Review
Pediatrics
Zhi-Yan Chen, Shuang-Fa Mao, Ling-Hong Guo, Jian Qin, Li-Xin Yang, Yin Liu
Summary: Maternal pregestational diabetes mellitus poses a high risk of congenital heart diseases in the offspring and causes various phenotypes of congenital heart diseases. Factors such as persistent maternal hyperglycemia, oxidative stress, gene polymorphisms, and viral etiologies are associated with the occurrence of congenital heart diseases in the offspring. Treatment options including blood sugar-reducing, anti-oxidative stress drug supplements, and exercise can help prevent maternal pregestational diabetes mellitus from inducing congenital heart diseases.
WORLD JOURNAL OF PEDIATRICS
(2023)
Article
Pharmacology & Pharmacy
Miaojuan Fan, Tongtong Pan, Wei Jin, Jian Sun, Shujun Zhang, Yali Du, Xinwei Chen, Qiong Chen, Wenxin Xu, Siew Woh Choo, Guanghui Zhu, Yongping Chen, Jie Zhou
Summary: The study revealed elevated expression of FGF4 in GDM patients, with rFGF4 treatment effectively normalizing adverse metabolic phenotypes and reducing neural tube defects in GDM mice. The findings suggest FGF4 as a potential diagnostic factor and therapeutic target for GDM.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Yandi Wu, Tongsheng Huang, Xinghui Li, Conghui Shen, Honglin Ren, Haiping Wang, Teng Wu, Xinlu Fu, Shijie Deng, Ziqi Feng, Shijie Xiong, Hui Li, Saifei Gao, Zhenyu Yang, Fei Gao, Lele Dong, Jianding Cheng, Weibin Cai
Summary: In this study, researchers discovered that there is a disorder in cardiac retinol metabolism in type 2 diabetic male mice and patients, characterized by retinol overload and all-trans retinoic acid deficiency. They demonstrated that both retinol overload and all-trans retinoic acid deficiency promote diabetic cardiomyopathy by supplementing retinol or all-trans retinoic acid to the mice. Through further experiments, they found that the reduction in cardiac retinol dehydrogenase 10 is the initiating factor for the disorder in cardiac retinol metabolism and leads to diabetic cardiomyopathy through lipotoxicity and ferroptosis. Therefore, they suggest that this reduction and disorder is a new mechanism underlying diabetic cardiomyopathy.
NATURE COMMUNICATIONS
(2023)
Article
Cell Biology
Agnieszka Kot, Radoslaw Kaczmarek
Summary: This study identified dysregulated expression of 26 miRNAs in vitreal exosomes of proliferative diabetic retinopathy (PDR) patients, including significant attenuation of the miR-125 family and enhanced miR-21-5p expression. Downregulation of miR-204-5p and upregulation of let-7g were also observed in PDR compared to controls. miR-125 and miR-21 were identified as potential targets for further functional analysis regarding their role in PDR pathogenesis.
Article
Cardiac & Cardiovascular Systems
Xuelian Yuan, Fengchao Liang, Jun Zhu, Keyong Huang, Li Dai, Xiaohong Li, Yanping Wang, Qi Li, Xiangfeng Lu, Jianfeng Huang, Lihui Liao, Yang Liu, Dongfeng Gu, Hanmin Liu, Fangchao Liu
Summary: This study investigated the association between maternal exposure to fine particulate matter (PM2.5) and fetal congenital heart defects (CHDs) in China. The results showed that higher maternal PM2.5 exposure, especially during the preconception period, increased the risk of certain types of CHDs in offspring. The findings highlight the importance of improving air quality in China and other highly polluted regions for CHD prevention.
Article
Cardiac & Cardiovascular Systems
Markus Schwerzmann, Francisco Javier Ruperti-Repilado, Helmut Baumgartner, Berto Bouma, Judith Bouchardy, Werner Budts, Laurence Campens, Massimo Chessa, Maria Jesus del Cerro Marin, Harald Gabriel, Pastora Gallego, Rocio Garcia-Orta, Ana Elvira Gonzalez, Annette Schophuus Jensen, Magalie Ladouceur, Berta Miranda-Barrio, Marielle Morissens, Agnes Pasquet, Joaquin Rueda, Annemien E. van den Bosch, Heleen Berdina van der Zwaan, Daniel Tobler, Matthias Greutmann
Summary: This study aimed to collect clinical outcome data and identify risk factors for a complicated course of COVID-19 in patients with adult congenital heart disease (ACHD). Risk factors such as age, obesity, and multiple comorbidities were associated with an increased risk of a complicated COVID-19 course in ACHD patients. Cyanotic heart disease, including unrepaired cyanotic defects or Eisenmenger syndrome, were identified as particularly high-risk congenital cardiac defects in ACHD patients.
Review
Obstetrics & Gynecology
Catarina Maduro, Luis Ferreira de Castro, Maria Lucia Moleiro, Luis Guedes-Martins
Summary: There is a significant increase in the risk of congenital heart defects in the offspring of diabetic mothers compared with nondiabetic pregnancies. Different types of pregestational diabetes have a stronger capacity to generate cardiac malformations. Research is being conducted to reduce the risks for diabetic pregnancies, but their effectiveness has not yet been fully proven.
REVISTA BRASILEIRA DE GINECOLOGIA E OBSTETRICIA
(2022)
Article
Endocrinology & Metabolism
Agnieszka Bielska, Magdalena Niemira, Witold Bauer, Iwona Sidorkiewicz, Anna Szalkowska, Anna Skwarska, Justyna Raczkowska, Damian Ostrowski, Kamil Gugala, Slawomir Dobrzycki, Adam Kretowski
Summary: The increasing morbidity and mortality of type 2 diabetic mellitus (T2DM) patients with ischemic heart disease (IHD) highlight the urgent need to identify early biomarkers for IHD development in diabetic individuals. This study suggests that circulating serum-derived micro RNAs (miRNAs) may serve as potential biomarkers for early diagnosis of IHD in T2DM patients. Six miRNAs were significantly upregulated in T2DM IHD patients and were associated with multiple signaling pathways. These miRNAs showed high diagnostic value, indicating their potential as biomarkers for early IHD detection in diabetic patients.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Cell Biology
Yuwen Chen, Deyong Xiao, Lu Zhang, Chen-Leng Cai, Bai-Yan Li, Ying Liu
Summary: Tbx20, a member of the T-box gene family, plays crucial roles in cardiovascular development and homeostasis, as well as cardiac remodeling in response to pathophysiological stresses. Mutations and genetic variants in TBX20 are associated with a wide spectrum of congenital heart defects and heart diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Medicine, General & Internal
Damiat Aoulad Fares, Rosalieke E. Wiegel, Alex J. Eggink, Sten P. Willemsen, Joyce B. J. van Meurs, Regine P. M. Steegers-Theunissen
Summary: This study investigated the association between maternal telomere length (TL) during periconception and the risk of congenital cardiac outflow defects (COD) in offspring. The study found that shorter maternal relative TL was associated with an increased risk of ventricular septal defect (VSD) in offspring. However, no association was observed between maternal TL and the risk of overall COD. Further studies are needed to confirm these findings.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Cardiac & Cardiovascular Systems
Danielle S. Burstein, Joseph W. Rossano, Heather Griffis, Xuemei Zhang, Rachel Fowler, Benjamin Frischertz, Yuli Y. Kim, JoAnn Lindenfield, Jeremy A. Mazurek, Jonathan B. Edelson, Jonathan N. Menachem
Summary: Limited contemporary data exist regarding outcomes and resource use among adults with congenital heart disease and heart failure. This study compared outcomes and resource use between adults with congenital heart disease and heart failure (ACHD-HF) and non-ACHD with heart failure (HF-non-ACHD). The study found that ACHD-HF patients have increased emergency department and hospital resource use over the past 10 years, but are less likely to receive advanced heart failure therapies such as ventricular assist device (VAD) or transplant compared with non-ACHD heart failure patients.
Article
Pediatrics
Bryanna N. Schwartz, Lisa A. Hom, Isabelle Von Kohorn, Jeffrey Becker, Sandra S. Cuzzi, Sue Ellin Grier Clarke, Sharon C. Kiernan, Gerard R. Martin
Summary: The study evaluated newborn pulse oximetry screening outcomes at a large community hospital and the impact of the recommended revised screening algorithm. Results showed that pulse oximetry screening is an effective tool for identifying critical congenital heart disease and other conditions.
Article
Biology
Sathiyanarayanan Manivannan, Corrin Mansfield, Xinmin Zhang, Karthik M. Kodigepalli, Uddalak Majumdar, Vidu Garg, Madhumita Basu
Summary: Congenital heart disease (CHD) is a common birth defect linked to genetic variations and environmental exposures. Maternal pregestational diabetes is associated with an increased risk of CHD in offspring, but the causal mechanisms in early embryonic development are poorly understood. This study used a mouse model to uncover the transcriptional responses in developing hearts exposed to maternal hyperglycemia (matHG) and found that matHG affects cardiomyocyte differentiation and the expression of lineage-specific genes, increasing the risk of CHD.
COMMUNICATIONS BIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Karrie F. Downing, Wendy N. Nembhard, Charles E. Rose, Jennifer G. Andrews, Anthony Goudie, Scott E. Klewer, Matthew E. Oster, Sherry L. Farr
Summary: Between 1980 and 1997, 8 out of 10 individuals with congenital heart defects (CHDs) in the US survived until 35 years of age, with survival rates varying based on the severity of CHDs, presence of noncardiac anomalies, birth weight, and maternal race and ethnicity. Among individuals without noncardiac anomalies, those with nonsevere CHDs had similar mortality rates between 1 and 35 years of age as the general population, and those with any CHD had similar mortality rates between 10 and 35 years of age as the general population.
Article
Cardiac & Cardiovascular Systems
Anjali Sadhwani, David Wypij, Valerie Rofeberg, Ali Gholipour, Maggie Mittleman, Julia Rohde, Clemente Velasco-Annis, Johanna Calderon, Kevin G. Friedman, Wayne Tworetzky, P. Ellen Grant, Janet S. Soul, Simon K. Warfield, Jane W. Newburger, Cynthia M. Ortinau, Caitlin K. Rollins
Summary: This study investigated whether fetal brain volume could predict neurodevelopmental outcomes in children with congenital heart disease (CHD). The results showed that fetal brain volume was correlated with cognitive, language, motor scores, and adaptive functioning scores. Fetal brain volume was found to be a strong independent predictor of neurodevelopmental outcomes, suggesting its potential as an important imaging biomarker for future risk assessment in CHD.
Article
Medicine, Research & Experimental
Andrea Fava, Jill Buyon, Chandra Mohan, Ting Zhang, H. Michael Belmont, Peter Izmirly, Robert Clancy, Jose Monroy Trujillo, Derek Fine, Yuji Zhang, Laurence Magder, Deepak A. Rao, Arnon Arazi, Celine C. Berthier, Anne Davidson, Betty Diamond, Nir Hacohen, David Wofsy, William Apruzzese, Soumya Raychaudhuri, Michelle Petri
Article
Biology
Degui Geng, Nicholas Ciavattone, Jackline Joy Lasola, Rojesh Shrestha, Amelia Sanchez, Jitao Guo, Alexandra Vlk, Rania Younis, Lucy Wang, Alex J. Brown, Yuji Zhang, Cruz Velasco-Gonzalez, Aik-Choon Tan, Eduardo Davila
COMMUNICATIONS BIOLOGY
(2020)
Article
Genetics & Heredity
Kathryn Hughes Barry, Kareshma Mohanty, Patricia A. Erickson, Difei Wang, Jianxin Shi, Gary Rose, Ashley Cellini, Kimberly Clark, Nicholas Ambulos, Jing Yin, Liying Yan, Matthew Poulin, Ann Meyer, Yuji Zhang, Soren M. Bentzen, Allen Burke, Arif Hussain, Sonja I. Berndt
Summary: The study found that hypomethylation of the MYC exon 3 in prostate cancer tumors is associated with increased aggressiveness.
Article
Oncology
Dana Ferraris, Rena Lapidus, Phuc Truong, Dominique Bollino, Brandon Carter-Cooper, Michelle Lee, Elizabeth Chang, Maria LaRossa-Garcia, Smaraki Dash, Ronald Gartenhaus, Eun Yong Choi, Olivia Kipe, Vi Lam, Kristopher Mason, Riley Palmer, Elijah Williams, Nicholas Ambulos, Farin Kamangar, Yuji Zhang, Bandish Kapadia, Yin Jing, Ashkan Emadi
Summary: This study aimed to improve the potency and bioavailability of BiQ compounds and investigate their anti-leukemic activity. The results showed that a compound called BaltBiQ demonstrated potent nanomolar anti-leukemic activity in AML cell lines. Although it did not significantly improve survival as a single agent, when combined with the Bcl-2 inhibitor Venetoclax, tumor growth was significantly inhibited.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Jacquelyn C. Serfecz, Afsoon Saadin, Clayton P. Santiago, Yuji Zhang, Soren M. Bentzen, Stefanie N. Vogel, Ricardo A. Feldman
Summary: Gaucher disease is caused by mutations in the GBA1 gene, leading to reduced activity of the lysosomal enzyme GCase and accumulation of glycolipids in tissues. The complement system may promote inflammation in GD, and targeting the C5a-C5aR1 receptor axis could potentially help mitigate chronic inflammatory abnormalities associated with the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Sarah E. Basehore, Samantha Bohlman, Callie Weber, Swathi Swaminathan, Yuji Zhang, Cholsoon Jang, Zoltan Arany, Alisa Morss Clyne
Summary: The study found that steady laminar flow reduces eNOS O-GlcNAcylation by limiting glycolysis and the availability of UDP-GlcNAc, leading to increased eNOS phosphorylation and NO production. This research demonstrates for the first time that O-GlcNAcylation is regulated by mechanical stimuli, which has implications for cardiovascular disease.
CIRCULATION RESEARCH
(2021)
Article
Cell Biology
Xianming Zhang, Hua Jin, Xiaojia Huang, Birendra Chaurasiya, Daoyin Dong, Thomas P. Shanley, You-Yang Zhao
Summary: A newly developed nanoparticle-based delivery system has shown high efficiency in genome editing of vascular endothelial cells. This system can selectively decrease protein expression by 80%, achieving a phenotype similar to genetic knockout mice. Furthermore, it has the capability to edit multiple genes or perform both genome editing and transgene expression simultaneously, making it a powerful tool for gene therapy and cardiovascular research.
Article
Oncology
Aaron J. Sorrin, Cindy Liu, Julia Cicalo, Jocelyn Reader, Daniel Najafali, Yuji Zhang, Dana M. Roque, Huang-Chiao Huang
Summary: The study investigated the combination of photodynamic priming and prostaglandin E receptor 4 inhibition in reducing ovarian cancer cell migration and invasion, showing promising results in attenuating metastatic behavior. The synergistic effects of the combination therapy were found to be mediated by key signaling pathways, providing insights for developing targeted strategies in cancer treatment.
Article
Medicine, Research & Experimental
Haisong Bu, Yonghe Ding, Jiarong Li, Ping Zhu, Yu-Huan Shih, Mingmin Wang, Yuji Zhang, Xueying Lin, Xiaolei Xu
Summary: Research identified vmhcl as a zebrafish homolog of human MYH7, with therapeutic benefits of mTOR or MAPK inhibition on VEC model. These findings were later validated in VAC model, offering a rapid in vivo platform for discovering candidate signaling pathways of MYH7 cardiomyopathy.
Article
Cell Biology
Ariana Joy L. DeCastro, Marina A. Pranda, Kelsey M. Gray, John Merlo-Coyne, Nathaniel Girma, Madelyn Hurwitz, Yuji Zhang, Kimberly M. Stroka
Summary: This study investigates the morphological and migratory phenotypes of TNBC cells that metastasize to bone or brain tissue. The researchers found that bone-seeking cells have distinct protrusive morphology and migrate over a larger area on a collagen I substrate compared to brain-seeking cells. The stiffness and focal adhesion characteristics also differ among the cell types. These findings provide a quantitative profile of mechanobiological phenotypes in TNBC and may have implications for predicting organ-specific metastasis in a clinical setting.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Elizabeth Thomas, Retheesh S. Thankan, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, David J. Weber, Vincent C. O. Njar
Summary: The lead next-generation galeterone analog VNPP433-3 beta has been found to effectively inhibit prostate CSCs in PCa by targeting critical pathways essential to stemness and EMT, potentially degrading the androgen receptor and reducing the transcription of stem cell markers. RNA-seq studies have shown that VNPP433-3 beta inhibits transcription of genes and pathways crucial to prostate CSCs, suggesting a potential therapeutic approach for CRPC.
MOLECULAR CARCINOGENESIS
(2022)
Editorial Material
Genetics & Heredity
Clement A. Adebamowo, Adebowale Adeyemo, Adeyinka Ashaye, Onoja M. Akpa, Tinashe Chikowore, Ananyo Choudhury, Yasmina J. Fakim, Segun Fatumo, Neil Hanchard, Michael Hauser, Braxton Mitchell, Nicola Mulder, Solomon F. Ofori-Acquah, Mayowa Owolabi, Michele Ramsay, Bamidele Tayo, Archana Bhavani VasanthKumar, Yuji Zhang, Sally N. Adebamowo
Summary: The CARDINAL study site is a well-powered resource that aims to develop, refine, and validate methods for researching polygenic risk scores, taking into account local ancestry, to improve risk prediction in diverse populations.
Review
Biology
Andrea L. DiCarlo, David R. Cassatt, Carmen I. Rios, Merriline M. Satyamitra, Yuji Zhang, Trevor G. Golden, Lanyn P. Taliaferro
Summary: The purpose of this mini review is to pay tribute to Dr. John E. Moulder's successful career in radiation science at the Medical College of Wisconsin. It examines his history of research on the biological pathways involved in radiation-induced tissue injuries, particularly to the kidneys and heart, as well as pharmacological interventions. It also highlights his mentorship of junior scientists and collaborations with other researchers.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2023)
Article
Engineering, Electrical & Electronic
Collin T. Inglut, Kelsey M. Gray, Shruti Vig, Jae W. Jung, Jillian Stabile, Yuji Zhang, Kimberly M. Stroka, Huang-Chiao Huang
Summary: Photodynamic priming (PDP) can improve cell junctions in human brain microvascular endothelial cells, enhancing blood brain barrier permeability and offering a new approach for drug delivery.
IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS
(2021)
Meeting Abstract
Cardiac & Cardiovascular Systems
Jingbo Dai, Zhiyu Dai, Mengqi Zhu, Daoyin Dong, Youyang Zhao
Article
Reproductive Biology
Lei Gong, Siyi Jiang, Jia Tian, Yong Li, Wansu Yu, Lubo Zhang, Daliao Xiao
Summary: Exposure to gestational diabetes mellitus during pregnancy can lead to the development of a neonatal brain hypoxia/ischemia-sensitive phenotype. The PTEN/AKT/mTOR/autophagy signaling pathway plays a role in this process.
REPRODUCTIVE TOXICOLOGY
(2024)
Article
Reproductive Biology
Sudipta Dutta, Kirthiram K. Sivakumar, John W. Erwin, Jone A. Stanley, Joe A. Arosh, Robert J. Taylor, Sakhila K. Banu
Summary: This study found that exposure to hexavalent chromium disrupts follicle development and causes apoptosis by altering epigenetic marks in the ovary.
REPRODUCTIVE TOXICOLOGY
(2024)
Article
Reproductive Biology
Yuxin Li, Xianzhi He, Bin Sun, Nannan Hu, Jiamin Li, Ruolan You, Feiyan Tao, Lei Fang, Yuanyuan Li, Qingfeng Zhai
Summary: This study investigated the toxic effects and mechanism of beta-CYP and EMB on the reproductive system of female rats. The results showed that exposure to these pesticides led to changes in hormone and gene expression in the hypothalamic-pituitary-ovarian axis, as well as alterations in oxidative damage indicators. The findings support the evaluation of the adverse effects of pesticide exposure on reproductive health in greenhouse operations.
REPRODUCTIVE TOXICOLOGY
(2024)
Article
Reproductive Biology
Ran Lee, Won-Young Lee, Hyun-Jung Park
Summary: This study investigates the toxicity of diuron on fetal mouse testes and finds that diuron has a negative impact on the development of fetal Leydig cells, while not affecting germ cells and Sertoli cells.
REPRODUCTIVE TOXICOLOGY
(2024)
