期刊
RUSSIAN CHEMICAL BULLETIN
卷 65, 期 5, 页码 1354-1359出版社
SPRINGER
DOI: 10.1007/s11172-016-1461-5
关键词
tetrahydrocarbazoles; epibromohydrin; 9-oxiranylmethyl-2,3,4,9-tetrahydro-1H-carbazoles; aminoadamantanes; 1-(adamantan-1-ylamino)-3-(1,2,3,4-tetrahydrocarbazol-9-yl)propan-2-ols; radioligand binding; neuronal NMDA receptors; mitochondria; neuro-protection; mitochondrial permeability transition
资金
- Russian Science Foundation [14-23-00160]
A synthetic approach to the design of new multitarget neuroprotectors consisting in combination of the tetrahydrocarbazole and aminoadamantane pharmacophore fragments through a 2-hydroxypropylene spacer upon the reaction of 9-oxiranylmethyl-2,3,4,9-tetrahydro-1H-carbazoles and aminoadamantanes, which affords 1-(adamantan-1-ylamino)-3-(1,2,3,4-tetra-hydrocarbazol-9-yl)-propan-2-ols, is proposed. The effect of the synthesized compounds on the neuronal NMDA receptors and the functional characteristics of rat liver mitochondria was studied.
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