Identification of novelPfDHODH inhibitors as antimalarial agents via pharmacophore-based virtual screening followed by molecular docking andin vivoantimalarial activity

Identification of potential Gly/NMDA receptor antagonists by cheminformatics approach: a combination of pharmacophore modelling, virtual screening and molecular docking studies

(2016) V. G. Ugale et al.   SAR AND QSAR IN ENVIRONMENTAL RESEARCH

A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria

(2015) Margaret A. Phillips et al.   Science Translational Medicine

Purine import into malaria parasites as a target for antimalarial drug development

(2014) I. J. Frame et al.   Annals of the New York Academy of Sciences

Fluorine Modulates Species Selectivity in the Triazolopyrimidine Class of Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors

(2014) Xiaoyi Deng et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pharmacophore modeling, virtual screening, docking and in silico ADMET analysis of protein kinase B (PKB β) inhibitors

(2013) Vivek K. Vyas et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

Lead Discovery, Chemistry Optimization, and Biological Evaluation Studies of Novel Biamide Derivatives as CB2 Receptor Inverse Agonists and Osteoclast Inhibitors

(2012) Peng Yang et al.   JOURNAL OF MEDICINAL CHEMISTRY

In silico identification of novel inhibitors against Plasmodium falciparum dihydroorate dehydrogenase

(2012) Abdul Wadood et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

Malarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised target

(2012) Y. Yuthavong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Purine and Pyrimidine Pathways as Targets in Plasmodium falciparum

(2011) Maria Belen Cassera et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Structure-Guided Lead Optimization of Triazolopyrimidine-Ring Substituents Identifies PotentPlasmodium falciparumDihydroorotate Dehydrogenase Inhibitors with Clinical Candidate Potential

(2011) Jose M. Coteron et al.   JOURNAL OF MEDICINAL CHEMISTRY

Recent Developments in the Medicinal Chemistry and Therapeutic Potential of Dihydroorotate Dehydrogenase (DHODH) Inhibitors

(2011) V. K. Vyas et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Optimization of Potent Inhibitors of P. falciparum Dihydroorotate Dehydrogenase for the Treatment of Malaria

(2011) Renato T. Skerlj et al.   ACS Medicinal Chemistry Letters

Discovery of novel inhibitors for DHODH via virtual screening and X-ray crystallographic structures

(2010) Larry R. McLean et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Novel Inhibitors ofPlasmodium falciparumDihydroorotate Dehydrogenase with Anti-malarial Activity in the Mouse Model

(2010) Michael L. Booker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Plasticity of Malaria Dihydroorotate Dehydrogenase Allows Selective Binding of Diverse Chemical Scaffolds

(2009) Xiaoyi Deng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure-Based Design, Synthesis, and Characterization of Inhibitors of Human andPlasmodium falciparumDihydroorotate Dehydrogenases†

(2009) Matthew Davies et al.   JOURNAL OF MEDICINAL CHEMISTRY

Identification of a Metabolically Stable Triazolopyrimidine-Based Dihydroorotate Dehydrogenase Inhibitor with Antimalarial Activity in Mice

(2009) Ramesh Gujjar et al.   JOURNAL OF MEDICINAL CHEMISTRY

Triazolopyrimidine-Based Dihydroorotate Dehydrogenase Inhibitors with Potent and Selective Activity against the Malaria ParasitePlasmodium falciparum

(2008) Margaret A. Phillips et al.   JOURNAL OF MEDICINAL CHEMISTRY