Article
Endocrinology & Metabolism
Bruno Garcia Montagnini, Simone Forcato, Karine Vandressa Pernoncine, Mariana Cunha Monteiro, Marina Rangel Ferro Pereira, Nathalia Orlandini Costa, Estefania Gastadello Moreira, Janete Aparecida Anselmo-Franci, Daniela Cristina Ceccatto Gerardin
Summary: The study found that TCS may act as an endocrine disruptor for the reproductive system. Exposure to TCS was shown to decrease sperm viability and motility, potentially related to the programming of reproductive cells during fetal/neonatal development.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Silvia Moreira, Ricardo Silva, David F. Carrageta, Marco G. Alves, Vicente Seco-Rovira, Pedro F. Oliveira, Maria de Lourdes Pereira
Summary: Carbamates, widely used as pesticides, have both medical applications and adverse effects on the male reproductive system. Their inhibitory effect on acetylcholine hydrolyzation can lead to male fertility problems and disrupt the male endocrine system. The molecular mechanisms behind these effects are not fully understood.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Zorimar Rivera-Nunez, Carolyn W. Kinkade, Leena Khoury, Jessica Brunner, Hannah Murphy, Christina Wang, Kurunthachalam Kannan, Richard K. Miller, Thomas G. O'Connor, Emily S. Barrett
Summary: The study found that maternal serum levels of poly- and perfluoroalkyl substances (PFAS) are associated with sex steroid hormone levels during pregnancy. Specifically, PFHxS is associated with increased testosterone levels in male fetuses, while PFNA and PFDA are associated with increased free testosterone levels in male fetuses. For female fetuses, PFHxS is associated with increased levels of estradiol and estriol. No associations were found for PFOS and PFOA.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Loise Serra, Anthony Estienne, Guillaume Bourdon, Christelle Rame, Claire Chevaleyre, Philippe Didier, Marine Chahnamian, Souleiman El Balkhi, Pascal Froment, Joelle Dupont
Summary: Chronic dietary exposure to Roundup (RU) in roosters reduces sperm motility, increases plasma testosterone levels, and affects offspring growth performance and obesity. However, these negative effects disappear within 14 days after RU exposure is removed.
Review
Pharmacology & Pharmacy
Maria Popescu, Talia B. Feldman, Tanuja Chitnis
Summary: This study examines the impact of endocrine disruptors on gender bias in autoimmune diseases, highlighting how environmental factors may interfere with immune-related endocrine signaling and potentially lead to autoimmunity. It also emphasizes that the heterogeneity in research on endocrine disruptors may pose challenges in interpreting and translating results.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Katelyn A. Bruno, Logan P. Macomb, A. Carolina Morales-Lara, Jessica E. Mathews, J. Augusto Frisancho, Alex L. Yang, Damian N. Di Florio, Brandy H. Edenfield, Emily R. Whelan, Gary R. Salomon, Anneliese R. Hill, Chathuranga C. Hewa-Rahinduwage, Ashley J. Scott, Henry D. Greyner, Frank A. Molina, Merci S. Greenaway, George M. Cooper, DeLisa Fairweather
Summary: The study found that housing mice in plastic cages increases the progression of viral myocarditis, with male mice being mainly affected by complement activation and increased macrophages, while female mice are mainly affected by mast cell activation and fibrosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Pan Yang, Bi-Gui Lin, Bin Zhou, Wen-Cheng Cao, Pan-Pan Chen, Yan-Ling Deng, Jian Hou, Sheng-Zhi Sun, Tong-Zhang Zheng, Wen-Qing Lu, Li-Ming Cheng, Wan-Jiang Zeng, Qiang Zeng
Summary: The study found that prenatal exposure to BPA, BPF, and BPS can have detrimental effects on fetal growth, with stronger effects noted in female infants. Associations were observed with birth length, ponderal index, and gestational age, showing different relationships with fetal growth parameters.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Environmental Sciences
Andrea Bellavia, Runyu Zou, Richelle D. Bjorvang, Kristine Roos, Ylva Sjunnesson, Ida Hallberg, Jan Holte, Anne Pikki, Virissa Lenters, Lutzen Portengen, Jacco Koekkoek, Marja Lamoree, Majorie Van Duursen, Roel Vermeulen, Andres Salumets, Agne Velthut-Meikas, Pauliina Damdimopoulou
Summary: This study investigated the associations between potential endocrine-disrupting chemicals (EDCs) and female fertility. By studying 333 women in fertility clinics in Sweden and Estonia, it was found that chemicals such as methylparaben, di-2-ethylhexyl phthalate (DEHP) metabolites, and per- and polyfluoroalkyl substances (PFAS) are associated with female fertility. In particular, DEHP metabolites and methylparaben showed inverse associations with ovarian sensitivity index (OSI), suggesting that these chemicals may affect ovarian function and fertility in women.
ENVIRONMENTAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Elisa Hug, Pauline Villeneuve, Stephanie Bravard, Areski Chorfa, Christelle Damon-Soubeyrand, Stephen G. Somkuti, Aron Moazamian, R. John Aitken, Parviz Gharagozloo, Joel R. Drevet, Fabrice Saez
Summary: Routine exposure to endocrine-disrupting chemicals (EDCs), such as DBP and BPAF, can lead to decreased sperm quality and DNA damage, while not affecting sperm viability or testicular structures. The observed damage is likely caused by oxidative stress induced by the pro-oxidant properties of the EDCs, as it can be largely prevented by co-administering antioxidants. These findings highlight the importance of understanding the effects of EDCs on male reproductive health.
Review
Cell Biology
Loise Serra, Anthony Estienne, Claudine Vasseur, Pascal Froment, Joelle Dupont
Summary: This review discusses the effects of glyphosate and glyphosate-based herbicides on reproductive functions and endocrine disruption, mainly by interfering with the hypothalamic-pituitary-gonadal axis in males and females, potentially leading to changes in cell viability and proliferation. The presence of formulants in GBHs makes them more toxic than glyphosate alone.
Article
Endocrinology & Metabolism
Sagi Enicole A. Gillera, William P. Marinello, Kevin T. Cao, Brian M. Horman, Heather M. Stapleton, Heather B. Patisaul
Summary: The study found that developmental exposure to the common FR mixture Firemaster 550 has gender-specific effects on social behaviors and neuronal populations in prairie voles. Exposed females showed changes in AVP neurons while exposed males had alterations in dopaminergic neurons, indicating potential endocrine disruption on OT/AVP pathways and coordination of behaviors.
Review
Reproductive Biology
Carla Giovana Basso, Anderson Tadeu de Araujo-Ramos, Anderson Joel Martino-Andrade
Summary: Endocrine-disrupting chemicals (EDCs) are exogenous compounds known for their ability to interfere with hormone action and affect the development and function of male and female reproductive systems. Among EDCs, phthalate esters have attracted special attention due to their widespread exposure and potential disruption of male androgen-dependent development. Recent research suggests that phthalates may also negatively impact female reproductive health, including ovarian and uterine functions.
REPRODUCTIVE TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ana C. A. Sousa, Marco G. Alves, Pedro F. Oliveira, Branca M. Silva, Luis Rato
Summary: The chronic exposure to obesogens in the environment can lead to weight gain and significantly impair male fertility. This review aims to contribute to the understanding of the molecular transformations induced by obesogens and their impact on male infertility, using an interdisciplinary approach.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
F. M. Peinado, O. Ocon-Hernandez, L. M. Iribarne-Duran, F. Vela-Soria, A. Ubina, C. Padilla, J. C. Mora, J. Cardona, J. Leon, M. F. Fernandez, N. Olea, F. Artacho-Cordon
Summary: The frequency of cosmetics and personal care product utilization is strongly associated with exposure to certain benzophenone and paraben congeners. These compounds may increase the risk of endometriosis in a manner that is independent of oxidative stress.
ENVIRONMENTAL RESEARCH
(2021)
Article
Environmental Sciences
Martina Capriotti, Paolo Cocci, Luca Bracchetti, Erika Cottone, Rosaria Scandiffio, Giovanni Caprioli, Gianni Sagratini, Gilberto Mosconi, Patrizia Bovolin, Francesco Alessandro Palermo
Summary: This study presented environmental baseline data on floating microplastics in Italian coastal waters of the Central Adriatic Sea, revealing the presence of various organic pollutants on the surface of collected microplastics. Furthermore, the study indicated potential metabolic effects of microplastics on adipocytes, resulting in both adipogenesis and lipid uptake/storage.
Editorial Material
Medicine, General & Internal
Germaine M. Buck Louis
ANNALS OF INTERNAL MEDICINE
(2022)
Article
Environmental Sciences
Vineet Kumar Pal, Kurunthachalam Kannan
Summary: This study is the first to report VOCM concentrations in urine of pet dogs and cats, highlighting the need to identify sources and health implications of VOCs exposure in these animals.
ENVIRONMENTAL POLLUTION
(2023)
Article
Environmental Sciences
Hongxiu Liu, Yuyan Wang, Kurunthachalam Kannan, Mengling Liu, Hongkai Zhu, Yu Chen, Linda G. Kahn, Melanie H. Jacobson, Bo Gu, Shilpi Mehta-Lee, Sara G. Brubaker, Akhgar Ghassabian, Leonardo Trasande
Summary: This study aimed to identify the food groups and demographic factors that predict phthalate exposure in an urban contemporary pregnancy cohort in the US. The results showed that urinary metabolite levels of phthalates in pregnant women in NYC varied by age, marital status, seasonality, race/ ethnicity, and diet.
ENVIRONMENTAL RESEARCH
(2022)
Article
Veterinary Sciences
Philibert Dougnon, Victorien Dougnon, Boris Legba, Kafayath Fabiyi, Arnaud Soha, Hornel Koudokpon, Kevin Sintondji, Esther Deguenon, Gildas Hounmanou, Carlos Quenum, Taeratou Aminou, Richard Lokossou, Innocent Togla, Cyrille Boko, Bruno Djossa, Francoise Assogba-komlan, Lamine Baba-moussa
Summary: This study assessed the presence of pathogenic bacteria in imported day-old chicks from Belgium to Benin. The results showed that Escherichia coli, Enterococcus spp., and coagulase-negative staphylococci were the most common bacteria identified. The Escherichia coli strains exhibited high resistance rates against ciprofloxacin and trimethoprim + sulfamethoxazole. Immediate detection of resistant bacteria in imported chicks is necessary to prevent their dissemination.
BMC VETERINARY RESEARCH
(2023)
Article
Environmental Sciences
Yumeng Shi, Shucong Chen, Mengqi Yan, Zhipeng Cheng, Leicheng Zhao, Yarui Liu, Bo Zhang, Hongkai Zhu, Tao Zhang, Kurunthachalam Kannan
Summary: Nitrogenous flame retardants (NFRs) have raised global concern due to their nephrotoxic effect, but the mechanism of exposure-induced kidney injury remains unknown. This study measured eight NFRs, four oxidative stress biomarkers (OSBs), and one kidney injury biomarker (NGAL) in urine samples collected from residents in e-waste disassembly and reference areas. Higher concentrations of NFRs and biomarkers were found in the urine of e-waste site residents, indicating that chronic exposure to NFRs can induce oxidative stress and kidney damage. Structure equation modeling revealed that oxidative stress mediated a significant portion of the effect of NFRs on NGAL in e-waste related people. Overall, this study suggests the long-term chronic exposure to NFRs can lead to oxidative stress and renal injury in humans, but the pathogenesis may be scenario-specific.
Article
Environmental Sciences
Alison G. Paquette, Samantha Lapehn, Sophie Freije, James MacDonald, Theo Bammler, Drew B. Day, Christine T. Loftus, Kurunthachalam Kannan, W. Alex Mason, Nicole R. Bush, Kaja Z. LeWinn, Daniel A. Enquobahrie, Carmen Marsit, Sheela Sathyanarayana
Summary: This study provides the first human transcriptomic assessment of PAHs in the placenta and identifies associations between prenatal PAH exposure and placental gene expression, shedding light on the mechanisms by which PAHs may disrupt placental function.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Biochemical Research Methods
Zhong-Min Li, Mathusa Lakuleswaran, Kurunthachalam Kannan
Summary: In this study, a method using liquid chromatography-tandem mass spectrometry (LC-MS/MS) was developed for the determination of various disinfectants, including BACs, ATMACs, DDACs, and QACs, in human serum and urine. The method involved the use of isotopically labelled internal standards and solid-phase extraction. Different LC columns were utilized for the separation of different compounds. The method showed good sensitivity and accuracy, and it was able to detect the presence of QACs and their metabolites in human serum and urine.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2023)
Article
Environmental Sciences
Zorimar Rivera-Nunez, Carolyn W. Kinkade, Leena Khoury, Jessica Brunner, Hannah Murphy, Christina Wang, Kurunthachalam Kannan, Richard K. Miller, Thomas G. O'Connor, Emily S. Barrett
Summary: The study found that maternal serum levels of poly- and perfluoroalkyl substances (PFAS) are associated with sex steroid hormone levels during pregnancy. Specifically, PFHxS is associated with increased testosterone levels in male fetuses, while PFNA and PFDA are associated with increased free testosterone levels in male fetuses. For female fetuses, PFHxS is associated with increased levels of estradiol and estriol. No associations were found for PFOS and PFOA.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Abigail Gaylord, Emily S. Barrett, Sheela Sathyanarayana, Shanna H. Swan, Ruby H. N. Nguyen, Nicole R. Bush, Kecia Carroll, Drew B. Day, Kurunthachalam Kannank, Leonardo Trasande
Summary: This study investigated the influence of prenatal exposure to the endocrine disrupting chemical bisphenol A on childhood atopic disease. The results showed that there were inverse associations between first trimester bisphenol A concentration and food allergy, while second trimester bisphenol A concentration was positively associated with food allergy. Additionally, prenatal exposure to bisphenol S was found to increase the risk of asthma among males.
ENVIRONMENTAL RESEARCH
(2023)
Article
Engineering, Environmental
Wei Wang, Kurunthachalam Kannan
Summary: This study collected 72 single-use medical products of four categories from a hospital in New York State in 2015 and analyzed their migration of 10 phthalates in an ethanol/water mixture. The results showed that the leached phthalate concentration ranged from 0.04 to 54,600 μg, with DEHP being the major phthalate found in 99% of the samples. DEHP was also found in notable concentrations in products labeled as DEHP-free. The study calculated the direct exposure to phthalates from medical devices and first aid supplies, as well as dermal intake from creams/lotions.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Engineering, Environmental
Henglin Zhang, You Wang, Huimin Zhu, Shaoyou Lu, Yu Wang, Jingchuan Xue, Tao Zhang, Kurunthachalam Kannan, Hongwen Sun
Summary: This study investigated the exposure of infants in South China to neonicotinoid insecticides (NEOs). The results showed that infants had detectable levels of NEOs in urine and blood samples, breast milk, infant formula, and tap water. The concentrations of specific NEOs varied in different samples, with dinotefuran and imidacloprid being the most abundant in urine, blood, breast milk, infant formula, and tap water. Older infants had higher NEO exposure than younger infants. Blood samples had higher concentrations of NEOs compared to urine samples, indicating that NEOs readily enter the bloodstream. Breast-fed infants had higher exposure levels than formula-fed infants. The study also found that external sources contributed to the majority of NEO exposure in infants.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Engineering, Environmental
Zhong-Min Li, Kurunthachalam Kannan
Summary: This study investigated the occurrence of synthetic chemicals including DPG, DTG, and TPG in indoor dust samples from 332 locations in 11 countries. DPG was detected in all dust samples, with varying concentrations among the countries. DPG accounted for over 87% of the total concentrations of the three compounds in all countries.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Engineering, Environmental
Zhong-Min Li, Kurunthachalam Kannan
Summary: A method using high-performance liquid chromatography-tandem mass spectrometry was developed for the quantification of Diphenylguanidine, 1,3-di-o-tolylguanidine, and 1,2,3-triphenylguanidine in human urine. The method had detection and quantification limits ranging from 0.002 to 0.02 ng/mL and 0.005 to 0.05 ng/mL, respectively. The method was applied to real human urine samples, revealing a detection frequency of 73% and a median concentration of 0.05 ng/mL for Diphenylguanidine in children's urine samples, and a detection frequency of 20% in adults' urine samples.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Engineering, Environmental
Vishal Midya, Cecilia Sara Alcala, Elza Rechtman, Jill K. Gregory, Kurunthachalam Kannan, Irva Hertz-Picciotto, Susan L. Teitelbaum, Chris Gennings, Maria J. Rosa, Damaskini Valvi
Summary: A study investigates the interactions between environmental chemicals (ECs) and their association with autism spectrum disorder (ASD). By combining weighted quantile sum regression and machine learning methods, two potential interactions between specific ECs and ASD diagnosis are identified.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Engineering, Environmental
Mengqi Yan, Hongkai Zhu, Haining Luo, Tao Zhang, Hongwen Sun, Kurunthachalam Kannan
Summary: This study analyzed urine samples collected from 12 cities in mainland China to determine the concentrations of volatile organic compounds (VOCs) and oxidative stress biomarkers. The results showed that VOC exposure primarily came from cooking, solvents, and vehicle emissions. Regional variations in VOC concentrations were observed, with higher levels found in North and South China. The study also revealed a positive correlation between most VOCs and oxidative stress markers, suggesting potential health risks associated with VOC exposure.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Environmental Sciences
Toshimi Nakajima, Mao Kuragano, Makoto Yamada, Ryo Sugimoto
Summary: This study compared the contribution of submarine groundwater discharge (SGD) to river nutrient budgets at nearshore and embayment scales, and found that SGD-derived nutrients become more important at larger spatial scales.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Fan Liu, Lei Zhang, Chongyang Zhang, Ziguang Chen, Jingguang Li
Summary: NO2 emissions from wall-mounted gas stoves used for household heating have become a significant source of indoor pollution in Chinese urban areas. The high indoor concentration of NO2 poses potential health risks to residents. It is urgently necessary to establish relevant regulations and implement emission reduction technologies to reduce NO2 emissions from wall-mounted gas stoves.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Letter
Environmental Sciences
Hans Peter H. Arp, Raoul Wolf, Sarah E. Hale, Sivani Baskaran, Juliane Gluege, Martin Scheringer, Xenia Trier, Ian T. Cousins, Harrie Timmer, Roberta Hofman-Caris, Anna Lennquist, Andre D. Bannink, Gerard J. Stroomberg, Rosa M. A. Sjerps, Rosa Montes, Rosario Rodil, Jose Benito Quintana, Daniel Zahn, Herve Gallard, Tobias Mohr, Ivo Schliebner, Michael Neumann
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Philomina Onyedikachi Peter, Binessi Edouard Ifon, Francois Nkinahamira, Kayode Hassan Lasisi, Jiangwei Li, Anyi Hu, Chang-Ping Yu
Summary: This study investigates the relationship between dissolved organic matter (DOM) and Rare Earth Elements (REEs) in sediments from Yundang Lagoon, China. The results show four distinct fluorescent components, with protein-like substances being the most prevalent. Additionally, the total fluorescence intensity and LREE concentrations exhibit a synchronized increase from Outer to Inner to Songbai Lake core sediments. The findings demonstrate a strong correlation between DOM content and pollution levels.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Surya Gupta, Pasquale Borrelli, Panos Panagos, Christine Alewell
Summary: The objective of this study is to incorporate soil hydraulic properties into the erodibility factor (K) of USLE-type models. By modifying and improving the existing equations for soil texture and permeability, the study successfully included information on saturated hydraulic conductivity (Ksat) into the calculation of K factor. Using the Random Forest machine learning algorithm, two independent K factor maps with different spatial resolutions were generated. The results show that the decrease in K factor values has a positive impact on the modeling of soil erosion rates.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Jesmin Akter, Wendy J. M. Smith, Yawen Liu, Ilho Kim, Stuart L. Simpson, Phong Thai, Asja Korajkic, Warish Ahmed
Summary: The choice of workflow in wastewater surveillance has a significant impact on SARS-CoV-2 concentrations, while having minimal effects on HF183 and no effect on HAdV 40/41 concentrations. Certain components in the workflow can be interchangeable, but factors such as buffer type, chloroform, and homogenization speed can affect the recovery of viruses and bacteria.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Yu Luo, Xueting Yang, Diwei Wang, Hongmei Xu, Hongai Zhang, Shasha Huang, Qiyuan Wang, Ningning Zhang, Junji Cao, Zhenxing Shen
Summary: Atmospheric PM2.5, which can generate reactive oxygen species (ROS), is associated with cardiorespiratory morbidity and mortality. The study found that both the mass concentration of PM2.5 and the DTT activity were higher during the heating season than during the nonheating season. Combustion sources were the primary contributors to DTT activity during the heating season, while secondary formation dominated during the nonheating season. The study also revealed that biomass burning had the highest inherent oxidation potential among all sources investigated.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Erin L. Murphy, Leah R. Gerber, Chelsea M. Rochman, Beth Polidoro
Summary: Plastic pollution has devastating consequences for marine organisms. This study uses a trait-based framework to develop a vulnerability index for marine mammals, seabirds, and sea turtles in Hawai'i. The index ranks 63 study species based on their vulnerability to macroplastic pollution, providing valuable information for species monitoring and management priorities.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Kenji Maurice, Amelia Bourceret, Sami Youssef, Stephane Boivin, Liam Laurent-Webb, Coraline Damasio, Hassan Boukcim, Marc-Andre Selosse, Marc Ducousso
Summary: Growing pressure from climate change and agricultural land use is destabilizing soil microbial community interactions. Little is known about microbial community resistance and adaptation to disturbances, hindering our understanding of recovery latency and implications for ecosystem functioning. This study found that anthropic disturbance and natural disturbance have different effects on the topology and stability of soil microbial networks.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Yunhao Li, Yali Feng, Haoran Li, Yisong Yao, Chenglong Xu, Jinrong Ju, Ruiyu Ma, Haoyu Wang, Shiwei Jiang
Summary: Deep-sea mining poses a serious threat to marine ecosystems and human health by disturbing sediment and transmitting metal ions through the food chain. This study developed a new regenerative adsorption material, OMN@SA, which effectively removes metal ions. The adsorption mechanism and performance of the material for metal ion fixation were investigated.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Antonio Medici, Margherita Lavorgna, Marina Isidori, Chiara Russo, Elena Orlo, Giovanni Luongo, Giovanni Di Fabio, Armando Zarrelli
Summary: Valsartan, a widely used antihypertensive drug, has been detected in high concentrations in surface waters due to its unchanged excretion and incomplete degradation in wastewater treatment plants. This study investigated the degradation of valsartan and identified 14 degradation byproducts. The acute and chronic toxicity of these byproducts were evaluated in key organisms in the freshwater trophic chain.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Jiang Lin, Lianbao Chi, Qing Yuan, Busu Li, Mingbao Feng
Summary: This study investigated the photodegradation behavior and product formation of two representative pharmaceuticals in simulated estuary water. The study found that the formed transformation products of these pharmaceuticals have potential toxicity on marine organisms, including oxidative stress and damage to cellular components.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Hua Fang, Dongdong Jiang, Ye He, Siyi Wu, Yuehong Li, Ziqi Zhang, Haoting Chen, Zixin Zheng, Yan Sun, Wenxiang Wang
Summary: This study revealed that exposure to lower levels of air pollutants led to decreased pregnancy rates, with PM10, NO2, SO2, and CO emerging as the four most prominent pollutants. Individuals aged 35 and above exhibited heightened susceptibility to pollutants.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Ali Shaan Manzoor Ghumman, Rashid Shamsuddin, Amin Abbasi, Mohaira Ahmad, Yoshiaki Yoshida, Abdul Sami, Hamad Almohamadi
Summary: In this study, inverse vulcanized polysulfides (IVP) were synthesized by reacting molten sulfur with 4-vinyl benzyl chloride, and then functionalized using N-methyl D-glucamine (NMDG). The functionalized IVP showed a high mercury adsorption capacity and a machine learning model was developed to predict the amount of mercury removed. Furthermore, the functionalized IVP can be regenerated and reused, providing a sustainable and cost-effective adsorbent.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Rita Bonfiglio, Renata Sisto, Stefano Casciardi, Valeria Palumbo, Maria Paola Scioli, Erica Giacobbi, Francesca Servadei, Gerry Melino, Alessandro Mauriello, Manuel Scimeca
Summary: This study investigated the presence of aluminum in human colon cancer samples and its potential association with biological processes involved in cancer progression. Aluminum was found in tumor areas of 24% of patients and was associated with epithelial to mesenchymal transition (EMT) and cell death. Additional analyses revealed higher tumor mutational burden and mutations in genes related to EMT and apoptosis in aluminum-positive colon cancers. Understanding the molecular mechanisms of aluminum toxicity may improve strategies for the management of colon cancer patients.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
