelia Bourceret, Sami Youssef, Stephane Boivin, Liam Laurent-Webb, Coraline Damasio, Hassan Boukcim, Marc-Andre Selosse, Marc Ducousso
Summary: Growing pressure from climate change and agricultural land use is destabilizing soil microbial community interactions. Little is known about microbial community resistance and adaptation to disturbances, hindering our understanding of recovery latency and implications for ecosystem functioning. This study found that anthropic disturbance and natural disturbance have different effects on the topology and stability of soil microbial networks.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Yunhao Li, Yali Feng, Haoran Li, Yisong Yao, Chenglong Xu, Jinrong Ju, Ruiyu Ma, Haoyu Wang, Shiwei Jiang
Summary: Deep-sea mining poses a serious threat to marine ecosystems and human health by disturbing sediment and transmitting metal ions through the food chain. This study developed a new regenerative adsorption material, OMN@SA, which effectively removes metal ions. The adsorption mechanism and performance of the material for metal ion fixation were investigated.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Antonio Medici, Margherita Lavorgna, Marina Isidori, Chiara Russo, Elena Orlo, Giovanni Luongo, Giovanni Di Fabio, Armando Zarrelli
Summary: Valsartan, a widely used antihypertensive drug, has been detected in high concentrations in surface waters due to its unchanged excretion and incomplete degradation in wastewater treatment plants. This study investigated the degradation of valsartan and identified 14 degradation byproducts. The acute and chronic toxicity of these byproducts were evaluated in key organisms in the freshwater trophic chain.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Jiang Lin, Lianbao Chi, Qing Yuan, Busu Li, Mingbao Feng
Summary: This study investigated the photodegradation behavior and product formation of two representative pharmaceuticals in simulated estuary water. The study found that the formed transformation products of these pharmaceuticals have potential toxicity on marine organisms, including oxidative stress and damage to cellular components.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Hua Fang, Dongdong Jiang, Ye He, Siyi Wu, Yuehong Li, Ziqi Zhang, Haoting Chen, Zixin Zheng, Yan Sun, Wenxiang Wang
Summary: This study revealed that exposure to lower levels of air pollutants led to decreased pregnancy rates, with PM10, NO2, SO2, and CO emerging as the four most prominent pollutants. Individuals aged 35 and above exhibited heightened susceptibility to pollutants.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Ali Shaan Manzoor Ghumman, Rashid Shamsuddin, Amin Abbasi, Mohaira Ahmad, Yoshiaki Yoshida, Abdul Sami, Hamad Almohamadi
Summary: In this study, inverse vulcanized polysulfides (IVP) were synthesized by reacting molten sulfur with 4-vinyl benzyl chloride, and then functionalized using N-methyl D-glucamine (NMDG). The functionalized IVP showed a high mercury adsorption capacity and a machine learning model was developed to predict the amount of mercury removed. Furthermore, the functionalized IVP can be regenerated and reused, providing a sustainable and cost-effective adsorbent.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Rita Bonfiglio, Renata Sisto, Stefano Casciardi, Valeria Palumbo, Maria Paola Scioli, Erica Giacobbi, Francesca Servadei, Gerry Melino, Alessandro Mauriello, Manuel Scimeca
Summary: This study investigated the presence of aluminum in human colon cancer samples and its potential association with biological processes involved in cancer progression. Aluminum was found in tumor areas of 24% of patients and was associated with epithelial to mesenchymal transition (EMT) and cell death. Additional analyses revealed higher tumor mutational burden and mutations in genes related to EMT and apoptosis in aluminum-positive colon cancers. Understanding the molecular mechanisms of aluminum toxicity may improve strategies for the management of colon cancer patients.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)