The role of ribosomal proteins in the regulation of cell proliferation, tumorigenesis, and genomic integrity

Over-expressed RPL34 promotes malignant proliferation of non-small cell lung cancer cells

(2016) Shaoxing Yang et al.   GENE

Ribosomal protein S3 regulates GLI2-mediated osteosarcoma invasion

(2015) Hiroko Nagao-Kitamoto et al.   CANCER LETTERS

Emerging roles of nucleolar and ribosomal proteins in cancer, development, and aging

(2015) Hitomi Takada et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Ribosomopathies: how a common root can cause a tree of pathologies

(2015) Nadia Danilova et al.   Disease Models & Mechanisms

RPS24 knockdown inhibits colorectal cancer cell migration and proliferation in vitro

(2015) Yue Wang et al.   GENE

Overexpression of SYF2 correlates with enhanced cell growth and poor prognosis in human hepatocellular carcinoma

(2015) Shusen Zhang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Down-regulation of ribosomal protein S15A inhibits proliferation of human glioblastoma cells in vivo and in vitro via AKT pathway

(2015) Yiqun Yao et al.   TUMOR BIOLOGY

Decreased expression of RPS15A suppresses proliferation of lung cancer cells

(2015) Xinmin Zhao et al.   TUMOR BIOLOGY

Ribosomal proteins: functions beyond the ribosome

(2015) Xiang Zhou et al.   Journal of Molecular Cell Biology

F-box protein FBXO22 mediates polyubiquitination and degradation of KLF4 to promote hepatocellular carcinoma progression

(2015) Xin Tian et al.   Oncotarget

The RP-Mdm2-p53 Pathway and Tumorigenesis

(2015) Paula L. Miliani de Marval et al.   Oncotarget

MicroRNA-130a associates with ribosomal protein L11 to suppress c-Myc expression in response to UV irradiation

(2015) Yuhuang Li et al.   Oncotarget

RPL24: a potential therapeutic target whose depletion or acetylation inhibits polysome assembly and cancer cell growth

(2015) Kathleen A. Wilson-Edell et al.   Oncotarget

Human rpL3 plays a crucial role in cell response to nucleolar stress induced by 5-FU and L-OHP

(2015) Davide Esposito et al.   Oncotarget

Ribosomal proteins as unrevealed caretakers for cellular stress and genomic instability

(2015) Tae-Hyung Kim et al.   Oncotarget

RPL41, a Small Ribosomal Peptide Deregulated in Tumors, Is Essential for Mitosis and Centrosome Integrity

(2015) Shan Wang et al.   NEOPLASIA

Ribosomal protein L19 overexpression activates the unfolded protein response and sensitizes MCF7 breast cancer cells to endoplasmic reticulum stress-induced cell death

(2014) Mina Hong et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ribosomal Protein S15A Augments Human Osteosarcoma Cell Proliferation In Vitro

(2014) Chen Zhang et al.   CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

Germline Mutation of RPS20, Encoding a Ribosomal Protein, Causes Predisposition to Hereditary Nonpolyposis Colorectal Carcinoma Without DNA Mismatch Repair Deficiency

(2014) Taina T. Nieminen et al.   GASTROENTEROLOGY

High Frequency ofRPL22Mutations in Microsatellite-Unstable Colorectal and Endometrial Tumors

(2014) Ana M. Ferreira et al.   HUMAN MUTATION

The Mdm Network and Its Regulation of p53 Activities: A Rheostat of Cancer Risk

(2014) Christine M. Eischen et al.   HUMAN MUTATION

Ribosomal Proteins and Human Diseases: Pathogenesis, Molecular Mechanisms, and Therapeutic Implications

(2014) Wei Wang et al.   MEDICINAL RESEARCH REVIEWS

Alternative Mammalian Target of Rapamycin (mTOR) Signal Activation in Sorafenib-resistant Hepatocellular Carcinoma Cells Revealed by Array-based Pathway Profiling

(2014) Mari Masuda et al.   MOLECULAR & CELLULAR PROTEOMICS

Short Hairpin RNA Library-Based Functional Screening Identified Ribosomal Protein L31 That Modulates Prostate Cancer Cell Growth via p53 Pathway

(2014) Yojiro Maruyama et al.   PLoS One

Targeting RPL39 and MLF2 reduces tumor initiation and metastasis in breast cancer by inhibiting nitric oxide synthase signaling

(2014) B. Dave et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bypass of the pre-60S ribosomal quality control as a pathway to oncogenesis

(2014) S. O. Sulima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systemic DNA damage responses: organismal adaptations to genome instability

(2014) Maria A. Ermolaeva et al.   TRENDS IN GENETICS

Ribosomal protein S27-like is a physiological regulator of p53 that suppresses genomic instability and tumorigenesis

(2014) Xiufang Xiong et al.   eLife

Low expression of the X-linked ribosomal protein S4 in human serous epithelial ovarian cancer is associated with a poor prognosis

(2013) Serges P Tsofack et al.   BMC CANCER

Metallopanstimulin-1 regulates invasion and migration of gastric cancer cells partially through integrin β4

(2013) Zhong-Yin Yang et al.   CARCINOGENESIS

Targeting RNA polymerase I transcription and the nucleolus for cancer therapy

(2013) Ross D Hannan et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Ribosomal protein S14 silencing inhibits growth of acute myeloid leukemia transformed from myelodysplastic syndromes via activating p53

(2013) Li Wang et al.   Hematology

Ribosomal Protein S14 Negatively Regulates c-Myc Activity

(2013) Xiang Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Down-regulation of ribosomal protein L22 in non-small cell lung cancer

(2013) Mingxia Yang et al.   MEDICAL ONCOLOGY

Ribosomal protein S7 regulates arsenite-induced GADD45  expression by attenuating MDM2-mediated GADD45  ubiquitination and degradation

(2013) M. Gao et al.   NUCLEIC ACIDS RESEARCH

Regulation of the HDM2-p53 pathway by ribosomal protein L6 in response to ribosomal stress

(2013) Dongmei Bai et al.   NUCLEIC ACIDS RESEARCH

Ribosomal proteins L5 and L11 co-operatively inactivate c-Myc via RNA-induced silencing complex

(2013) J-M Liao et al.   ONCOGENE

The ribosomal protein S26 regulates p53 activity in response to DNA damage

(2013) D Cui et al.   ONCOGENE

Ribosomal Protein S27-Like in Colorectal Cancer: A Candidate for Predicting Prognoses

(2013) Chi-Jung Huang et al.   PLoS One

Ribosomal Proteins RPL37, RPS15 and RPS20 Regulate the Mdm2-p53-MdmX Network

(2013) Lilyn Daftuar et al.   PLoS One

Small Ribosomal Protein Subunit S7 Suppresses Ovarian Tumorigenesis through Regulation of the PI3K/AKT and MAPK Pathways

(2013) Ziliang Wang et al.   PLoS One

DNA Damage Sensing by the ATM and ATR Kinases

(2013) A. Marechal et al.   Cold Spring Harbor Perspectives in Biology

Over-expression of RPL23 in myelodysplastic syndromes is associated with apoptosis resistance of CD34+ cells and predicts poor prognosis and distinct response to CHG chemotherapy or decitabine

(2012) Lingyun Wu et al.   ANNALS OF HEMATOLOGY

Ribosomal protein S3 interacts with TRADD to induce apoptosis through caspase dependent JNK activation

(2012) Chang-Young Jang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ribosomal protein S3 localizes on the mitotic spindle and functions as a microtubule associated protein in mitosis

(2012) Chang-Young Jang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inactivation of ribosomal protein L22 promotes transformation by induction of the stemness factor, Lin28B

(2012) S. Rao et al.   BLOOD

Inhibition of RNA Polymerase I as a Therapeutic Strategy to Promote Cancer-Specific Activation of p53

(2012) Megan J. Bywater et al.   CANCER CELL

Ribosome Biogenesis and Control of Cell Proliferation: p53 Is Not Alone

(2012) G. Donati et al.   CANCER RESEARCH

Human rpL3 induces G₁/S arrest or apoptosis by modulating p21waf1/cip1levels in a p53-independent manner

(2012) Annapina Russo et al.   CELL CYCLE

Ribosomal Protein L17, RpL17, is an Inhibitor of Vascular Smooth Muscle Growth and Carotid Intima Formation

(2012) Elaine M. Smolock et al.   CIRCULATION

Prognostic significance and function of phosphorylated ribosomal protein S6 in esophageal squamous cell carcinoma

(2012) Seok-Hyung Kim et al.   MODERN PATHOLOGY

Silencing expression of ribosomal protein L26 and L29 by RNA interfering inhibits proliferation of human pancreatic cancer PANC-1 cells

(2012) Chaodong Li et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Exome sequencing identifies mutation in CNOT3 and ribosomal genes RPL5 and RPL10 in T-cell acute lymphoblastic leukemia

(2012) Kim De Keersmaecker et al.   NATURE GENETICS

Ribosomal protein S14 unties the MDM2–p53 loop upon ribosomal stress

(2012) X Zhou et al.   ONCOGENE

Identification of ribosomal protein S25 (RPS25)–MDM2–p53 regulatory feedback loop

(2012) X Zhang et al.   ONCOGENE

The Structure and Function of the Eukaryotic Ribosome

(2012) D. N. Wilson et al.   Cold Spring Harbor Perspectives in Biology

Ribosomal protein S3 is phosphorylated by Cdk1/cdc2 during G2/M phase

(2011) In-Soo Yoon et al.   BMB Reports

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Knockdown of metallopanstimulin-1 inhibits NF-κB signaling at different levels: The role of apoptosis induction of gastric cancer cells

(2011) Zhong-Yin Yang et al.   INTERNATIONAL JOURNAL OF CANCER

Interplay between Ribosomal Protein S27a and MDM2 Protein in p53 Activation in Response to Ribosomal Stress

(2011) Xiao-Xin Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective inhibition of rRNA transcription downregulates E2F-1: a new p53-independent mechanism linking cell growth to cell proliferation

(2011) Giulio Donati et al.   JOURNAL OF CELL SCIENCE

The HBx protein of hepatitis B virus regulates the expression, intracellular distribution and functions of ribosomal protein S27a

(2011) G. Fatima et al.   JOURNAL OF GENERAL VIROLOGY

Ribosomal protein RPL41 induces rapid degradation of ATF4, a transcription factor critical for tumour cell survival in stress

(2011) Aiyuan Wang et al.   JOURNAL OF PATHOLOGY

Ribosomal Protein L11 Recruits miR-24/miRISC To Repress c-Myc Expression in Response to Ribosomal Stress

(2011) K. B. Challagundla et al.   MOLECULAR AND CELLULAR BIOLOGY

Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer

(2011) Kai Wang et al.   NATURE GENETICS

Recruitment of RPL11 at promoter sites of p53-regulated genes upon nucleolar stress through NEDD8 and in an Mdm2-dependent manner

(2011) B Mahata et al.   ONCOGENE

RPL36 as a prognostic marker in hepatocellular carcinoma

(2011) Myeong Jun Song et al.   PATHOLOGY INTERNATIONAL

Downregulation of RPL6 by siRNA Inhibits Proliferation and Cell Cycle Progression of Human Gastric Cancer Cell Lines

(2011) Qiong Wu et al.   PLoS One

Ribosomal Protein Genes RPS10 and RPS26 Are Commonly Mutated in Diamond-Blackfan Anemia

(2010) Leana Doherty et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Ribosomal protein L6 promotes growth and cell cycle progression through upregulating cyclin E in gastric cancer cells

(2010) Yawen Gou et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ribosomopathies: human disorders of ribosome dysfunction

(2010) A. Narla et al.   BLOOD

An ARF-Independent c-MYC-Activated Tumor Suppression Pathway Mediated by Ribosomal Protein-Mdm2 Interaction

(2010) Everardo Macias et al.   CANCER CELL

New insights into 5q- syndrome as a ribosomopathy

(2010) Jillian L. Barlow et al.   CELL CYCLE

Ribosomal protein L37 and the p53 network

(2010) Lilyn Daftuar et al.   CELL CYCLE

Depletion of ribosomal protein L37 occurs in response to DNA damage and activates p53 through the L11/MDM2 pathway

(2010) Susana Llanos et al.   CELL CYCLE

The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation

(2010) Jiangbin Ye et al.   EMBO JOURNAL

Perturbation of 60 S Ribosomal Biogenesis Results in Ribosomal Protein L5- and L11-dependent p53 Activation

(2010) Xiao-Xin Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ribosomal Protein L11 Associates with c-Myc at 5 S rRNA and tRNA Genes and Regulates Their Expression

(2010) Mu-Shui Dai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Nucleolus under Stress

(2010) Séverine Boulon et al.   MOLECULAR CELL

Ribosomal protein S27-like and S27 interplay with p53-MDM2 axis as a target, a substrate and a regulator

(2010) X Xiong et al.   ONCOGENE

PIM1 kinase is destabilized by ribosomal stress causing inhibition of cell cycle progression

(2010) V Iadevaia et al.   ONCOGENE

Silencing of Ribosomal Protein S9 Elicits a Multitude of Cellular Responses Inhibiting the Growth of Cancer Cells Subsequent to p53 Activation

(2010) Mikael S. Lindström et al.   PLoS One

Dystroglycan and Mitochondrial Ribosomal Protein L34 Regulate Differentiation in the Drosophila Eye

(2010) Yougen Zhan et al.   PLoS One

Depletion of ribosomal protein L8 impairs Drosophila development and is associated with apoptosis

(2010) HongYan Li et al.   Science China-Life Sciences

Identification of suitable reference genes for gene expression studies of human serous ovarian cancer by real-time polymerase chain reaction

(2009) Yan-Li Li et al.   ANALYTICAL BIOCHEMISTRY

Signaling to p53: Ribosomal Proteins Find Their Way

(2009) Yanping Zhang et al.   CANCER CELL

Mdm2 Affects Genome Stability Independent of p53

(2009) A. Bouska et al.   CANCER RESEARCH

Modes of p53 Regulation

(2009) Jan-Philipp Kruse et al.   CELL

Ribosomal protein S3: A multi-functional protein that interacts with both p53 and MDM2 through its KH domain

(2009) Sridevi Yadavilli et al.   DNA REPAIR

Rplp1 bypasses replicative senescence and contributes to transformation

(2009) A. Artero-Castro et al.   EXPERIMENTAL CELL RESEARCH

Down-regulation of ribosomal protein L7A in human osteosarcoma

(2009) Shui-er Zheng et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Human ribosomal protein S13 promotes gastric cancer growth through down-regulating p27Kip1

(2009) Xueyan Guo et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

RPS2: a novel therapeutic target in prostate cancer

(2009) Min Wang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

The p53 Tumor Suppressor Causes Congenital Malformations in Rpl24-Deficient Mice and Promotes Their Survival

(2009) M. Barkic et al.   MOLECULAR AND CELLULAR BIOLOGY

How Common Are Extraribosomal Functions of Ribosomal Proteins?

(2009) Jonathan R. Warner et al.   MOLECULAR CELL

Ribosomal Protein S7 Is Both a Regulator and a Substrate of MDM2

(2009) Yan Zhu et al.   MOLECULAR CELL

Absence of nucleolar disruption after impairment of 40S ribosome biogenesis reveals an rpL11-translation-dependent mechanism of p53 induction

(2009) Stefano Fumagalli et al.   NATURE CELL BIOLOGY

Lin28 promotes transformation and is associated with advanced human malignancies

(2009) Srinivas R Viswanathan et al.   NATURE GENETICS

A p53-dependent mechanism underlies macrocytic anemia in a mouse model of human 5q– syndrome

(2009) Jillian L Barlow et al.   NATURE MEDICINE

Ribosomal Protein L5 and L11 Mutations Are Associated with Cleft Palate and Abnormal Thumbs in Diamond-Blackfan Anemia Patients

(2008) Hanna T. Gazda et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Abnormalities of the large ribosomal subunit protein, Rpl35a, in Diamond-Blackfan anemia

(2008) J. E. Farrar et al.   BLOOD

Haploinsufficiency of RPS14 in 5q− syndrome is associated with deregulation of ribosomal- and translation-related genes

(2008) Andrea Pellagatti et al.   BRITISH JOURNAL OF HAEMATOLOGY

Pim Kinases Promote Cell Cycle Progression by Phosphorylating and Down-regulating p27Kip1 at the Transcriptional and Posttranscriptional Levels

(2008) D. Morishita et al.   CANCER RESEARCH

Elevated Phospho-S6 Expression Is Associated with Metastasis in Adenocarcinoma of the Lung

(2008) J. M. McDonald et al.   CLINICAL CANCER RESEARCH

Mutation of ribosomal protein RPS24 in Diamond-Blackfan anemia results in a ribosome biogenesis disorder

(2008) V. Choesmel et al.   HUMAN MOLECULAR GENETICS

Ribosomal Protein S9 Is a Novel B23/NPM-binding Protein Required for Normal Cell Proliferation

(2008) Mikael S. Lindström et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Faecal ribosomal protein L19 is a genetic prognostic factor for survival in colorectal cancer

(2008) C.-J Huang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The potential role of ribosomal protein S5 on cell cycle arrest and initiation of murine erythroleukemia cell differentiation

(2008) Christina N. Matragkou et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Mdm2 Regulates p53 mRNA Translation through Inhibitory Interactions with Ribosomal Protein L26

(2008) Yaara Ofir-Rosenfeld et al.   MOLECULAR CELL

Identification of RPS14 as a 5q- syndrome gene by RNA interference screen

(2008) Benjamin L. Ebert et al.   NATURE

Suppression of Myc oncogenic activity by ribosomal protein haploinsufficiency

(2008) Maria Barna et al.   NATURE

A ribosomal protein L23-nucleophosmin circuit coordinates Miz1 function with cell growth

(2008) Michael Wanzel et al.   NATURE CELL BIOLOGY

Stromal gene expression predicts clinical outcome in breast cancer

(2008) Greg Finak et al.   NATURE MEDICINE

Ribosomal protein S6 is a selective mediator of TRAIL-apoptotic signaling

(2008) Y-J Jeon et al.   ONCOGENE