期刊
SCIENCE
卷 354, 期 6311, 页码 459-465出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aaf2156
关键词
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资金
- CONICET fellowships
- Howard Hughes Medical Institute SIRS grant [55007652]
- Argentine Agency for the Promotion of Science and Technology grant [PICT2013-1685]
- NIH grant FIRCA [R03TW008607-01]
Experience shapes the development and connectivity of adult-born granule cells (GCs) through mechanisms that are poorly understood. We examined the remodeling of dentate gyrus microcircuits in mice in an enriched environment (EE). Short exposure to EE during early development of new GCs accelerated their functional integration. This effect was mimicked by in vivo chemogenetic activation of a limited population of mature GCs. Slice recordings showed that mature GCs recruit parvalbumin g-aminobutyric acid-releasing interneurons (PV-INs) that feed back onto developing GCs. Accordingly, chemogenetic stimulation of PV-INs or direct depolarization of developing GCs accelerated GC integration, whereas inactivation of PV-INs prevented the effects of EE. Our results reveal a mechanism for dynamic remodeling in which experience activates dentate networks that prime young GCs through a disynaptic feedback loop mediated by PV-INs.
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