☆ 4.8 Article

Exposure to Parental Smoking in Childhood Is Associated With Increased Risk of Carotid Atherosclerotic Plaque in Adulthood The Cardiovascular Risk in Young Finns Study

CIRCULATION (2015)

期刊

CIRCULATION

卷 131, 期 14, 页码 1239-1246

出版社

LIPPINCOTT WILLIAMS & WILKINS

DOI: 10.1161/CIRCULATIONAHA.114.013485

关键词

child; epidemiology; plaque, atherosclerotic; risk factors; tobacco smoke pollution

类别

Cardiac & Cardiovascular Systems Peripheral Vascular Disease

资金

Academy of Finland [134309, 126925, 121584 124282, 129378, 117787, 41071]
Social Insurance Institution of Finland
Kuopio, Tampere, and Turku University Hospital Medical Funds
Juho Vainio Foundation
Paavo Nurmi Foundation
Finnish Foundation of Cardiovascular Research
Finnish Cultural Foundations
Tampere Tuberculosis Foundation
Emil Aaltonen Foundation
National Heart Foundation of Australia [PH 11H 6047]
National Health and Medical Research Council [APP1037559]

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摘要

Background-The association between passive smoking exposure in childhood and adverse cardiovascular health in adulthood is not well understood. Using a 26-year follow-up study, we examined whether childhood exposure to passive smoking was associated with carotid atherosclerotic plaque in young adults. Methods and Results-Participants were from the Cardiovascular Risk in Young Finns Study (n=2448). Information on childhood exposure to parental smoking was collected in 1980 and 1983. Carotid ultrasound data were collected in adulthood in 2001 or 2007. Childhood serum cotinine levels from 1980 were measured from frozen samples in 2014 (n=1578). The proportion of children with nondetectable cotinine levels was highest among households in which neither parent smoked (84%), was decreased in households in which 1 parent smoked (62%), and was lowest among households in which both parents smoked (43%). Regardless of adjustment for potential confounding and mediating variables, the relative risk of developing carotid plaque in adulthood increased among those children with 1 or both parents who smoked (relative risk, 1.7; 95% confidence interval, 1.0-2.8; P=0.04). Although children whose parents exercised good smoking hygiene (smoking parents whose children had nondetectable cotinine levels) had increased risk of carotid plaque compared with children with nonsmoking parents (relative risk, 1.6; 95% confidence interval, 0.6-4.0; P=0.34), children of smoking parents with poor smoking hygiene (smoking parents whose children had detectable serum cotinine levels) had substantially increased risk of plaque as adults (relative risk, 4.0; 95% confidence interval, 1.7-9.8; P=0.002). Conclusions-Children of parents who smoke have increased risk of developing carotid atherosclerotic plaque in adulthood. However, parents who exercise good smoking hygiene can lessen their child's risk of developing plaque.

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Factors related to caregivers' risk perception of secondhand smoke exposure on children's health

Xavier Continente, Alejandro Rodriguez, Monica Perez-Rios, Anna Schiaffino, Esteve Fernandez, Maria J. Lopez

Summary: Factors associated with higher caregivers' risk perception of secondhand smoke exposure on children included high education level, living in a non-smoking family unit, having smoke-free rules at home, and having only girls in the family. This study highlights the need for interventions with a social equity perspective to reduce children's secondhand smoke exposure.

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