期刊
SCIENCE CHINA-LIFE SCIENCES
卷 59, 期 12, 页码 1297-1304出版社
SCIENCE PRESS
DOI: 10.1007/s11427-016-0097-y
关键词
malignant pleural effusion; interleukin 17; Th9 cells
类别
资金
- National Natural Science Foundation of China [91442109, 31470883, 81270149, 81272591]
- National Basic Research Program of China [2012CB518706]
Th17 and Th9 cells have been demonstrated to possess immune regulatory functions in malignant pleural effusion (MPE). However, whether IL-17 can affect differentiation and function of Th9 cells in MPE remains unknown. The objective of the present study was to explore the impact of IL-17 on the in vivo differentiation of Th9 cells in relation to Th2 cells in a murine model of MPE, and to explore whether IL-17 inhibits MPE formation via IL-9. dependent mechanism. It was found that Th9 and Th2 cells were decreased in MPE from IL-17(-/-) mice as compared with wild type mice. IL-17 deficiency inhibited Th9 and Th2 cell differentiation via suppressing transcription factors IRF4 and GATA-3, respectively. IL-17 deficiency enhanced MPE formation by promoting angiogenesis and proliferation of pleural tumors, and thus accelerated the death of mice bearing MPE. The in vivo administration of anti-IL-9 neutralizing mAb accelerated the death of WT mice; whereas administration of exogenous IL-9 improved the survival of IL-17-/-mice. Our data provide the first definitive evidence that IL-17 promotes the differentiation of Th9 and Th2 cells in MPE. Our findings also demonstrate that IL-17 inhibits the formation of MPE and improves the survival of mice bearing MPE via an IL-9-dependent mechanism.
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