Article
Cardiac & Cardiovascular Systems
Alexander C. Razavi, S. M. Iftekhar Uddin, Zeina A. Dardari, Daniel S. Berman, Matthew J. Budoff, Michael D. Miedema, Albert D. Osei, Olufunmilayo H. Obisesan, Khurram Nasir, Alan Rozanski, John A. Rumberger, Leslee J. Shaw, Laurence S. Sperling, Seamus P. Whelton, Martin Bodtker Mortensen, Michael J. Blaha, Omar Dzaye
Summary: Coronary artery calcium (CAC) is associated with the risk of incident sudden cardiac death (SCD), particularly among primary prevention patients with low-intermediate risk. Stratification of SCD risk through CAC measurement can identify patients who are most likely to benefit from further downstream testing in the early stages of coronary heart disease (CHD).
JACC-CARDIOVASCULAR IMAGING
(2022)
Article
Cardiac & Cardiovascular Systems
Francesco Gentile, Vincenzo Castiglione, Raffaele De Caterinao
Summary: CAAs are a group of congenital conditions characterized by abnormal origin or course of the 3 main epicardial coronary arteries. While they have been identified as a common underlying condition in young athletes, their recognition among adults has increased with the widespread use of invasive and noninvasive coronary imaging. The clinical correlates and therapeutic choices for CAAs remain poorly understood, with studies suggesting that multimodality imaging may play a key role in management.
Article
Cardiac & Cardiovascular Systems
Linfeng Li, Xiangwang He, Min Liu, Libing Yun, Bin Cong
Summary: This study found that cardiac miR-126-5p and miR-499a-5p were downregulated in CAD-SCD patients, and their combination had good diagnostic capabilities. These miRNAs are expected to serve as novel biomarkers for CAD-SCD and help differentiate the detailed causes in SCD cases.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Katherine A. Martinez, J. Martijn Bos, Aaron L. Baggish, Dermot M. Phelan, Kathryn E. Tobert, Darrel B. Newman, Erica Scherer, Bradley J. Petek, Michael J. Ackerman, Matthew W. Martinez
Summary: Recent data suggest that the cardiac event rates for athletes with genetic heart diseases (GHDs) may be lower than previously thought, indicating a need to reconsider the restrictions on their participation in competitive sports. This study evaluated clinical outcomes among American university and professional athletes with GHDs, finding that after shared decision making, the return-to-play experiences were associated with low rates of nonfatal cardiac events.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Stefania Rizzo, Monica De Gaspari, Carla Frescura, Massimo Padalino, Gaetano Thiene, Cristina Basso
Summary: This chapter explores the wide spectrum of congenital coronary artery anomalies (CAA), ranging from asymptomatic cases to those with a risk of sudden cardiac death (SCD). It discusses normal coronary artery anatomy, pathology of CAA at risk of SCD, and shares experiences with young individuals and athletes who have succumbed to SCD.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Medicine, Legal
Qing Zhang, Yan He, Hongfei Xu, Lijuan Li, Yadong Guo, Jianhua Zhang, Lei Cheng, Huan Yu, Yunda Dai, Qi Yang, Zhenzhen Yang, Chengtao Li, Suhua Zhang, Shaohua Zhu, Bin Luo, Yuzhen Gao
Summary: This study identified an association between the rs3061890 variant in the promoter region of STIM1 and susceptibility to SCD-CAD in Chinese Han populations. The homozygote del/del genotype increased the risk for SCD-CAD, with the risk allele showing lower transcriptional capacity. Genotype-phenotype correlation studies revealed an association between STIM1 expression and the rs3061890 genotype.
FORENSIC SCIENCE INTERNATIONAL
(2021)
Review
Cardiac & Cardiovascular Systems
Jennie Han, Andrea Lalario, Enzo Merro, Gianfranco Sinagra, Sanjay Sharma, Michael Papadakis, Gherardo Finocchiaro
Summary: Exercise has numerous benefits for cardiovascular and general health, but even seemingly healthy athletes can experience sudden cardiac death (SCD). The causes of SCD in athletes vary depending on age, with older individuals commonly affected by atherosclerotic coronary artery disease, while younger individuals are more likely to have primary cardiomyopathies and ion channelopathies. Preventing SCD in athletes requires early identification of arrhythmogenic diseases through cardiac screening and effective resuscitation measures such as widespread use of automatic external defibrillators and CPR training. This review discusses the epidemiology, causes, and preventive strategies for SCD in athletes.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Article
Cardiac & Cardiovascular Systems
Juha H. Vaehaetalo, Lauri T. A. Holmstroem, Katri Pylkaes, Sini Skarp, Katja Porvari, Lasse Pakanen, Kari S. Kaikkonen, Juha S. Perkioemaeki, Risto Kerkelae, Heikki V. Huikuri, Robert J. Myerburg, M. Juhani Junttila
Summary: This study aims to investigate the genetic background of cardiac hypertrophy in sudden cardiac death (SCD) victims with single vessel coronary artery disease (CAD). The study found that rare variants associated with cardiomyopathies were common among SCD victims with single vessel disease and myocardial hypertrophy, suggesting that these variants may increase the risk for fatal arrhythmias and SCD.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Steve Bibevski, Mark Ruzmetov, Immanuel I. Turner, Frank G. Scholl
Summary: Anomalous aortic origin of right coronary artery (AAORCA) is a congenital heart lesion that can lead to coronary ischemia and sudden death. This study analyzed patients with AAORCA managed at the center, finding that 30% underwent surgical management while 70% were monitored nonsurgically. The outcomes in the midterm were excellent with functional testing showing no evidence of ischemia in the surgical patients.
ANNALS OF THORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Linda C. Schroder, Arttu Holkeri, Antti Eranti, M. Anette E. Haukilahti, Tuomas Kerola, Tuomas Kentta, Kai Noponen, Tapio Seppanen, Harri Rissanen, Markku Heliovaara, Paul Knekt, M. Juhani Junttila, Heikki Huikuri, Aapo L. Aro
Summary: This study investigated the occurrence and prognostic implications of Poor R-wave progression (PRWP) in a general population. The findings suggest that PRWP is associated with an increased risk of cardiac death and all-cause mortality.
Article
Cardiac & Cardiovascular Systems
Jenni J. Hekkanen, Tuomas Kentta, Mikko P. Tulppo, Antti M. Kiviniemi, Olavi H. Ukkola, M. Juhani Junttila, Heikki Huikuri, Juha S. Perkiomaki
Summary: This study evaluated the prognostic significance of temporal variability of P-wave morphology in relation to cardiac autonomic regulation. The results showed that the variability of P-wave morphology, when combined with cardiac autonomic regulation, independently predicts the risk of sudden cardiac death in patients with coronary artery disease.
Article
Cardiac & Cardiovascular Systems
Silvia Castelletti, Belinda Gray, Cristina Basso, Elijah R. Behr, Lia Crotti, Perry M. Elliott, Cecilia M. Gonzalez Corcia, Flavio D'Ascenzi, Jodie Ingles, Bart Loeys, Antonis Pantazis, Guido E. Pieles, Johan Saenen, Georgia Sarquella Brugada, Maria Sanz de la Garza, Sanjay Sharma, Emeline M. Van Craenebroek, Arthur Wilde, Michael Papadakis
Summary: Sports Cardiology practice involves evaluating athletes for genetic cardiac conditions that may lead to serious heart problems. Genetic testing has become more accessible and affordable, but its role and significance in athletes with suspected cardiac conditions are still unclear.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Article
Medicine, General & Internal
Dmitrij Fomin, Sigitas Chmieliauskas, Sigitas Laima, Jurgita Stasiuniene, Algimantas Jasulaitis, Pranas Serpytis
Summary: The present study aimed to assess the prevalence and causal relationship of alcohol intake prior to sudden cardiac death events in patients with coronary artery disease. The study found that in Lithuania, one out of every three sudden cardiac deaths in coronary artery disease patients had signs of antemortem alcohol consumption. Men and younger patients were more likely to consume alcohol, and alcohol positivity was more common during the winter months and holidays.
Article
Cardiac & Cardiovascular Systems
Yan Dong, Wen Yang, Chongchong Chen, Jiamei Ji, Wei Zheng, Fengxiang Zhang, Bing Yang, Xiaorong Li, Xiujuan Zhou
Summary: This study aimed to validate three SCD risk stratifications in Chinese HCM patients, with the 2020 AHA/ACC guideline showing better discrimination than previous guidelines in identifying high-risk patients.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Medicine, Legal
Xiaoyuan Zhen, Wenfeng Zhao, Jiawen Wang, Lijuan Li, Yan He, Jianhua Zhang, Chengtao Li, Suhua Zhang, Bin Luo, Jiang Huang, Yuzhen Gao
Summary: Sudden cardiac death (SCD) is a significant public health problem and has a higher incidence in males compared to females. This study analyzed the (CAG)(n) repeat polymorphism within the Androgen Receptor (AR) gene and found that it is associated with SCD-CAD risk in Chinese populations, with different effects in males and females.
FORENSIC SCIENCE INTERNATIONAL
(2023)
