Article
Biochemistry & Molecular Biology
Lucie Larigot, Linh-Chi Bui, Marine de Bouvier, Ophelie Pierre, Gregory Pinon, Justine Fiocca, Mohammad Ozeir, Cendrine Tourette, Chris Ottolenghi, Sandrine Imbeaud, Clement Pontoizeau, Benjamin J. Blaise, Aline Chevallier, Celine Tomkiewicz, Beatrice Legrand, Benedicte Elena-Herrmann, Christian Neri, Vanessa Brinkmann, Pierre Nioche, Robert Barouki, Natascia Ventura, Julien Dairou, Xavier Coumoul
Summary: This study reveals the biological functions of AhR-1 in C. elegans and its role in the regulation of amino acid, carbohydrate, and fatty acid metabolism, as well as neuronal and metabolic functions. In addition, the study identifies several modulators of AhR-1, including bacterial, dietary, and environmental compounds, providing insights into the evolution of AhR functions across species.
Review
Biochemistry & Molecular Biology
Domenico Tierno, Gabriele Grassi, Serena Scomersi, Marina Bortul, Daniele Generali, Fabrizio Zanconati, Bruna Scaggiante
Summary: The poor survival of triple-negative breast cancer (TNBC) is attributed to its aggressive behavior, large heterogeneity, and high risk of recurrence. Next-generation sequencing (NGS) has been used to investigate the molecular characteristics of TNBC, revealing recurrent pathogenic alterations in TP53, immunocheckpoint response genes, and PIK3CA and DNA repair pathways. NGS has also identified potential personalized treatments and novel biomarkers such as AURKA, MYC, and JARID2 mutations. Additionally, NGS studies have identified ethnicity-specific alterations in African and African American TNBC, including EZH2 overexpression, BRCA1 alterations, and a BRCA2-delaAAGA mutation. The development of long-read sequencing methods and their combination with optimized short-read techniques hold promise for improving the efficiency of NGS approaches in future clinical use.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biology
Heena Satam, Kandarp Joshi, Upasana Mangrolia, Sanober Waghoo, Gulnaz Zaidi, Shravani Rawool, Ritesh P. Thakare, Shahid Banday, Alok K. Mishra, Gautam Das, Sunil K. Malonia
Summary: Next-generation sequencing (NGS) is a powerful tool that can sequence millions of DNA fragments simultaneously, providing detailed information about genomes, genetic variations, gene activity, and changes in gene behavior. Recent advancements have focused on improving sequencing speed and accuracy, reducing costs, and enhancing data analysis. These advancements have great potential for advancing genomics research and improving our understanding of diseases and personalized healthcare.
Article
Food Science & Technology
Lijin Duan, Shasha Zhang, Yingxia Yang, Qian Wang, Qingkuo Lan, Yong Wang, Wentao Xu, Wujun Jin, Liang Li, Rui Chen
Summary: This study introduces a novel GMO testing method, "SSH-seq", based on suppressive subtractive hybridization and next-generation sequencing, which can be used to detect unknown GMOs and has shown promising results in experiments. Although the method may be influenced by multiple factors, further optimizations could make SSH-seq a powerful tool in the field of GMO testing.
Review
Cell Biology
Tamer Butto, Kanak Mungikar, Peter Baumann, Jennifer Winter, Beat Lutz, Susanne Gerber
Summary: In the last decade, there has been a significant increase in nuclei-based studies, especially in combination with next-generation sequencing. These studies aim to understand the molecular states in heterogeneous cell populations using more affordable sequencing approaches and optimized nuclei isolation methods. While these powerful new methods offer unprecedented insights, it is important to consider the associated challenges critically. This article provides a comprehensive overview of the rise of nuclei-based studies and discusses their advantages and disadvantages, with a specific focus on their utility for transcriptomic sequencing analyses. Improving experimental designs and using various strategies appropriately will lead to biologically accurate and meaningful information.
Article
Chemistry, Multidisciplinary
Vasilka Chopkova, Mariana Petkova, Stefan Shilev
Summary: This study investigated the bacterial diversity of mesophilic and thermophilic phases of composting in two different sites using Illumina HiSeq sequencing and phylogenetic analysis. The results showed that the mesophilic phase had a higher number of bacterial species compared to the thermophilic phase, and there were differences in bacterial diversity between the two composting sites.
APPLIED SCIENCES-BASEL
(2023)
Article
Ophthalmology
Sean Mullany, Henry Marshall, Tiger Zhou, Daniel Thomson, Joshua M. Schmidt, Ayub Qassim, Lachlan S. W. Knight, Georgina Hollitt, Ella C. Berry, Thi Nguyen, Minh-Son To, David Dimasi, Abraham Kuot, Joshua Dubowsky, Rhys Fogarty, Michelle Sun, Luke Chehade, Shilpa Kuruvilla, Devaraj Supramaniam, James Breen, Shiwani Sharma, John Landers, Stewart Lake, Richard A. Mills, Mark M. Hassall, Weng O. Chan, Sonja Klebe, Emmanuelle Souzeau, Owen M. Siggs, Jamie E. Craig
Summary: The study identified significant gene expression differences in patients with PEX, with upregulation of genes associated with viral gene expression pathways and downregulation of cell adhesion protein transcripts. This comprehensive transcriptomic resource sheds light on novel and previously recognized pathogenic pathways in PEX.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Pharmacology & Pharmacy
Shuangyu Han, Zhan Zhao, Lei Yang, Jie Huang, Yubao Wang, Jing Feng
Summary: mNGS has become increasingly popular for detecting infectious organisms. This study compared the performance of Illumina and BGI platforms in detecting pulmonary pathogens, and found that both platforms had similar diagnostic performance and were superior to conventional examinations.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Environmental Sciences
Tessa M. Page, Jonathan W. Lawley
Summary: As we enter the United Nations Decade of Ocean Science for Sustainable Development, efforts to reverse ocean health decline are urgent. Transcriptomic technologies are playing an increasingly important role in marine ecology research, providing researchers with valuable tools to understand genetic variation, cellular processes, and pathways.
FRONTIERS IN MARINE SCIENCE
(2022)
Article
Biotechnology & Applied Microbiology
Stephan Weissbach, Stanislav Sys, Charlotte Hewel, Hristo Todorov, Susann Schweiger, Jennifer Winter, Markus Pfenninger, Ali Torkamani, Doug Evans, Joachim Burger, Karin Everschor-Sitte, Helen Louise May-Simera, Susanne Gerber
Summary: The study demonstrates systematic heterogeneity in variant calls between different experimental and data analysis setups, and highlights the benefit of reprocessing genomic data with harmonized pipelines for improving concordance.
Review
Pharmacology & Pharmacy
Ziyue Kou, Wei Dai
Summary: Aryl hydrocarbon receptor (AHR) is a cellular protein involved in detoxification of xenobiotic compounds. Research has shown that AHR plays important roles in normal development and homeostasis, and its deficiency can lead to various developmental abnormalities.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Genetics & Heredity
Ekaterina Ilgisonis, Nikita Vavilov, Elena Ponomarenko, Andrey Lisitsa, Ekaterina Poverennaya, Victor Zgoda, Sergey Radko, Alexander Archakov
Summary: The study compared different transcriptome analysis platforms to determine the optimal strategy for reliable RNA transcriptome data analysis, ultimately recommending the combination of Illumina RNASeq and MinION nanopore technologies. This combination significantly reduced false-positive detection of low-copy transcripts and ensured complete coverage of all genes.
FRONTIERS IN GENETICS
(2021)
Article
Genetics & Heredity
Afiahayati, Stefanus Bernard, Gunadi, Hendra Wibawa, Mohamad Saifudin Hakim, Marcellus, Arli Aditya Parikesit, Chandra Kusuma Dewa, Yasubumi Sakakibara
Summary: This study compares two bioinformatics pipelines to investigate the target enrichment workflow by Illumina in characterizing SARS-CoV-2 samples. The results show that the Fast Pipeline works well when time is critical, while the Normal Pipeline requires more time due to mapping reads to the human genome. It is recommended to design an integrated pipeline algorithm in future studies.
Article
Infectious Diseases
Twinkle Soni, Ramesh Pandit, Damer Blake, Chaitanya Joshi, Madhvi Joshi
Summary: The study compared two sequencing platforms for analyzing AMR genes in a veterinary/public health setting. Results showed that the Illumina MiSeq and Ion Torrent platforms performed almost equally in comparing AMR genes and candidate host organisms, with minor differences.
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2022)
Review
Cell Biology
Claudia Rejano-Gordillo, Ana Ordiales-Talavero, Ana Nacarino-Palma, Jaime M. Merino, Francisco J. Gonzalez-Rico, Pedro M. Fernandez-Salguero
Summary: The transcription factor aryl hydrocarbon receptor (AHR) is a key regulator involved in cell functions and tumor progression. It can act as either an oncogene or a tumor suppressor, depending on the specific organ, tissue and cell type. In addition to its role in cell adhesion and migration, AHR has potential as a therapeutic tool, diagnosis and prognosis marker.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Engineering, Environmental
Sarah E. Crawford, Markus Brinkmann, Jacob D. Ouellet, Frank Lehmkuhl, Klaus Reicherter, Jan Schwarzbauer, Piero Bellanova, Peter Letmathe, Lars M. Blank, Roland Weber, Werner Brack, Joost T. van Dongen, Lucas Menzel, Markus Hecker, Holger Schuettrumpf, Henner Hollert
Summary: While the frequency and intensity of floods are increasing globally, the indirect effects of pollutants remobilized and redistributed during flood events are often overlooked. A global examination of floods caused by extreme events and the subsequent distribution of sediment-bound pollutants is essential to improve interdisciplinary investigations and develop action plans to address environmental pollution issues from flooding. Action plans for river basins and coastal lowlands need to balance flood retention, catchment conservation, and economical water use.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Environmental Sciences
Abigail DeBofsky, Yuwei Xie, Jonathan K. Challis, Phillip J. Ankley, Markus Brinkmann, Paul D. Jones, John P. Giesy
Summary: The study investigated the effects of BaP on the active gut microbiome of juvenile fathead minnows, finding that BaP reduces microbiome diversity, alters community composition, and leads to differential proportions of taxa associated with hydrocarbon degradation and fish health. The results also indicated ecological resistance and/or resilience of gut microbiota to BaP exposure.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Environmental Sciences
Markus Schmitz, Bjoern Deutschmann, Nele Markert, Thomas Backhaus, Werner Brack, Mario Brauns, Markus Brinkmann, Thomas-Benjamin Seiler, Patrick Fink, Song Tang, Shawn Beitel, Jon A. Doering, Markus Hecker, Ying Shao, Tobias Schulze, Markus Weitere, Romy Wild, Mirna Velki, Henner Hollert
Summary: The study demonstrated the potential of an Aggregated Biomarker Response approach in evaluating the exposure and impacts on wild brown trout. It identified significant toxic effects from wastewater treatment plants and agricultural runoff, allowing for comprehensive ecotoxicological assessment of fish along the river. Using aggregated biomarker responses combined with chemical analyses enabled an evidence-based ranking of sites with different degrees of pollution according to toxic stress and observed effects.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Environmental Sciences
S. L. Kober, P. Schaefer, H. Hollert, M. Frohme
Summary: The investigation of large contaminated sites is limited due to the cost of traditional analysis methods. The authors propose a new high-throughput screening system that combines GPS data collection, quantitative analysis of explosives, and visualization of heatmaps. This system allows for fast characterization of contaminated areas.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL SCIENCE AND TECHNOLOGY
(2023)
Article
Environmental Sciences
Susari Malala Irugal Bandaralage, Juan Ignacio Bertucci, Brad Park, Derek Green, Markus Brinkmann, Anita Masse, Doug Crump, Niladri Basu, Natacha Hogan, Markus Hecker
Summary: This study investigated the effects of dietary HBCD on adult fathead minnows and the accumulation and maternal transfer dynamics of HBCD in adult tissue and eggs. The results showed that exposed adults had significantly increased egg production in the medium treatment group. The study also found a correlation between HBCD accumulation in eggs and exposure time.
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
(2023)
Article
Engineering, Environmental
Xiaowen Ji, Jenna Cantin, Ana S. Cardenas Perez, Yufeng Gong, John P. Giesy, Markus Brinkmann
Summary: This study investigated the passive adsorption of nine antipsychotic drugs by the benthic oligochaete in spiked freshwater sediments. The results showed that some drugs had positive fluxes from sediment to water, and the oligochaetes accumulated certain drugs. The simulation model indicated that the antipsychotic compounds in sediment were predominantly present in stable or bound fractions, and dissolved organic carbon and degradation played important roles in the dissipation rates of the drugs. The uptake and diffusion-induced model matched the measured concentrations well.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Environmental Sciences
Saurabh Prajapati, Pouya Sabokruhie, Markus Brinkmann, Karl-Erich Lindenschmidt
Summary: The South Saskatchewan River is a crucial water source for residents, industries, and power plants in Saskatchewan and Canada. Using a 1D modeling approach coupled with the HEC-RAS system and the WASP-TOXI module, this study analyzed the concentrations of copper and nickel at different sites along the river. The model successfully estimated the concentrations in water samples and performed reasonably well for sediment samples, providing valuable insights for future studies on water quality in the Canadian prairies.
Review
Environmental Sciences
Christy Morrissey, Clementine Fritsch, Katharine Fremlin, William Adams, Katrine Borga, Markus Brinkmann, Igor Eulaers, Frank Gobas, Dwayne R. J. Moore, Nico van den Brink, Ted Wickwire
Summary: The exposure assessment component of a Wildlife Ecological Risk Assessment aims to estimate exposure to a chemical or environmental contaminant in wildlife, but there is often high uncertainty and error due to limited data. Both USEPA and EFSA require exposure assessments to include estimates of the quantity, frequency, and duration of exposure while considering all relevant factors. In this review, we propose a new framework for constructing an exposure matrix to better inform and communicate the complexity and realism in exposure assessments for wildlife.
INTEGRATED ENVIRONMENTAL ASSESSMENT AND MANAGEMENT
(2023)
Article
Marine & Freshwater Biology
Hannah Mahoney, Jenna Cantin, Yuwei Xie, Markus Brinkmann, John P. Giesy
Summary: This study aimed to characterize the effects of PFECHS using in vitro systems, such as rainbow trout liver cells and lymphocytes. The results showed that exposure to PFECHS caused minor acute toxic effects and had a low bioconcentration factor. However, PFECHS was observed to affect mitochondrial membrane and key molecular receptors related to oxidative stress.
AQUATIC TOXICOLOGY
(2023)
Article
Engineering, Environmental
Hannah Mahoney, Jenna Cantin, Josephine Rybchuk, Yuwei Xie, John P. Giesy, Markus Brinkmann
Summary: This study evaluated the toxic potency of PFECHS, an emerging PFAS, on zebrafish embryos and its potential effects in aquatic environments. The results showed that PFECHS caused fewer mortalities than PFOS in both acute and chronic exposures but resulted in a similar incidence of deformities. Exposure to PFECHS also increased the levels of specific genes at concentrations relevant to the environment. These findings provide insights into the safety of emerging PFAS alternatives in the aquatic environment and highlight the potential similarity of effects with legacy PFASs.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Environmental Sciences
Xiaowen Ji, Catherine Estefany Davila Arenas, Ana Sharelys Cardenas Perez, John P. Giesy, Markus Brinkmann
Summary: The present study used DGT samplers to develop a predictive model between antipsychotic compounds in water and crayfish. The model accurately predicted the uptake by organisms, except for one compound. The study also showed partial resupply of antipsychotic compounds from sediments to the aqueous phase.
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
(2023)
Article
Environmental Sciences
Mohsen Asadi, Femi F. Oloye, Yuwei Xie, Jenna Cantin, Jonathan K. Challis, Kerry N. McPhedran, Warsame Yusuf, David Champredon, Pu Xia, Chantel De Lange, Seba El-Baroudy, Mark R. Servos, Paul D. Jones, John P. Giesy, Markus Brinkmann
Summary: Wastewater surveillance is useful for understanding the spread of COVID-19 in communities. This study developed the Wastewater Viral Load Risk Index (WWVLRI) to interpret wastewater surveillance results. The index considers the reproduction number, clinical data, daily per capita concentrations of virus particles in wastewater, and weekly viral load change rate. It provides a valuable resource for decision-makers and health authorities.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Marina Tenorio Botelho, Gabriely Groto Militao, Markus Brinkmann, Gisela de Aragao Umbuzeiro
Summary: This study found that 6PPD-quinone has moderate mutagenicity in the marine amphipod Parhyale hawaiensis and weak mutagenicity in bacteria.
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
(2023)
Article
Environmental Sciences
Markus Brinkmann, Stephanie Petersen, Alexander Pelletier, Leland Bryshun, Nicole Schaefer, Michaella Barnes, Lorne Doig, Graham Strickert, Timothy Jardine
Summary: Many large inland rivers are polluted by industrial and agricultural activities, and the redistribution of contaminated sediments can reintroduce toxic pollutants into the aquatic environment. The study used chemical measurements and bioassays to assess the risk to aquatic biota in the Saskatchewan River. The results showed low concentrations of pollutants in sediments, indicating limited risk to biota and human consumers.
JOURNAL OF SOILS AND SEDIMENTS
(2023)
Article
Environmental Sciences
Iyanu Kumayon, Saurabh Prajapati, Markus Brinkmann, Tara Tara Kahan
Summary: In recent decades, contamination of the environment with microplastics and microfibers has become a global concern. While marine environments have been extensively studied, rivers have been identified as major contributors of plastic pollution. However, studies on microplastic and microfiber contamination in rivers of the Canadian prairie region, particularly the South Saskatchewan River (SSR), are limited. This study fills this gap by analyzing samples from the SSR and providing insights into the levels and composition of microplastic and microfiber contamination in this vital water source.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Toshimi Nakajima, Mao Kuragano, Makoto Yamada, Ryo Sugimoto
Summary: This study compared the contribution of submarine groundwater discharge (SGD) to river nutrient budgets at nearshore and embayment scales, and found that SGD-derived nutrients become more important at larger spatial scales.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Fan Liu, Lei Zhang, Chongyang Zhang, Ziguang Chen, Jingguang Li
Summary: NO2 emissions from wall-mounted gas stoves used for household heating have become a significant source of indoor pollution in Chinese urban areas. The high indoor concentration of NO2 poses potential health risks to residents. It is urgently necessary to establish relevant regulations and implement emission reduction technologies to reduce NO2 emissions from wall-mounted gas stoves.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Letter
Environmental Sciences
Hans Peter H. Arp, Raoul Wolf, Sarah E. Hale, Sivani Baskaran, Juliane Gluege, Martin Scheringer, Xenia Trier, Ian T. Cousins, Harrie Timmer, Roberta Hofman-Caris, Anna Lennquist, Andre D. Bannink, Gerard J. Stroomberg, Rosa M. A. Sjerps, Rosa Montes, Rosario Rodil, Jose Benito Quintana, Daniel Zahn, Herve Gallard, Tobias Mohr, Ivo Schliebner, Michael Neumann
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Philomina Onyedikachi Peter, Binessi Edouard Ifon, Francois Nkinahamira, Kayode Hassan Lasisi, Jiangwei Li, Anyi Hu, Chang-Ping Yu
Summary: This study investigates the relationship between dissolved organic matter (DOM) and Rare Earth Elements (REEs) in sediments from Yundang Lagoon, China. The results show four distinct fluorescent components, with protein-like substances being the most prevalent. Additionally, the total fluorescence intensity and LREE concentrations exhibit a synchronized increase from Outer to Inner to Songbai Lake core sediments. The findings demonstrate a strong correlation between DOM content and pollution levels.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Surya Gupta, Pasquale Borrelli, Panos Panagos, Christine Alewell
Summary: The objective of this study is to incorporate soil hydraulic properties into the erodibility factor (K) of USLE-type models. By modifying and improving the existing equations for soil texture and permeability, the study successfully included information on saturated hydraulic conductivity (Ksat) into the calculation of K factor. Using the Random Forest machine learning algorithm, two independent K factor maps with different spatial resolutions were generated. The results show that the decrease in K factor values has a positive impact on the modeling of soil erosion rates.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Jesmin Akter, Wendy J. M. Smith, Yawen Liu, Ilho Kim, Stuart L. Simpson, Phong Thai, Asja Korajkic, Warish Ahmed
Summary: The choice of workflow in wastewater surveillance has a significant impact on SARS-CoV-2 concentrations, while having minimal effects on HF183 and no effect on HAdV 40/41 concentrations. Certain components in the workflow can be interchangeable, but factors such as buffer type, chloroform, and homogenization speed can affect the recovery of viruses and bacteria.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Yu Luo, Xueting Yang, Diwei Wang, Hongmei Xu, Hongai Zhang, Shasha Huang, Qiyuan Wang, Ningning Zhang, Junji Cao, Zhenxing Shen
Summary: Atmospheric PM2.5, which can generate reactive oxygen species (ROS), is associated with cardiorespiratory morbidity and mortality. The study found that both the mass concentration of PM2.5 and the DTT activity were higher during the heating season than during the nonheating season. Combustion sources were the primary contributors to DTT activity during the heating season, while secondary formation dominated during the nonheating season. The study also revealed that biomass burning had the highest inherent oxidation potential among all sources investigated.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Erin L. Murphy, Leah R. Gerber, Chelsea M. Rochman, Beth Polidoro
Summary: Plastic pollution has devastating consequences for marine organisms. This study uses a trait-based framework to develop a vulnerability index for marine mammals, seabirds, and sea turtles in Hawai'i. The index ranks 63 study species based on their vulnerability to macroplastic pollution, providing valuable information for species monitoring and management priorities.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Kenji Maurice, Amelia Bourceret, Sami Youssef, Stephane Boivin, Liam Laurent-Webb, Coraline Damasio, Hassan Boukcim, Marc-Andre Selosse, Marc Ducousso
Summary: Growing pressure from climate change and agricultural land use is destabilizing soil microbial community interactions. Little is known about microbial community resistance and adaptation to disturbances, hindering our understanding of recovery latency and implications for ecosystem functioning. This study found that anthropic disturbance and natural disturbance have different effects on the topology and stability of soil microbial networks.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Yunhao Li, Yali Feng, Haoran Li, Yisong Yao, Chenglong Xu, Jinrong Ju, Ruiyu Ma, Haoyu Wang, Shiwei Jiang
Summary: Deep-sea mining poses a serious threat to marine ecosystems and human health by disturbing sediment and transmitting metal ions through the food chain. This study developed a new regenerative adsorption material, OMN@SA, which effectively removes metal ions. The adsorption mechanism and performance of the material for metal ion fixation were investigated.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Antonio Medici, Margherita Lavorgna, Marina Isidori, Chiara Russo, Elena Orlo, Giovanni Luongo, Giovanni Di Fabio, Armando Zarrelli
Summary: Valsartan, a widely used antihypertensive drug, has been detected in high concentrations in surface waters due to its unchanged excretion and incomplete degradation in wastewater treatment plants. This study investigated the degradation of valsartan and identified 14 degradation byproducts. The acute and chronic toxicity of these byproducts were evaluated in key organisms in the freshwater trophic chain.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Jiang Lin, Lianbao Chi, Qing Yuan, Busu Li, Mingbao Feng
Summary: This study investigated the photodegradation behavior and product formation of two representative pharmaceuticals in simulated estuary water. The study found that the formed transformation products of these pharmaceuticals have potential toxicity on marine organisms, including oxidative stress and damage to cellular components.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Hua Fang, Dongdong Jiang, Ye He, Siyi Wu, Yuehong Li, Ziqi Zhang, Haoting Chen, Zixin Zheng, Yan Sun, Wenxiang Wang
Summary: This study revealed that exposure to lower levels of air pollutants led to decreased pregnancy rates, with PM10, NO2, SO2, and CO emerging as the four most prominent pollutants. Individuals aged 35 and above exhibited heightened susceptibility to pollutants.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Ali Shaan Manzoor Ghumman, Rashid Shamsuddin, Amin Abbasi, Mohaira Ahmad, Yoshiaki Yoshida, Abdul Sami, Hamad Almohamadi
Summary: In this study, inverse vulcanized polysulfides (IVP) were synthesized by reacting molten sulfur with 4-vinyl benzyl chloride, and then functionalized using N-methyl D-glucamine (NMDG). The functionalized IVP showed a high mercury adsorption capacity and a machine learning model was developed to predict the amount of mercury removed. Furthermore, the functionalized IVP can be regenerated and reused, providing a sustainable and cost-effective adsorbent.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Rita Bonfiglio, Renata Sisto, Stefano Casciardi, Valeria Palumbo, Maria Paola Scioli, Erica Giacobbi, Francesca Servadei, Gerry Melino, Alessandro Mauriello, Manuel Scimeca
Summary: This study investigated the presence of aluminum in human colon cancer samples and its potential association with biological processes involved in cancer progression. Aluminum was found in tumor areas of 24% of patients and was associated with epithelial to mesenchymal transition (EMT) and cell death. Additional analyses revealed higher tumor mutational burden and mutations in genes related to EMT and apoptosis in aluminum-positive colon cancers. Understanding the molecular mechanisms of aluminum toxicity may improve strategies for the management of colon cancer patients.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)