Article
Cardiac & Cardiovascular Systems
Anida Velagic, Mandy Li, Minh Deo, Jasmin Chendi Li, Helen Kiriazis, Daniel G. Donner, Dovile Anderson, Miles J. De Blasio, Owen L. Woodman, Barbara K. Kemp-Harper, Cheng Xue Qin, Rebecca H. Ritchie
Summary: This study investigated the effects of a high-fat diet and low-dose streptozotocin treatment on type 2 diabetes mellitus-related cardiomyopathy in a rat model. The results showed that a high-sucrose diet combined with low-dose streptozotocin treatment closely resembled the phenotype of type 2 diabetes mellitus-induced cardiomyopathy. These findings highlight the importance of sucrose content in diet composition in preclinical studies of diabetic cardiomyopathy.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Critical Care Medicine
Sarah J. Beesley, Jeff Sorensen, Allan J. Walkey, Joseph E. Tonna, Michael J. Lanspa, Ellie Hirshberg, Colin K. Grissom, Benjamin D. Horne, Rebecca Burk, Theodore P. Abraham, Robert Paine, Samuel M. Brown
Summary: Septic cardiomyopathy is associated with long-term outcomes after sepsis, with a linear and non-linear association between left ventricular global longitudinal systolic strain and major adverse cardiovascular events. This relationship is particularly strong in patients with pre-existing cardiac disease, showing a U-shaped association, especially among younger patients with more comorbidities.
CRITICAL CARE MEDICINE
(2021)
Article
Peripheral Vascular Disease
Yue Deng, Wei Liu, Xinchun Yang, Zihong Guo, Juyan Zhang, Rongjie Huang, Xiaomin Yang, Chunli Yu, Jing Yu, Jun Cai
Summary: Intensive systolic blood pressure lowering can protect against the development of left ventricular hypertrophy in older hypertensive patients, but this favorable effect cannot fully account for the reduction in cardiovascular events associated with intensive systolic blood pressure lowering.
Article
Cardiac & Cardiovascular Systems
Ricardo Carnicer, Drew Duglan, Klemen Ziberna, Alice Recalde, Svetlana Reilly, Jillian N. Simon, Simona Mafrici, Ritu Arya, Esther Rosello-Lleti, Surawee Chuaiphichai, Damian Tyler, Craig A. Lygate, Keith M. Channon, Barbara Casadei
Summary: Myocardial BH4 was found to prevent and reverse left ventricular diastolic and systolic dysfunction associated with diabetes by increasing insulin-independent myocardial glucose uptake and utilization. This mechanism highlights the potential for GCH1/BH4-based therapeutics in human diabetic cardiomyopathy.
CIRCULATION RESEARCH
(2021)
Review
Cardiac & Cardiovascular Systems
Mohapradeep Mohan, Adel Dihoum, Ify R. Mordi, Anna-Maria Choy, Graham Rena, Chim C. Lang
Summary: Left ventricular hypertrophy is common in patients with type 2 diabetes and is a strong predictor of adverse cardiovascular outcomes, including heart failure. While antihypertensive treatment can reduce LVH and cardiovascular morbidity and mortality, it is not completely effective. Other potential mechanisms such as inflammation, oxidative stress, AMP-activated kinase, and insulin resistance may also play a role in the development of LVH.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Miriam Longo, Lorenzo Scappaticcio, Paolo Cirillo, Antonietta Maio, Raffaela Carotenuto, Maria Ida Maiorino, Giuseppe Bellastella, Katherine Esposito
Summary: Diabetic cardiomyopathy (DC) is a significant complication of diabetes, characterized by chronic hyperglycemia and hyperinsulinemia. Lifestyle changes promoting healthy dietary patterns and physical activity, along with innovative anti-diabetes therapies, are current treatment strategies to protect the cardiovascular system.
Article
Multidisciplinary Sciences
Yiming Li, Cungang Wu, Yuhong Li
Summary: The global incidence of diabetes and its complications, particularly cardiovascular complications, is increasing. This study examined left ventricular function in individuals with type 2 diabetes mellitus (T2D) using automated cardiac motion quantification (aCMQ) and found significant differences in strain parameters among different disease stages and decreased parameters with longer disease duration. The study also demonstrated that aCMQ and tissue motion mitral annular displacement technique (TMAD) were effective in detecting altered left ventricular function in T2D patients, with high agreement and predictive value. Overall, this study highlights the importance of assessing and monitoring left ventricular function in T2D patients.
SCIENTIFIC REPORTS
(2023)
Article
Cell Biology
Xinyu Feng, Shanjie Wang, Xingjun Yang, Jie Lin, Wanrong Man, Yuan Dong, Yan Zhang, Zhijing Zhao, Haichang Wang, Dongdong Sun
Summary: Knockout of the Mst1 gene alleviates left ventricular remodeling and cardiac dysfunction in diabetic mice, while overexpression of Mst1 enhances mitochondrial fission in diabetic cardiomyopathy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Simon B. Ascher, James A. de Lemos, MinJae Lee, Elaine Wu, Elsayed Z. Soliman, Ian J. Neeland, Dalane W. Kitzman, Christie M. Ballantyne, Vijay Nambi, Anthony A. Killeen, Joachim H. Ix, Michael G. Shlipak, Jarett D. Berry
Summary: Intensive systolic blood pressure control can prevent malignant left ventricular hypertrophy and significantly reduce the risk of acute decompensated heart failure (ADHF) events and death among SPRINT participants.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Manpreet K. Virk, Muhammad Umair M. Mian, Dalia A. Bashir, John K. Wilkes, Tobias Schlingman, Saul Flores, Curtis Kennedy, Fong Lam, Ayse A. Arikan, Trung Nguyen, Krupa Mysore, Nhu Thao Nguyen Galvan, Jorge Coss-Bu, Saul J. Karpen, Sanjiv Harpavat, Moreshwar S. Desai
Summary: In children with biliary atresia, elevated serum bile acid levels are associated with abnormal left ventricular geometry, suggesting that bile acid excess may be a potential trigger for myocardial structural changes.
HEPATOLOGY COMMUNICATIONS
(2023)
Article
Pharmacology & Pharmacy
Raffaele Marfella, Lucia Scisciola, Nunzia D'Onofrio, Ciro Maiello, Maria Consiglia Trotta, Celestino Sardu, Iacopo Panarese, Franca Ferraraccio, Annalisa Capuano, Michelangela Barbieri, Maria Luisa Balestrieri, Claudio Napoli, Giuseppe Paolisso
Summary: The study focused on investigating SGLT2 expression in human cardiomyocytes, revealing higher levels in diabetic patients compared to non-diabetic patients.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Multidisciplinary Sciences
Qing Zou, Rong Xu, Xiao Li, Hua-yan Xu, Zhi-gang Yang, Yi-ning Wang, Hai-ming Fan, Ying-kun Guo
Summary: This study found that mitral regurgitation (MR) is common in left ventricular noncompaction (LVNC) patients, and those with MR exhibit more severe morphological and functional changes in their hearts, including deteriorated cardiac function and a higher incidence of arrhythmia. Hypertrabeculation is not a significant factor affecting structure and function at the heart failure stage in LVNC patients.
SCIENTIFIC REPORTS
(2021)
Review
Urology & Nephrology
Patrick B. Mark, Kenneth Mangion, Alastair J. Rankin, Elaine Rutherford, Ninian N. Lang, Mark C. Petrie, Sokratis Stoumpos, Rajan K. Patel
Summary: Chronic kidney disease (CKD) is a risk factor for premature cardiovascular disease and is often accompanied by left ventricular hypertrophy. While there has been significant research on cardiac abnormalities in CKD using echocardiography, there is a need to translate this knowledge into clinical outcomes, particularly for heart failure with preserved ejection fraction (HFpEF). CKD is a risk factor for HFpEF, and recent data suggests that sodium-glucose cotransporter 2 inhibition may offer a new evidence-based therapy for HFpEF. This review focuses on the epidemiology, pathophysiology, diagnosis, and treatment of HFpEF in patients with CKD.
CLINICAL KIDNEY JOURNAL
(2022)
Article
Acoustics
Ying-Yan Qiao, Zhi-Min Hou, Xiao-Mei Li, Hua-Li Guo, Xing-Hua Wang
Summary: This study aimed to investigate the time course changes in left ventricular myocardial deformation using layer-specific strain echocardiography to provide insights into the cardiac pathophysiology of diabetes mellitus. The results showed that endocardial function is more susceptible to being affected by diabetes, and layer-specific strain echocardiography can identify cardiac dysfunction in the early phase of the disease.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Rui Shi, Yi-Ning Jiang, Wen-Lei Qian, Ying-Kun Guo, Yue Gao, Li-Ting Shen, Li Jiang, Xue-Ming Li, Zhi-Gang Yang, Yuan Li
Summary: The study aimed to evaluate the impact of co-occurrence of diabetes mellitus and hypertension on left atrioventricular coupling index and left atrial function. The results showed that individuals with both diabetes and hypertension had poorer left atrial function compared to those with diabetes only, indicating potential alterations in atrioventricular coupling index.
CARDIOVASCULAR DIABETOLOGY
(2023)