Article
Biochemistry & Molecular Biology
Chang-Li Yang, Jian-Yu Meng, Lv Zhou, Chang-Yu Zhang
Summary: UV-B radiation directly affects insect growth, development, and reproduction. Heat shock protein 70s (Hsp70s) plays a crucial role in insect adaptation to the environment. This study identified seven complete complementary DNA sequences of MpHsp70s in Myzus persicae and found that they were expressed ubiquitously during different developmental stages. Exposure to UV-B stress significantly upregulated the expression of MpHsp70s. Suppression of MpHsp70 expression using dsMpHsp70 nanocarriers reduced the body size, weight, survival rate, and fecundity of M. persicae under UV-B exposure. Combining RNAi approaches showed greater effects on survival rate and fecundity under UV-B stress, except for MpHsc70-4.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Mingzu Guo, Wenxi Xu, Yoshinari Yamamoto, Takuya Suzuki
Summary: The study found that curcumin can increase the expression of HSP70 in intestinal Caco-2 cells through transcriptional activation, possibly enhancing cell integrity. The effects of curcumin are regulated by various signaling pathways. This discovery is expected to contribute to a deeper understanding of the regulation of intestinal HSP70 by dietary components.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Neurosciences
Zhongting Zhao, Zheng Li, Fangning Du, Yixin Wang, Yue Wu, Kah-leong Lim, Lin Li, Naidi Yang, Changmin Yu, Chengwu Zhang
Summary: Parkinson's disease (PD) is a neurodegenerative disease characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc). Misfolding, aggregation, and abnormal degradation of proteins are believed to be key factors in the pathogenesis of PD. Heat shock protein 70 (Hsp70) and Parkin, an E3 ubiquitin ligase, have been found to play important roles in PD pathogenesis. This review focuses on the dysregulation of Hsp70 and Parkin, their interaction, and their potential therapeutic applications in PD.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Zifei Han, Shelli R. McAlpine, Robert Chapman
Summary: This study demonstrates the successful delivery of inhibitors to block the interaction between Hsp70 and HOP using polymer nanogels. The results show the effectiveness of these inhibitors in inhibiting Hsp70 and inducing cancer cell death.
BIOORGANIC CHEMISTRY
(2022)
Article
Agriculture, Dairy & Animal Science
Ahmad Hanafi Sulong, Idrus Zulkifli, Suriya Kumari Ramiah, Eric Lim Teik Chung, Elmutaz Atta Awad, Awis Qurni Sazili
Summary: The study detected APPs in the blood of chicken embryos and neonates for the first time, with levels varying depending on the developmental stage.
ITALIAN JOURNAL OF ANIMAL SCIENCE
(2021)
Article
Agronomy
Chuanbei Tian, Yaying Li, Yixia Wu, Wenqiang Chu, Huai Liu
Summary: In fluctuating climatic environments, heat acclimation in predatory mites is a superior adaptation strategy for effective agricultural pest management. The sustained accumulation of HSP70 proteins results in predatory mites with thermotolerance advantage, promoting their biological control function to pests. The divergent constitutive regulation of HSP70 to a thermal environment allows predators to adapt flexibly to extreme stress.
PEST MANAGEMENT SCIENCE
(2021)
Review
Biology
Xun Fu, Jiang Liu, Xin Yan, Michael E. DiSanto, Xinhua Zhang
Summary: Prostate cancer is the second most common cancer in aging men globally, but its exact pathogenesis is not fully understood. The heat shock protein (HSP) family plays a significant role in promoting tumor growth and protecting cancer cells from death. HSP molecules are closely involved in important biological processes such as cell differentiation, epithelial-mesenchymal transition, and fibrosis. Agents and inhibitors targeting the critical structure of HSP molecules have been developed for their potent antitumor effects. However, only a small number of them have been clinically tested. Further clinical studies are needed to establish the relationship between HSP70 family, HSP90 molecule, and prostate cancer treatment.
Article
Biochemistry & Molecular Biology
Precious Adedayo Adesina, Itsuki Saeki, Yoshinari Yamamoto, Takuya Suzuki
Summary: Impaired integrity of the intestinal epithelium can lead to intestinal and extraintestinal diseases. Heat shock protein 70 (HSP70) plays a crucial role in maintaining intestinal homeostasis. This study investigates the molecular mechanisms behind the upregulation of HSP70 by n-butyrate, a major metabolite of the intestinal microbiota. The findings suggest that n-butyrate enhances HSP70 expression through the activation of heat shock factor 1 (HSF1) and AMP-activated protein kinase (AMPK) pathways.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2023)
Article
Environmental Sciences
Tian Zhang, Wenhua Yan, Cong Liu, Weixia Duan, Yu Duan, Yuanyuan Li, Qin Yu, Yapei Sun, Jiacheng Tian, Jie Zhou, Zhiqin Xia, Guixue Wang, Shangcheng Xu
Summary: Cadmium (Cd) exposure induces ferroptosis of vascular endothelial cells (ECs), resulting in endothelial dysfunction and cardiovascular disease. Cd accumulates in ECs, leading to increased lipid peroxidation and disrupted oxidoreductase system. Cd decreases Gpx4 expression and alters mitochondrial morphology, causing reduced ECs and caudal venous plexus in zebrafish embryos, as well as decreased survival rate of HUVECs. Inhibition of Hsp70 ameliorates Cd-induced ferroptosis by targeting multiple factors, including Gpx4, Fth1, Nrf2, and Acsl4. Regulation of Hsp70 is therefore a promising approach for alleviating Cd-induced endothelial damage.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Parasitology
Desmond O. Agwunobi, Tongxuan Wang, Meng Zhang, Tianhong Wang, Qingying Jia, Miao Zhang, Xinyue Shi, Zhijun Yu, Jingze Liu
Summary: In this study, genes of hsp70 and hsp90 cDNA were cloned and characterized from the tick Dermacentor silvarum, and their functions in cold stress were evaluated. Results showed that Dshsp70 and Dshsp90 play essential roles in the low-temperature adaptation of ticks. This study contributes to understanding the survival and acclimatization of overwintering ticks.
PARASITES & VECTORS
(2021)
Article
Entomology
Shou-Min Fang, Qian Zhang, Yu-Li Zhang, Gui-Zheng Zhang, Ze Zhang, Quan-You Yu
Summary: The heat shock protein 70 family was identified in the whole genome of the silkworm, showing important roles in protecting against environmental stresses. The stress-inducible forms were found to play more crucial roles in adaptation to various stresses compared to the heat shock cognates.
Article
Veterinary Sciences
Jae-Yeon Park, Jihoon Ryu, Jung-Eun Park, Eui-Ju Hong, Hyun-Jin Shin
Summary: This study found that HSP70 plays an important role in PEDV replication, with its overexpression increasing the speed of viral replication, while knockout significantly reduces PEDV protein expression and replication. Furthermore, the study confirmed the crucial role of the PEDV membrane (M) protein in collaboration with HSP70 in viral replication in infected cells.
VETERINARY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Tal Belity, Michal Horowitz, Jay R. Hoffman, Yoram Epstein, Yaron Bruchim, Doron Todder, Hagit Cohen
Summary: Exposure to high ambient temperature can have extensive effects on brain structure and function. This study found that preconditioning with heat stress can improve resilience to predator-scent stress and may involve the induction of heat shock protein-70. Targeting this protein could be an attractive strategy for treating stress-related psychopathology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Seung Yeob Hyun, Huong Thuy Le, Hye-Young Min, Honglan Pei, Yijae Lim, Injae Song, Yen T. K. Nguyen, Suckchang Hong, Byung Woo Han, Ho-Young Lee
Summary: The HSP system was found to be activated in CSCs, especially HSP70. Evo was identified to induce apoptosis in both CSC and non-CSC populations in various cancer cell lines. Mechanistically, Evo disrupted the HSP system by binding the N-terminal ATP-binding pocket of HSP70 and causing its ubiquitin-mediated degradation.
Article
Agronomy
Jiahui Tian, Youssef Dewer, Cheng Qu, Fengqi Li, Chen Luo
Summary: The study found that S. habrochaites significantly increased the mortality of whitefly adults and decreased their fertility and fecundity. The expression of heat-shock protein (HSP), multicopper oxidase, and 2-Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) decarboxylase genes were induced in whitefly after exposure to S. habrochaites. In addition, RNAi-mediated depletion of the HSP gene increased the mortality of whitefly, suggesting a potential implication of HSPs in whitefly-wild plant interactions.
PEST MANAGEMENT SCIENCE
(2022)
Article
Environmental Sciences
Monica Aquilino, Jose Luis Martinez-Guitarte, Pilar Garcia, Eulalia Maria Beltran, Carlos Fernandez, Paloma Sanchez-Arguello
SCIENCE OF THE TOTAL ENVIRONMENT
(2018)
Article
Marine & Freshwater Biology
Pedro Martinez-Paz, Viviana Negri, Adrian Esteban-Arranz, Jose Luis Martinez-Guitarte, Paloma Ballesteros, Monica Morales
AQUATIC TOXICOLOGY
(2019)
Article
Environmental Sciences
Ana-Belen Muniz-Gonzalez, Jose-Luis Martinez-Guitarte
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2018)
Article
Environmental Sciences
Monica Aquilino, Paloma Sanchez-Arguello, Marta Novo, Jose-Luis Martinez-Guitarte
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2019)
Article
Environmental Sciences
M. Novo, A. B. Muniz-Gonzalez, D. Trigo, S. Casquero, J. L. Martinez Guitarte
SCIENCE OF THE TOTAL ENVIRONMENT
(2019)
Article
Environmental Sciences
Raquel Martin-Folgar, Jose-Luis Martinez-Guitarte
SCIENCE OF THE TOTAL ENVIRONMENT
(2019)
Article
Soil Science
Silvia Casquero, Dolores Trigo, Jose L. Martinez Guitarte, Marta Novo
APPLIED SOIL ECOLOGY
(2020)
Article
Environmental Sciences
Ana-Belen Muniz-Gonzalez, Jose-Luis Martinez-Guitarte
SCIENCE OF THE TOTAL ENVIRONMENT
(2020)
Article
Multidisciplinary Sciences
Maria Alonso-Trujillo, Ana-Belen Muniz-Gonzalez, Jose-Luis Martinez-Guitarte
SCIENTIFIC REPORTS
(2020)
Article
Environmental Sciences
Ana-Belen Muniz-Gonzalez, Jose-Luis Martinez-Guitarte
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2020)
Article
Environmental Sciences
Ana-Belen Muniz-Gonzalez, Marta Novo, Jose-Luis Martinez-Guitarte
Summary: Exposure of Chironomus riparius larvae to endosulfan resulted in significant alterations in different metabolic pathways at the molecular level, as well as modifications in all measured enzymatic activities, despite the absence of lethality. These findings highlight the need to consider effects at the sub-organismal level in addition to traditional ecologically relevant parameters in new risk assessment strategies for toxicants in the environment.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Environmental Sciences
Victor Carrasco-Navarro, Ana-Belen Muniz-Gonzalez, Jouni Sorvari, Jose-Luis Martinez-Guitarte
Summary: The study found alterations in the expression of twelve genes in the aquatic insect Chironomus riparius after 36 h exposures to polystyrene and tire rubber microplastics, with overexpression of heat shock protein genes. The changes mainly occurred at higher concentrations of microplastics, but did not result in mortality.
ENVIRONMENTAL POLLUTION
(2021)
Article
Multidisciplinary Sciences
Marina Prieto-Amador, Patricia Caballero, Jose-Luis Martinez-Guitarte
Summary: This study analyzed the impact of three phthalates on the gastropod Physella acuta at the molecular level, showing that BBP had a significant effect on gene expression. Further research is needed to understand the differences in the impact of these compounds on the gastropod P. acuta.
SCIENTIFIC REPORTS
(2021)
Article
Environmental Sciences
Ana-Belen Muniz-Gonzalez, Carlos J. M. Silva, Ana L. Patricio Silva, Diana Campos, Joao L. T. Pestana, Jose-Luis Martinez-Guitarte
Summary: The study reveals that exposure to environmental concentrations of LDPE MPs affects energy reserves, antioxidant responses, detoxification responses, and neurotransmission in Chironomus riparius larvae, as well as induces significant changes at the gene level, thereby impacting development and response to unfavorable situations in these organisms.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Multidisciplinary Sciences
Africa Sanchiz, Dario Lopez-Garcia, Carlos Garcia-Garcia, Irene Ozaez, Begona Aguado, Jose Maria Requena
Article
Environmental Sciences
Toshimi Nakajima, Mao Kuragano, Makoto Yamada, Ryo Sugimoto
Summary: This study compared the contribution of submarine groundwater discharge (SGD) to river nutrient budgets at nearshore and embayment scales, and found that SGD-derived nutrients become more important at larger spatial scales.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Fan Liu, Lei Zhang, Chongyang Zhang, Ziguang Chen, Jingguang Li
Summary: NO2 emissions from wall-mounted gas stoves used for household heating have become a significant source of indoor pollution in Chinese urban areas. The high indoor concentration of NO2 poses potential health risks to residents. It is urgently necessary to establish relevant regulations and implement emission reduction technologies to reduce NO2 emissions from wall-mounted gas stoves.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Letter
Environmental Sciences
Hans Peter H. Arp, Raoul Wolf, Sarah E. Hale, Sivani Baskaran, Juliane Gluege, Martin Scheringer, Xenia Trier, Ian T. Cousins, Harrie Timmer, Roberta Hofman-Caris, Anna Lennquist, Andre D. Bannink, Gerard J. Stroomberg, Rosa M. A. Sjerps, Rosa Montes, Rosario Rodil, Jose Benito Quintana, Daniel Zahn, Herve Gallard, Tobias Mohr, Ivo Schliebner, Michael Neumann
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Philomina Onyedikachi Peter, Binessi Edouard Ifon, Francois Nkinahamira, Kayode Hassan Lasisi, Jiangwei Li, Anyi Hu, Chang-Ping Yu
Summary: This study investigates the relationship between dissolved organic matter (DOM) and Rare Earth Elements (REEs) in sediments from Yundang Lagoon, China. The results show four distinct fluorescent components, with protein-like substances being the most prevalent. Additionally, the total fluorescence intensity and LREE concentrations exhibit a synchronized increase from Outer to Inner to Songbai Lake core sediments. The findings demonstrate a strong correlation between DOM content and pollution levels.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Surya Gupta, Pasquale Borrelli, Panos Panagos, Christine Alewell
Summary: The objective of this study is to incorporate soil hydraulic properties into the erodibility factor (K) of USLE-type models. By modifying and improving the existing equations for soil texture and permeability, the study successfully included information on saturated hydraulic conductivity (Ksat) into the calculation of K factor. Using the Random Forest machine learning algorithm, two independent K factor maps with different spatial resolutions were generated. The results show that the decrease in K factor values has a positive impact on the modeling of soil erosion rates.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Jesmin Akter, Wendy J. M. Smith, Yawen Liu, Ilho Kim, Stuart L. Simpson, Phong Thai, Asja Korajkic, Warish Ahmed
Summary: The choice of workflow in wastewater surveillance has a significant impact on SARS-CoV-2 concentrations, while having minimal effects on HF183 and no effect on HAdV 40/41 concentrations. Certain components in the workflow can be interchangeable, but factors such as buffer type, chloroform, and homogenization speed can affect the recovery of viruses and bacteria.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Yu Luo, Xueting Yang, Diwei Wang, Hongmei Xu, Hongai Zhang, Shasha Huang, Qiyuan Wang, Ningning Zhang, Junji Cao, Zhenxing Shen
Summary: Atmospheric PM2.5, which can generate reactive oxygen species (ROS), is associated with cardiorespiratory morbidity and mortality. The study found that both the mass concentration of PM2.5 and the DTT activity were higher during the heating season than during the nonheating season. Combustion sources were the primary contributors to DTT activity during the heating season, while secondary formation dominated during the nonheating season. The study also revealed that biomass burning had the highest inherent oxidation potential among all sources investigated.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Erin L. Murphy, Leah R. Gerber, Chelsea M. Rochman, Beth Polidoro
Summary: Plastic pollution has devastating consequences for marine organisms. This study uses a trait-based framework to develop a vulnerability index for marine mammals, seabirds, and sea turtles in Hawai'i. The index ranks 63 study species based on their vulnerability to macroplastic pollution, providing valuable information for species monitoring and management priorities.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Kenji Maurice, Amelia Bourceret, Sami Youssef, Stephane Boivin, Liam Laurent-Webb, Coraline Damasio, Hassan Boukcim, Marc-Andre Selosse, Marc Ducousso
Summary: Growing pressure from climate change and agricultural land use is destabilizing soil microbial community interactions. Little is known about microbial community resistance and adaptation to disturbances, hindering our understanding of recovery latency and implications for ecosystem functioning. This study found that anthropic disturbance and natural disturbance have different effects on the topology and stability of soil microbial networks.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Yunhao Li, Yali Feng, Haoran Li, Yisong Yao, Chenglong Xu, Jinrong Ju, Ruiyu Ma, Haoyu Wang, Shiwei Jiang
Summary: Deep-sea mining poses a serious threat to marine ecosystems and human health by disturbing sediment and transmitting metal ions through the food chain. This study developed a new regenerative adsorption material, OMN@SA, which effectively removes metal ions. The adsorption mechanism and performance of the material for metal ion fixation were investigated.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Antonio Medici, Margherita Lavorgna, Marina Isidori, Chiara Russo, Elena Orlo, Giovanni Luongo, Giovanni Di Fabio, Armando Zarrelli
Summary: Valsartan, a widely used antihypertensive drug, has been detected in high concentrations in surface waters due to its unchanged excretion and incomplete degradation in wastewater treatment plants. This study investigated the degradation of valsartan and identified 14 degradation byproducts. The acute and chronic toxicity of these byproducts were evaluated in key organisms in the freshwater trophic chain.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Jiang Lin, Lianbao Chi, Qing Yuan, Busu Li, Mingbao Feng
Summary: This study investigated the photodegradation behavior and product formation of two representative pharmaceuticals in simulated estuary water. The study found that the formed transformation products of these pharmaceuticals have potential toxicity on marine organisms, including oxidative stress and damage to cellular components.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Hua Fang, Dongdong Jiang, Ye He, Siyi Wu, Yuehong Li, Ziqi Zhang, Haoting Chen, Zixin Zheng, Yan Sun, Wenxiang Wang
Summary: This study revealed that exposure to lower levels of air pollutants led to decreased pregnancy rates, with PM10, NO2, SO2, and CO emerging as the four most prominent pollutants. Individuals aged 35 and above exhibited heightened susceptibility to pollutants.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Ali Shaan Manzoor Ghumman, Rashid Shamsuddin, Amin Abbasi, Mohaira Ahmad, Yoshiaki Yoshida, Abdul Sami, Hamad Almohamadi
Summary: In this study, inverse vulcanized polysulfides (IVP) were synthesized by reacting molten sulfur with 4-vinyl benzyl chloride, and then functionalized using N-methyl D-glucamine (NMDG). The functionalized IVP showed a high mercury adsorption capacity and a machine learning model was developed to predict the amount of mercury removed. Furthermore, the functionalized IVP can be regenerated and reused, providing a sustainable and cost-effective adsorbent.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Rita Bonfiglio, Renata Sisto, Stefano Casciardi, Valeria Palumbo, Maria Paola Scioli, Erica Giacobbi, Francesca Servadei, Gerry Melino, Alessandro Mauriello, Manuel Scimeca
Summary: This study investigated the presence of aluminum in human colon cancer samples and its potential association with biological processes involved in cancer progression. Aluminum was found in tumor areas of 24% of patients and was associated with epithelial to mesenchymal transition (EMT) and cell death. Additional analyses revealed higher tumor mutational burden and mutations in genes related to EMT and apoptosis in aluminum-positive colon cancers. Understanding the molecular mechanisms of aluminum toxicity may improve strategies for the management of colon cancer patients.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)