Article
Medicine, General & Internal
Ewa Dudzinska, Kinga Szymona, Jacek Bogucki, Wojciech Koch, Ewelina Cholewinska, Robert Sitarz, Katarzyna Ognik
Summary: The study found that oxidative stress markers in the plasma of patients with schizophrenia were elevated, indicating lipid damage and decreased antioxidant capacity. In addition, there was a positive correlation between CRP and the PANSS P scale.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Clinical Neurology
T. V. Zhilyaeva, E. D. Kasyanov, G. V. Rukavishnikov, A. S. Piatoikina, A. P. Bavrina, O. V. Kostina, E. S. Zhukova, T. G. Shcherbatyuk, G. E. Mazo
Summary: This study investigated the correlations and factor analysis of biochemical markers related to pterin metabolism, inflammation, and oxidative stress in patients with schizophrenia. It found significant correlations within the groups of pterin metabolism, inflammatory markers, and redox imbalance, suggesting that each component contributes to the pathology of schizophrenia.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2023)
Article
Psychiatry
Gianluca Pandolfo, Giovanni Genovese, Antonio Bruno, Domenica Campolo, Valeria Tigano, Mariateresa Cristani, Marco Casciaro, Giovanni Pioggia, Sebastiano Gangemi
Summary: The pathophysiology of schizophrenia is still not well understood. Genetic factors and oxidative stress play key roles in its development and progression. Oxidative stress leads to the continuous production of oxidation products, such as AGEs and AOPPs, which interact with their receptors, amplifying the production of reactive oxygen species (ROS) and pro-inflammatory cytokines. In this study, plasma levels of AGEs and AOPPs were found to be significantly higher in schizophrenia patients compared to controls, confirming their involvement in mental disorders. Antioxidant nutraceuticals and a healthy lifestyle could reduce oxidative stress and alleviate schizophrenia symptoms.
PSYCHIATRY RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Valtieri Bortoluzzi Lima, Altevir Rossato Viana, Daniel Santos, Narieli Felipetto, Natalia Fernandes Mezzomo, Adriana Maria Zago, Erico Marlon Moraes Flores, Alencar Kolinski Machado, Alexandre Krause, Luis Ricardo Peroza, Larissa Finger Schaffer, Luciana Maria Fontanari Krause
Summary: The present study investigated the effects of Harpagophytum procumbens (HP) on microglial activation and neurodegenerative diseases. The results suggest that HP can reduce inflammation-induced oxidative stress and cell proliferation, and it may have potential as an adjuvant treatment for neurodegenerative and neuropsychiatric disorders.
NEUROCHEMICAL RESEARCH
(2023)
Article
Psychiatry
Haiting Xu, Yanyan Wei, Lina Zheng, Hua Zhang, Tangren Luo, Hongjuan Li, Jinbao Ma, Jingxu Chen
Summary: Inflammation and oxidative stress are major hypothetical causes of schizophrenia. This study found that UCB has a protective effect on the acute stage of schizophrenia, likely by affecting proinflammatory processes. The combination of MLR, MPV, PLR, and UCB could be used to predict the acute stage of schizophrenia.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Biochemistry & Molecular Biology
Michael Maes, Decio Sabbatini Barbosa, Abbas F. Almulla, Buranee Kanchanatawan
Summary: This study aimed to develop a precision medicine model for temporal lobe epilepsy (TLE) and associated mental comorbidities. The results showed that oxidative stress and antioxidant biomarkers could explain a large part of the variability in TLE and psychopathology features. Based on these findings, a new phenotype class was constructed, characterized by increased severity of TLE, psychopathology, and oxidative stress features, and decreased antioxidant defenses. Furthermore, increased levels of malondialdehyde, decreased antioxidants, and nitric oxide metabolites were associated with increased episode frequency.
Article
Pharmacology & Pharmacy
Xiying Wang, Jia Liu, Zhiping Dai, Yuxiu Sui
Summary: Andrographolide, a compound from Andrographis paniculate, shows potential in ameliorating schizophrenia-like behaviors induced by PCP through inhibition of inflammation and oxidative stress. It not only inhibits the production of inflammatory cytokines but also enhances antioxidative enzyme activity and NRF-2 pathway, leading to improvements in schizophrenia-like symptoms.
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Marika Cordaro, Angela Trovato Salinaro, Rosalba Siracusa, Ramona D'Amico, Daniela Impellizzeri, Maria Scuto, Maria Laura Ontario, Roberto Crea, Salvatore Cuzzocrea, Rosanna Di Paola, Roberta Fusco, Vittorio Calabrese
Summary: Traumatic brain injuries are a significant public health issue with long-term consequences such as cerebral atrophy and increased risk of dementia and Alzheimer's Disease. Hidrox (R) treatment has shown benefits in reducing TBI-induced neurodegeneration and improving cognitive function and memory impairment.
Review
Psychiatry
Alex J. Murray, Jack C. Rogers, Mohammad Zia Ul Haq Katshu, Peter F. Liddle, Rachel Upthegrove
Summary: Schizophrenia is associated with increased oxidative stress, potentially leading to a worsening of symptoms and poor outcomes. Targeting oxidative stress may be a promising approach for future pharmacotherapy in schizophrenia.
FRONTIERS IN PSYCHIATRY
(2021)
Review
Biochemistry & Molecular Biology
Michal Krawczyk, Izabela Burzynska-Pedziwiatr, Lucyna A. Wozniak, Malgorzata Bukowiecka-Matusiak
Summary: This review explores the potential of polyphenol antioxidants in improving antidiabetic therapy, including attenuation of oxidative stress, improvement of insulin sensitivity, and preservation of beta-cell function.
Article
Biochemistry & Molecular Biology
Shasha Chen, Na Hu, Honglun Wang, Yongning Wu, Guoliang Li
Summary: Pn3G5G, derived from LRF, exhibited strong antioxidant capacity and protective effects on CML-treated cells. In aging mice, Pn3G5G improved cognitive impairment, neuroinflammation, and neuronal apoptosis. These findings suggest the potential development of Pn3G5G as a healthcare product or potent dietary supplement with antioxidant and neuroprotective effects.
Article
Biochemistry & Molecular Biology
Diego Romero-Miguel, Marta Casquero-Veiga, Javier Fernandez, Nicolas Lamanna-Rama, Vanessa Gomez-Rangel, Carlos Galvez-Robleno, Cristina Santa-Marta, Claudio J. Villar, Felipe Lombo, Raquel Abalo, Manuel Desco, Maria Luisa Soto-Montenegro
Summary: N-acetylcysteine (NAC) administration during pregnancy can prevent inflammation-induced brain changes and improve memory deficits in offspring. This suggests a potential role of NAC in modulating the microbiota-gut-brain axis.
Review
Pharmacology & Pharmacy
Ammara Saleem, Muhammad Furqan Akhtar
Summary: Schizophrenia is a chronic mental and behavioral disorder characterized by symptoms such as hallucinations, delusions, disorganized thoughts and social withdrawal. This study explores the potential of phytochemicals as new drug candidates for the treatment and management of schizophrenia. These phytochemicals can affect neurotransmission, cell signaling pathways, immune system activation, and oxidative stress.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Renata Saucedo, Clara Ortega-Camarillo, Aldo Ferreira-Hermosillo, Mary Flor Diaz-Velazquez, Claudia Meixueiro-Calderon, Jorge Valencia-Ortega
Summary: Gestational diabetes mellitus (GDM) is a common pregnancy complication related to oxidative stress and inflammation. This review evaluates the mechanisms through which oxidative stress and inflammation contribute to the development of GDM. Additionally, it discusses therapies that can modulate oxidative stress and inflammation.
Review
Clinical Neurology
Daniella Dwir, Ines Khadimallah, Lijing Xin, Meredith Rahman, Fei Du, Dost Ongur, Kim Q. Do
Summary: Redox biology and immune signaling are important in brain function and are implicated in neuropsychiatric conditions such as schizophrenia, bipolar disorder, autism, and epilepsy. This article reviews the literature on these topics, discusses their implications for the pathophysiology of schizophrenia, and explores the potential for novel treatment interventions targeting redox and immune signaling.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2023)
